Arne Jensen

Arne Jensen
Ruhr-Universität Bochum | RUB · Campus Klinik Gynäkologie Bochum, Obstetrics and Gynecology

Prof. Dr. med., MD MBA

About

556
Publications
56,475
Reads
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3,373
Citations
Introduction
Arne Jensen develops autologous cord blood mononuclear cell therapies for the treatment of brain damage in newborns that have been granted 'Orphan Drug Designation' by the European Medicinal Agency EMA in 2016 (EU/3/16/1744 and EU/3/16/1743).
Additional affiliations
February 2003 - December 2019
Ruhr-Universität Bochum
Position
  • Neuroregeneration by human mononuclear cells from cord blood after cerebral hypoxic-ischemia. Mechanisms of 'homing' of cord blood cells and neuroregeneration. Clinical application of autologous cord blood in cerebral palsy.
Description
  • Neuroregeneration by human mononuclear cells from cord blood after cerebral hypoxic-ischemia. Mechanisms of 'homing' of cord blood cells and neuroregeneration. Clinical application of autologous cord blood for cerebral palsy.
January 2003 - January 2004
Universiteit Maastricht
Position
  • Brain damage by endotoxine (LPS) in chronically prepared fetal sheep
Description
  • Brain damage by endotoxine (LPS) in chronically prepared fetal sheep.
July 1995 - July 2009
Universitätsklinikum Bochum
Position
  • Cerebral ischemia. Neuroprotection. Apoptosis of neurones. Perinatal Neuroprotection by creatine. Neuroregeneration after cerebral ischemia by mononuclear (stem-) cells derived from human cord blood.
Description
  • Cerebral ischemia. Neuroprotection. Apoptosis of neurones. Perinatal Neuroprotection by creatine. Neuroregeneration after cerebral ischemia by mononuclear (stem) cells derived from human cord blood.
Education
July 1984 - July 1985
Cardiovascular Research Institute University of California San Francisco, USA
Field of study
  • Fetal Physiology
January 1984 - July 1984
Nuffield Institute for Medical Research University of Oxford, U.K.
Field of study
  • Fetal Physiology

Publications

Publications (556)
Data
This is a subsection from a review in which the concept that oxygen delivery determines cellular oxygen consumption was first presented before the cells' oxygen sensing discovery was made (HIF mechanism - Nobel Prize 2019). Fetal circulatory responses to oxygen lack. Jensen A, Berger R. J Dev Physiol. 1991 Oct;16(4):181-207. Department of Obstetr...
Article
Full-text available
Each year, thousands of children incur brain damage that results in lifelong sequelae. Therefore, based on experimental evidence, we explored the therapeutic potential of human cord blood, known to contain stem cells, to examine the functional neuroregeneration in a child with cerebral palsy after cardiac arrest. The boy, whose cord blood was store...
Article
Full-text available
Case Reports in Transplantation, http://www.hindawi.com/journals/crit/2016/1717426/ Intracranial laceration due to traumatic birth injury is an extremely rare event affecting approximately one newborn per a population of 4.5 million. However, depending on the mode of injury, the resulting brain damage may lead to lifelong sequelae, for example, cer...
Article
Full-text available
http://www.hindawi.com/journals/ogi/2014/976321/ About 17 million people world wide live with cerebral palsy, the most common disability in childhood, with hypoxic-ischemic encephalopathy, preterm birth, and low birth weight being the most important risk factors. This review will focus on recent developments in cell therapy for infantile cerebral p...
Article
Full-text available
Background: Infantile brain damage and dysfunction are prime risk factors for developmental delay and cerebral palsy in childhood that may affect school performance and educational success. Prediction of developmental performance would improve current preschool support strategies. Objective: To explore both the effects of perinatal brain damage on...
Book
Full-text available
Das vorliegende Buch ‚The Cord Blood Story VIII’ gibt einen Überblick über die von uns erreichten Ziele auf dem Wege zur Einführung der autologen Stammzelltherapie zur Behandlung Frühkindlicher Hirnschäden im Jahr 2021, wobei die Entscheidung eine Aktiengesellschaft zu gründen und einen Börsengang zu erwägen ein wirklicher Durchbruch war. Auslöser...
Book
Full-text available
This book 'The Cord Blood Story VII' provides an overview of the goals we have achieved on the way to the introduction of autologous stem cell therapy for the treatment of early childhood brain damage in 2020, with the final approval of the study protocol ('Pediatric Investigation Plan, PIP') for the use of our stem cell preparation for the treatme...
