Árpád TurcsányiUniversity of Szeged · Department of Physical Chemistry and Materials Science
Árpád Turcsányi
Master of Science
About
9
Publications
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Citations since 2017
Introduction
Publications
Publications (9)
Fabrication protocol of bovine serum albumin-(BSA) and lysozyme-(LYZ) stabilized gold/silver bimetallic nanoclusters (Au/Ag NCs) have been reported via optimization of the protein/metal ion ratios, metal concentration, pH and incubation time. No other reducing and stabilizing compounds were used to produce these nanoclusters at room temperature. In...
In actual work we clearly highlight in the first time the experimental factors (dominantly the concentration of the macromolecule components) influencing the formation of human serum albumin/hyaluronic acid (HSA/HyA) complex carrier particles which is not available in the literature despite the several published articles. We have shown that the cha...
In medical research the visualization of drug carrier accumulation and release of the loaded drugs in vivo is an important field. In this work, two protein-stabilized gold nanoclusters (Au NCs) as effective fluorescent reporters (FRs) were investigated for labeling of biocompatible chitosan-modified hyaluronic acid based nanocarriers having two dif...
Fabrication possibilities, detailed size and structural characterization of biodegradable chitosan (Chit) polysaccharide-modified hyaluronic acid (HyA)-based colloidal carriers are demonstrated. The negatively charged and highly hydrophilic HyA polymer chains have been ionically modified by positively charged pure Chit and crosslinked Chit macromol...
The (±)-α-Tocopherol (TP) with vitamin E activity has been encapsulated into biocompatible poly(lactic acid) (PLA) and poly(lactide-co-glycolide) (PLGA) carriers, which results in the formation of well-defined nanosized (d ~200–220 nm) core-shell structured particles (NPs) with 15–19% of drug loading (DL%). The optimal ratios of the polymer carrier...
This paper presents some findings from the rheological and drug dissolution characterizations of hyaluronic acid (HyA)-based colloidal drug delivery systems. During this investigations the widely applied, non-steroidal, anti-inflammatory ketoprofen (KP) has been used as model drug. For the moderation of the hydrophilic character of HyA and encapsul...
The experiments in the present work describe, the synthesis and preparation, rheological, conductometric and titration calorimetry based characterization, and drug dissolution of different hyaluronic acid (HyA)-based colloidal drug delivery systems. During this investigations the hydrophobic ketoprofen (KP), one of the most used non-steroidal anti-...
Graphite-oxide/TiO2 (GO/TiO2) composite materials were prepared by heterocoagulation method from Brodie’s graphite-oxide (GO) in order to test them as catalysts in the methanol photocatalytic reforming reaction in liquid phase. The preparation of the composite itself resulted in only little changes in the structure of GO as it was indicated by atte...
The pH-responsive intelligent drug release facility of hydrophobically modified chitosan nanoparticles (Chit NPs) (d = 5.2 ± 1.1 nm) was presented in the case of poorly water soluble Ca2+ channel blocker nimodipine (NIMO) drug molecules. The adequate pH-sensitivity, i.e. the suitable drug carrier properties of the initial hydrophilic Chit were achi...
Projects
Projects (3)
The use of colloidal delivery systems, such as nanoparticles and associated colloids, has drawn a particular attention in the clinical therapy. These nanosized carriers can also be manipulated to guide the drugs toward desired cells and improve the biodistribution. Formulation and physicochemical properties of these solid and semi-solid particles play an important role in bioavailability and targeting efficiency of drugs.
One of the main aims of the research program is the development of new eco-friendly synthetic routes that produce noble metal nanoclusters having size- and composition-dependent fluorescence. In addition to the structural analysis of the fluorescent systems, the stability, as well as the biocompatibility measurements of the sub-nanometer-sized particles are also investigated.
Within the framework of the biomedical applications of the noble metal nanoclusters, the diagnostic possibilities, and the sensor measurements are decisively highlighted.
The aim of this project is to create new biopolymer based drug delivery systems. These systems are mainly nanoparticles and nanocomposites, and they will be used for encapsulating new pharmaceuticals and investigating their release capabilities.
