Arnaud Attyé

Arnaud Attyé
GeodAIsics

MD PhD
Developing XAI apps for healthcare providers #GeodAIsics

About

128
Publications
18,437
Reads
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1,314
Citations
Introduction
Arnaud Attyé is employed by Grenoble Alps University as researcher in neurosciences. Arnaud is currently sent in secondment in the Sydney Imaging Lab (Prof Fernando Calamante, Australia). His clinical work relies on hearing and visual process with Diffusion MRI and Contrast-enhanced MRI (hydrops imaging). The current methodological research project is on Manifold Learning medical applications, with a special focus on brain connectomics (graph metrics) and analysis of the Diffusion-weighted signal.
Additional affiliations
July 2019 - July 2020
The University of Sydney
Position
  • PostDoc Position
July 2011 - July 2019
Centre Hospitalier Universitaire de Grenoble
Position
  • Medical Doctor

Publications

Publications (128)
Article
Objectives: The aim of this study was to shorten the 4-h delay between the intravenous administration of gadolinium and MRI acquisition for hydrops evaluation using an optimized 3D-FLAIR sequence in patients with Menière's disease. Methods: This was a single-center prospective study including 29 patients (58 ears), recruited between November 202...
Preprint
Approximately 65% of moderate to severe traumatic brain injury (msTBI) patients present with poor long-term behavioural outcomes, which can significantly impair activities of daily living. Numerous diffusion-weighted MRI studies have linked these poor outcomes to decreased white matter integrity of several commissural tracts, association fibres and...
Article
Introduction La maladie de Parkinson est habituellement détectée par un examen clinique spécialisé avec de bonnes performances diagnostiques. Néanmoins le diagnostic de la maladie à un stade précoce avec des signes moteurs débutants peut être difficile. Des analyses morphométriques des IRM pondérées T1 ont été proposé pour le diagnostic différentie...
Article
Introduction Les dysplasies corticales de type 2 (FCD) sont difficiles à diagnostiquer en IRM cérébrale. La morphométrie cérébrale basée sur des réseaux de neurones permet maintenant de sous-segmenter le cortex (1). Les mesures volumiques corticales pourraient être ensuite être utilisé pour détecter des FCD. Néanmoins, les valeurs de références hab...
Article
Full-text available
Purpose Benign recurrent vestibulopathy is a recent entity, close to probable Meniere’s disease and vestibular-migraine. So far, no study has systematically investigated the presence of endolymphatic hydrops of the lateral semicircular canal in benign recurrent vestibulopathy using magnetic resonance imaging. The aim of this study was to determine...
Article
Full-text available
White matter bundle segmentation using diffusion MRI fiber tractography has become the method of choice to identify white matter fiber pathways in vivo in human brains. However, like other analyses of complex data, there is considerable variability in segmentation protocols and techniques. This can result in different reconstructions of the same in...
Article
Purpose The purpose of this study was to compare the degree of perilymphatic enhancement between 4 hour post-contrast constant flip angle three-dimensional fluid attenuated inversion recovery (3D-FLAIR) images obtained with short repetition time (TR) and those obtained with long TR. Materials and methods This single-center, prospective study inclu...
Article
Purpose The purpose of this study was to describe the MRI characteristics of intralabyrinthine schwannoma (ILS) on post contrast three-dimensional (3D) fluid-attenuation-inversion-recovery (FLAIR) images obtained four hours after intravenous administration of a gadolinium-based contrast agent (4h-3D-FLAIR). Materials and methods This IRB-approved...
Article
Full-text available
White matter bundle segmentation using diffusion MRI fiber tractography has become the method of choice to identify white matter fiber pathways in vivo in human brains. However, like other analyses of complex data, there is considerable variability in segmentation protocols and techniques. This can result in different reconstructions of the same in...
Article
Full-text available
PurposePatients with superior semicircular canal dehiscence syndrome, which can only be treated by surgery, present cochleo-vestibular symptoms related to a third-mobile window but also endolymphatic hydrops. Since cVEMP and oVEMP are disturbed by the presence of the dehiscence, the aim of the study is to assess the value of MRI for the diagnosis o...
Article
Full-text available
The gold standard to diagnose intracerebral lesions after traumatic brain injury (TBI) is computed tomography (CT) scan, and due to its accessibility and improved quality of images, the global burden of CT scan for TBI patients is increasing. The recent developments of automated determination of traumatic brain lesions and medical-decision process...
Article
Full-text available
Subjective tinnitus is a symptom characterized by the perception of sound with no external acoustic source, most often accompanied by co-morbidities. To date, the specific role of white matter abnormalities related to tinnitus reaches no consensus in the literature. The goal of this study was to explore the structural connectivity related to tinnit...
