Artak Heboyan

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Verified

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• BDSc MSD DClinDent PhD
• Associate Professor at Yerevan State Medical University

The present in vivo study determined the microbiological counts of the gingival crevicular fluid (GCF) among patients with fixed dental prostheses fabricated using three different techniques. A total of 129 subjects were divided into three study groups: first, cobalt-chrome-based, metal-ceramic prostheses fabricated by the conventional method (MC,...

Recently, polyetheretherketone (PEEK) has been introduced to the dental market as a high-performance and chemically inert biomaterial. This study aimed to compare the wear resistance, abrasiveness, color stability, and displacement resistance of zirconia and PEEK milled crowns. An ideal tooth preparation of a first maxillary molar was done and scan...

The aim of this study was to assess and compare the stress–strain pattern of zygomatic dental implants supporting different superstructures using 3D finite element analysis (FEA). A model of a tridimensional edentulous maxilla with four dental implants was designed using the computer-aided design (CAD) software. Two standard and two zygomatic impla...

The success of a prosthetic treatment is closely related to the periodontal health of the individual. The aim of this article was to review and present the importance of prosthetic restorative materials on the condition of the periodontium, the changes that occur in the composition of the subgingival microbiota and the levels of inflammatory marker...

Background Titanium is a commonly used material for dental implants owing to its excellent biocompatibility, strength-to-weight ratio, corrosion resistance, lightweight nature, hypoallergenic properties, and ability to promote tissue adhesion. However, alternative materials, such as titanium alloys (Ti–Al-2 V) and zirconia, are available for dental...

Monocyte chemoattractant protein 1 (MCP‐1) is involved in monocyte chemotaxis, endothelial activation and regulation of leukocyte function in biological activities that promote inflammation, such as in periodontitis. A systematic review and meta‐analysis was conducted with the primary objective of investigating the roles of MCP‐1 in the gingival cr...

The addition of zinc oxide (ZnO) to mineral trioxide aggregate (MTA) has been shown to prevent tooth discoloration; however, its biological effects remain unclear. This study aimed to evaluate the pulpal responses to MTA containing 5% ZnO in full pulpotomy of dogs’ teeth. Forty caries-free premolars from mixed-breed dogs were subjected to full pulp...

Toll-like receptors (TLR2 and TLR4) are crucial in the detection of pathogen-associated molecular patterns (PAMPs) during periodontitis, resulting in exacerbated production of proinflammatory cytokines and ultimately tissue damage and bone loss associated with this periodontal disease. This systematic review and meta-analysis aimed to systematicall...

Age-related macular degeneration (AMD) is a leading cause of significant vision impairment in individuals aged 50 and older, primarily impacting central vision. This study seeks to investigate potential associations between periodontal disease and age-related maculopathy in the analyzed clinical case. A male subject of 66 years old, with age-relate...

Objective The aim of this systematic review was to investigate, identify, and summarize the existing literature on the levels of proinflammatory cytokines and chemokines present in gingival crevicular fluid (GCF) of primary teeth restored with stainless steel crowns (SSC) versus control teeth. Materials and methods The systematic review was regist...

Background and Objective Proinflammatory cytokines and enzymes responsible for tissue destruction are important in the development of periodontitis. This study compared salivary concentrations of interleukin‐1 beta (IL‐1β), matrix metalloproteinases (MMP‐8), and (MMP‐9) in individuals with and without periodontitis to evaluate their diagnostic util...

Bruxism affects millions worldwide, leading to dental damage like worn teeth and tooth loss. Resin 3D printing presents a promising method for creating intricate, comfortable, and durable occlusal splints. This study examines how printing parameters-layer thickness, orientation angle, and curing time-affect the mechanical (compressive strength, wea...

Background The objective of this study was to design and assess the quality of PropoLid, a propolis-based, lidocaine-contained hydrophilic oromucosal film for the treatment of aphthous, ulcerative, and traumatic lesions in the oral cavity. Methods PropoLid oromucosal films containing Lidocaine (4%) and Propolis extract (1:10), known for its analge...

Background All patients deserve quality care, regardless of their cultural, ethnic, or linguistic backgrounds. In Pakistan's diverse society, cultural competence in dentistry is crucial for patient‐centered care. This study assesses and compares cultural competence levels between dental house officers (DHOs) and general dentists (GDs). Methods A c...

