Arja L T Uusitalo

Arja L T Uusitalo
Finnish Institute of Occupational Health | FIOH · Quantfy Employee

MD, PhD, Adjunct Professor

About

93
Publications
18,715
Reads
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2,108
Citations
Additional affiliations
August 2016 - present
Finnish Institute for Occupational Health
Position
  • Leading Medical Specialist
August 2015 - December 2016
University of Helsinki
Position
  • Professor
January 2008 - December 2013
University of Helsinki
Position
  • Senior Researcher

Publications

Publications (93)
Article
Full-text available
Background: We investigated the effects of sex, energy availability (EA), and health status on the change in hemoglobin mass (ΔHbmass) in elite endurance athletes over ~3 to 4 weeks of Live-High/Train-High altitude training (Flagstaff, AZ, 2135m; n=27 females; n=21 males; 27% 2016 Olympians). Methods: Pre- and post-camp Hbmass (optimized CO re-b...
Article
Full-text available
We aimed to (1) report energy availability (EA), metabolic/reproductive function, bone mineral density (BMD) and injury/illness rates in national/world-class female and male distance-athletes; and (2) investigate the robustness of various diagnostic criteria from the Female Athlete Triad (Triad), Low Energy Availability in Females Questionnaire (LE...
Article
Full-text available
We investigated one week of dietary micro-periodization in elite female (n=23) and male (n=15) runners and race-walkers by examining the frequency of training sessions and recovery periods conducted with recommended carbohydrate (CHO) and protein availability. Food and training diaries were recorded in relation to HARD (intense or >90min sessions;...
Article
Full-text available
Contemporary nutrition guidelines promote a variety of periodized and time-sensitive recommendations, but current information regarding the knowledge and practice of these strategies among world-class athletes is limited. The aim of this study was to investigate this theme by implementing a questionnaire on dietary periodization practices in nation...
Article
Full-text available
We investigated how cytokines are implicated with overtraining syndrome (OTS) in athletes during a prolonged period of recovery. Plasma IL-6, IL-10, TNF-α, IL-1β, adipokine leptin, and insulin like growth factor-1 (IGF-1) concentrations were measured in overtrained (OA: 5 men, 2 women) and healthy control athletes (CA: 5 men, 5 women) before and af...
Conference Paper
Full-text available
We investigated nutrient timing in elite Finnish female (n = 11) and male (n = 7) distance runners by examining the frequency of training sessions and recovery periods done with optimal carbohydrate (CHO) and protein (PRO) availability. Seven-day food and training diaries were recorded during a pre-competition phase examining nutrient timing in rel...
Article
Blood O(2) carrying capacity affects aerobic capacity (VO(2max)). Patients with type 1 diabetes have a risk for anaemia along with renal impairment, and they often have low VO(2max). We investigated whether total haemoglobin mass (tHb-mass) and blood volume (BV) differ in men with type 1 diabetes (T1D, n = 12) presently without complications and in...
Article
Full-text available
Objective: If the body fails to acclimatize at high altitude, acute mountain sickness (AMS) may result. For the early detection of AMS, changes in cardiac autonomic function measured by heart rate variability (HRV) may be more sensitive than clinical symptoms alone. The purpose of this study was to ascertain if the changes in HRV during ascent are...
Article
The present study examined whether activity energy expenditure related to body mass (AEE/kg) is associated with maximal aerobic fitness (VO(2max)), energy balance, and body mass index (BMI) during the 2 hardest weeks of the military basic training season (BT). An additional purpose was to study the accuracy of the pre-filled food diary energy intak...
Article
Full-text available
This study compared the autonomic responses to an active orthostatic test and Stroop Color Word Test (Stroop) as well as cognitive performance in Stroop in twelve severely overtrained (OA, 6 men and 6 women) and twelve control athletes (CA, 6 men and 6 women). RR-intervals were recorded during the orthostatic test, the Stroop, and a relaxation peri...
Article
Full-text available
Our aim was to estimate causal relationships of genetic factors and different specific environmental factors in determination of the level of cardiac autonomic modulation, i.e., heart rate variability (HRV), in healthy male twins and male twins with chronic diseases. The subjects were 208 monozygotic (MZ, 104 healthy) and 296 dizygotic (DZ, 173 hea...
Article
Full-text available
Brain 5-HT neurotransmission has been described to be down-regulated in depressed people, and also suspected to be changed in overtraining state, the consequence of long-term physical overloading and stress in athletes. We studied brain serotonin (5-HT) transporter binding i.e., 5-HT reuptake with the specific radioligand (123-I-labelled 2beta-carb...
Article
Full-text available
Whole-body cryotherapy (WBC) is one mode of cold therapy, during which rheumatic patients are exposed to very cold air (-110 degrees C) in minimal clothing. It is also proposed to have a bronchodilatory effect. The aim was to examine the effects of WBC on lung function in healthy humans after acute and repeated exposures. Twenty-five healthy, non-s...
Article
Heart rate monitoring was used to measure heart rate variability (HRV) at thermoneutral conditions (Ta 24°C) in healthy women resting in supine position before and after acute and after repeated (3 times a week during a 3-month period) whole-body cryotherapies (WBC), at −110°C. The observed acute cooling-related increase in high frequency power (HF...
Article
Full-text available
