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Publications (168)
Microgravity is a state of free fall which one experiences in space. Human-crewed missions are becoming more sophisticated in the ongoing times. The altered gravitational conditions exert several physiological changes in the astronauts. Among many, one of the significantly affected systems and least discussed so far is the neurological system. Earl...
Bio-minerals are one of the secondary plant metabolites that are imperative for their existence. Raphides or calcium oxalate (CaC2O4) crystals are the
most abundantly synthesized bio-minerals in plants. Direct bio-autography followed by agar well diffusion assay reveals the in-vitro antimicrobial property of the crystals against fish pathogen Citro...
Every year, insect pest infestation causes the destruction of one-fifth of total crop production worldwide. Conventional methods of insect control not only contaminate the environment but also affect the economy of the agricultural sector, as most of the insecticides applied are lost in the environment. The application of the baculovirus biopestici...
A strong enhancement of electromagnetic field generated through resonating surface polaritons on metal films and particles has stimulated considerable interest in diverse research fields such as photobiology as, for example, in photosynthesis. This surface plasmon resonance (SPR) of metal nanoparticles (NPs) can augment photosynthetic chemical ener...
The present study was aimed to evaluate the impact of nanohexaconazole, a highly effective fungicide, on the target enzyme and genetic variation caused by it. To compare the degree of inhibition
of ergosterol biosynthesis in Rhizoctonia solani caused by nanohexaconazole (NH) and commercial
hexaconazole (CH), a UHPLC method was developed to estimate...
Nanohexaconazole is a highly efficient fungicide against Rhizoctonia solani. Nanoparticles are alleged to adversely affect the non-target organisms. In order to evaluate such concern, the present study was carried out to investigate the effect of nanohexaconazole and its commercial formulation on sensitive nitrogen fixing blue green algae (BGA) and...
We investigate how the evolutionary network is associated among Human, Chimpanzee and Mouse with regards to their genomic information. We provide a quantitative description of genomic evolution through indexes based on fractals and mathematical morphology. These indexes are carefully chosen and reveal quantitatively the similarity or differences am...
Copper deficiency or toxicity in agricultural soil circumscribes plant's growth and physiology hampering photochemical and biochemical network within the system. So far copper sulfate (CS) has been used widely despite its toxic effect. To get around this long-standing problem copper nanoparticles (CuNP) have been synthesized, characterized and test...
The study was aimed to develop a nano form of an existing fungicide for improving plant protection and reducing crop losses caused by fungal pathogens. The protocol for the preparation and estimation of nanohexaconazole was developed. Technically pure hexaconazole was converted into
its nanoform using polyethyleneglycol-400 (PEG) as the surface sta...
The antifungal effects of orthorhombic (~10 nm; spherical) and monoclinic
(~50 nm; tetrapod) sulfur nanoparticles (SNPs) were studied against the
NADPH-dependent glutathione reductase (GR) mediated xenobiotic detoxification
system (GSH-GSSG) in filamentous fungi (Aspergillus niger as a model organism).
Both the SNPs induced significant reduction in...
Zinc oxide nanoparticle (ZNP) has been synthesized by microwave-assisted technique with the aid of a buffer solution. ZNP inhibited the growth of bacterial system Escherichia coli, even its multidrug-resistant counterpart as well. Systematic evaluation reveals that bioavailable crystalline ZNP damages the lipopolysaccha-ride layer from outer membra...
Elemental sulfur (S
0
), man’s oldest eco-friendly fungicide for curing fungal infections
in plants and animals, is registered in India as a non-systemic and contact fungicide. However
due to its high volume requirement, Indian agrochemical industry and farmers could not
effectively use this product till date. We hypothesize that intelligent nanosc...
A simple modification of the Rosenzweig-MacArthur predator (zooplankton)-prey (phytoplankton) model with the interference of the predators by adding the effect of nanoparticles is proposed and analyzed. It is assumed that the effect of these particles has a potential to reduce the maximum physiological per-capita growth rate of the prey. The dynami...