Data
Program of the International Symposium 'Brain & Breathing', September 26-27, 1997, Bochum Germany
Preprint
Full-text available
http://apmultimedianewsroom.com/multimedia-newsroom/rub-medics-art-of-social-distancing -- RUB Medics send out an urgent reminder to comply with security measures during Corona pandemic by featuring the oil painting 'Social Distancing' of the well-known artist Sarena Rosenfeld, Los Angeles, USA. "The artist was inspired by an x-ray with clear sign...
Preprint
Full-text available
As is likely true for most researchers, it was with utmost pleasure that I have read Talha Burki's expert interview of the 2019 Nobel Laureates for Physiology or Medicine. Their innate curiosity, reasoning, and deep understanding along with their joy of discovery comes to light in a most inspiring and instructive way. Their discovered cellular HIF...
Patent
Full-text available
Die vorliegende Erfindung betrifft ein Verfahren zur Detektion von saurem Gliafaserprotein (GFAP) im Blut, insbesondere im Blut von Früh- oder Reifgeborenen, mittels PCR, das auch zur Detektion im Blut unmittelbar nach Geburt anwendbar und so schnell und zuverlässig durchführbar ist, dass eine Nabelschnurbluttherapie - Entscheidung getroffen werden...
Article
Full-text available
http://doi.org/10.26420/jstemcellrestransplant.2019.1029 Pediatric cerebrovascular disorders like stroke are among the top 10 causes of death in children, with rates highest in the first year of life, while survivors may face lifelong sequelae, disability, and/or cerebral palsy for which there is no cure at present. Individual treatments using hum...
Article
Full-text available
During his studies with Bossard, Jensen could have gained inspiring stimuli outside school in Hamburg, especially through local exhibitions and acquisitions of works by Moissey Kogan, Gustav Heinrich Wolff, and Richard Haizmanns. But these contemporaries - apart from Kogan? – do not appear to have interested him. His conception of sculpture was clo...
Data
Herr Prof. Dr. Heinz Spielmann ist der Verfasser des Artikels 'Zum Werk des Bildhauers Emil Jensen', der auch online zugänglich ist (https://schleswig-holstein.sh/blog/2019/01/08/emil-jensen/). Prof Spielmann war von 1986 bis 1998 Museumsdirektor des Landes Schleswig-Holstein und von 2002 bis 2005 Gründungsdirektor und Leiter des Bucerius Kunst For...
Book
Full-text available
This book, 'The Cord Blood Story V', provides an overview of the goals we have achieved towards the introduction of autologous stem cell therapy for the treatment of early childhood brain damage in 2018, with the most important event being undoubtedly the successful involvement of two investors. Together, they acquired 1% of the shares of BrainRepa...
Article
Full-text available
Brain damage is a prime risk factor for cerebral palsy causing livelong neurologic sequelae with severe consequences for the young patients and their families. It is believed that brain damage is primarily a problem of the immature brain of preterm infants if, for example, cerebral haemorrhage or injury to the white matter in the periventricular re...
Article
Full-text available
E ach year, thousands of children incur brain damage that results in cerebral palsy, the most common disability in childhood, for which there is no cure at present beyond supportive and occupational care. Cerebral palsy leads to complex disabilities, including movement and posture disorder, chronic pain, mental retardation, inability to walk, and a...
Data
This application represents a full account of life and estate of the sculptor and 'Villa Massimo' laureate Emil Rasmus Jensen (1888 - 1967) including a list of his national and international exhibitions and bibliography of the artist. "I was born in Nordschleswig in the small town of Tondern. I did not actually have a childhood. In any case, it is...
Article
Full-text available
Background . White matter damage (WMD) is a prime risk factor for cerebral palsy, in part occuring unexplained. Though primarily a problem of preterm infants, there is growing evidence that in large newborns cephalopelvic disproportion and prolonged labor are involved. Objective . To explore both incidence of and morphometric risk factors for WMD i...
Article
Full-text available
Das Leben des 1888 in Tondern geborenen und in Schleswig-Holstein weitgehend vergessenen Bildhauers Emil Rasmus Jensen steht im Mittelpunkt des folgenden biographischen Beitrags. Verfasser ist der Großneffe des Künstlers, der ehemalige Direktor und leitende Arzt der Universitätsfrauenklinik Bochum, Prof. Arne Jensen. Basierend auf einigen wenigen V...
