Arsalan Jalili

Royan Institute · Institute for Stem Cell Biology and Technology (RI-SCBT)

Tamoxifen is one of the most used drugs for breast cancer. This study aimed to investigate the effect of the Tamoxifen mechanism on the epithelial-mesenchymal transition (EMT) pathway among breast cancer patients due to its resistance to breast cancer cells. We selected the appropriate datasets from the GEO database using continuous and integrated...

Objective: Different Cell Culture medias can affect the expansion of T cells. The aim of this study is to assess signaling pathways, protein interactions and genes in T cells cultured in different common T cell expansion medias to select the best candidate. Materials and methods: In this in silico observational study, with the use of bioinformat...

Background Diabetes mellitus (DM) is a chronic metabolic disorder, increasing in the number of patients and poses a severe threat to human health. Significant advances have been made in DM treatment; the most important of which is differentiation and proliferation of beta cells from IPSCs.Methods Data were collected from PUBMED at various time poin...

Background: Studies reported an association between interleukin (IL)-10 -819T>C polymorphism and the risk of developing Acute myeloid leukemia (AML), however due to inconsistency among these results, relationship between IL-10 -819T>C polymorphism and AML remained unclear. We herein performed this meta-analysis to investigate the association of IL...

Background and Aim: Glioblastoma multiform (GBM) is considered as one of the malignant brain tumors that affect a wide range of people every year. Cancer stem cells, as essential factors, are resistant to chemotherapy drugs and complicate treatments. Therefore, finding critical molecular pathways in GBM-derived stem cells, and selecting the appropr...

Many genes induce angiogenesis in tumors, and among them, Notch family genes have received particular attention due to their extensive network of connections with other genes active in this function. Suppression of angiogenic signaling has been studied in various cancers, confirming Notch's fundamental and extensive role. According to studies, four...

Over the recent years, studies in the area of cancer microenvironment and the cellular groups existing in this environment have indicated the significant role of them in progression of cancer studies. Among the mentioned cellular groups, as the main inflammatory components of stroma, Tumor associate macrophage (TAM) cells have the capacity of affec...

Among the vaccines have been developed thus far against SARS-CoV-2, the mRNA-based ones have demonstrated more promising results regarding both safety and efficacy. Two remarkable features of the mRNA vaccines introduced by the Pfizer/BioNTech and Moderna companies are the use of (N1-methyl-pseudouridine-) modified mRNA and the microfluidics-based...

COVID 19 disease has become a global catastrophe over the past year that has claimed the lives of over two million people around the world. Despite the introduction of vaccines against the disease, there is still a long way to completely eradicate it. There are concerns about the complications following infection with SARS-CoV-2. This research aime...

Background Coronavirus disease 2019 (COVID-19) is an emerged pandemic disease with no specific treatment. One of the potential treatments in newly found infectious disease is plasma exchange (PE) with convalescent plasma transfusion (CPT). This case series aimed to evaluate the primary PE and CPT in five Iranian COVID-19 patients. Methods Five pat...

Background: Parathyroid hormone (PTH) is a calcium homeostasis regulator and can affect bone marrow niche. PTH leads to the bone marrow stem cell niche expansion as well as the induction of stem cell mobilization from the bone marrow into peripheral blood. In this study, we evaluated the association between pre- transplantation serum PTH levels an...

Background The migration of bone marrow mesenchymal stem cells (BMMSCs) from bone marrow (BM) to the damaged sites is the first step in regenerative medicine. BMMSCs express all urokinase system components include; urokinase plasminogen activator (uPA), uPA receptor (uPAR), and plasminogen activator inhibitor-1 (PAI-1) that are shown to affect BMMS...

Antioxidants are commonly used for maturation, fertilization and early development of embryos. Melatonin as an antioxidant have been recently proven to be useful for the assisted reproductive technology. In the present study, we evaluated the roles of melatonin in the in vitro maturation, fertilization, development and also the gene expression of h...