Mung bean plants were grown under controlled condition and supplemented with macro- and micro-nutrients. The objective of this study was to determine the response of manganese nanoparticles (MnNP) in nitrate uptake, assimilation and metabolism compared with commercially used manganese salt, manganese sulfate (MS). MnNP was modulated to affect the a...
A GdIII-based porous metal–organic framework (MOF), Gd-pDBI, has been synthesized using fluorescent linker pDBI (pDBI=(1,4-bis(5-carboxy-1H-benzimidazole-2-yl)benzene)), resulting in a three-dimensional interpenetrated structure with a one-dimensional open channel (1.9×1.2 nm) filled with hydrogen-bonded water assemblies. Gd-pDBI exhibits high ther...
Toxicological properties of orthorhombic (~10 nm) and monoclinic (~50 nm) allotropes of sulfur nanoparticles (SNPs) of antimicrobial importance have been evaluated against mice (Mus musculus) model. The present study investigates possible bio-adverse properties of SNP-allotropes on hematological (haemoglobin, total count, differential count), bioch...
Gradual development of antibiotic resistant bacteria is producing severe global threat. Newer strategies are now being employed in order to control the microbial infections and to reduce the mortality as well as infection rates. Herein we describe successful synthesis of ZnO nanoparticles (ZNP) under microwave assisted condition followed by functio...
A biocompatible amine functionalized fluorescent carbon dots were developed and isolated for gram scale applications. Such carbogenic quantum dots can strongly conjugate over the surface of the chloroplast and due to that strong interaction the former can easily transfer electrons towards the latter by assistance of absorbed light or photons. An ex...
As per conservative estimate, approximately 51-105 Olfactory Receptors (ORs) loci are present in human genome occurring in clusters. These clusters are apparently unevenly spread as mosaics over 21 pairs of human chromosomes. Olfactory Receptor (OR) gene families which are thought to have expanded for the need to provide recognition capability for...
Nanotechnology research and development is directed towards the understanding and control of matter at dimension of roughly 1–100 nm. At this size, the physical, chemical, and biological properties of materials differ in fundamental and potentially useful ways from the properties of individual’s atoms and molecules. Its applications advanced very q...
Manganese (Mn) is an essential element for plants which intervenes mainly in photosynthesis. In this study we establish that manganese nanoparticles (MnNP) work as a better micronutrient than commercially available manganese salt, MnSO4 (MS) at recommended doses on leguminous plant mung bean (Vigna radiata) under laboratory condition. At higher dos...
A comprehensive pharmacokinetic profiling of novel drugs and therapeutics is a definite prerequisite of drug discovery and development. The present study expedites the in vivo and in vitro pharmacokinetic properties of colloidal sulfur nanoparticles (SNPs). In vitro dissolution properties of SNPs have been demonstrated and compared with the in vivo...
This is a report of an experimental study on a nanoencapsulation of the organophosphate acephate. Acephate was encapsulated in polyethylene glycol, using a simple, easy-to-replicate method that required no special equipment or conditions. The nanoencapsulation (nanoacephate) was characterized and its bioefficacy as compared to the regular commercia...
A facile route has been developed to synthesise and isolate sulphur doped fluorescent carbon dots for the first time. Such carbogenic quantum dots exhibit a wide band gap of 4.43 eV with a high open circuit voltage (VOC) of 617 mV along with a fill factor (FF) as high as 37%, using phenyl-C60-butyric acid methyl ester (PCBM) as the electron transpo...
Grasserie, a polyorganotrophic disease caused by Bombyx mori nucleopolyhedrovirus (BmNPV), accounts for lethal infection to fifth instar silkworm larvae. It was found that nanoparticle (NP)-induced morphological transformation of BmNPV polyhedra could reduce the infectivity of BmNPV both in cell line and in silkworm larvae. Initially, 11 NPs were s...
