Arzoo Pannu

• Doctor of Pharmacy
• Senior Researcher at Delhi Pharmaceutical Science and Research University

Depression is one of the most frequently observed psychological disorders, affecting thoughts, feelings, behavior and a sense of well-being in person. As per the WHO, it is projected to be the primitive cause of various other diseases by 2030. Clinically, depression is treated by various types of synthetic medicines that have several limitations su...

Trachyspermum ammi, commonly known as Ajwain or Carom seeds, is a versatile medicinal plant of the Apiaceae family, widely utilized in traditional medicine systems, including Ayurveda, Unani, and Siddha. This review consolidates the phytochemical composition, traditional applications, and pharmacological activities of T. ammi alongside its potentia...

The dopamine (DA) system is central to mood regulation, motivation, and reward processing, making it a critical focus for understanding Major Depressive Disorder (MDD). While the dopaminergic system's role in MDD pathophysiology has been acknowledged, gaps remain in linking specific receptor subtypes and genetic factors to depression-like phenotype...

Neurodisease, caused by undesired substances, can lead to mental health conditions like depression, anxiety and neurocognitive problems like dementia. These substances can be referred to as contaminants that can cause damage, corruption, and infection or reduce brain functionality. Contaminants, whether conceptual or physical, have the ability to d...

Depression is a serious mental health disorder that impacts more than 350 million individuals globally. While the roles of serotonin and norepinephrine in depression have been extensively studied, the importance of dopaminergic pathways-essential for mood, cognition, motor control, and endocrine function-often gets overlooked. This review focuses o...

Background and Aims: Scutellaria barbata D. Don, a perennial herb with a rich history in traditional medicine, is known for its bioactive compounds, including wogonin. It possesses anti-inflammatory, antioxidant, and anticancer properties. Together with other bi-oactive compounds, wogonin contributes to the pharmacological activities associated wit...

Background and Aim This study aims to investigate the antidepressant properties of Hispidulin, a flavonoid present in Scutellaria barbata D. Don. The selection of Hispidulin stems from its notable inhibitory activity against Xanthine Oxidase (XO), a parameter in the pathophysiology of depression. Material and Methods Mice were subjected to a rigor...

Depression is a widespread mental health challenge, necessitating diverse therapeutic approaches. Emerging research suggests that laughter may offer a valuable adjunctive intervention for individuals grappling with depressive symptoms. This review systematically investigates the multifaceted relationship between laughter and depression, elucidating...

Background The prevalence of cognitive diseases, including Alzheimer’s disease and other forms of dementia, poses a significant global health challenge due to the limited availability of effective therapeutic options. Recent years have witnessed a growing emphasis in research on the exploration of natural compounds and their derivatives as prospect...

Depression, a debilitating mental health disorder affecting millions worldwide, con-tinues to challenge the medical community. While several pharmacological interventions ex-ist, their efficacy and side effects often warrant the exploration of alternative treatments. Natu-ral products derived from plants have gained attention for their potential an...

This review summarizes various polyherbal formulations investigated for antidepres-sant activity in preclinical and clinical studies. Ayurveda, an alternative medical system from India, employs both single herbs and polyherbal formulations to enhance therapeutic efficacy. Evidence suggests that whole herb extracts can be more potent than isolated c...

Abstract: Backgrounds: Alzheimer's disease (AD) impacts a total of 30 million individuals worldwide, resulting in the impairment of brain cells. Despite the approval of medications, there are still poor results and adverse effects that continue to exist, which has led to continued research for more effective treatments. Objectives: In this study pr...

Background Hispidulin, a flavonoid renowned for its diverse pharmacological activities, is abundant in S. barbata D. Don. Given its prevalence, it is essential to establish a dependable analytical method for quantifying hispidulin in this plant. Methods This study introduces a sensitive and reliable high-performance thin-layer chromatographic (HPT...

Depression, a pervasive and disabling mental health disorder, presents a global healthcare challenge. Despite persistent research on its etiology and pathophysiology, many aspects remain unclear. Predominant neurobiological research and traditional pharmacotherapies have pointed out the monoamine hypothesis as a pivotal factor in the pathophysiolog...

With an ageing global population, understanding the potential links between mental health and neurodegenerative disorders has become increasingly crucial for comprehensive patient care. A comprehensive search of electronic databases yielded a selection of studies encompassing clinical trials, longitudinal cohorts, and cross-sectional analyses, publ...