Presentation
Full-text available
Video presentation on Youtube: https://www.youtube.com/watch?v=QddITVrjFfc Blog: https://scupturest.tumblr.com/ . Presentation of life and estate of the sculptor Emil Rasmus Jensen (1888 - 1967) on the occasion of the award ceremony of the ’Heinrich Sauermann-Foundation’ for young sculptors to receive the ’Heinrich-Sauermann Award’ at Flensburg,...
Article
Full-text available
"I was born in Nordschleswig in the small town of Tondern. I did not actually have a childhood. In any case, it is dark, I almost wish to say, sad, and therefore I am not quite aware of it as such." So oppressive and sober commences the only printed biographical reference from the hand of the sculptor Emil Rasmus Jensen (1888-1967), who, despite se...
Cover Page
Full-text available
Bin in Nordschleswig in der kleinen Stadt Tondern geboren. Eine Kindheit habe ich eigentlich nicht gehabt, jedenfalls liegt sie dunkel, ich möchte fast sagen, traurig vor mir, und ist mir deshalb als solche nicht recht bewusst." 1 So bedrü-ckend und nüchtern beginnt der einzige gedruckte biographische Hinweis aus der Hand des Bildhauers Emil Rasmus...
Article
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Prolog: Die Großplastik „Erscheinung“ des in Tondern, Nordschleswig, gebürtigen Bildhauers und Villa Massimo Preisträgers Emil Rasmus Jensen (1888-1967) zierte über Jahrzehnte die an der Flensburger Straße gelegene erste Frauenklinik in Schleswig, die 1954 von dem Neffen des Künstlers, Dr. med. Uwe Jensen (1916-1984), und seiner Frau, Dr. med. Ing...
Book
Full-text available
Das vorliegende Buch ‚The Cord Blood Story IV’ gibt einen Überblick über die von uns erreichten Ziele auf dem Wege zur Einführung der autologen Stammzelltherapie zur Behandlung Frühkindlicher Hirnschäden im Jahr 2017, wobei die Eintragungen unseres Stammzellpräparates für den Einsatz bei ‚Periventrikulärer Leukomalazie’ und ‚Neonataler Enzephalopat...
Book
Full-text available
Book
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Das vorliegende Buch ‚The Cord Blood Story III’ faßt in zwei Bänden die wichtigsten Meilensteine, die wir auf dem Weg der Entwicklung der Stammzelltherapie zur Behandlung von Kindern mit Frühkindlichen Hirnschäden im Jahr 2016 erreichen konnten, zusammen. Hierbei wird deutlich, daß unsere im letzten Jahr angekündigte Entscheidung, bei der Europäisc...
Article
Aim: Umbilical cord blood and Wharton's jelly (WJ) are potential sources of mesenchymal stem cells (MSCs). We investigated whether harvesting and donor characteristics affected yield and neuronal differentiation, and compared human umbilical cord blood (hUCB) and WJ-derived MSCs regarding neuronal differentiation and cytokine secretion. Materials...
Article
Dr. Longo, one of the most influential figures in the fields of prenatal and perinatal biology, maternal-fetal and neonatal physiology, and basic sciences research, the founder and chairman emeritus of the NIH 'Center for Perinatal Biology' at Loma Linda University, died on January 5, 2016, aged 89 years. His scientific accomplishments on the effec...
Article
Dr. Longo, one of the most influential figures in the fields of prenatal and perinatal biology, maternal-fetal and neonatal physiology, and basic sciences research, the founder and chairman emeritus of the NIH 'Center for Perinatal Biology' at Loma Linda University, died on January 5, 2016, aged 89 years. His scientific accomplishments on the effec...
Book
Full-text available
Das vorliegende Buch 'The Cord Blood Story II' geht über die im Band I im Jahr 2013 geschilderten Erkenntnisprozesse und konzeptionellen Entwicklungen der Stammzelltherapie mit (autologem) Nabelschnurblut zur Behandlung von Kindern mit Zerebralparese hinaus und stellt wichtige Etappen auf dem langwierigen Weg zur Zulassung dieses innovativen Behand...
Research
Full-text available
This is the first international presentation of a successful autologous cord blood transplantation in a child suffering from cerebral palsy and persistent vegetative state after global brain damage caused by cardiac arrest. This individual clinical trial was based on pre-clinical studies in which 'homing' and therapeutic effects of mononuclear cell...
Data
Full-text available
A child's smile is one of life's greatest joys but here it's being used to measure the success of a pioneering therapy for cerebral palsy (http://en.wikipedia.org/wiki/Cerebral_palsy) – a condition caused by damage, during early childhood, to those areas of the brain that control muscle movement and balance. There is currently no cure although trea...