Nanosized elemental sulfur (ES) is already reported to exert superior antimicrobial efficacy than micron-sized ES, which encourages their use in drugs and therapeutics. The aim of the present study is to explore the possible route and mode of antimicrobial action of orthorhombic (α-SNPs) and monoclinic (β-SNPs) allotropes of sulfur, respectively, a...
Stable nanocolloids of monoclinic sulfur
(b-SNPs) were prepared through ‘water-in-oil microemulsion
technique’ at room temperature after suitable
modifications of the surface. The morphology
(rod shaped; *50 nm in diameter) and allotropic
nature (monoclinic) of the SNPs were investigated
with Transmission Electron Microscopy and X-ray
Diffraction t...
The pre-treatment of Tas-A-Ganesh bunches affected the quality parameters of raisins when bunches were dried under raisin sheds. Various combinations of ethyl oleate and potassium carbonate affected the moisture content and other quality parameters of raisins. The dynamics of changes in content of moisture and colour intensity was also affected by...
Morphological changes in the polyhedra of the Bombyx mori L. nuclear poly-hedrosis virus (BmNPV), a baculovirus causing the deadly grasserie disease in silkworms, brought about by mixing with lipophilically capped amorphous silica nanoparticles (LASN, average size 10 ± 2 nm) were studied with scanning electron microscopy (SEM) and Fourier transform...
Highly fluorescent, self passivated carbon quantum dots (CQDs) have been synthesized using PEG-200 at room temperature for the first time followed by solvothermal modification to increase the quantum yield of these nano carbons. At elevated temperature and pressure good surface passivation has been observed. No sophisticated instrument nor passivat...
Phytotoxic and agro beneficial properties of antimicrobially efficient Sulfur nanoparticles (SNPs) and ZnO nanoparticles (ZNPs) were evaluated on Mung (Vigna
radiata). Mung seeds were germinated with an increasing concentration gradient of nanoparticles. The extent of phtotoxicity were assessed depending upon the effect of used nanoparticles on phy...
New nano-sulphur synthesized at IARI and three other commercial products namely commercial sulphur (Merck), commercial nano-sulphur (M K Impex, Canada) and Sulphur 80 WP (Corel Insecticide) were evaluated in vitro for fungicidal efficacy at 1000 ppm against Erysiphe cichoracearum of okra. All the sulphur fungicides significantly reduced the germina...
Chloroform–methanol plant lipid extracts of 19 Indian medicinal plants from 15 plant families were screened for feeding deterrence, contact toxicity and fumigant toxicity properties on grain weevil Sitophilus oryzae L. (Coleoptera: Curculionidae). Fifteen Indian medicinal plant derived lipids showed weak to strong antifeedant activities against S....
Here we describe a simple, novel method of zinc oxide nanoparticles (ZNPs) synthesis and their physicochemical characterizations. Dose dependent antifungal effect of ZNPs, compared with micronized zinc oxide (MZnO), was studied on two pathogenic fungi Aspergillus niger and Fusarium oxysporum. Superoxide dismutase (SOD) activity, ascorbate peroxidas...
Fluorescent hydrophobic carbon dots (HCDs) have been fabricated from a poloxamer by a simple microwave assisted process within a few minutes for the first time. Small and distinct spherical HCDs emitted bright blue and green fluorescent light depending upon the excitation wavelength and were dispersed easily in a wide variety of organic solvents. H...
Cancer cell specific targeted delivery (TDD) by porous nanocarrier is on a high role. Here in a simple route for the synthesis of porous ZnO nanorods (ZnO) has been demonstrated. ZnO expressed very high surface area of 305.14 m2 g−1 (SBET) and uniformly distributed pores of 5 nm. In continuation ZnO has been fabricated with 3-aminophosphonic acid f...
Versatile use of zinc oxide nanoparticles (ZNPs) in semiconductors, optical device and solar cells has already been established. Herein we describe synthesis of surface-functionalized ZNP to highly water dispersible constituent and its antibacterial efficiency against clinically isolated bacterial system. ZNP was synthesized by single-step microwav...
