Aron Grubesić
Emergency medical centre Rijek...

Medical doctor
14.06

Publications

  • Ivan Sosa · Aron Grubesic
    [Show abstract] [Hide abstract]
    ABSTRACT: It was confirmed that bone morphogenetic protein-9 (BMP-9), like insulin, improves glycemia in diabetic mice and regulates glucose metabolism in hepatocytes, which is why it is proposed as a candidate for the hepatic insulin-sensitizing substance (HISS). Regarding the fact that BMP-9 has a signaling pathway similar to other BMPs as well as insulin, it is expected that BMP-9 would also have certain effects on the liver. In our 2011 hypothesis, we aimed towards BMP-9 as a possible "hepatic insulin-sensitizing substance" (HISS) and in this article, we provide further evidence, derived from existing studies, suggesting that this putative hormone might in fact be none other than BMP-9.
    No preview · Article · Jan 2016 · International journal of immunopathology and pharmacology
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: The terminology of the optic nerve had already been changed three times, since 1895 until 1955 when the term »nervus opticus« was introduced in the »Terminologia Anatomica«. Following our study we claim that, from the aspectof phylogenetic evolution of binocular vision development as well as optical embryogenesis where opticus is evidently presented as a product of diencephalic structures, the addition of the term »nervus« to opticus is not adequate and justified.From the clinical aspect the term »nervus opticus« is also inadequate, both as a »nerve« that has no functional regenerative properties, unlike other cranial nerves, as well as from a pedagogical and didactical aspect of educating future physicians. We suggest that the term »Fasciculus Opticus Cerebralis« should be used as it much better explains the origin as well as its affiliation to the central nervous system.
    Full-text · Article · Jul 2013 · Collegium antropologicum
  • [Show abstract] [Hide abstract]
    ABSTRACT: Three institutions: Teaching Institute of Public Health of Primorsko-Goranska County, Croatian Association "Albert Einstein" and Eye Clinic "Dr B.Vojnikovid" Rijeka agreed a five-year project to study children's health status of vision at Primorsko-Goranska County. Main task was the study of damage of vision in children due to prolonged sun exposure. Examination were conducted on a three locations, with the assumption of varying insolation: Island of Rab, Novi Vinodolski and Delnice. The study included children aged between 9 to 14 years. The study included 189 children. Except routine ophthalmologic examinations in addition were preformed biomicroscopic examination of the anterior segment of the eye, intraocular pressure and eye fundus. In a certain number of children with suspect of a specific disease (macular degeneration, glaucoma and refractive error), additional tests were performed: glaucoma treatment, field of vision, optical coherence tomography (OCT) of the eye and detailed eye refraction. This study specifically addressed of refractive error at that three different regions. It was found that the most difficult situation was at the Novi Vinodolski where as many as 40% of children have a refractive error, followed by Island of Rab with 17% and Delnice with 9%. Especially like to mention that on the island of Rab, 50-60 years ago, it was a very rare occurrence of some refractive errors in children.
    No preview · Article · Apr 2013 · Collegium antropologicum
  • [Show abstract] [Hide abstract]
    ABSTRACT: Three institutions: Teaching Institute of Public Health of Primorsko-Goranska County, Croatian Association »Albert Einstein« and Eye Clinic »Dr B.Vojnikovi}« Rijeka agreed a five-year project to study children´s health status of vision at Primorsko-Goranska County. Main task was the study of damage of vision in children due to prolonged sun exposure. Examination were conducted on a three locations, with the assumption of varying insolation: Island of Rab, Novi Vinodolski and Delnice. The study included children aged between 9 to 14 years. The study included 189 children. Except routine ophthalmologic examinations in addition were