Data
First Autologous Cell Therapy of Cerebral Palsy Caused by Hypoxic-Ischemic Brain Damage in a Child after Cardiac Arrest—Individual Treatment with Cord Blood A. Jensen1 and E. Hamelmann2 1 Campus Clinic Gynecology, Ruhr-University Bochum, Universit¨atsstrasse 140, 44799 Bochum, Germany, 2 Department of Pediatrics, Ruhr-University Bochum, St. Josef-...
Data
First Autologous Cell Therapy of Cerebral Palsy Caused by Hypoxic-Ischemic Brain Damage in a Child after Cardiac Arrest—Individual Treatment with Cord Blood A. Jensen1 and E. Hamelmann2 1 Campus Clinic Gynecology, Ruhr-University Bochum, Universit¨atsstrasse 140, 44799 Bochum, Germany, 2 Department of Pediatrics, Ruhr-University Bochum, St. Josef-...
Data
First Autologous Cell Therapy of Cerebral Palsy Caused by Hypoxic-Ischemic Brain Damage in a Child after Cardiac Arrest—Individual Treatment with Cord Blood A. Jensen1 and E. Hamelmann2 1 Campus Clinic Gynecology, Ruhr-University Bochum, Universit¨atsstrasse 140, 44799 Bochum, Germany, 2 Department of Pediatrics, Ruhr-University Bochum, St. Josef-...
Data
First Autologous Cell Therapy of Cerebral Palsy Caused by Hypoxic-Ischemic Brain Damage in a Child after Cardiac Arrest—Individual Treatment with Cord Blood A. Jensen1 and E. Hamelmann2 1 Campus Clinic Gynecology, Ruhr-University Bochum, Universit¨atsstrasse 140, 44799 Bochum, Germany, 2 Department of Pediatrics, Ruhr-University Bochum, St. Josef-...
Data
First Autologous Cell Therapy of Cerebral Palsy Caused by Hypoxic-Ischemic Brain Damage in a Child after Cardiac Arrest—Individual Treatment with Cord Blood A. Jensen1 and E. Hamelmann2 1 Campus Clinic Gynecology, Ruhr-University Bochum, Universit¨atsstrasse 140, 44799 Bochum, Germany, 2 Department of Pediatrics, Ruhr-University Bochum, St. Josef-...
Data
First Autologous Cell Therapy of Cerebral Palsy Caused by Hypoxic-Ischemic Brain Damage in a Child after Cardiac Arrest—Individual Treatment with Cord Blood A. Jensen1 and E. Hamelmann2 1 Campus Clinic Gynecology, Ruhr-University Bochum, Universit¨atsstrasse 140, 44799 Bochum, Germany, 2 Department of Pediatrics, Ruhr-University Bochum, St. Josef-...
Article
Full-text available
Glial cells play a crucial role in the pathomechanism of perinatal hypoxic-ischemic brain injury (HI) and are involved in the maintenance of a chronic state of inflammation that causes delayed neuronal damage. Activation of astrocytes is one factor prolonging brain damage and contributing to the formation of a glial scar that limits neuronal plasti...
Book
Full-text available
Kreißsaalführungsseminar B-O-C-H-U-M: B - BEL-Entbindung (A.Feige) O - Organisation und Dokumentation im Kreißsaal (W. Müller, M. Kumbartski) C - CTG-Kurs und Risikomanagement (R. Berger, J. Middelanis) H - Hands on am Phantom: Glocke-ZangeSchulterdystokie (K. Marschner, B. Holmer, B. Karbowski) U - Untersuchung und Reanimation des Neugebornen (N...
Chapter
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Bei der gutachterlichen Beurteilung im Bereich der Geburtshilfe geht es fast immer um Ansprüche eines geschädigten Kindes oder dessen Eltern gegen den Geburtshelfer oder die Hebamme bzw. den Krankenhausträger. Andererseits kann auch ein behindertes Kind, dessen angeborene Behinderung nicht während der Geburt entstanden ist, von Seiten der Eltern al...
Article
Full-text available
Ziel dieses Konsensuspapiers ist es, die Anwendung des Kardiotokogramms (CTG) zur Überwachung des ungeborenen Kindes auf der Basis evidenzbasierter Methoden zu standardisieren. Dies erfolgt unter Berücksichtigung von Stör- und Einflussgrößen auf das CTG, unter Verwendung einheitlicher Definitionen und objektiver Bewertungsmöglichkeiten sowie durch...