Background Titanium is commonly used for dental implants due to its high biocompatibility and durability. However, concerns about metal ion release and aesthetic limitations in certain tissue biotypes have driven the search for alternative materials. Polyetherketoneketone (PEKK), a high-performance polymer, has emerged as a promising option due to...

Objective This study aimed to evaluate the influence of scanning speed and distance on the precision and quality of digital intraoral scans. Data The PICO strategy was employed to delineate the inclusion and exclusion criteria. The acquired records underwent filtration according to eligibility criteria, with essential information subsequently extr...

Maxillofacial materials have been developed to provide natural and long-lasting prosthetic solutions for patients with facial anomalies caused by trauma, surgery, or congenital diseases. The durability and lifespan of maxillofacial silicone materials are important factors to consider in prosthetic rehabilitation. The tear strength of these material...

Background: Molar-incisor hypomineralization (MIH) is a qualitative defect in enamel formation with a multi-factorial etiology. Studies indicate a high prevalence of MIH across the Americas, yet the prevalence in Mexico remains uncertain. Aim: This study aimed to review the literature on the prevalence of MIH in the Mexican population and its assoc...

Introduction and aims Virtual articulator software platforms have gained popularity in dentistry for simulating dental articulations, but a comprehensive comparison of their accuracy, user-friendliness, and clinical relevance is lacking. This study aimed to evaluate various virtual articulator software platforms, focusing on accuracy, user-friendli...

Aim The aim of this study was to compare the retentive strengths of various forms of denture adhesives (paste, powder, and strips) on different types of mandibular residual alveolar ridges, considering their respective denture weights. Materials and Methods In this crossover randomized‐controlled trial, the patients were randomly and equally divid...

Graphene has attracted significant attention in dentistry due to its structural and adhesive properties, enhancing the mechanical performance of dental composites. This study investigates the behavior and interaction of monomers and graphene-based adhesives using molecular docking and molecular dynamics (MD) simulations. Binding energies and intera...

Background: The primary goal of this in vivo study was to ascertain if systemic bisphosphonates (BPs) positively affect bone repair in non-critical defects when assisted with a carbonated hydroxyapatite graft biomaterial (Bio-mat). Material and Methods: Thirty-six female rats were allocated into two control groups (blood clot [BC] and alloplas-tic...

Objective This systematic review aimed to evaluate the current evidence regarding the impact of postbiotics on dental caries, focusing on the effectiveness of postbiotic interventions in caries prevention, mechanisms of action, optimal dosages, and administration protocols. Methods A literature search was conducted across PubMed/MEDLINE, Scopus, W...

Background and Aims Psychological disorders like anxiety and depression are prevalent among dental professionals, being responsible for negatively affecting their mental health. Such factors are detrimental and may lead to suicidal thoughts and ideation. This study aimed to evaluate the impact of anxiety and depression on suicidal thoughts and idea...

Aim: To investigate the efficacy of medicinal plant bioactive secondary metabolites as inhibitors of voltage-gated sodium channels (Nav1.7, Nav1.8, and Nav1.9) in managing painful states of dental pulps. Methodology: Molecular docking, ADME prediction, toxicity profiling, and pharmacophore modeling were used to assess the binding affinities, pharma...

Endodontic infections include conditions such as pulp necrosis, apical periodontitis, abscesses, granulomas, and periapical cysts. Detection of pathogenic microorganisms responsible for these diseases is essential for accurate diagnosis and future therapy. Enterococcus faecalis, Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticol...

The success of hemisection is based on meticulous case selection, considering the quality and quantity of bone surrounding the remaining roots. Additionally, a well-devised prosthetic plan is crucial to direct forces along the preserved roots, and ongoing maintenance is imperative for long-term success. This case report aims to present two differen...

Background The objective of this systematic review was to identify genetic variants of the IL‐23, IL‐17, IL‐23R and IL‐17R genes and isoforms and its possible association with increased development of periodontitis and peri‐implantitis. Methods A systematic review was prepared according to the guidelines, registered in the OSF database with the re...

A BSTRACT Background and Objectives Oral submucous fibrosis (OSMF) is a chronic oral potentially malignant disorder affecting the oral mucosa. The habit of areca nut chewing is established to be the causative factor. Various treatment modalities are available for managing OSMF. Colchicine obtained from plants of the Colchicum genus can downregulat...

