Arja Asikainen

Arja Asikainen
Labroc Oy

PhD

About

75
Publications
6,581
Reads
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923
Citations
Citations since 2016
30 Research Items
461 Citations
2016201720182019202020212022020406080
2016201720182019202020212022020406080
2016201720182019202020212022020406080
2016201720182019202020212022020406080
Introduction
I've worked for 13 years as a researcher in field of environmental health. I did health impact assessements of environmental agents and developed tools for decision making. My expertises are exposure modelling, health impact assessment, data mining and databases. I also have expertise for general development of assessment methods and performing health impact assessments with statistical and mathematical methods.
Additional affiliations
March 2013 - August 2014
City of Kuopio
Position
  • Coordinator
January 2006 - March 2019
Finnish Institute for Health and Welfare
Position
  • Researcher
January 1999 - December 2005
University of Kuopio
Position
  • Researcher
Education
September 1994 - January 2006
University of Kuopio
Field of study
  • Environmental sciences

Publications

Publications (75)
Data
It was highlighted that the original article [1] contained a formatting error in the equations. These were all erroneously captured as Eq. 1. This Correction article shows the correct Eqs. 1–4. The original article has been updated.
Article
Full-text available
Background Health risks linked with dioxin in fish remain a complex policy issue. Fatty Baltic fish contain persistent pollutants, but they are otherwise healthy food. We studied the health benefits and risks associated with Baltic herring and salmon in four countries to identify critical uncertainties and to facilitate an evidence-based discussion...
Preprint
Background Health risks linked with dioxin in fish remain a complex policy issue. Fatty Baltic fish contain persistent pollutants, but they are otherwise healthy food. We studied the health benefits and risks associated with Baltic herring and salmon in four countries to identify critical uncertainties and to facilitate an evidence-based discussion...
Preprint
Background Health risks linked with dioxin in fish remain a complex policy issue. Fatty Baltic fish contain persistent pollutants, but they are otherwise healthy food. We studied the health benefits and risks associated with Baltic herring and salmon in four countries to identify critical uncertainties and to facilitate an evidence-based discussion...
Technical Report
The project Costs and Risk Assessment of the Health Effects of the Food System employed biological, chemical and nutritional examples to investigate the health and economic risks of food and nutrition in Finland and the cost effectiveness of controls. The project explored the causes and consequences of the health risks associated with food in Finla...
Technical Report
The project Costs and Risk Assessment of the Health Effects of the Food System employed biological, chemical and nutritional examples to investigate the health and economic risks of food and nutrition in Finland and the cost effectiveness of controls. The project explored the causes and consequences of the health risks associated with food in Finla...
Preprint
Background Dioxin health risks from fish remains a complex policy issue. Especially fatty Baltic fish, such as herring and salmon, contain relatively high concentrations of pollutants although they are otherwise healthy food. We studied the health benefits and risks of Baltic herring and salmon in four countries to identify critical uncertainties a...
Preprint
Background Dioxin health risks from fish remains a complex policy issue. Especially fatty Baltic fish, such as herring and salmon, contain relatively high concentrations of pollutants although they are otherwise healthy food. We studied the health benefits and risks of Baltic herring and salmon in four countries to identify critical uncertainties a...
Article
Full-text available
Using fish resources for food supply in a sustainable and efficient way requires an examination of the feasibility of prioritising the use of forage species. The present paper deals with the issue from the consumer perspective. Using Baltic herring as a case study, the role of sociodemographic determinants, the drivers and barriers of Baltic herrin...
Article
Full-text available
Air pollution has been estimated to be one of the leading environmental health risks in Finland. National health impact estimates existing to date have focused on particles (PM) and ozone (O3). In this work, we quantify the impacts of particles, ozone, and nitrogen dioxide (NO2) in 2015, and analyze the related uncertainties. The exposures were est...
Poster
Full-text available
Dietary factors were the leading health risk in the EU in 2015 according to IHME GBD 2015 study. In Finland dietary factors posed the second highest health risk from the 79 risk factors included in the study. In the GBD study health impacts of 14 dietary risk factors were evaluated. However, the food safety related health impacts have not been eval...
Article
Ambient air pollution is a leading environmental risk factor causing substantial losses of life and significant morbidity. Concentration-response (CR) functions used globally to estimate such effects are largely based on ambient epidemiology, using centrally monitored outdoor air quality as an exposure indicator and various indices of population he...
Article
Full-text available
