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Arthur S. C. França

Arthur S. C. França
Hands-on Scientist

BS; MsC; PhD.
Research Analyst at AMC Medical Research (WILLUHN's Group)

About

21
Publications
4,951
Reads
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171
Citations
Citations since 2016
18 Research Items
165 Citations
2016201720182019202020212022010203040
2016201720182019202020212022010203040
2016201720182019202020212022010203040
2016201720182019202020212022010203040
Additional affiliations
October 2020 - April 2021
Vrije Universiteit Amsterdam
Position
  • Research Associate
March 2017 - March 2020
Radboud University
Position
  • PostDoc Position
October 2016 - February 2017
Universidade Federal do Rio Grande do Norte
Position
  • PostDoc Position
Education
April 2009 - April 2012

Publications

Publications (21)
Article
Controlling aggression is a crucial skill in social species like rodents and humans and has been associated with anterior cingulate cortex (ACC). Here, we directly link the failed regulation of aggression in BALB/cJ mice to ACC hypofunction. We first show that ACC in BALB/cJ mice is structurally degraded: neuron density is decreased, with pervasive...
Article
Full-text available
Background With the growing size and richness of neuroscience datasets in terms of dimension, volume, and resolution, identifying spatiotemporal patterns in those datasets is increasingly important. Multivariate dimension-reduction methods are particularly adept at addressing these challenges. New Method In this paper, we propose a novel method, w...
Article
Full-text available
Pathological aggression is a debilitating feature of many neuropsychiatric disorders, and cingulate cortex is one of the brain areas centrally implicated in its control. Here we explore the specific role of midcingulate cortex (MCC) in the development of pathological aggression. To this end, we investigated the structural and functional degeneratio...
Article
Full-text available
Neural activity is coordinated across multiple spatial and temporal scales, and these patterns of coordination are implicated in both healthy and impaired cognitive operations. However, empirical cross-scale investigations are relatively infrequent, due to limited data availability and to the difficulty of analyzing rich multivariate datasets. Here...
Preprint
Full-text available
Background With the growing size and richness of neuroscience datasets in terms of dimension, volume, and resolution, identifying spatiotemporal patterns in those datasets is increasingly important. Multivariate dimension-reduction methods are particularly adept at addressing these challenges. New Method In this paper, we propose a novel method, w...
Article
Full-text available
Novelty detection is a core feature of behavioral adaptation and involves cascades of neuronal responses-from initial evaluation of the stimulus to the encoding of new representations-resulting in the behavioral ability to respond to unexpected inputs. In the past decade, a new important novelty detection feature, beta2 (∼20-30 Hz) oscillations, ha...
Preprint
Full-text available
Neural activity is coordinated across multiple spatial and temporal scales, and these patterns of coordination are implicated in both healthy and impaired cognitive operations. However, empirical cross-scale investigations are relatively infrequent, due to limited data availability and to the difficulty of analyzing rich multivariate datasets. Here...
Preprint
Novelty detection is a core feature of behavioral adaptation, and involves cascades of neuronal responses – from initial evaluation of the stimulus to the encoding of new representations – resulting in the behavioral ability to respond to unexpected inputs. In the past decade, a new important novelty detection feature, beta2 (~20 - 30 Hz) oscillati...
Preprint
Full-text available
Novelty detection is a core feature of behavioral adaptation, and involves cascades of neuronal responses – from initial evaluation of the stimulus to the encoding of new representations – resulting in the behavioral ability to respond to unexpected inputs. In the past decade, a new important novelty detection feature, beta2 (~20 - 30 Hz) oscillati...
Preprint
Full-text available
Controlling aggression is a crucial skill in social species like rodents and humans, and has been associated with anterior cingulate cortex (ACC). Here, we demonstrate a causal link between ACC hypofunction and failed aggression control in BALB/cJ mice. We first show that ACC in BALB/cJ mice is structurally degraded: Neuron density is decreased, wi...
Article
Full-text available
Electrophysiological data are used to investigate fundamental properties of brain function, its relation to cognition, and its dysfunction in diseases. The development of reliable and open-source systems for electrophysiological data acquisition is decreasing the total cost of constructing and operating an electrophysiology laboratory, and facilita...
Preprint
Full-text available
Electrophysiological data are used to investigate fundamental properties of brain function, its relation to cognition, and its dysfunction in diseases. The development of reliable and open-source systems for electrophysiological data acquisition is decreasing the total cost of constructing and operating an electrophysiology laboratory, and facilita...
Article
Full-text available
Successfully navigating social interactions requires the precise and balanced integration of social and environmental cues. When such flexible information integration fails, maladaptive behavioral patterns arise, including excessive aggression, empathy deficits, and social withdrawal, as seen in disorders such as conduct disorder and autism spectru...
Article
Full-text available
Sleep plays a crucial role in the regulation of body homeostasis and rhythmicity in mammals. Recently, a specific component of the sleep structure has been proposed as part of its homeostatic mechanism, named micro-arousal. Here, we studied the unique progression of the dynamic behavior of cortical and hippocampal local field potentials (LFPs) duri...
Article
Inhibitory interneurons participate in mnemonic processes. However, defined roles for identified interneuron populations are scarce. A subpopulation of oriens lacunosum-moleculare (OLM) interneurons genetically defined by the expression of the nicotinic receptor α2 subunit has been shown to gate information carried by either the temporoammonic path...
Article
Full-text available
Anxiety-like behaviors have been related to chronic stress in rodents and humans. In rats, forced swimming test (FST) is used as a chronic stress–inducing task. Here we test the validity of FST as an anxiety inducer in mice. We divided animals in two groups, FST (exposed to FST for 15 consecutive days) and control (handled in similar sessions). Plu...
Article
Full-text available
Dopamine and sleep have been independently linked with hippocampus-dependent learning. Since D2 dopaminergic transmission is required for the occurrence of rapid-eye-movement (REM) sleep, it is possible that dopamine affects learning by way of changes in post-acquisition REM sleep. To investigate this hypothesis, we first assessed whether D2 dopami...
Article
Full-text available
In this work we devise a classification of mouse activity patterns based on accelerometer data using Detrended Fluctuation Analysis. We use two characteristic mouse behavioural states as benchmarks in this study: waking in free activity and slow-wave sleep (SWS). In both situations we find roughly the same pattern: for short time intervals we obser...
Article
The oscillatory activity of hippocampal neuronal networks is believed to play a role in memory acquisition and consolidation. Particular focus has been given to characterising theta (4–12 Hz), gamma (40–100 Hz) and ripple (150–250 Hz) oscillations. Beyond these well-described network states, few studies have investigated hippocampal beta2 (23–30 Hz...

Questions

Questions (2)
Question
I'm trying to implement the use of rabies virus for tracing and optogenetics purposes in the university that I'm working. Does anyone have the approval to work with rabies in Netherlands that could give me the orientation in the bureaucracy process? 
Question
Object recognition; Natural behavior of roedents to explore novelty.

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