Arpan Mohanty

Yale University | YU · Section of Digestive Diseases

Chronic hepatitis B infection represents a global public health burden, infecting over 240 million persons worldwide. It is associated with significant morbidity and mortality and represents a leading cause for cirrhosis, liver failure, liver cancer, and liver-related death. Current treatment of hepatitis B is focused on identification of patients...

Background & aims: Statins decrease portal pressure in patients with cirrhosis and increase survival times of those who have bled from varices. However, statins can be hepatotoxic. It is important to determine whether long-term statin use will be beneficial or detrimental for patients with cirrhosis because physicians are reluctant to prescribe st...

This review will focus on the efficacy and tolerability of the combination of sofosbuvir and simeprevir in genotype 1 chronic HCV infection. The goal of HCV therapy is to attain cure, which is defined by the US FDA as a sustained virologic response (SVR) or undetectable HCV RNA 12 weeks after HCV therapy, based on data confirming that over 99% pati...

Hyponatremia and hepatorenal syndrome are severe complications in patients with cirrhosis and ascites resulting from circulatory abnormalities (splanchnic and systemic vasodilatation) that develop with portal hypertension. Both conditions are associated with an increased risk of death. Hyponatremia and renal failure may develop in patients with cir...

Background. Understanding the predictors of mortality in individuals with human immunodeficiency virus and hepatitis C virus (HIV/HCV) coinfection can be useful in management of these patients. Methods. We used the Electronically Retrieved Cohort of HCV Infected Veterans (ERCHIVES) for these analyses. Multivariate Cox-regression models were used to...

The impact of pretreatment anaemia on survival in individuals with hepatitis C virus (HCV) and human immunodeficiency virus (HIV) co-infection is not known. Moreover, HCV treatment is offered less frequently to individuals with anaemia, due to haematological side effects of the treatment regimen. This study aimed to determine the effect of HCV trea...

Background & Aims Individuals with chronic hepatitis C virus (HCV) infection and pretreatment anemia are less likely to begin and complete a full course of treatment for HCV. However, among those who are treated for HCV infection, the effect of treatment on mortality is not clear. Methods We performed a retrospective analysis of 200,139 HCV-infect...

Paper #781 HIV Infection and Risk of Venous Thromboembolism Pashtoon Kasi*1, A Mohanty1, S Erqou1, K McGinnis2, K Crothers3, K Corey4,5, R Chung4,5, M Freiberg2, and A Butt2,6 1Univ of Pittsburgh Med Ctr, PA, US; 2Univ of Pittsburgh Sch of Med, PA, US; 3Univ of Washington, Seattle, US; 4Massachusetts Gen Hosp, Boston, US; 5Harvard Med Sch, Boston...

Acute aortic dissection (AAD) is a life-threatening condition associated with high morbidity and mortality. The most important recognized acquired cause that leads to dissection is chronic arterial hypertension. With respect to the anuria and renal failure, aortic dissection is not something that is always considered and is still not a very common...

The purpose of this article is to develop and validate a chemical-shift imaging-derived color mapping system for evaluation of liver steatosis. Opposed phase MRI was evaluated for 85 subjects (51 with presumed nonalcoholic fatty liver disease and 34 healthy volunteers). Liver signal intensity loss was compared with histologic analysis for 52 subjec...

Magnetic resonance (MR) imaging of bone marrow provides a noninvasive diagnosis of the vascularity, cell quantity, and composition of the normal and pathological bone marrow. This article reviews new and evolving techniques for bone marrow MR imaging with a special focus on translational and clinical applications. Evaluations of bone marrow perfusi...