Article
Full-text available
Deep learning-based convolutional neural networks have recently proved their efficiency in providing fast segmentation of major brain fascicles structures, based on diffusion-weighted imaging. The quantitative analysis of brain fascicles then relies on metrics either coming from the tractography process itself or from each voxel along the bundle. S...
Article
Background: Since the first description by Hallpike and Cairns, the excess of endolymphatic fluid, also known as endolymphatic hydrops (EH), has been established as being the main biomarker in patients with Menière's disease. Recently, the concept of primary (PHED) and secondary hydropic ear disease (SHED) has been introduced. PHED corresponded to...
Article
There is currently a great interest in the study of Ménière's disease using imaging. Magnetic resonance imaging (MRI) with delayed acquisition provides a powerful means to characterize endolymphatic hydrops noninvasively by using the properties of contrast media on inner ear peri-lymph. Despite their popularity and widespread use, there are a numbe...
Preprint
Full-text available
White matter bundle segmentation using diffusion MRI fiber tractography has become the method of choice to identify white matter fiber pathways in vivo in human brains. However, like other analyses of complex data, there is considerable variability in segmentation protocols and techniques. This can result in different reconstructions of the same in...
Article
Full-text available
Background: Combining MRI techniques with machine learning methodology is rapidly gaining attention as a promising method for staging of brain gliomas. This study assesses the diagnostic value of such a framework applied to dynamic susceptibility contrast (DSC)-MRI in classifying treatment-naïve gliomas from a multi-center patients into WHO grades...
Article
Purpose The purpose of this study was to create an algorithm that combines multiple machine-learning techniques to predict the expanded disability status scale (EDSS) score of patients with multiple sclerosis at two years solely based on age, sex and fluid attenuated inversion recovery (FLAIR) MRI data. Materials and methods Our algorithm combined...
Poster
Full-text available
The extent and spatial location of white matter (WM) MRI abnormalities are related to distinct cognitive profiles in epilepsy [1]. Diffusion MRI (dMRI) appears, in addition, clinically relevant to predict the surgical outcomes in intractable forms, notably in temporal lobe epilepsy (TLE) [2]. However, dMRI metrics remain complex to analyze and are...
Article
Objectives Menière’s disease (MD) is associated with endolymphatic hydrops (EH), which is an accumulation of excessive endolymphatic fluid in the inner ear. However, using temporal bone CT, lower visualization rates of the vestibular aqueduct (VA) in these patients have also been reported.Methods In this retrospective single-center imaging study, w...
Preprint
Full-text available
Deep learning-based convolutional neural networks have recently proved their efficiency in providing fast segmentation of major brain fascicles structures, based on diffusion-weighted imaging. The quantitative analysis of brain fascicles then relies on metrics either coming from the tractography process itself or from each voxel along the bundle. S...
Article
Full-text available
Purpose Bilateral vestibulopathy (BV) is an uncommon disorder and the etiology remained idiopathic in most cases. Delayed 3D-FLAIR sequences have provided new insights into various inner ear diseases, allowing the evaluation of the endolymphatic space and the permeability of the blood–labyrinthine barrier (BLB). The aim of this study was to assess...
Poster
Full-text available
We present an application of a non-linear manifold learning for fMRI data with the aim of exploring the abnormal patterns of activations within high-dimensional language and memory network in patients with temporal lobe epilepsy. The presented approach can be very useful for small sample or single case studies.
Article
Purpose The purpose of this study was to investigate the clinical features of ears with otosclerosis and their correlation with endolymphatic hydrops and blood-labyrinth barrier (BLB) impairment on 3 T magnetic resonance imaging (MRI). Materials and methods This was a single-center retrospective imaging study. Thirty-nine ears from 29 patients (17...
Article
Background and purpose: Endolymphatic hydrops in patients with Menière disease relies on delayed postcontrast 3D-FLAIR sequences. The purpose of this study was to compare the degree of perilymphatic enhancement and the detection rate of endolymphatic hydrops using constant and variable flip angles sequences. Materials and methods: This was a ret...
Article
Full-text available
COVER ILLUSTRATION Representation of a resting‐state fMRI map projected on a 3D brain render and on which is affixed/anchored a correlation matrix derived from resting‐state fMRI data, serving as the basis for assessing functional connectivity.
Article
Résumé L’hydrops endolymphatique est caractérisé par un excès d’endolymphe dans le labyrinthe membraneux et est considéré comme un marqueur histologique de la maladie de Menière. Entre le début des années 1980 et la fin des années 2000, l’exploration en IRM des patients porteurs d’une maladie de Menière visait uniquement à éliminer une cause tumora...
