Arturo Nuara

Arturo Nuara
Italian National Research Council | CNR · Institute of Neuroscience IN

MD

About

70
Publications
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430
Citations

Publications

Publications (70)
Article
Full-text available
Motor learning can be defined as a process that leads to relatively permanent changes in motor behavior through repeated interactions with the environment. Different strategies can be adopted to achieve motor learning: movements can be overtly practiced leading to an amelioration of motor performance; alternatively, covert strategies (e.g., action...
Article
Full-text available
Ensuring proper dosage of treatment and repetition over time is a major challenge in neurorehabilitation. However, a requirement of physical distancing to date compromises their achievement. While mostly associated to COVID-19, physical distancing is not only required in a pandemic scenario, but also advised for several clinical conditions (e.g. im...
Article
Full-text available
There is a growing interest in action observation treatment (AOT), i.e., a rehabilitative procedure combining action observation, motor imagery, and action execution to promote the recovery, maintenance, and acquisition of motor abilities. AOT studies employed basic upper limb gestures as stimuli, but—in principle—the AOT approach can be effectivel...
Article
Full-text available
There is rich clinical evidence that observing normally executed actions promotes the recovery of the corresponding action execution in patients with motor deficits. In this study, we assessed the ability of action observation to prevent the decay of healthy individuals’ motor abilities following upper-limb immobilization. To this end, upper-limb k...
Preprint
BACKGROUND AND OBJECTIVE Action observation can sustain motor skill improvement. At the neurophysiological level, action observation affects the excitability of the motor cortices, as measured by transcranial magnetic stimulation. However, whether the cortical modulations induced by action observation may explain the amount of motor improvement dri...
Article
While it is well documented that the motor system is more than a mere implementer of motor actions, the possible applications of its cognitive side are still under-exploited, often remaining as poorly organized evidence. Here, we will collect evidence showing the value of action observation treatment (AOT) in the recovery of impaired motor abilitie...
Article
Objective To explore neurophysiological features of musicogenic epilepsy (ME), discussing experimental findings in the framework of a systematic review on ME. Methods Two patients with ME underwent high-density-electroencephalography (hd-EEG) while listening to ictogenic songs. In one case, musicogenic seizures were elicited. Independent component...
Article
Here we describe a rare case of Capgras delusion – a misidentification syndrome characterized by the belief that a person has been replaced by an imposter – in a patient without evident neurological or psychiatric symptoms. Intriguingly, delusional belief was selective for both person and modality, as the patient believed that his son – not his dau...
Chapter
Musical abilities arise from an extensive practice—starting in childhood and going on throughout musician’s lifetime—engaging perceptual, motor, and cognitive domains. The shaping of brain networks that induces music skills development is sustained by the growing capability to transform auditory stimuli into their motor representation. As a result...
Article
Full-text available
Slow gait speed has been shown to predict incident dementia and cognitive decline in older individuals. We aimed to summarize the evidence concerning the association of slow gait speed with cognitive decline and dementia, and discuss the possible shared pathways leading to cognitive and motor impairments, under the unifying hypothesis that body and...
Article
Aim To evaluate the feasibility and effectiveness of an action observation treatment (AOT) home‐based platform promoting child‐to‐child interaction to improve hand motor function in unilateral cerebral palsy (CP). Method Twenty children (14 males, six females; mean age 6y 7mo, standard deviation 1y 7mo; range 5y 1mo–10y 6mo) with unilateral CP und...
Article
Full-text available
Drawings produced by children provide insights about their physical and psychological status. In children suffering from unilateral cerebral palsy (UCP), self-portraits constitute a unique opportunity to study whether and how their disease affects self-body representation. The aim of the present study is to evaluate self-body representation in UCP...
Article
Objective Within the last decade, many changes have been made to the management of patients with multiple sclerosis (MS). The aim of our study was to investigate the global impact of all these changes on the disease's course. Materials and methods This single‐centre study was carried out on patients with multiple sclerosis (pwMS) who started treat...