Antimicrobial resistance continues to be an inexorable threat for the biomedical and biochemical researchers. Despite the novel discoveries in drug designing and delivery, high-throughput screening and surveillance data render the prospects for new antimicrobial agents as bleak as ever. The advent of nanotechnology, however, strengthens pharmacolog...
The molecular nanotechnology is the concept of functional mechanical system at the molecular scale, i.e., machines at the molecular scale, designed and built atom by atom. This idea along with self recognition (self assembly) can be used in the development of intelligent nanoparticles (NPs). In this paper we present a mathematical formalism of forc...
Nowadays gold nanoparticle (GNP) is increasingly being used in drug delivery and diagnostics. Here we have reported a comparative analysis of detailed stability and toxicity (in vitro and in vivo) profile of three water soluble spherical GNPs, having nearly similar size, but the surfaces of which were modified with three different capping materials...
In deciphering the DNA structures, evolutions and functions, Cellular Automata (CA) plays a significant role. DNA can be thought as a one-dimensional multi-state CA, more precisely four states of CA namely A, T, C, and G which can be taken as numerals 0, 1, 2 and 3. Earlier, Sirakoulis et al. (2003) reported the DNA structure, evolution and functio...
Relatively little is known regarding the interaction of nanoscale objects with dynamic complex biological systems. Microarray-based toxicogenomics studies may serve as a suitable technique to explore the genome wide effects of nanoparticles on any organism through a single experiment. The influence of nanoporous aluminosilicate nanoparticles (NP),...
Pest management researchers currently reappraise the use of inert dust-based insecticides because of the growing problem of environmental pollution and increasing insect resistance associated with conventional insecticides. Diatomaceous earth, which is amorphous micron-sized silica derived from fossilized phytoplankton, has become popular as an alt...
Though, silica nanoparticle (SNP) synthesized by sol–gel method is being used in various fields for the last two decades, its application in agro-veterinary sector is very limited. The potential of surface functionalized SNP as a novel nanocide was investigated for its prospective use in agrochemical industry. Spherical, monosidperse SNP was synthe...
Sleeping sickness (causal agent, Trypanosoma sp. parasite) causes huge morbidity and mortality in Africa (both human and livestock) in particular and zoo animals worldwide. Three of the four currently approved drugs (Pentamidine, Melarsoprol, Eflornithine, and Nifurtimox) were developed over 50 years ago. Current therapies are unsatisfactory due to...
Orthorhombic (spherical; ~10 nm) and monoclinic (cylindrical; ~50 nm) sulfur nanoparticles (SNPs) were synthesized and examined for their effects on the total lipid content and desaturase enzymes of Aspergillus niger. Synthesized SNPs were characterized for size with transmission electron microscopy, elemental composition with energy dispersive X-r...
Colloidal stability and coagulation kinetics of orthorhombic and monoclinic sulphur nanoparticles (SNPs) were determined in terms of their size distribution along a gradient of temperature, dilution and time-drive. Dynamic light scattering (DLS) was used to determine the size and shape of SNPs in the colloidal suspension. A simultaneous study with...
A simple microwave assisted route has been formulated to synthesise various surface functionalized carbogenic quantum dots from biodegradable polysaccharides. The photoluminescence (PL) properties of such surface functional carbon quantum dots (CQDs) have been tuned by the in situ addition of high boiling organic solvents during the synthesis of CQ...
Agriculture and livestock industries constitute the backbone of Indian economy. Nanobiotechnology is expected to make a seminal contribution in these areas in coming years. Two major constraints in these areas of research are as follows-(a) interventions should be low cost, preferably cheaper than the currently used products or technologies, so tha...
To elucidate the antibacterial efficacy of chemically synthesized and custom-made sulphur nanoparticles (SNPs) of two different sizes and surface modifications against a number of multidrug-resistant Gram-negative bacilli (GNB) harbouring the New Delhi metallo-β-lactamase 1 enzyme (NDM-1).
