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Synapses in the central nervous system (CNS) are highly dynamic structures that undergo reorganisation in response to synaptic activity. Dysfunctional structural synaptic plasticity is associated with impaired brain function and several neurological disorders. As response to synaptic activity, dendritic spines of excitatory synapses were reported t...
Ca(2+) -dependent adhesion molecules, cadherins, localised at synaptic sites are critically involved in long-term potentiation (LTP). Whereas N-cadherin is thought to promote LTP cadherin-11 seems to counteract LTP. Since high synaptic activity is accompanied by local transient changes of the pH in the synaptic cleft we asked in this study if the b...