Armando Guerra-Ruiz

Armando Guerra-Ruiz
Hospital Universitario Marques de Valdecilla | HUMV · Servicio de Análisis Clínicos

PhD

About

34
Publications
12,357
Reads
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515
Citations
Introduction
Researcher with experience in Molecular Biology, Lipids and Cardiovascular Risk, Liver and Gastrointestinal Diseases, Biostatistics, and Biomarkers. Currently interested in the field of Dyslipidaemias and Cardiovascular Risk. Other interests: Biomarkers of Liver damage, New therapeutic targets, microRNAs
Additional affiliations
May 2013 - present
Hospital Universitario Marques de Valdecilla
Position
  • Researcher
January 2007 - December 2009
Fundación Marqués de Valdecilla
Position
  • Tecnico Superior de apoyo a Investigación
Description
  • Apoyo a grupos de investigación clínicos en cuanto a uso de técnicas de biología molecular
Education
September 2004 - March 2008
Universidad de Cantabria
Field of study
  • Biología Molecular y Biomedicina

Publications

Publications (34)
Article
Full-text available
Water retention is a major clinical problem in patients with liver cirrhosis. The factors that predispose to water retention are poorly understood but may involve genetic factors. Recent research suggests that renal aquaporins may be a pathophysiological factor involved in this condition. Aquaporin-1 (AQP1) is expressed in the proximal tubule and a...
Article
High levels of endotoxin in patients with cirrhosis are thought to be responsible for the activation of tumour necrosis factor-alpha (TNF)-alpha-mediated pro-inflammatory pathways involved in haemodynamic alterations. Bactericidal/permeability increasing protein (BPI) is a protein found in neutrophils with endotoxin-binding and neutralization capac...
Article
Some lines of evidence suggest that endotoxin may induce non-alcoholic steatohepatitis (NASH) in a background of fatty liver. However, a clear association between increased endotoxemia and development of steatohepatitis in obese patients has not been confirmed. We aim to assess the endotoxemic state of patients with non-alcoholic fatty liver diseas...
Article
Full-text available
Background The diagnosis of hepatitis B virus (HBV) infection requires HBV DNA testing and serologic testing for detection of the surface antigen (HBsAg) and the hepatitis B core antibody (anti-HBc). There is a population of patients with occult HBV infection (OBI), which is not detected by HBsAg or HBV DNA quantification in blood, despite the pres...
Article
Full-text available
Resumen Introducción El diagnóstico actual del virus de la hepatitis B (VHB) está basado en la detección mediante técnicas moleculares de ADN de VHB y ensayos serológicos, como el antígeno de superficie (HBsAg) y anticuerpos frente al core VHB (anti-HBc). Existe un grupo de pacientes con infección oculta de VHB (OBI) en los que estos ensayos no so...
Article
Full-text available
Introduction Abnormal liver biochemistry is not a rare finding in the context of SARS-CoV-2 infection, regardless of patients having pre-existing chronic disease or not Content This review examines the current body of knowledge on the relationship between COVID-19 and liver injury, which is frequently found in this setting Summary Although the pa...
Article
Full-text available
Resumen Introducción En el contexto de la infección por SARS-CoV-2 no es infrecuente encontrar alteraciones hepáticas, tanto en pacientes con enfermedad hepática crónica previa como sin ella. Contenido En esta revisión, se examina el conocimiento actual sobre la relación entre la COVID-19 y el daño hepático, frecuentemente observado en el seno de...
Article
Full-text available
Elevated plasma bilirubin levels are a frequent clinical finding. It can be secondary to alterations in any stage of its metabolism: (a) excess bilirubin production (i.e., pathologic hemolysis); (b) impaired liver uptake, with elevation of indirect bilirubin; (c) impaired conjugation, prompted by a defect in the UDP-glucuronosyltransferase; and (d)...
Article
Full-text available
Resumen Un aumento en los niveles plasmáticos de bilirrubina es una alteración frecuente. Puede deberse a cualquier causa que altere alguna de las fases de su metabolismo: a) producción excesiva de bilirrubina (ej. hemólisis patológica); b) defecto en la captación hepática, con aumento de bilirrubina indirecta); c) defecto de conjugación, por alter...
Article
Full-text available
