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Introduction
Arnaud Pautrat currently works at Fonds Clinatec a spin-off of the Commissariat à l'énergie atomique et aux énergies alternatives in Grenoble. Arnaud does research in Neuroscience oriented on Parkinson's disease, astrocytes metabolism and deep brain stimulation.
Current institution
Additional affiliations
September 2020 - September 2022
Publications
Publications (9)
A classical theory of a key pathophysiological change in Parkinson's disease (PD) is that GABAergic neurons in the substantia nigra pars reticulata (SNr), an output structure of the basal ganglia, become hyperactive following the dopaminergic loss. Increased GABA release from the SNr neurons is thus likely to induce neuroadaptations in structures r...
The basal ganglia have the key function of directing our behavior in the context of events from our environment and/or our internal state. This function relies on afferents targeting the main input structures of the basal ganglia, entering bids for action selection at the level of the striatum or sig- nals for behavioral interruption at the level o...
The presence of central neuropathic pain in Parkinson’s disease suggests that the brain circuits that allow us to process pain could be dysfunctional in the disorder. However, there is to date no clear pathophysiological mechanism to explain these symptoms. In this work, we present evidence that the dysfunction of the subthalamic nucleus and/or sub...
The subthalamic nucleus (STN) is classically subdivided into sensori-motor, associative and limbic regions which is consistent with the involvement of this structure in motor control, but also in cognitive and emotional tasks. However, the function of the sensory inputs to the STN’s sensori-motor territory is comparatively less well explored, altho...
We compared the morphological aspect of glioblastoma associated microglia/macrophages cells in 15 paired recurrent glioblastomas to check the ability of glioblastoma to recreate its microenvironment. The absolute number of GAMs is lower in normal tissue (21/mm2) than in the isolated tumor cells area (100-112/mm2) than in the solid tumor area (212-2...
Significance
The network connecting the insular cortex, the central nucleus of the amygdala, and a caudal hypothalamic nuclear complex including the parasubthalamic nucleus (PSTN) is of interest due to its role in controlling feeding behavior. Here, we show that the organization of this network is similar to that of the basal ganglia network, imply...
La maladie de Parkinson (MP) est une maladie neurodégénérative caractérisée par la perte progressive des neurones dopaminergiques de la substance noire compacte. Cette dégénérescence engendre de profonds dysfonctionnements au sein d’un réseau cérébral essentiel pour de nombreuses fonctions, les ganglions de la base (GB). Bien que ce réseau soit cla...
Pain is a prevalent symptom of Parkinson's disease, and is effectively treated by deep brain stimulation of the subthalamic nucleus (STN). However, the link between pain and the STN remains unclear. In the present work, using in vivo electrophysiology in rats, we report that STN neurons exhibit complex tonic and phasic responses to noxious stimuli....
