Arumugam Suresh

Meenakshi Medical College Hospital and Research Institute · Central Research Laboratory

Propolis is a natural compound collected by honeybees from different parts of plants. Honeybees produce a sticky component besides honey by mixing the tree resin and other botanical sources with saliva called propolis or bee glue. Propolis was traditionally used as a wound healing substance, cosmetic, medicine, and many other conditions. Till now,...

Abstract Marine wastes pose a great threat to the ecosystem leading to severe environmental hazards and health issues particularly the shellfish wastes. The shellfish waste which contains half of the amount of chitin can be efficiently transformed into useful products. Various approaches for the hydrolysis of chitin like physical, chemical, and enz...

Background. The direct or indirect effect of chemicals on the nervous system of humans or animals is referred to as neurotoxicity. Trimethyltin chloride (TMT) intoxication causes behavioral and cognitive deficiencies in humans and experimental animals. TMT has long been used as a model toxicant in the study of central nervous system (CNS) toxicity....

Planum sphenoidale meningiomas are rare slow growing tumours that impair cognition and lead to behavioural changes. Other common presentations of this condition include persistent headache followed by vision diminution. Dismissing cognitive impairment and behavioural changes as part of dementia, depression or aging might lead to loss of opportunity...

The initial cases of severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) occurred in Wuhan, China, in December 2019 and swept the world by 23 June 2020 with 8,993,659 active cases, 469,587 deaths across 216 countries, areas or territories. This strongly implies global transmission occurred before the lockdown of China. However, the initial...

Background The initial cases of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) occurred in Wuhan, China, in December 2019 and swept the world by 13 May 2020 with 4,179,479 active cases, 287,525 deaths across 215 countries, areas or territories. This strongly implies global transmission occurred before the lockdown of China. However, t...

Klebsiella pneumoniae that is resistant to carbapenem antibiotic has emerged as the fourth common cause of pneumonia in intensive care units. There is a dire need for unique antibiotics since the treatment options for Carbapenem resistant - Klebsiella pneumoniae (CR-KP) are very limited. Ninety eight marine actinobacterial strains were screened for...

Several antiviral compounds for HBV have been identified from traditionally used medicinal plants. We have earlier described the immune modulation properties of P. pinnata, a traditionally used Indian medicinal plant. Therefore, it is of interest to explore the anti-Hepatitis B virus activity of P. pinnata extracts by in-vitro screening assays. Thi...

HIV remains a challenging life threatening viral agent for humans despite available anti HIV drugs. The known effective drug named HAART clears the circulating viruses but not the intracellular viruses. Therefore, it is of interest to identify molecules with improved anti-HIV activity from natural plant sources. Hence, we studied the anti-HIV poten...

To study the involvement of compounds stigmasterol and oleic acid isolated from marine sponge Aurora globostellata and docking against the Human Epidermal Growth Factor Receptor-2 in breast cancer. The comparative molecular docking was performed with the natural compounds from marine sponge and the synthetic drugs used in breast cancer treatment ag...

The development of shrimp aquaculture has been severely affected by viral diseases resulting in a huge economic burden to the industry. White spot disease (WSD) has caused severe mortality in farmed shrimp in many countries. Globally aquaculture industries face huge economic losses due to rapid spread of White Spot Syndrome Virus (WSSV) disease tha...

The present study reports the characterization and antimicrobial potential of actinobacterial strain TFA1 isolated from Thalakona forest soil, Andhra Pradesh. Phenotypic, cell wall and molecular characteristics of strain TFA1 was studied by adopting standard procedures. Strain TFA1 produced powdery colonies on ISP2 agar medium with aerial and subst...

Introduction: Typhoid fever is endemic in India and other developing countries, causing major public health problems with high morbidity and mortality. The resistance of Salmonella enterica serovar Typhi (S. Typhi) towards commonly prescribed antimicrobials is increasing in developing countries. However, there have been several reports of the thera...

Purpose:To evaluate the wound healing activity of ethyl acetate fraction of Barleria noctiflora against the STZ induced diabetic rats. Approach: The ethyl acetate fraction of Barleria noctiflora (EAFBN) was evaluated for its wound healing activity in Streptozotocin induced diabetic rats using excision and incision wound models. In case of excision...

The aim of the investigation is to achieve molecular characterization of the medicinal plant Citrullus colocynthis through short orthologous DNA marker. The molecular characterization of Citrullus colocynthis is performed by following standard protocols for DNA barcoding specific to Angiogerms based on trnH-psbA intergenic spacer region. The method...