The emergence of PROTACs as a transformative class of therapeutic agents has prompted an intense investigation into their potential role in breast cancer. This chapter consolidates current knowledge on the application of PROTACs in breast cancer treatment. The primary objective is to elucidate the mechanisms by which PROTACs operate, emphasizing th...

Background Wogonin, a bioactive compound isolated from S. barbata D. Don, has been identified in the literature as a potential inhibitor of monoamine oxidase (MAO), a key enzyme involved in the degradation of neurotransmitters associated with mood regulation. This study aims to investigate the antidepressant-like activity of wogonin in vivo, utiliz...

Background S. barbata D. Don, a perennial herb from the Lamiaceae family, is renowned for its medicinal properties, with scutellarin and scutellarein being key bioactive constituents. Aim In this study, we present the development and validation of a High-Performance Thin- Layer Chromatography (HPTLC) method for the simultaneous quantitative and qu...

Background S. barbata D. Don is a Chinese herb, that belongs to the family Lami-aceae. It has established traditional use in ethnomedicine for treating various ailments, includ-ing mood disorders and sleep disorders, which led to growing interest in exploring its neuro-logical potential, particularly as a potential anti-depressant agent. Aims This...

p> Aim: This systematic review critically evaluates the efficacy of bibliotherapy in addressing mental health concerns across various populations and intervention modalities. Methods: A comprehensive bibliographic search was conducted, identifying 20 articles from databases PubMed, Scopus, and Google Scholar, representing studies published in Eng...

Gastrointestinal parasites have become the most common reason for infection in humans, affecting many people in the world. Helminthic infections pose a large threat to public health in developing countries. The most common parasites of helminths in humans are whipworms(Trichuristrichiura), roundworms(Ascarislumbricoides), tapeworms(Taenia solium),...

Diabetes mellitus, an epidemic of the 21st century, is listed as one of the top ten causes of death around the world by the World Health Organization and is a complicated disease to deal with. Medically, a metabolic disorder characterized by elevated blood glucose levels and altered metabolism of biological macromolecules, mainly carbohydrates. Dia...

Depression, a pervasive mental health disorder, affects millions worldwide, necessitating the widespread use of synthetic anti-depressant medications. While these pharmaceutical interventions have demonstrated efficacy in alleviating depressive symptoms, they are not without their associated side effects. This review provides a comprehensive overvi...

Cancer is a lethal disease and is one of the leading causes of morbidity worldwide. Chemotherapy is successful to combat cancer but medical applicability of many chemotherapeutic agents is limited by the non-specific targeting of malignant cells, leading to unwanted side effects. Nanoparticles (NPs) are well-established nano-carriers that can prote...

The "serotonin hypothesis of depression" is approximately fifty years old, and in spite of vast literature, the exact role of serotonin in depression pathophysiology is still unclear, as whether a lower serotonin level causes depression or depression causes a reduction in serotonin level has become a tough challenge for researchers to understand th...

Objective:In the present study, hydroethanolic extract of aerial part of S. barbatawas investigated for acute oral toxicity in female mice as per OECD guidelines. Material and methods:Ten mice were divided into 2 groups (n=5) i.e. control and test. Control group received normal water and the test group received a single dose of 2000 mg/kg per oral...

Curcumin is a natural yellow pigmented phytoconstituent isolated from the powdered rhizome of Curcuma longa linn belongs to family Zinzieberacea. Curcuma longa linn is commonly known as turmeric (Haldi), a well-known Indian spice used as a traditional medicine from ancient era. In literature, there are different analytical methods for detection of...

Transdermal drug delivery systems (TDDS) are used to deliver the drug(s) or the therapeutically active substances through topical route primarily through skin. Relatively very small numbers of drugs are administered transdermally because in many cases the physical properties of drugs, including polarity and molecular size, have limited its capacity...

Background: Malathion, an organophosphate compound has been proved to play a major role in tissue damage by inducing oxidative stress via generation of free radical. Aim:In this study, we examined the consequence of exposure to organophosphate compound malathion of commercial grade and evaluated the protective effect of ellagic acid, vitamin c pres...