Article
Background: Delayed 3D-FLAIR sequences enable the distinction between the utricle and the saccule. Aims/objectives: We sought to evaluate the clinical and radiological findings in patients with no visible saccule (NVS) on 4-hour post-contrast MRI. Material and Methods: We retrospectively assessed the presence of NVS signs in 400 patients who underw...
Article
Purpose: New multiple sclerosis (MS) disease-modifying therapies (DMTs), which exert beneficial effects through prevention of relapse, limitation of disability progression, and improvement of patients' quality of life, have recently emerged. Nonetheless, these DMTs are not without associated complications (severe adverse events like. progressive mu...
Article
Endolymphatic hydrops features excess endolymph in the membranous labyrinth, and is a marker of Menière's disease. Between the early 1980s and late 2000s, MRI in Menière's disease aimed purely to rule out tumor or malformation as differential diagnoses for the pressure disorder. Progress in high-resolution MRI, however, now enables excess endolymph...
Article
Full-text available
Mesial temporal lobe epilepsy (mTLE) affects the brain networks at several levels and patients suffering from mTLE experience cognitive impairment for language and memory. Considering the importance of language and memory reorganization in this condition, the present study explores changes of the embedded language‐and‐memory network (LMN) in terms...
Preprint
Full-text available
Background: Machine learning assisted MRI radiomics, which combines MRI techniques with machine learning methodology, is rapidly gaining attention as a promising method for staging of brain gliomas. Our study assess the diagnostic value of such machine learning for DSC-MRI radiomics in classifying treatment-naive gliomas from a multi-center patient...
Article
OBJECTIVE Diffusion imaging tractography has allowed the in vivo description of brain white matter. One of its applications is preoperative planning for brain tumor resection. Due to a limited spatial and angular resolution, it is difficult for fiber tracking to delineate fiber crossing areas and small-scale structures, in particular brainstem trac...
Article
PURPOSE: Currently, 3D-FLAIR sequence performed 4 hours after the intravenous administration of a single dose of contrast media is the imaging technique of choice for the diagnosis of saccular hydrops (SH). Recently, the diagnosis of SH has also been reported with heavily-T2 weighted sequences. MATERIALS AND METHODS: In this retrospective imaging s...
Article
Full-text available
Purpose: The purpose of this study was to assess whether the volume of the vestibular endolymphatic space correlates with the degree of hearing loss using heavily T2-weighted fast imaging employing steady-state acquisition with cycle phase (FIESTA-C) MRI. Materials and methods: A total of 23 patients with vestibular schwannoma, as diagnosed on t...
Article
Objectives/Hypothesis Because delayed post‐contrast three‐dimensional fluid‐attenuated inversion recovery imaging sequences enable the distinction between the utricle and the saccule, we raised the hypothesis that patients with vestibular atelectasis (VA) could show unilateral collapse of the utricle and the ampullas on imaging. Study Design Retro...
Article
The diagnostic criteria for Meniere Disease (MD) are clinical and include two categories: definite MD and probable MD, based on clinical examination and without the necessity of advanced vestibular or audiological testing. The condition is a heterogeneous disorder and it is associated with endolymphatic hydrops (EH), an accumulation of endolymph in...
Thesis
Sensorineural hearing loss (SNHL) is a common functional disorder in humans. Besides clinical investigations, magnetic resonance imaging (MRI) is the modality of choice to explore the central auditory pathways. Indeed, new MRI sequences and postprocessing methods have revolutionized our understanding of inner ear and brain disorders.The inner ear i...
Article
Full-text available
Background: Predicting the displacement of cranial nerves by tumors could make surgery safer and the outcome better. Recent advances in imaging and processing have overcome some of the limits associated with cranial nerve tractography, such as spatial resolution and fiber crossing. Among others, probabilistic algorithms yield to a more accurate de...
Article
Purpose 3D-FLAIR sequences with delayed acquisition after contrast medium injection have demonstrated new insights into blood-labyrinthine barrier (BLB) abnormalities in various diseases. The aim of this study was to assess the BLB in patients referred with unilateral acute vestibular syndrome (UAVS). Materials and methods In this retrospective mu...
Article
Background and purpose: In patients with Meniere's disease (MD), saccular hydrops can only be studied by magnetic resonance imaging (MRI) at a late stage when the disease is already responsible for moderate to severe hearing loss. However, these patients may also present vestibular aqueduct (VA) abnormalities. Materials and methods: In this pros...