Lymphatic Filariasis is one of the most neglected tropical diseases caused by Brugia malayi. The existing classical drugs act mostly on the larval stages of the parasite. The target Asparaginyl tRNA synthetase is an excellent molecular target due to its pivotal role in protein synthesis. Literature based evidence provided clue to explore the phyto-...

Objective: surgical and non surgical wound infections in diabetics is the major problem faced by the physicians due to poor healing and occasionally leads to life threatening complications if not treated with proper antibiotics. In recent years the frequent and multiple use of antibiotics for the treatment of these infections leads to the developme...

Sea Buckthorn (SBT) is distributed in the plains of India. The plant parts are used traditionally for several ailments. Medicinally, it has been proven to possess various pharmacological activities such as antioxidant, antimicrobial, antifungal, metabolic disorders, immunostimulatory activity, hepatoprotectant and anticancer activity. Several studi...

Diabetic Foot ulcer (DFU) is an infection, ulcer or destruction of deep tissue, associated with neurological abnormalities and various degrees of peripheral vascular disease of lower limb, collectively known as the diabetic foot syndrome. Foot ulceration and amputation are economically most expensive diabetic complications. Diabetic foot infection...

Diabetic foot infection (DFI) is poly-microbial in nature, pathogenic microorganism such as Pseudomonas spp., Enterococcus spp. and Proteus spp. are mainly responsible for continuing and extensive tissue destruction with the poor blood circulation of the foot. The present study was aimed to characterize the ESBL and MBL producing non-fermentative a...

Objective: Enteric fever is an endemic disease, causing major public health problems with high morbidity and mortality in India and other developing countries. The present study to investigate the prevalence of antimicrobial resistance and detection of mutation Methods: Detection fluroquinolone resistance and detection of gyrAgenemutation by PCR-RF...

ABSTRACT The present study was undertaken to detect the two genes, namely, Salmonella enterotoxin (stn) and plasmid encoded fimbrial (pef) genes, among clinical isolates of three Salmonella species from humans. A total of 176 isolate belonging to Salmonella enterica serovar Typhi (133), Salmonella enterica serovar paratyphi A (41) and Salmonella en...

The present study compared the antagonistic activity and probiotic properties of two Lactic Acid Bacteria (LAB) such as Enterococcus faecium NCIM 2605 and Lactococcus lactis NCIM 2606. Bacteriocin from both the cultures was produced using MRS broth by shake flask fermentation. In well diffusion method, the cell free supernatant (CFS) of E. faecium...

An attempt was made for the isolation of colicinogenic E. coli from cow and sheep dung samples. Total of 112 E. coli isolates were collected from sheep and cow dung samples in which 63 isolates are from cow dung and 49 isolates are from sheep dung samples. In the screening for colicin production, two E. coli isolates C22 and C51 from cow dung sampl...

During the course of the anti-infective drug discovery programme, actinomycete strain D25 was recovered from the Thar Desert soil, Rajasthan, India. Actinomycin type of compound isolated from the strain D25 showed promising activity against multi drug resistant and extensively drug resistant M. tuberculosis isolates. The present study reports the c...

Typhoid fever is a major health problem as the causative agent Salmonella enterica serovar typhi and paratyphi A has developed resistance to many antimicrobial agents. The study was undertaken to find out the antimicrobial susceptibility pattern of Salmonella isolates. We have studied 176 Salmonella isolates - 172 blood isolates, 3 stools isolates...

Fifteen percent of all diabetics develop a foot ulcer at some point in their lives that is highly susceptible to infection and that spreads quite rapidly, leading to overwhelming tissue destruction and subsequent amputation. Wound specimens were collected and processed from patients attending diabetic foot clinic tertiary care Hospital isolates wer...

No abstract available.

Serious chromium (Cr6+) contamination of both surface water and ground water has been reported in the Palar River Basin of Vellore District (Tamil Nadu), India due to the discharge of improperly treated effluents from tanneries and other industries in and around Ranipet. The primary objective of this study was to isolate and identify a potent chrom...

Considering the significance of phytochemicals as antimicrobial agents, attempt was made in the present study, to categorize several rare plant species present in and around Palar river basin and to assess their antimicrobial activity. The densities of the green cover of the Palar river basin flora were assessed by the Google Earth software. Totall...