preformed biomicroscopic examination of the anterior segment of the eye, intraocular pressure and eye fundus. In a certain number of children with suspect of a specific disease (macular degeneration, glaucoma and refractive error), additional tests were performed: glaucoma treatment, field of vision, optical coherence tomography (OCT) of the eye and detailed eye refraction. This study specifically addressed of refractive error at that three different regions. It was found that the most difficult situation was at the Novi Vinodolski where as many as 40% of children have a refractive error, followed by Island of Rab with 17% and Delnice with 9%. Especially like to mention that on the island of Rab, 50–60 years ago, it was a very rare occurrence of some refractive errors in children. Key words: childhood, refractive error, epidemiological study, Primorsko-Goranska County, Croatia
    No preview · Article · Apr 2013 · Collegium antropologicum
  • [Show abstract] [Hide abstract]
    ABSTRACT: Cerebrovascular diseases are a significant public health issue in the world as well as in our own country and represent one of the leading causes of death. Early screening in carotid stenosis patients, CEA (carotid endthrombarterectomy) and CAS (carotid artery stenting) endovascular treatment as well as modification of cardiovascular risk factors is of paramount importance in primary and secondary prevention of stroke. Color Doppler ultrasound procedures play a key role in cerebrovascular disease diagnostics and enable an objective real time approximation of cerebral haemodynamics. In order to maximalize success, surgical procedures must be performed immediately following a TIA (Transitory ischemic attack). Summated analysis of randomized control studies lean towards a maximum success of CEA following no more than 2 weeks after a mild stroke or TIA. Endovascular should be complementary to surgical treatment and all decisions on the course of the treatment should be delivered by a team of neurologists, vascular surgeons and an intervention neuroradiologist. Medicamentous treatment of carotid stenosis includes antiagreggational therapy, treatment of risk factors, change of life habits as well as dietary measures. Today, there are several controversies when considering treatment of carotid stenosis, many of which are still underway.
    No preview · Article · Mar 2013 · Medicina Fluminensis
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Cerebrovaskularne bolesti predstavljaju značajan javnozdravstveni problem u svijetu i u našoj zemlji, a jedan su od vodećih uzroka smrti u svijetu. Rani probir bolesnika sa stenozom karotidnih arterija, liječenje karotidnom trombendarekterektomijom (CEA; engl. carotid endarterectomy) ili endovaskularnim liječenjem (CAS; engl. carotid artery stenting) te modifikacija kardiovaskularnih čimbenika rizika od ključne je važnosti u primarnoj i sekundarnoj prevenciji moždanog udara. U dijagnostici cerebrovaskularnih bolesti jednu od najznačajnijih uloga imaju ultrazvučne pretrage upotrebom obojenog doplera koje omogućavaju neinvazivnu, objektivnu dijagnostiku i procjenu moždane hemodinamike u realnom vremenu. Kako bi se maksimalizirao uspjeh kirurškog zahvata, liječenje treba biti izvedeno žurno nakon TIA-a. Zbirne analize randomiziranih kontroliranih studija govore u prilog činjenici da je učinak CEA-a maksimalan u bolesnika koji se operiraju unutar 2 tjedna od neurološkog incidenta, odnosno u bolesnika koji se prezentiraju s blažim moždanim udarom ili TIA-om. Endovaskularno liječenje treba biti komplementarno kirurškom liječenju, a sve odluke o načinu liječenja potrebno je zajednički donositi, dakle skupina u kojoj su neurolog, vaskularni kirurg i intervencijski neuroradiolog. Medikamentno liječenje podrazumijeva uzimanje dvojne antiagregacijske terapije uz liječenje svih čimbenika rizika, promjenu životnih navika te dijetetske mjere. Trenutno u liječenju karotidnih stenoza postoji nekoliko kontroverza koje su i dalje predmet mnogobrojnih prospektivnih studija, od kojih su neke dovršene, a neke su još uvijek u tijeku
    Full-text · Article · Jan 2013 · Medicina
  • Source
    Dataset: tablice