Implementation of greenhouse gas (GHG) abatement strategies often ends up as the responsibility of municipal action rather than national policies. Impacts of local GHG reduction measures were investigated in the EU FP7 funded project Urban Reduction of Greenhouse Gas Emissions in China and Europe (URGENCHE). Kuopio in Finland was one of the case st...
Article
Full-text available
Climate change mitigation policies aim to reduce climate change through reducing greenhouse gas (GHG) emissions whereas adaption policies seek to enable humans to live in a world with increasingly variable and more extreme climatic conditions. It is increasingly realised that enacting such policies will have unintended implications for public healt...
Article
Full-text available
Ulkoilman saasteiden terveyshaitat ovat huomattavasti aikaisempia arvioita suuremmat. Aikaisemmissa kansallisissa arvioissa terveyshaitat on arvioitu ulkoilman saasteista vain pienhiukkasille ja otsonille, nyt terveysvaikutukset on lisäksi arvioitu 12 muulle säännellylle ulkoilman saasteelle. Ilmansaasteiden terveyshaitta-arvion kasvuun ovat vaikut...
Poster
Full-text available
Tässä työssä esittellään neljän ulkoilman saasteen aiheuttamat terveyshaitat Suomessa vuonna 2013 käyttäen tautitaakkamenetelmiä. Tarkastelussa mukana olivat pienhiukkaset (PM2.5), hengitettävät hiukkaset (PM10), typpidioksidi (NO2) ja otsoni (O3). In this poster we present the disease burden of four ambient air pollutants in Finland in 2013. Disea...
Poster
Full-text available
In this work we calculated tentative disease burden estimates for fine particles (PM2.5), nitrogen dioxide (NO2) and ozone (O3) in the five Nordic countries. Another aim was to compare measurement station based and model based exposure estimates for PM2.5 in Finland.
Article
Objectives: We investigated the effect of weekends and school holidays on the daily frequency and severity of respiratory and other symptoms among children attending schools with (index) or without (reference) moisture damage in Spain, the Netherlands and Finland. Methods: Throughout one year, parents of 419 children with a respiratory condition...
Article
Full-text available
Ozone has been the second most important air pollutant for which environmental health risk estimates have been presented. In earlier estimates only mortality and subsequent ‘harvesting’ deaths due to acute exposure have been accounted for. Now for the first time World Health Organization working group recommended concentration response functions fo...
Article
Full-text available
Background Climate change is a global threat to health and wellbeing. Here we provide findings of an international research project investigating the health and wellbeing impacts of policies to reduce greenhouse gas emissions in urban environments. Methods Five European and two Chinese city authorities and partner academic organisations formed the...
Article
Full-text available
Background: The annual burden of disease caused indoor air pollution, including polluted outdoor air used to ventilate indoor spaces, is estimated to correspond to a loss of over 2 million healthy life years in the European Union (EU). Based on measurements of the European Environment Agency (EEA), approximately 90 % of EU citizens live in areas wh...
Article
Full-text available
Public health is often affected by societal decisions that are not primarily about health. Climate change mitigation requires intensive actions to minimise greenhouse gas emissions in the future. Many of these actions take place in cities due to their traffic, buildings, and energy consumption. Active climate mitigation policies will also, aside of...
Article
http://urn.fi/URN:NBN:fi-fe2015111117079
Article
Full-text available
Background Socioeconomic status (SES) and wellbeing measurements are often neglected in intervention evaluations. Wellbeing can have subjective and objective components. The subjective aspect of wellbeing involve an individual’s feelings and is normally measured through a number of Likert scale items whereas objective wellbeing involves a compari...
Article
This review set out to identify data sets for airborne chemical pollutants measured in domestic dwellings within European Union (EU) countries from the literature published during 1995-2010. A total of 74 papers satisfied inclusion criteria, and from those papers data on country location, population sampled, sampling period, number of samples and s...
Article
Full-text available
The rate of ventilation in buildings is regulated in most European countries to provide a sufficient exchange of clean air to maintain and ensure the health and comfort of building occupants. Information on the actual level of ventilation rates is needed to estimate the consequences of reduced ventilation on the potential increasing risk of health...
Conference Paper
Background: Previous risk assessments conducted for European countries in the EnVIE and IAIAQ studies estimated that the burden of disease caused by inadequate indoor air quality in EU causes an annual loss of 2 million DALYs. HEALTHVENT project was launched in 2010 to quantitatively and qualitatively study the relationship between ventilation and...
Conference Paper
Full-text available
Background: Recent estimates show that 2 million DALYs (disability adjusted life years) are lost annually witin the EU due to poor indoor air quality. Energy performance of buildings is one of the key areas where energy consumption and climate change abatement is pressed. The current work evaluates the European ventilation guidelines proposed by th...