Terminalia chebulais a medicinal plant widely distributed throughout India, Burma and Srilanka. It is called as black Myrobalan, ink tree or chebulinic myrobalan; belonging to the Combretaceae family. T.chebulais the ‘king of medicine’ in Tibet and it has been extensively used in Ayurveda, Unani and Homeopathic system of medicine. T.chebulahas been...

The easy, rapid, accurate, and specific demonstrating UV spectroscopic process for validation of Dopamine in pure bulk and nanoformulation has been developed. Dopamine works as a precursor in a biosynthetic pathway of epinephrine and nor-epinephrine. Mainly it is a neurotransmitter in the central nervous systems and peripheral nervous systems to co...

Objective: In this study, evaluation of physicochemical, phytochemical parameters, and antioxidant activity of S. barbata was done to ensure the quality of plant material and analysis of the phytoconstituents qualitatively as well as quantitatively responsible for its pharmacological values. Material and methods: The physicochemical parameters such...

A. sieversiana is an annual or biennial herb belonging to family Asteraceae and is found in different countries like Korea, Northern Pakistan, Nepal, India (ladakh and Jammu & Kashmir), North and South Africa, Europe, Afghanistan, Tajikistan (Central Asia) and China. It is traditionally used to treat diarrhea, cold, detumescence, maintaining hemost...

Lipids are used as vehicles for the preparation of various formulations prescribed for administrations, including emulsions, ointments, suspension, tablets, and suppositories. The first parental nano-emulsion was discovered from the 1950s when it was added to the intravenous administration of lipid and lipid-soluble substances. Lipid-based drug del...

Fennel (Foeniculum vulgare) is flowering plant species in the carrot family of Apiacae. It is a small, erect and aromatic herb full of volatile compounds, flavonoids, phenolic compounds, fatty acids, and amino acids. Fennel contains volatile compounds, flavonoids, phenolic compounds, fatty acids, and amino acids. There is no documented report on ut...

Anxiety is a state of psychological, physiological, and behavioral distress which interferes with normal life. Disorganised lifestyles, hectic schedules, social and occupational impairment make lives more prone to these mental problems. Among all these mental disorders anxiety disorder is the most prevalent one affecting approximately 10- 30% of th...

Nature is full of numerous supernatural fragrances, which have their own magic and are pleasant to our senses. Fennel is one of them, generally known as Saunf (Foeniculum vulgare) belonging to Apiacae family. India is the greatest manufacturer of fennel in the world. Fennel is mainly cultivated in Gujarat, Rajasthan and Uttar Pradesh. Fennel contai...

Malaria has long been recognized as a crucial as well life- threatening parasitic disease of humans caused by parasites transmitted to human by bite of female anopheles mosquitoes. There are about 3-500 million clinical cases of per year and 1.5-2.7 million deaths annually worldwide just because of malaria. The parasite passes through several stage...

Objective: The present study aim to investigate the anti-obsessive compulsive disorder potential of honey in mice.Methods: The honey was given orally in two concentrations of 17.5 ml/kg and 35 ml/kg to mice for 21 days. The anti-obsessive compulsive activity was assessed on 21th day by in-vitro methods viz flickering-light induced obsessive- compul...

Obsessive compulsive disorder (OCD) is a disabling psychiatric condition. Obsessions are defined as recurrent, persistent, thoughts, images or impulses that are experienced as intrusive & inappropriate. Compulsions are repetitive behaviours or mental acts that the person feels driven to perform in response to an obsession. There are only potent sel...

Objective: The present study aim to investigate the anti-psychotic potential of pyrus communis in the rodents.Methods: The fresh juice of pyrus communis (Pear) was administered orally to rodents for 21 d and the anti-psychotic activity was assessed by in vitro methods viz ketamine induced stereotypic behaviour, pole climbing avoidance in rats and s...

Foeniculum vulgare (Fennel), generally known as Saunf belonging to Apiacae family is one of the most popular and widely used medicinal plants in traditional medicine. Fennel contains volatile compounds, flavonoids, phenolic compounds, fatty acids, and amino acids. There is no documented report on utility of Fennel in psychiatric disorders in litera...

Honey, a natural sweetener derived from insects is not only a sweetener but it’s a unique gift from nature to mankind. Honey has been used since ancient times to fulfil medical and domestic needs. It contains proteins, enzymes, amino acids (glycine etc), minerals, vitamins, aromatic compounds and polyphenols, which contribute to its magical therape...