    Full-text · Dataset · Nov 2012
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: As cardiovascular pathology grows in numbers, research into the discovery of new chemokine biomarkers should not be neglected, as they seem to be paramount in atherosclerosis prevention and its early detection. Chemokines attract and activate leukocytes and are well recognized in the environment of inflammatory response. MCP-1 is a valuable chemokine whose potential to become a new crucial atherosclerosis marker is surely worth investigating. Since quantities of MCP-1 found in lesions are as low as immeasurable, we propose the use of an immunohistochemical method for the quantification of MCP-1 levels in atherosclerotic lesions. Additionally, serum levels of MCP-1 can be measured by commercially available immunoassays. Proposed MCP-1 concentration increase may explain the acceleration in lesion's atherosclerosis progression as chemokine activation occurs once they bind to specific ligands. If proven, this hypothesis would indicate the need for further studies in order to objectively link the increased MCP-1 expression with carotid re-stenosis.
    Full-text · Article · Oct 2012 · Medical Hypotheses
  • Source
    Ivan Sosa · Aron Grubesic · Alan Bosnar
    [Show abstract] [Hide abstract]
    ABSTRACT: Abstract is missing (Debate).
    Full-text · Article · Oct 2012 · Journal of rehabilitation medicine: official journal of the UEMS European Board of Physical and Rehabilitation Medicine
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: In the pursuit to advance diagnostic procedures with colon carcinoma patients, we included the 15 MHz mini radial endoscopic ultrasound (MREUS) in our work up algorithm, following PH verification. When compared to surgical and final pathohistological (PH) findings, MREUS shows that it can differentiate colon layers in great detail and therefore we can determine the degree of carcinoma dissemination (T1, T2, T3, T4) as well as to make a correct therapeutic choice. MREUS (12–15–20 MHz) is a highly reliable colon layer structural analysis method. As we have shown in our study, the accuracy of T stage colon carcinoma visualization in correlation to equivalent PH studies varies from 90–100% which makes MREUS the best as well as the most reliable method in determining preoperative T stage colon carcinoma.
    Full-text · Article · Sep 2012 · Collegium antropologicum
  • [Show abstract] [Hide abstract]
    ABSTRACT: In the pursuit to advance diagnostic procedures with colon carcinoma patients, we included the 15 MHz mini radial endoscopic ultrasound (MREUS) in our work up algorithm, following PH verification. When compared to surgical and final pathohistological (PH) findings, MREUS shows that it can differentiate colon layers in great detail and therefore we can determine the degree of carcinoma dissemination (T1, T2, T3, T4) as well as to make a correct therapeutic choice. MREUS (12-15-20 MHz) is a highly reliable colon layer structural analysis method. As we have shown in our study, the accuracy of T stage colon carcinoma visualization in correlation to equivalent PH studies varies from 90-100% which makes MREUS the best as well as the most reliable method in determining preoperative T stage colon carcinoma.
    No preview · Article · Sep 2012 · Collegium antropologicum
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Aim: Our aim is to underline the superiority of Wolf endocam among other high resolution close-up laryngoscopy devices. We use a camera made by Richard Wolf GmbH (Knittlingen, Germany). High-Speed Endocam 5562 was constructed specifically for laryngoscopy, so it is equipped with an automatic focus. Case report: Patient whom we present is a 58-years old female who displayed throat discomfort and harsh voice for nearly a month. Her medical history was unremarkable except for the cervical spine tenderness. When examined with High-Speed Endocam 5562, vocal fold hematoma became visible. Discussion: So far, we have found various anatomical variations with or without epithelial damage. High resolution laryngoscopy shows a better and more objective view of vocal fold defects with no room for speculation based on subjective observation of obvious defects. With the use of Wolf endocamera precise positions are determined and accurate treatment can be achieved, also choosing a suitable approach. When surgical treatment is indicated, this imagining improves preoperative understanding of the problem, subsequently increasing the odds of success. Conclusion: Once handled by an experienced physician, up to 20 patients can be examined each day. Examination is performed quickly and without the need for local anesthesia. Endocamera offers reliability and objectivity as findings may be recorded and reviewed when necessary. This enables treating the patients adequately as making a fully informed decision is significantly upgraded by superior visual documentation of local condition.
    Full-text · Article · Jun 2012 · Medicina Fluminensis