Conference Paper
Background: Indoor air quality has been identified as a significant determinant of health and comfort. Recent development of energy efficient buildings and corresponding tightening building regulations including requirements for sufficient ventilation and control of indoor air quality internationally and nationally potentially provide means for imp...
Technical Report
Full-text available
Indoor exposures to air pollutants are associated with a significant burden of disease. In EU-27 the burden is estimated to be over 2 million healthy life years annually. This report investigates how this burden can be mitigated and in particular presents health based estimates for ventilation, including discussion of necessary control strategies f...
Article
Full-text available
The INTERA project developed an online accessible, full-chain modelling platform, incorporating tools and databases for indoor chemical source release, exposure and risk assessment. It includes four modules (i) emissions to concentrations (air, dust), (ii) concentrations to exposures (inhalation, ingestion and dermal), (iii) internal dosimetry (gen...
Article
Full-text available
Everyone has a right to safe living environment, including indoor air quality (IAQ) that does not endanger the health. Nevertheless the recent European EnVie project estimated that the annual burden of disease (BoD) related to inadequate IAQ is 2 million disability adjusted life years (DALY) in EU27 in 2008. Reducing this BoD is a high priority in...
Article
This study aims at developing a mechanistic model for assessing exposure and health risks posed by indoor air pollution. The modeling approach is implemented in a computational platform that allows the interconnection between several steps of the full-chain assessment through proper models and algorithms. The integrated modelling environment compri...
Article
Full-text available
The intake fraction (iF) gives a measure of the portion of a source's emissions that is inhaled by an exposed population over a defined period of time. This study examines spatial and population-based iF distributions of a known human carcinogen, benzene, from a ubiquitous urban source, local vehicular traffic, in the Helsinki Metropolitan Area usi...
Article
Self-Organizing Molecular Field Analysis (SOMFA) comes with a built-in regression methodology, the Self-Organizing Regression (SOR), instead of relying on external methods such as PLS. In our recent paper, we presented a proof of the equivalence among SOR, SIMPLS, and NIPALS with one principal component. Thus, the modest performance of SOMFA on com...
Article
The performance of decision tree (DT), learning vector quantization (LVQ), and k-nearest neighbour (kNN) methods classifying active and inactive estrogenic compounds in terms of their structure activity relationship (SAR) was evaluated. A set of 311 compounds was used for construction of the models, the predictive power of which was verified with s...
Article
The performance of the spectroscopic EVA (eigenvalue) and EEVA (electronic eigenvalue) methods was tested with data sets applying coumarin 7-hydroxylation inhibitors (28 compounds) for cytochrome P450 mouse CYP2A5 and human CYP2A6 enzymes and 11ss-, 16a-, and 17a-substituted estradiol derivatives (30 compounds) for the lamb uterine estrogen recepto...
Article
Quantitative structure-activity relationships (QSARs) have proved increasingly useful for predicting the biological activities of molecules (e.g., their binding affinities to different receptors) and can be used in environmental chemistry as a preliminary tool for screening the activities of untested molecules, producing valuable information on whi...
Article
This review summarises results of our pilot-scale experiments to find suitable inhibitors for preventing the formation of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/F) during waste incineration and to specify the role of the main factors affecting the inhibition process, and is based on doctoral dissertation of Ruokojaärvi (2002). Re...
Article
A novel method (in the context of quantitative structure-activity relationship (QSAR)) based on the k nearest neighbour (kNN) principle, has recently been introduced for the derivation of predictive structure-activity relationships. Its performance has been tested for estimating the estrogen binding affinity of a diverse set of 142 organic molecule...
Article
The performance of three "spectroscopic" quantitative structure-activity relationship (QSAR) methods (eigenvalue (EVA), electronic eigenvalue (EEVA), and comparative spectra analysis (CoSA)) for relating molecular structure and estrogenic activity are critically evaluated. The methods were tested with respect to the relative binding affinities (RBA...
Article
The pathways by which polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) are formed and the interactions between their aromatic precursors, in particular chlorophenols (ClPhs), and transition metal catalysts are discussed. A literature survey and data from pilot-scale combustion experiments allow conclusions to be drawn on the relations...
Article
The objects of this study were first to compare how well the recently constructed structure-inhibition activity relationship models of mouse CYP2A5 and human CYP2A6 predict the interaction of naphthalene in liver microsomes and secondly to study if these CYP enzymes actually oxidize naphthalene. The CoMFA model of CYP2A5 predicted the IC(50) value...