A BSTRACT Background Iron deficiency anemia (IDA) is a microcytic-hypochromic anemia prevalent in African and South Asian countries including India. Along with systemic, it presents various oral manifestations that can be diagnosed in dental setups. Literature suggests that there is a state of iron deficiency before it manifests as anemia, which e...

Background and Aims Oral Lichen Planus (OLP) is a common chronic inflammatory autoimmune illness that mostly affects the oral mucosa but may also affect other mucous membrane. It has higher prevalence in female patients of fourth to sixth decade of life with reticular being the commonest clinical variant. Clinical assessment, patient history, biops...

Background In the oral environment, the production of bacteriocins or antimicrobial peptides (AMPs) plays a crucial role in maintaining ecological balance by impeding the proliferation of closely related microorganisms. This study aims to conduct in silico genome screening of Streptococcus salivarius to identify potential antimicrobial compounds ex...

Objective This systematic review and meta-analysis aims to assess the knowledge and awareness of oral cancer risk factors among medical and dental students. Methods This study followed the PRISMA guidelines and was registered in INPLASY (ID: 2024110035). Four databases were consulted (PubMed, Science Direct, Scopus, and Web of Science) from Februa...

Background Oral cancer remains 1 of the biggest health care challenges; it has a poor response to treatment, and treatment often results in severe side effects. Nano-targeted drug carrier-assisted drug delivery systems can improve the benefits of targeted drug delivery and treatment efficacy. A systematic review and meta-analysis was conducted to i...

This study aimed to present a complete overview of the trends, difficulties, and improvements in dental treatment for children diagnosed with autism spectrum disorder through rigorous bibliometric analysis. The dimensional database field was chosen to enable the inclusion and recall of the greatest number of relevant entries. All peer-reviewed inte...

Background: Digital technologies are widely used today to fabricate prosthodontic restorations, including complete dentures. The aim of this review was to provide information about the technologies for fabricating digitally manufactured complete dentures, the materials used, the digital methods for obtaining impressions, and the digital design of p...

Objective This study aimed to identify and evaluate scholarly research on the efficacy, durability, and long-term stability of various adhesive systems used for bonding direct resin composite restorations and to identify factors influencing bonding performance, such as adhesive composition, application protocol, substrate type, and etching techniqu...

Background Oral leiomyomatous hamartoma (OLH) corresponds to an abnormal, benign and disorganized overgrowth of mature smooth muscle tissue, which can develop in any site where this tissue is found in healthy conditions. The present systematic review aimed to analyze the clinicopathological characteristics of OLH. Materials and methods The protoco...

Oral cancer commonly affects various parts of the oral cavity, including the lips, tongue, gums, palate, and inner cheeks. Oral rehabilitation involves multiple approaches aimed at restoring and improving oral function, esthetics, and overall well-being. This study assessed the functional outcomes and quality of life in patients who underwent rehab...

Objective This study aimed to develop novel gadolinium and selenium-doped bioactive glass (gsBG)-coated titanium dental implants and analyse their surface, chemical, corrosion, and biocompatibility properties. Methods A sol-gel method was used to prepare gsBG by hydrolysing 45% tetraethyl orthosilicate (TEOS) in water with nitric acid, followed by...

Objective: The main aim of this study was to identify the existing literature on the association between sporting activities and temporomandibular disorders and to critically appraise evidence of this association through a systematic review and meta-analysis. Design: A comprehensive search was conducted using PubMed, ScienceDirect, Dimensions, Goog...

Digital dentures are removable dental prostheses fabricated using computer-aided design/computer-aided manufacturing (CAD/CAM) technology. This study aimed to explore the trends in digital dentures. A comprehensive four-phase search and selection strategy was framed. Dimensions and Lens.org databases were used. Boolean operators were used to combin...

Meta-learning of dental X-rays is a machine learning technique that can be used to train models to perform new tasks quickly and with minimal input. Instead of just memorizing a task, this is accomplished through teaching a model how to learn. Algorithms for meta-learning are typically trained on a collection of training problems, each of which has...

Objective This study aimed to assess tobacco and vaping habits among university students, exploring awareness of university policies, attitudes, and behaviors related to smoking and vaping. Methods An online questionnaire was distributed among students from various universities, including institutions in Pakistan, covering demographics, smoking an...

This study aimed to comprehensively investigate the degradation behavior of 3D printed polymethyl methacrylate (PMMA) dental materials, with a specific focus on the influential factors of temperature and moisture, by employing molecular dynamics simulations. Owing to their aesthetic properties, 3D-printed PMMA dental materials play a pivotal role i...