Metabolic-associated fatty liver disease (MAFLD) is defined as fat accumulation in the liver in the presence of metabolic alterations. This disorder is generally asymptomatic and may progress to severe liver disease, which are linked to inflammation and/or fibrosis. MAFLD has a high prevalence (26%) and therefore a considerable number of patients a...
Article
Full-text available
Resumen Introducción La enfermedad hepática grasa asociada a la disfunción metabólica (MAFLD) se define por el acúmulo de grasa en el hígado en presencia de alteraciones metabólicas. Suele cursar de forma asintomática y puede progresar a formas graves de enfermedad hepática, ligadas a la aparición de inflamación y/o fibrosis. Su prevalencia es muy...
Preprint
Full-text available
BACKGROUND: Higher cardiovascular risk has been largely described in rheumatoid arthritis as well as different effects of biologic agents in theses patients. The aim of present study is to analyze the effects of tumor necrosis factor inhibitors (TNFi) in the lipoprotein profile of rheumatoid arthritis (RA) patients using a broad laboratory assessme...
Article
Background: In chronic obstructive pulmonary disease (COPD), low muscle mass has been associated with several clinical outcomes such as low exercise capacity, hospital admission, and mortality. The Sarcopenia Index (SI) is a novel way to estimate muscle mass based on the ratio of serum creatinine (produced exclusively by muscle)/cystatin C (produc...
Article
In congestive heart failure (CHF), arterial response is regulated by endothelial molecules. The aim of this study was to evaluate whether endothelial dysfunction (ED) was a predictor of outcome in a cohort of patients with heart failure. Endothelial function was assessed in 242 patients with CHF by forearm reactive hyperaemia measured with intermit...
Article
Although the molecular basis for the pathophysiology of non-alcoholic steatohepatitis (NASH) is poorly understood, we evaluate the hepatic gene expression of cytokines, chemokines, cell receptors, growth factors, intracellular transducers and extracellular communication proteins in liver tissue of obese patients (with and without NASH), and we dete...
Article
Full-text available
Unlabelled: Although the molecular basis for the pathophysiology of non-alcoholic steatohepatitis (NASH) is poorly understood, we evaluate the hepatic gene expression of cytokines, chemokines, cell receptors, growth factors, intracellular transducers and extracellular communication proteins in liver tissue of obese patients (with and without NASH)...
Article
The main aim of this study was to examine the relationship of the leptin system in steatosis and nonalcoholic steatohepatitis (NASH). The study also analysed the pathogenic role of the leptin system in the development of hepatic fibrosis and its relation with the TGF-beta1 system. The study included 90 subjects, 55 with NASH and 35 with simple stea...
Article
Full-text available
Background: Intestinal bacterial overgrowth (IBO) is related to small bowel motility and has been involved in the pathogenesis of bacterial translocation (BT) in experimental models, and both overgrowing gut flora and translocating bacteria to mesenteric lymph nodes are common features in cirrhosis. Objectives: The aims of this study were to ana...
Article
The enduring shortfall of organ donors has inspired the widespread utilization of hepatic allografts from donors with hepatitis B core antibodies in spite of the potential risk of transmitting hepatitis B virus (HBV) infection to the recipient. Here we report a protocol of naive recipients receiving livers from hepatitis B core antibody-positive do...

Questions

Question (1)
Question
We are looking for an english native speaker (or someone with excellent English ability) to help us write an original paper on the subject. We'd like help mostly at developing discussion, although you may review the rest of the paper for grammar and style improvement. You will take credit for that task (take part of authorship). A gross line-up for the discussion will be provided by me, along with the relevant bibliography.

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Projects

Projects (3)
Project
To study new biomarkers in the metabolism of lipoproteins and its relation to the diagnosis of dyslipidaemias.
Project
Indagar en los mecanismos fisiopatológicos y la expresión de genes relacionados con la enfermedad hepática no alcoholica por depósito de grasa (EHNA, NASH). Indagar asimismo en la asociación de polimorfismos genéticos con la predisposición a la enfermedad.