Chapter
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Der Frauenarzt wird häufig von den Ermittlungsbehörden zur Beurteilung des Opfers bei Verdacht auf ein Sexualdelikt hinzugezogen, nachdem Anzeige erstattet worden ist. Statt eines ausführlichen gynäkologischen Fachgutachtens wird von den Ermittlungsbehörden oft lediglich eine Untersuchung des Opfers zur Beweissicherung und stichpunktartige Beantwor...
Chapter
Bei der gutachterlichen Beurteilung im Bereich der Geburtshilfe geht es fast immer um Ansprüche eines geschädigten Kindes oder dessen Eltern gegen den Geburtshelfer oder die Hebamme bzw. den Krankenhausträger. Andererseits kann auch ein behindertes Kind, dessen angeborene Behinderung nicht während der Geburt entstanden ist, von Seiten der Eltern al...
Chapter
Gutachterliche Beratung: Nach der Primärbehandlung von malignen gynäkologischen Erkrankungen wie Brustkrebs, Ovarialkarzinom, während der in der Regel Arbeitsunfähigkeit besteht, entsteht meist in der gesetzlichen Renten- und Unfallversicherung die Frage der Rehabilitation und Wiedereingliederung ins Erwerbsleben. Mehr als die Hälfte der Betroffene...
Article
Full-text available
Each year, thousands of children incur perinatal brain damage that potentially results in lifelong sequelae. Therefore, we wished to explore the therapeutic potential of human cord blood mononuclear cells, known to contain stem cells, to examine the functional neuroregeneration after perinatal hypoxic ischemic brain damage. Recent publications [1,...
Article
Full-text available
Previous studies have shown that transplanted human umbilical cord blood (hUCB)-derived mononuclear cells exert therapeutic effects in various animal models of CNS impairments, including those of perinatal hypoxic-ischemic brain injury. However, the mechanisms of how transplanted cells exert their beneficial effects on the damaged tissue are still...
Presentation
Full-text available
Präsentation auf dem Kongreß ’Geburtshilfe - sanft und sicher:Stammzelltherapie mit Nabelschnurblut bei kindlichen Hirnschäden, Programm
Presentation
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Video-Dokumentation auf YouTube - https://www.youtube.com/watch?v=6L4LUcFDTR8&t=2394s - Am 23. April 2008 wurde der Jubiläumskongreß '110 Jahre Niederrheinisch-Westfälische Gesellschaft für Gynäkologie und Geburtshilfe (NWGGG)' in Bochum am Ort ihrer Gründung durch den 1. Vorsitzenden, Herrn Prof. Dr. med. Arne Jensen, dem Leiter der Universität...
Chapter
Full-text available
There is a growing body of evidence from clinical and epidemiologic studies that in utero exposure to infection plays an important role in the genesis of fetal or neonatal injury leading to cerebral palsy and chronic lung disease. Thus, after chorioamnionitis the incidence of immature neonates with periventricular white matter damage and periventri...
Conference Paper
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Im Spannungsfeld zwischen Qualität und zunehmendem ökonomischem Druck/nötiger Kostenbegrenzung müssen und können Behandlungsprozesse in hohem Maße standardisiert werden. Immer knapper werdende Ressourcen im Personal- und Sachkostenbereich müssen durch Vermeidung redundanter Leistungen, fehlender Absprachen oder von Zeitverlusten durch divergierende...
Chapter
Full-text available
Der Frauenarzt wird häufig von den Ermittlungsbehörden zur Beurteilung des Opfers bei Verdacht auf ein Sexualdelikt hinzugezogen, nachdem Anzeige erstattet worden ist. Statt eines ausführlichen gynäkologischen Fachgutachtens wird von den Ermittlungsbehörden oft lediglich eine Untersuchung des Opfers zur Beweissicherung und stichpunktartige Beantwor...
Chapter
Full-text available
Die Diskussionen über die sog.Wunschsectio hat ihren Ursprung in Großbritannien und im deutschsprachigen Ausland [1, 3, 14].Diese „importierte Diskussion“ hat zu einer großen Verunsicherung bei Eltern und Ärzten geführt. Es ist das Verdienst des Präsidenten unserer Gesellschaft, durch Aufnahme dieser Pro- und Kontradebatte in das Kongressprogramm,...
Chapter
There is a growing body of evidence from clinical and epidemiologic studies that in utero exposure to infection plays an important role in the genesis of fetal or neonatal injury leading to cerebral palsy and chronic lung disease. Thus, after chorioamnionitis the incidence of immature neonates with periventricular white matter damage and periventri...