Background and Objectives: The aim of this bibliometric analysis is to explore the impact of 3D imaging in dentistry by examining articles published over the past two decades. Materials and Methods: The electronic search utilized the terms "digital dentistry" AND "implant placement" OR "radiation dose" OR "accuracy" OR "clinical outcomes" OR "3D im...

Background: Local anesthetics (LAs) are frequently utilized in dentistry. Despite their generally well-tolerated nature, they can occasionally induce adverse reactions of varying types and severity. The actual prevalence of allergic reactions to these agents remains unknown. The review objectives were to evaluate the occurrence of immediate adverse...

Background The production of inflammatory factors in periodontium is increased by LPS, particularly from P. gingivalis, and the damage to periodontal tissues is exacerbated. Exosomes from periodontal ligament stem cells change regeneration and repair brought on by bacterial LPS. MiRNAs are carried by exosomes to recipient cells to affect epigenetic...

Aim The Insilco study uses deep learning algorithms to predict the protein-coding pg m RNA sequences. Material and methods The NCBI GEO DATA SET GSE218606’s GEO R tool discovered P.G’s outer membrane vesicles’ most differentially expressed mRNA. Genemania analyzed differentially expressed gene networks. Transcriptomics data were collected and labe...

Background Polyetherketoneketone (PEKK) is a high-performance thermoplastic polymer with unique structural and mechanical properties that make it a promising candidate for surface modification of dental implants. This study was conducted to investigate the feasibility of PEKK for this purpose using the Cambridge Serial Total Energy Package (CASTEP)...

Background Fixed dental prostheses (FDP) can affect the production of inflammatory cytokines causing damage to periodontal tissues. A systematic review and meta-analysis was carried out with the following two objectives: (1) to determine the prevalence and function of the different inflammatory cytokines present in gingival crevicular fluid (GCF) o...

Background Activation of the IL-33/ST2 axis leads to the production of proinflammatory cytokines and thus to the triggering of osteoclastogenesis, which is why it plays an important role in the immunopathogenesis of periodontitis. The aim of this study was to compare IL-33 levels in serum, plasma, saliva and gingival crevicular fluid (GCF) of subje...

Background: Dental implants restore functionality and aesthetics in patients with missing teeth. Osseointegration, the direct structural and functional connection between living bone and the implant's surface, is essential for implant stability and success. This retrospective multicenter clinical trial aimed to assess the survival rate and effectiv...

Background Podoplanin (PDPN) is a transmembrane glycoprotein implicated in the pathogenesis of odontogenic lesions (OL). It is localized at the membrane and cytoplasmic level, and its interaction with other proteins could trigger cell proliferation, invasion and migration. The main objective of this systematic review is to explore the immunoexpress...

Background The presence of a polymicrobial dysbiotic film in direct and constant contact with periodontal tissues initiates the host immune response. Interleukin 18 (IL-18) triggers up-regulates the production of other proinflammatory cytokines (TNF-α, IL-1β, IL-6), creating a vicious cycle that expands the inflammatory and destructive process in t...

Objective The objective of the study was to explore the extent to which faculty members in undergraduate medical education apply cognitive psychology principles in their teaching practices, and to evaluate the perceived effectiveness of these principles in enhancing student learning. Methods This mixed method study was conducted on faculty members...

INTRODUCTION. Endodontic posts play a vital role in strengthening debilitated teeth. They are luted into the radicular space using dental cements that are generally resinous. Given that the forces faced by human teeth are loading in nature and the stresses are accumulative, the bond strength of the interfaces at both the radicular dentin and luting...

Implant-supported complete dentures are a common procedure for patients with mandibular edentulism problems. This article documents the protocol for immediate functional loading of fixed transient mandibular prostheses with fully moldable attachments and distal extensions to prevent fractures. A 56-year-old female patient was referred to the Oral R...

Background This study focuses on the determination and classification of patients as rapid or slowcalculusformersbasedontherateofcalculusformationafteroralprophylaxis. It also aims to determine the factors that positively impact the formation and deposition of calculus in patients and identify the factors that accelerate or decelerate the depositio...

A 65-year-old Caucasian male was referred to an endodontic specialist practice in a private clinic in December 2019 for the management of an asymptomatic, radiolucent lesion located at the cervical level of the distal root of his right lower first molar, noticed during a routine periapical radiograph. After an accurate evaluation with cone-beam com...