Part of the association between physical activity and low blood pressure (BP) may be a consequence of genetic selection. We investigated the association of genetic factors and physical activity in adolescence and adulthood with BP. BP was measured with a Finapres device in 71 monozygotic and 104 dizygotic male twin pairs using no antihypertensive m...
Article
Full-text available
The blood pressure responses to an acute and long-term (three months) whole-body cryotherapy (WBC) were measured in men and women. Acute cold exposure (−10°C, −60°C, −110°C) increased both systolic and diastolic blood pressures temporarily. Neither significant gender differences nor adaptation in blood pressures were found during WBC. The variation...
Article
The purpose of this report is to study serotonin reuptake of the brain in a severely overtrained athlete by using single-photon emission computed tomography (SPECT). A 26-year-old team athlete increased his training volume (by 200 %) and intensity markedly in a new high-level team. After two months, he started to feel continuous fatigue. He had tin...
Article
Full-text available
Overtraining syndrome is a serious problem marked by decreased performance, increased fatigue, persistent muscle soreness, mood disturbances, and feeling 'burnt out' or 'stale.' The diagnosis of overtraining is usually complicated, there are no exact diagnostic criteria, and physicians must rule out other diseases before the diagnosis can be made....
Article
Full-text available
We investigated heavy training- and overtraining-induced changes in heart rate and blood pressure variability during supine rest and in response to head-up tilt in female endurance athletes. Nine young female experimental athletes (ETG) increased their training volume at the intensity of 70-90% of maximal oxygen uptake (VO2max) by 125% and training...
Article
Full-text available
We investigated the effects of progressively increased training load and overtraining on resting and intrinsic heart rate (IHR) and cardiac autonomic modulation (CAM), and their relationships to performance variables. Nine athletes (ETG) increased training volume at 70-90% of maximal oxygen uptake (VO2max) by 130% (p<0.01) and training volume at <7...
Article
We examined heavy training-induced changes in baroreflex sensitivity, plasma volume and resting heart rate and blood pressure variability in female endurance athletes. Nine athletes (experimental training group, ETG) increased intense training (70-90% VO2max) volume by 130% and low-intensity training (< 70% Vo2max) volume by 100% during 6-9 weeks,...
Article
To examine different hormonal responses to heavy endurance training and overtraining in female athletes. Submaximal and maximal treadmill tests, self-report mood measures, and stress hormone analyses were repeated at baseline, after 4 weeks and at the end of 6 to 9 weeks of experimental intensive training and after 4 to 6 weeks of recovery. Fifteen...
Article
A series of standardized laboratory tests [10 min sitting and supine, 9 min standing, dynamic; cycle ergometer (ERG) and isometric exercise; handgrip (HG)] were performed during intra-arterial blood pressure (BP) recording in 97 healthy unmedicated men, initially classified as normotensive (NT, n = 34), borderline hypertensive (BHT, n = 29) or mild...
Article
The effects of antihypertensive treatment with ramipril and enalapril on the activity of angiotensin converting enzyme (ACE), blood pressure and heart rate, were investigated in a clinical study. The study was randomized, double-blind and of a two-way crossover design. Nineteen patients with primary hypertension were included and 18 completed the s...
Article
To evaluate the reliability of whole-body impedance cardiography with electrodes on wrists and ankles in the measurement of cardiac output compared with the thermodilution method. Prospective, clinical investigation. Surgical intensive care unit and operating room at a university hospital. Simultaneous cardiac output measurements by thermodilution...
Article
Full-text available
The aim of this study was to quantify the frequency shift in vasomotor oscillations in blood pressure we observed in borderline hypertensive individuals in our previous study. Electrocardiogram and intraarterial blood pressure were recorded in 33 normotensive, 29 borderline hypertensive, and 33 mildly hypertensive men (aged 35 to 45 years). Five-mi...
Article
Full-text available
The majority of the reference data on ambulatory blood pressure (ABP) monitoring is based on fixed, predefined times for waking hours and sleep. Our aim was to determine the level of ABP according to diary entries when awake, at work, at home and during sleep in a sample of normotensive, middle-aged men. The dipping-status was also determined. All...
Article
Full-text available
There is considerable disagreement in the literature on the clinical usefulness of exercise testing as a tool for prediction of future hypertension. Much of the discrepancy between various reports is attributable to the difficulties of blood pressure (BP) measurement during exercise. Therefore, we investigated whether accurate intraarterial. BP mea...
Article
We examined how the time and frequency domain measures of heart rate and blood pressure variability at supine rest reflect the sympathovagal balance of 23 female and male endurance athletes. Pharmacological blocking by atropine and propranolol was used as a standard for defining autonomic control of the heart. The Rosenblueth and Simeone model for...
Article
The aims of this study were to determine the importance of ambulatory blood pressure measurement, diurnal blood pressure (BP) profile, and variability in the evaluation of left ventricular (LV) parameters, and the impact of smoking on these factors. We performed intraarterial ambulatory BP (IAMB) recording and echocardiography in 80 healthy, unmedi...