Article
Functional disorders-FD account for major disability and impairment. As multidisciplinary approach appears to be the most effective treatment, placebo can effectively relieve symptoms in some cases. Our aim was to assess FD outcome after sham rTMS and to identify response predictors. Sixteen consecutive patients (13 females, age 29.9 ± 11.2 years,...
Article
Walking impairment has a strong impact on quality of life of multiple sclerosis (MS) patients. Excitatory Transcranial-Repetitive-Magnetic-Stimulation (rTMS) enhances corticospinal excitability and plasticity, potentially favouring the effects of neurorehabilitation. The aim of this study is to explore the impact of neurophysiological and clinical...
Data
database of behavioural data. Abbreviations: C: controls, P: pianists, L: left, R: right, NHPT: nine hole peg test, FT: finger tapping, AI: asymmetry index. (XLS)
Data
database of TMS mapping parameters. Abbreviations: C: controls, P: pianists, L: left, R: right, RMT: resting motor threshold, AI: asymmetry index. (XLS)
Data
database of iSP (ipsilateral silent period) measurements. Abbreviations: C: controls, P: pianists, L: left, R: right, niSP: normalized ipsilateral silent period, AI: asymmetry index. (XLS)
Article
Full-text available
The neuronal mechanisms involved in brain plasticity after skilled motor learning are not completely understood. We aimed to study the short-term effects of keyboard training in music-naive subjects on the motor/premotor cortex activity and interhemispheric interactions, using electroencephalography and transcranial magnetic stimulation (TMS). Twel...
Data
Training exercises. During each training session, subjects had to practice playing with their right hand only, then left hand only, and finally with both hands together. The exercises were decomposed so that the fingers’ involvement was brought progressively in order for the subjects to learn the whole sequence in a more pedagogic manner. The last...
Article
Walking impairment affects multiple sclerosis (MS) patients and impacts their quality of life. Despite a known relationship between objective and subjective walking measures, gait and neurophysiological motor parameters relationships remains to be explored. 50 progressive MS people underwent functional and neurophysiological assessments: 10-meters-...
Article
We aimed to study short-term effects of keyboard training in music-naive subjects on motor cortex activity and interhemispheric interactions, using electroencephalography and transcranial magnetic stimulation (TMS). Twelve subjects underwent, before and after a two week-piano training: (1) hand-motor function tests: Jamar, grip and nine-hole peg te...
Article
Objective To study short-term effects of keyboard training in music-naive subjects on motor cortex activity and interhemispheric interactions, using electroencephalography and transcranial magnetic stimulation (TMS). Methods Twelve subjects underwent, before and after a two week-piano training: (1) hand-motor function tests: Jamar, grip and nine-h...
Article
Objective Focal rTMS in Alzheimer’s disease (AD) revealed cognitive benefits. H-coil depolarize deeper and wider structures compared with focal coils, maybe targeting widespread networks involved in neurodegenerative disorders. We explored H-coil safety and efficacy in AD. Methods Thirty AD subjects (70.21 ± 8.66 y.o.), randomized in real or sham...
Article
Objective Walking impairment affect multiple sclerosis (MS) patients, impacting their quality of life. Despite a known relationship between objective and subjective walking measures, gait and neurophysiological motor parameters relationships remains to be explored. Methods 50 progressive MS people underwent following assessments: 10-meters-walking...
Article
Multiple sclerosis (MS) patients frequently suffer from limb spasticity and pain despite antispastic treatments. To investigate nabiximols efficacy and safety in a real-world monocentric Italian cohort, the following data were collected at baseline, week 4, 14 and 48: Ambulation Index (AI), 10-min walking test (10MWT), combined Modified Ashworth sc...
Data
10MWT in responders at different time-point. 10MWT values at baseline, 4-, 14- and 48-week visit in responder patients
Article
Despite the proven efficacy of Sativex(®) (9-delta-tetrahydrocannabinol plus cannabidiol) oromucosal spray in reducing spasticity symptoms in multiple sclerosis (MS), little is known about the neurophysiological correlates of such effects. The aim of the study was to investigate the effects of Sativex on neurophysiological measures of spasticity (H...
Article
Repetitive transcranial magnetic stimulation (rTMS) has been recognized as a promising intervention for treatment of post-stroke deficits. We evaluated the feasibility, safety and efficacy of excitatory Hz rTMS with H-coil over the leg motor areas combined with active cycling on paretic lower limb motor function in chronic post-stroke. rTMS was del...