Objective: This study aimed to explore the therapeutic potential of medicinal herbs for chronic periodontitis by examining the molecular interactions between specific herbal compounds and the heme-binding protein of Porphyromonas gingivalis, a key pathogen involved in the disease. Methods: The crystal structure of heme-binding protein was obtained...

Background DNA is an important target for oxidative attack and its modification may increase the risk of mutagenesis. The aim of this study was to evaluate and compare salivary levels of the oxidative stress biomarker 8-hydroxy-2′-deoxyguanosine (8-OHdG) in patients with oral cancer (OC) compared to the control group by a comprehensive search of th...

Plain language summary Interactions between oral microbiota shifts and cancer: The oral microbiome potentially wields significant influence in the development of cancer. Within the human oral cavity, an impressive diversity of more than 700 bacterial species resides, making it the second most varied microbiome in the body. This finely balanced oral...

Aim This study aimed to assess the effectiveness of photobiomodulation therapy (PBM) in enhancing bone integration with dental implants. Method PubMed, ScienceDirect, the Cochrane Library, Scopus, and Google Scholar were searched. Studies assessing PBM effectiveness with defined intervention/control groups were included, while those lacking specif...

Objective To identify the frequency and types of prescription errors, assess adherence to WHO prescribing indicators, and highlight the gaps in current prescribing practices of Junior dental practitioners in a tertiary care hospital in Karachi, Pakistan. Methods This cross-sectional study was conducted from January 2021 to March 2021. The study in...

Introduction and aims Root canal therapy is a crucial aspect of endodontic treatment aimed at preserving natural dentition. Over the years, advancements in three-dimensional (3D) technology have revolutionized diagnosis and treatment planning. Different 3D technologies are used in dental care, such as cone-beam computed tomography (CBCT), which ens...

Background Cytokines play an important role in the immunopathogenesis of dental caries. A systematic review and meta-analysis was carried out with the following three objectives: 1)To deepen and discuss through a comprehensive analysis of the literature the effects of dental caries on the activity and levels of TNF-α, IL-6 and IL-8 in saliva of chi...

Background Focal and florid cemento-osseous dysplasia are benign fibro-osseous lesions affecting the quality and quantity of the jawbones. This study aimed to determine the viability of implant-based approaches in the affected patients. Main text Different scientific databases, including PubMed/MEDLINE, Scopus, Web of Science, Embase, the Cochrane...

Objective This study aimed to investigate the correlation between genetic factors and the occurrence and progression of temporomandibular disorders (TMDs) using a comprehensive review and meta-analysis. Design A comprehensive search was conducted using the ScienceDirect, PubMed, Cochrane Library, Dimensions, and Emerald databases. A reviewer selec...

Objective To analyze the satisfaction levels, perceptions of developing clinical competencies through objective structured clinical examination and to explore the experiences, challenges, and suggestions of undergraduate dental students. Methods The study adopted a mixed-method convergent design. Quantitative data were collected from 303 participa...

Objective This study aimed to provide valuable insights into the current research status and gaps in digital intraoral scanner literature in dentistry. Methodology Scopus Search Query TITLE-ABS-KEY (intraoral AND scanners AND (dentistry OR digital AND dentistry)). The search query used in Scopus for the bibliometric analysis was “TITLE-ABS-KEY (in...

Aim: This study aimed to comprehensively assess the biocompatibility and toxicity profiles of poly(methyl methacrylate) (PMMA) and its monomeric unit, methyl methacrylate (MMA), crucial components in dental materials for interim prosthetic restorations. Methodology: Molecular docking was employed to predict the binding affinities, energetics, and s...

Background Nanoparticles are increasingly used in dentistry for various applications, including enhancing the mechanical properties of denture base resins. This study aimed to comprehensively review and analyze the research landscape of nanoparticles and their effect on the flexural strength of denture base resins to identify key research areas and...

Introduction Gingival darkening, known as smokers' gingival melanosis or smoker's melanosis, is a benign symptom attributed to excessive deposition of melanin pigment. Melanin, responsible for skin, hair, and eye coloration, accumulates excessively, resulting in darkened gums. While not typically a severe health concern, smokers and former smokers...

Purpose Virtual reality (VR) simulations have been increasingly employed to train dental students prior to clinical practice. According to the literature, blended learning designs in the form of VR simulations can be utilized by both dental students and instructors to provide quality education. They can also save time and improve motor skills befor...