Article
We compared mean intra-arterial ambulatory blood pressure (IAMB), blood pressure (BP) diurnal profiles are variability, and postural measurements with casual sphygmomanometric measurements for the prediction of future BP. We studied 97 healthy, ummedicated men classified as normotensive (NT, n = 34), borderline hypertensive (BHT, n = 29), or mildly...
Article
The decrease in mortality among patients receiving thrombolytic therapy for myocardial infarction is greater than would be expected from the improvement in left ventricular contractile function alone; thus some additional advantage of recanalization of the infarct-related coronary artery probably exists. Changes in the post-infarction myocardial me...
Article
Fatty acid scintigraphy is an interesting new technique for assessing the extent of myocardial infarction. We studied 19 patients with electrocardiographically verified first anterior myocardial infarction using radioiodinated phenylpentadecanoic acid and single photon emission computed tomography (SPECT). Besides the expected lesions in the territ...
Article
Electrocardiogram and intra-arterial blood pressure were recorded in 96 men (aged 35 to 45 years) by the Oxford method over a 30-hour period. The study involved 33 normotensive, 29 borderline hypertensive, and 34 mildly hypertensive individuals, as assessed by the cuff method. Five-minute periods during sleep and with subjects in supine, sitting, a...
Article
The diagnostic value of 123I-phenylpentadecanoic acid (IPPA) metabolic cardiac imaging was studied in a group (n=29) of patients with angiographically confirmed CAD using single photon emission computed tomography (SPECT). A symptom-limited exercise test was first done with IPPA, and 2 days later with thallium. Medications were not withheld during...
Article
Full-text available
Of 46 patients who had Nissen fundoplication for proved gastro-oesophageal reflux, 25 were available for follow up after a median of 20 years, 15 had died of unrelated causes, and six could not be traced. All 25 patients in the follow up study were personally interviewed: 21 consented to an endoscopy, 14 to 24 hour recording of oesophageal pH and m...
Article
This investigation studied the effect of 50 Hz electric and magnetic fields on the human heart. The electrocardiograms of 27 transmission-line workers and 26 male volunteers were recorded with a Holter recorder both in and outside the fields. The measurements took from half an hour to a few hours. The electric field strength varied from 0.14 to 10....
Article
Short-term fluctuations in systolic blood pressure (SBP) and heart rate (HR) and their inter-relationship were analysed in a group of normotensive middle-aged men (n = 16) using a multivariate autoregressive modelling technique. This study is the first to evaluate the beat-to-beat variability of SBP and HR in a group of real normotensive subjects....
Article
Short-term temporal reproducibility of intra-arterially determined systolic and diastolic blood pressure (SBP and DBP) and heart rate (HR) were studied in nine healthy subjects at rest and during performance of mental arithmetic, isometric exercise and a complex motor task. All tasks were completed twice during 2 hours. Both resting and task-induce...
Article
In a single-blind study of 6 weeks' duration, 32 patients with stable angina pectoris, who hadbeen receiving controlled-release, Durules®, isosorbide-5-monoitrate (Imdur®) 60 to 180 mg daily for at least 1 year, were assessed after abrupt withdrawal of the nitrate. After 2 weeks of placebo treatment nitrate therapy was re-instituted, and the patien...
Article
The aim of this study was to continue our previously published work and to compare the different indirect diagnostic methods for hypolactasia with the lactase to sucrase ratio obtained by jejunal biopsy. The following tests were performed in 63 adult patients: the breath hydrogen test, the lactose tolerance test with ethanol (serum galactose measur...
Article
Enterogastric reflux was studied using the scintigraphic method in 20 patients with colonic interposition for benign esophageal disease. The state of the transplanted colonic mucosa was evaluated by endoscopy. In 16 patients, reflux of the duodenal contents into the stomach could be seen. In eight, reflux of the duodenal contents into the interpose...
Article
With the aid of a special questionnaire 16 healthy persons were divided to morning or evening types of personalities. Their arterial blood pressure was registered ambulatorily for 24 hours in order to elucidate the difference of blood pressure reactions between the groups. The average maximum blood pressure occurred 3.5 hours later in evening types...
Article
In our previous studies strenuous exercise, adrenaline infusion and surgical stress have been shown to evoke increased plasma thromboxane B2 (TxB2) concentrations and production by platelets. Here we report the effects of acute psychological and physical tests, during 24 h direct monitoring of blood pressure and heart rate, on plasma catecholamine...
Article
The anti-anginal effect of a controlled-release (Durules) formulation of isosorbide-5-mononitrate (5-ISMN) 60 mg, Imdur, once daily was evaluated in a randomised double-blind, placebo-controlled, crossover study with a placebo run-in period. Each period lasted for 2 weeks. A total of 70 patients (58 men and 12 women) with stable exertional angina p...
Article
The 24-hour variability in blood pressure and heart rate of 14 normotensive subjects was examined under ambulatory conditions with a continuous, invasive method. The results were analysed with 30-second means calculated from beat-to-beat values. The registered time series had three different types of variation: (1) a continuous, fast variation arou...