Exosome‐based therapy is an emerging novel approach for myocardial infarction (MI) treatment. Exosomes are identified as extracellular vesicles that are produced within multi vesicular bodies in the cells cytosols and then are secreted from the cells. Exosomes are 30–100 nm in diameter that are released from viable cells and are different from othe...

Exosomes are small vesicles outside the membrane, which are secreted by healthy, cancerous, and bacterial infected cells. These worthy vesicles carry shared information between adjacent cells and cause cell-cell communication. Bacteria can also secrete vesicles similar to exosomes called outer membrane vesicles (OMVs). The OMVs, also called quasi-e...

The aim of this paper is to study the pathogenesis, significant biomarkers and treatment strategies in ovarian cancer. Because of poor prognosis, ovarian cancer is usually diagnosed in final stages and although the first phase of treatment and chemotherapy usually seems to be a nice therapeutic approach but after a while, in many cases the disease...

Purpose: Mesenchymal stem cells (MSCs) have immunomodulatory traits making them a promising choice in the treatment of inflammatory diseases such as graft-versus-host disease (GVHD). Tumor necrosis factor-alpha (TNFα) is a major player of inflammatory disease which is blocked by infliximab to reduce the inflammation. The present study aims to asses...

Background: Tissue engineering has attracted a lot of attention, especially regarding wound and skin damage repair. PLLA is a biocompatible and biodegradable polymer. It has excellent mechanical properties and is able to support cell proliferation and growth. Electrospinnig is a fabrication method which has gained a lot of attention over the past y...

Background: Mesenchymal stem cells (MSCs) as pluripotent stem cells are able to migrate toward tumor cells and inflammation due to uPA and uPAR expression in these cells and tumor cells. Platelet relesate (PR) contains different growth factors can be used for FBS replacement in cell culture medium for in vitro expansion of MSCs in cell therapy. In...

In this study, angiogenesis inducers and inhibitors and some important drugs are introduced. Abnormal angiogenesis can occur if the balance between inhibitory and inducible factors disappears. Angiogenesis inducers include EGF, FGF2, TGF-β, VEGF, G-CSF, HGF, TGF-α, IL-8, TNF-α and angiogenesis inhibitors such as endostatin, interleukin, prolactin,...

Background: Nocturia is a common cause of night awakenings which bothers many patients with urinary tract diseases. NSAIDs can improve nocturia by decreasing urine production and modify the altered neural pathways between bladder and CNS. The aim of this study was to evaluate the efficacy of NSAID in the treatment of nocturia secondary to BPH. Seve...

Autophagy, the molecular machinery of self‐eating, plays a dual role of a tumor promoter and tumor suppressor. This mechanism affects different clinical responses in cancer cells. Autophagy is targeted for treating patients resistant to chemotherapy or radiation. Limited reports investigate the significance of autophagy in cancer therapy, the regul...

Objective(s): Chronic myeloid leukemia (CML) is a myeloid clonal proliferation disease defining by the presence of the Philadelphia chromosome that shows the movement of BCR-ABL1. In this study, the critical role of the Musashi2-Numb axis in determining cell fate and relationship of the axis to important signaling pathways such as Hedgehog and Notc...

Background and Aim: The structure of biocompatible scaffolds is one of the biggest concerns of tissue engineers. Ideally, a scaffold should mimic structural and biological functions of the extracellular matrix (ECM); both in terms of physical structure and chemical component. Finding a feasible combination of polymers to fabricate a feasible scaffo...

Background and Aim: At now the major obstacle on the way of CML treatment is TKIs resistance patients. So many mechanisms have been proposed. One of the major targets of ABL kinase is FOXO3 that introduced as a mechanistically driver of CML initiating leukemia cells maintaining. We hypothesized that TKI resistance can be predicted by evaluating the...

Studying the results of the prevalence of a particular genetic translocation of acute lymphoblastic leukemia (ALL) could predict the incidence rate of overall survival (OS) and event-free survival (EFS). 283 patients from northeastern of Iran with new diagnosis of ALL by bone marrow aspiration or peripheral blood sample were enrolled in the study....

