Arron Sullivan

Arron Sullivan
Cellstate Biosciences · Research and Development

PhD Molecular and Cellular Biology

About

10
Publications
706
Reads
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588
Citations
Additional affiliations
August 2016 - December 2016
The University of Arizona
Position
  • Research Assistant
Description
  • MCB 305 Cell and Developmental Biology
August 2014 - December 2014
The University of Arizona
Position
  • Research Assistant
Description
  • MCB 302 Biology of Cancer
March 2013 - present
The University of Arizona
Position
  • PhD Student
Education
August 2012 - December 2018
The University of Arizona
Field of study
  • Molecular and Cellular Biology
August 2005 - June 2009
University of Wisconsin - Milwaukee
Field of study
  • Biochemistry

Publications

Publications (10)
Article
The Target of Rapamycin kinase Complex I (TORC1) is the master regulator of cell growth and metabolism in eukaryotes. In the presence of pro-growth hormones and abundant nutrients, TORC1 is active and drives protein, lipid, and nucleotide synthesis by phosphorylating a wide range of proteins. In contrast, when nitrogen and/or glucose levels fall, T...
Article
Full-text available
The Target of Rapamycin Kinase Complex 1 (TORC1) regulates cell growth and metabolism in eukaryotes. In Saccharomyces cerevisiae, TORC1 activity is known to be controlled by the conserved GTPases, Gtr1/2, and movement into and out of an inactive agglomerate/body. However, it is unclear if/how these regulatory steps are coupled. Here we show that ac...
Article
Full-text available
The Target of Rapamycin kinase Complex I (TORC1) is a master regulator of cell growth and metabolism in eukaryotes. Studies in yeast and human cells have shown that nitrogen/amino acid starvation signals act through Npr2/3 and the small GTPases Gtr1/2 (Rags in humans) to inhibit TORC1. However, it is unclear how other stress and starvation stimuli...
Article
The recent article "Evaluation of pK(a) Estimation Methods on 211 Druglike Compounds" ( Manchester, J.; et al. J. Chem Inf. Model. 2010, 50, 565-571 ) reports poor results for the program Epik. Here, we highlight likely sources for the poor performance and describe work done to improve the performance. Running Epik in the mode intended to calculate...
Article
Generating the appropriate protonation states of drug-like molecules in solution is important for success in both ligand- and structure-based virtual screening. Screening collections of millions of compounds requires a method for determining tautomers and their energies that is sufficiently rapid, accurate, and comprehensive. To maximise enrichment...
Article
Imaging cell topography to high spatial and temporal resolution is key for many areas of biological research. SICM, based on the scanned nanopipette, is a technique ideally suited to this and works by regulation of the ion current flowing through the tip opening.1 SICM is a noncontact method and works under physiological conditions making it an exc...
Article
Resonant Energy Transfer (RET) from an optically excited molecule to a non-excited molecule residing nearby has been used to detect molecular interactions in living cells. Information such as the number of proteins forming a molecular complex has been obtained so far for a handful of proteins, but only after exposing the samples sequentially to at...
Article
Full-text available
Resonant Energy Transfer (RET) from an optically excited molecule to a non-excited molecule residing nearby has been used to detect molecular interactions in living cells. Information such as the number of proteins forming a molecular complex has been obtained so far for a handful of proteins, but only after exposing the samples sequentially to at...