Article
High frequency transcranial repetitive magnetic stimulation (rTMS) enhances corticospinal excitability and plasticity, potentially favouring the effects of neurorehabilitation, as in a preliminary study by our group. We aimed at replicating our previous study and at combining results exploring baseline features. Twenty subjects with progressive MS,...
Article
To evaluate the effect of repetitive deep transcranial magnetic stimulation—rDTMS on motor symptoms in Parkinson’s Disease—PD in a randomized, placebo controlled study. Sixty patients underwent 12 sessions (3 sessions/week) of 10 Hz rDTMS, after randomization into 3 groups: Group 1 (real rDTMS on primary motor—M1 and prefrontal—PF areas); Group 2 (...
Article
IntroductionHigh levels of autoantibodies directed against glutamic acid decarboxylase (GAD) are associated with stiff-person syndrome (SPS). However, other neurological syndromes have been described in association with anti-GAD antibodies, defining a novel group of syndromes, collectively named “hyperexcitability disorders”. Here, we describe a pa...
Article
Full-text available
Dear Sirs,SPG4 or SPAST-associated hereditary spastic paraplegia (HSP) is an autosomal dominant (AD) disorder characterized by corticospinal tract degeneration causing lower limb weakness and spasticity [1]. Facioscapulohumeral muscular dystrophy (FSHD) is an AD muscular dystrophy characterized by progressive atrophy and weakness of facial, shoulde...
Article
Objectives To assess the efficacy of high frequency (20 Hz) brain stimulation on lower limb motor function in subjects with chronic (> 6 months) subcortical stroke in a double-blind, placebo-controlled crossover study. Design double-blind, placebo controlled, crossover study Setting University hospital. Participants ten right-handed subjects aff...
Article
Background Repetitive transcranial magnetic stimulation (rTMS) has been proposed as a potential treatment for Parkinson's disease (PD). H-coils, inducing deeper and wider magnetic fields compared to traditional coils, may be potentially useful in PD, characterized by widespread, bilateral involvement of cortico-subcortical circuits. Objective To e...
Article
. The role of the right hemisphere in poststroke aphasia recovery is still controversial and the effects of repetitive transcranial magnetic stimulation (rTMS) over the right homologous Broca's region have been seldom investigated. . This study aimed to compare the effect of excitatory, inhibitory, and sham rTMS delivered with H-coil over the right...
Article
Our aim was to investigate, in a pilot study, the clinical and neurophysiological effects of non-invasive, deep repetitive transcranial magnetic stimulation (DrTMS) in Parkinson’s disease (PD), using the H coil. Twenty patients (3F; 63 ± 9 y.o.; PD duration: 6 ± 3 y) underwent 12 DrTMS sessions in 4 weeks. Excitatory 10 Hz DrTMS was applied over th...
Article
Our aim was to evaluate safety and clinico-neurophysiological effects of repetitive Deep Transcranial Magnetic Stimulation (DTMS) in Parkinson’s Disease (PD), using the novel H-COIL. Fourteen PD-patients underwent 12 sessions 10 Hz-DTMS (4 weeks) over primary motor area opposite to their most affected side (W-M1) and prefrontal cortices. Clinical a...
Article
Repetitive transcranial magnetic stimulation (rTMS) has been recognized as a promising intervention for treatment of stroke patients. The purpose of this double-blind placebo-controlled crossover study was to assess the efficacy of 20 Hz rTMS delivered with H-coil on lower limb (LL) motor function in patients with chronic (>6 months) subcortical st...
Article
Neuroimaging studies have reported mirroring motor activation to music listening in musicians. Actual corticospinal modulation remains to be clarified. We tested the motor cortex modulation in pianists while listening to well-known, predictable melodic sequences, using Transcranial Magnetic Stimulation (TMS) and electroencephalography (EEG). Two gr...
Article
Full-text available
To identify clinical predictors of effectiveness of a motor rehabilitation treatment in a cohort of multiple sclerosis (MS) patients. We analysed 212 consecutive patients who underwent a short-term (3-7 weeks) intensive (two hours per day, five days per week), individualised, goal-oriented inpatient rehabilitation program. Activity limitation and i...
Article
Background: Parkinson's disease (PD) is characterized by various changes in motor excitability. Objective: To examine through Transcranial Magnetic Stimulation (TMS) cortical excitability, specifically addressing interhemispheric connections in PD. Methods: Nineteen PD patients with a predominant involvement of the left hemibody (7 females, age 61....

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