  • No preview · Article · Jan 2012 · Journal of biological regulators and homeostatic agents
  • Sosa · Ivan · Grubesic · Aron · Persic · Viktor · Strenja-Linic · Ines · Bosnar · Alan

    No preview · Article · Jan 2012
  • Source
    Girotto D · Ledić D · Strenja-Linić I · Peharec S · Grubesić A.
    [Show abstract] [Hide abstract]
    ABSTRACT: The predominance in performing surgery of major spine injuries by neurosurgeons usually has the consequence of treating all types of spine injuries by neurosurgeons – neurotraumatologists. In the neurosurgical wards of Clinical Hospital Rijeka, we take care of the majority of these patients, following both the major, as well as minor – whiplash injuries of the neck. This article is an overview of the patients admitted in the one year period (October 1st 2009–October 1st 2010) where 1077 cases of neck injuries were analyzed. Vast majority of these injuries were due to traffic accidents (over 94%), and only a small proportion were serious injuries that needed a surgical approach – decompression and stabilization (~1%). We analyzed minor neck injuries thoroughly both because of the increasing number of whiplash neck injuries and because more complicated diagnostic and therapeutic protocols occupy too much time in the ambulatory practice of our neurotraumatologists each year thus representing a growing financial burden to the health organizations and to the society as a whole. Our results proved that the majority of the injured are male (over 60%), young and active (almost two thirds 21–40 years of age), had commonly sustained a Quebec Task Force (QTF) injury of grades 2 and 3 (almost 90%), and, if properly treated, recovered completely after a mean therapy period of ten weeks. Only a minority complained of prolonged residual symptoms, some of them connected with medico-legal issues (less than 20%). The results shown are in contrast with the general opinion that malingerers in search of financial compensation prevail in these cases, and leads to the conclusion that minor neck injuries (including whiplash) as well as Whiplash Associated Disorder (WAD) are real traumatological entities, that have to be seriously dealt with.
    Full-text · Article · Sep 2011 · Collegium antropologicum
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Voice is one of the most important means of communication and as such should be taken care of. The etiology of voice disorders is diverse. Due to the development of the society we live in, way of life, environmental factors, and exposure to pharmacological agents as well as demands we make towards our voice, there is a substantial growth in the number of people with voice disorders. We tasked ourselves to find out if it is possible to enlighten people on the importance of voice, to motivate them to take care of it, to notice the changes in its quality and eventually ask for help. We assessed in which measure do we understand the importance of a healthy voice, and do we know which is the most important factor that adds to its decline. For a long number of years voice therapists and other experts in the voice disorder field have been discussing the optimal voice impostation as well as vocal exercises and methods behind voice recovery. They have all come to the same conclusion that phonation is dependant on the sort of the voice disorder and the patient motivation. We wanted to go one step further and investigate, dependence of voice quality and the damage etiology (organic - functional), which are the predominant causes, what are the factors that account for the damage and how the disorder motivates the patient and therefore influences the rehabilitation success rate.
    Full-text · Article · Sep 2011 · Collegium antropologicum
  • [Show abstract] [Hide abstract]
    ABSTRACT: Despite the effect corticosteroids exert on blood clotting and the irrefutable impact of intracranial sure decreasing shortly after lumbar puncture, a certain number of intracranial thromboses remain unexplained. Corticosteroids are useful in reducing the severity and duration of relapses of multiple sclerosis. Several questions emerge concerning the reasons behind thrombosis occurring so sporadically, not pertaining to any rule, the most important of which regard the location and timing. We developed this hypothesis as an obverse to chronic endothelial injury theory which, only partially explains atherosclerosis development. We followed Virchows classical triad of conditions which are believed to be connected to the development of thrombosis. Although corticosteroids affect more than vessel wall injury, component of Virchows triad that has been our narrowest interest is exactly vessel wall injury.
    No preview · Article · Jan 2011 · Journal of biological regulators and homeostatic agents

15 Following View all

11 Followers View all