Background: Despite the importance of routine factors like Human leukocyte antigens in the selection of a suitable allogeneic donor, some other factors like ABO antigens can be considered as a really important factor in different stages of transplantation. Due to the fact that the human leukocyte antigen system is inherited independently of the blo...

MicroRNA-9 (MiR-9) dysregulation has been observed in various cancers. Recently, MiR-9 is considered to have a part in hematopoiesis and hematologic malignancies. However, its importance in blood neoplasms is not yet well defined. Thus, this study was conducted in order to assess the significance of MiR-9 role in the development of hematologic neop...

MicroRNA-9 (MiR-9) dysregulation has been observed in various cancers. Recently, MiR-9 is considered to have a part in hematopoiesis and hematologic malignancies. However, its importance in blood neoplasms is not yet well defined. Thus, this study was conducted in order to assess the significance of MiR-9 role in the development of hematologic neop...

The glutathione S-transferase (GST) is a polymorphic supergene family of detoxification enzymes that are involved in the metabolism of potential carcinogens. To evaluate the association between polymorphisms in the GSTs (GSTT1, GSTM1 and GSTP1) and basal cell carcinoma (BCC), 50 BCC patients and 50 healthy controls were studied. Based on our findin...

Every year a large number of people die because of different types of cancers. Cancers are a group of diseases with abnormal cell growth and have a potential to spread to different tissues of body. Cancers can be malignant or benign. Several symptoms like bleeding, weight loss, lump and lesion can be seen in different types of cancers. Two views ar...

Background: Spurge family is a large family of plants that contains more than 300 genera and 800 species of which 5 genera and 72 species are native to Iran. This important family of plants can be used in various disease treatments such as cancer, arthritis, asthma, bacterial infections, and neuralgia. This study investigated the anticancer effects...

Bladder cancer arises from the epithelial lining layer of the urinary bladder. Understanding the molecular pathway of that can provide some useful information's about therapeutic manners. Hyper activity of P21and p53 genes has been reported in recent years. The purpose of this study was to assess the increased expression of p21 gene in paraffin-emb...

Classical macrophages (M1) and alternative macrophages (M2) are responsible for various functions in order to maintain homeostasis. The BCG vaccine and hydatid cyst fluid can be examples of stimulants which can cause M1 and M2 macrophage polarization. Evaluating the expression of markers such as IFNγ and TNFα for M1 phenotype and TGFβ and IL4 for M...

Colorectal cancer is the second cancer related deaths in the world. Studying the molecular pathway of that can provide some useful information about therapeutic manners. Hyper activity of P21 and TP53 genes has been reported in recent years. The purpose of this study was assessing the expression of TP53 and P21 tumor suppressor genes in blood sampl...

An important part of solar radiation is considered to be Ultraviolet radiation. Though through passing ozone layer it is progressively filtered. Due to the depletion of the ozone layer, the filtering activity of the latter is reduced and as a result more UV radiation, UVB in particular, reaches the Earth's surface. Ultraviolet radiation is composed...

Colorectal cancer is the second cancer related deaths in the world. Understanding the molecular pathway of that can provide some useful information about therapeutic manners. Hyper activity of BRAF gene has been reported in recent years and it can be proposed as a diagnostic molecular marker in many cancers. The purpose of this study was to assess...

Cancer is a group of diseases which evince abnormal cell growth with the potential to invade or spread to other parts of the body.There is a variety of reasons that cause cancer. One of the most common ones which is common among many places in the world is air pollution. Particles derive from different sources. Some of which are possess natural ori...

background: Classical macrophages (M1) and alternative macrophages (M2) are responsible for various functions in order to maintain homeostasis. BCG vaccine and hydatid cyst fluid can be examples of stimulants which can cause M1and M2 macrophage polarization. Evaluating the expression of markers such as IFNγ and TNFα for M1 phenotype and TGFβ and IL...