Article
Full-text available
Purpose: To report the postoperative magnetic resonance imaging (MRI) features after superior semicircular canal plugging in patients with Minor syndrome. Materials and methods: The MRI examinations with 3D T2-weighted SPACE sequence of 12 patients with superior semicircular canal dehiscence syndrome (SCDS) were retrospectively assessed. Two rad...
Article
Full-text available
Low back pain (LBP) is the most common pain syndrome, and is an enormous burden and cost generator for society. Lumbar facet joints (FJ) constitute a common source of pain, accounting for 15–45% of LBP. Facet joint degenerative osteoarthritis is the most frequent form of facet joint pain. History and physical examination may suggest but not confirm...
Article
Full-text available
Background: Diffusion imaging tractography caught the attention of the scientific community by describing the white matter architecture in vivo and noninvasively, but its application to small structures such as cranial nerves remains difficult. The few attempts to track cranial nerves presented highly variable acquisition and tracking settings. O...
Article
Objectives: To determine whether facial nerve MR tractography is useful in detecting PeriNeural Spread in parotid cancers. Methods: Forty-five participants were enrolled. Thirty patients with surgically managed parotid tumors (15 malignant, 15 benign) were compared with 15 healthy volunteers. All of them had undergone 3T-MRI with diffusion acqui...
Article
Full-text available
Objectives: Meniere's disease is an inner ear disorder generally attributed to an endolymphatic hydrops. Different electrophysiological tests and imaging techniques have been developed to improve endolymphatic hydrops diagnosis. The goal of our study was to compare the sensitivity and the specificity of delayed inner ear magnetic resonance imaging...
Article
Objectives: A case-controlled imaging study demonstrated that saccular hydrops was specific to Meniere's disease (MD), but only present in a subset of patients. Here, we compared patients with definite MD, vertigo and sensorineural hearing loss (SNHL) to elucidate the relationship between saccular hydrops and extent of SNHL. Methods: In this pro...
Article
Purpose Due to the increased protein concentration in the perilymph liquid, FIESTA-C has recently been proposed to assess endolymphatic spaces without administration of contrast media in patients with vestibular schwannoma. The aim of this study was to assess whether vestibular endolymphatic space dilatation, as evaluated with 3D-FIESTA-C sequences...
Article
In evaluating a 3-month-old boy with horizontal nystagmus, brain MRI revealed absence of the optic chiasm. The remainder of the brain was normal in appearance. Achiasma was confirmed with diffusion tensor imaging and best visualized with optimized probabilistic-based tractography.
Article
Full-text available
Primary open-angle glaucoma (POAG) firstly mainly affects peripheral vision. Current behavioral studies support the idea that visual defects of patients with POAG extend into parts of the central visual field classified as normal by static automated perimetry analysis. This is particularly true for visual tasks involving processes of a higher level...
Article
Full-text available
Purpose: To compare the degree of enhancement of the perilymph between two macrocyclic gadolinium-based contrast agents (gadobutrol and gadoterate meglumine) in patients with Meniere's disease at 3-T magnetic resonance imaging (MRI). Materials and methods: The MRI examinations of 20 patients with Meniere's disease obtained 4hours after a single...
Article
Background: The use of MRI-tractography to explore the human neuroretina is yet to be reported. Track-weighted imaging (TWI) was recently introduced as a qualitative tractography-based method with high anatomical contrast. Purpose: To explore the human retina in healthy volunteers and patients with anterior ischemic optic neuropathy (AION) using...
Article
Objective: To assess technical feasibility of cryoneurolysis of the greater occipital nerve in the management of occipital neuralgia. Methods: Six patients suffering from unilateral refractory greater occipital neuralgia and who underwent 7 GON cryoneurolysis were assessed between October 2015 and January 2017. All procedures were performed unde...
Article
Background and purpose: To assess the feasibility of greater occipital nerve (GON) tractography using a fully automated tractography technique on the whole-neck volume, in comparison with anatomical knowledge. Methods: Healthy subjects were consecutively included in this study if they had no history or symptoms of headache or brain disorder. A 3...
Article
The MRI evaluation of endolymphatic hydrops currently relies on inversion recovery sequences. Signal intensity of such sequences depends on the Inversion Time (TI) parameter. Here, we assessed endolymphatic compartment variation with two 3D-FLAIR sequences, closely similar except for the TI (2300 and 2400 ms), in healthy volunteers and patients. We...
Article
Objective Spontaneous cerebrospinal fluid rhinorrhea (SCSFR) might be the only clinical manifestation of idiopathic intracranial hypertension (IIH), which has been historically related to overweight. Our goal was to search for an association between SCSFR and increased body weight on the one hand and SCSFR and imaging findings suggestive of IIH on...