Antimicrobial susceptibility of the isolates was determined...
Acephate is the most widely used organophosphorous insecticide in Indian subcontinent. In order to prepare ecofriendly and hydrophilic formulation of acephate, nanotechnology-based research is necessary. Here, we report a novel method of preparation and subsequent characterisation of the acephate nano-encapsulation complex. Nanoparticles of the enc...
A laboratory study was undertaken to assess the antifungal property of the nano ZnO against a food borne pathogen Aspergillus fumigatus. In this study nano ZnO was synthesized from zinc nitrate solution using sodium hydroxide. Synthesized nano ZnO was characterized by DLS, SEM, TEM and EDAX analysis. Nano ZnO was used for antifungal assay against A...
A facile one step route has been developed for the synthesis of highly fluorescent matrix embedded carbonquantum dots (MCQDs) by the assistance of microwave irradiation. The material shows a homogeneous distribution of carbonquantum dots throughout the surfaces of the carbon matrices with an average size of 1 to 3 nm. The synthetic MCQDs can be emp...
The behavior and pattern of NPs of minerals in the evolutionary history of the earth vis – a –vis the environmental context are inquired into, with a riverine system as a model. The study of fractal dimensions of NPs of interest serves as an aid to obtain a comprehensive view of natural NPs in the model system. The present study combines inputs fro...
In recent years, pest management scientists are reappraising the use of inert dusts as alternative insecticides because of several growing problem of the conventional insecticides like cumulative environmental pollution, increasing insect resistance to them etc. The naturally occurring amorphous micron sized silica (Diatomaceous Earth), derived fro...
The behavior and pattern of NPs of minerals in the evolutionary history of the earth vis – a –vis the environmental context are inquired into, with a riverine system as a model. The study of fractal dimensions of NPs of interest serves as an aid to obtain a comprehensive view of natural NPs in the model system. The present study combines inputs fro...
10 The behavior and pattern of NPs of minerals in the evolutionary history of the earth 11 visa -vis the environmental context are inquired into, with a riverine system as a 12 model. The study of fractal dimensions of NPs of interest serves as an aid to obtain a 13 comprehensive view of natural NPs in the model system. The present study combines 1...
This article presents the development of nanoparticles (NPs) with potentially useful size and shape dependent properties that
have the advantage of ultra-fine size, high surface area and useful interfacial imperfections. When developing NPs as catalysts,
their shape is very important. For a certain volume of material, nanoparticles make the best ca...
A novel route has been developed to fabricate different carbon nanostructures having individual morphology of carbon nanoparticles: nanofullerene, nanocube, nanoleaf and porous nanorods, through the combustion of carbon xerogel with nitric acid. These fabricated nanostructures exhibited bright green fluorescence under the exposure of UV light.
MicroRNAs (miRNAs) which are on average only 21-25 nucleotides long are key post-transcriptional regulators of gene expression in metazoans and plants. A proper quantitative understanding of miRNAs is required to comprehend their structures, functions, evolutions etc. In this paper, the nucleotide strings of miRNAs of three organisms namely Homo sa...
Fumigants and residual insecticides are commonly used to combat stored grain pests. In recent years, consumer awareness of
the health hazard from residual toxicity and the growing problem of insect resistance to these conventional insecticides have
led the researchers to look for alternative strategies for stored grains protection. For example, dia...
In deciphering the DNA structures, evolutions and functions, Cellular Automata (CA) do have a significant role. DNA can be thought of as a one-dimensional multi-state CA, more precisely four states of CA namely A, T, C, and G which can be taken as numerals 0, 1, 2 and 3. Earlier, G.Ch. Sirakoulis et al reported the DNA structure, evolution and func...
Fractals and Mathematical Morphology are immensely used to study many problems in different branches of science and technology including the domain of Biology. There are many more unrevealed facts and figures of genes and genome in Computational Biology. In this paper, our objective is to explore how the evolutionary network is associated among Hum...