Ariel Caviedes

Ariel Caviedes
  • Doctor of Philosophy
  • Postdoctoral Fellow at Brainlat

About

24
Publications
2,945
Reads
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588
Citations
Current institution
Brainlat
Current position
  • Postdoctoral Fellow
Additional affiliations
September 2023 - present
Adolfo Ibáñez University
Position
  • PostDoc
Education
March 2015 - October 2019
University of the Andes, Chile
Field of study
  • Biomedicine
March 2005 - December 2011
University of Chile
Field of study
  • Biochemistry

Publications

Publications (24)
Article
Full-text available
Background Chronic pain (CP) is defined as the persistence of pain beyond the expected recovery period of an injury, or alternatively, with a duration exceeding three months. It has been recognized as a risk factor for dementia in European and North American cohorts. However, in Latin America (LA), there remains a significant gap in understanding C...
Article
Full-text available
Background The content of circulating exosomes has been observed to be altered in response to changes in physiological and pathological conditions, and they are detectable in different human fluids such as blood. Studies focused on the quantification of Aβ and tau proteins, as molecules contained within exosomes, suggest that they are related with...
Article
Full-text available
Background Dementia, encompassing Alzheimer's disease (AD) and frontotemporal dementia (FTD), poses a substantial public health challenge in Latin America. Barriers such as a shortage of healthcare professionals, limited medical accessibility, and underdiagnosis contribute to the complexity. While biomarkers aligned with the ATN framework (Amyloid,...
Article
Background Timely diagnosis of Alzheimer’s disease (AD) is a critical first step in clinical care treatment. However, the availability of diagnostic tools for these conditions is either unavailable or unaffordable, especially in Latin American and the Caribbean (LAC) countries. In this scenario, microRNAs (miRNA) have recently emerged as promising...
Preprint
Full-text available
Emerging evidence highlights the relevance of the protein post-translational modification by SUMO (Small Ubiquitin-like Modifier) in the central nervous system for modulating cognition and plasticity in health and disease. In these processes, astrocyte-to-neuron crosstalk mediated by extracellular vesicles (EVs) plays a yet poorly understood role....
Article
Full-text available
Cell death by glutamate excitotoxicity, mediated by N -methyl- d -aspartate (NMDA) receptors, negatively impacts brain function, including but not limited to hippocampal neurons. The NF-κB transcription factor (composed mainly of p65/p50 subunits) contributes to neuronal death in excitotoxicity, while its inhibition should improve cell survival. Us...
Preprint
Full-text available
Cell death by glutamate excitotoxicity, mediated by N-methyl-D-aspartate (NMDA) receptors, negatively impacts brain function affecting hippocampal, i.e. sensitive neurons. The NF-κB transcription factor (composed mainly of p65/p50 subunits) contributes to neuronal death in excitotoxicity, while its inhibition should improve cell survival. Using the...
Article
Full-text available
Repetitive stress negatively affects several brain functions and neuronal networks. Moreover, adult neurogenesis is consistently impaired in chronic stress models and in associated human diseases such as unipolar depression and bipolar disorder, while it is restored by effective antidepressant treatments. The adult neurogenic niche contains neural...
Article
Full-text available
Nitric oxide exerts important regulatory functions in various brain processes. Its synthesis in neurons has been most commonly ascribed to the neuronal nitric oxide synthase (nNOS) isoform. However, the endothelial isoform (eNOS), which is significantly associated with caveolae in different cell types, has been implicated in synaptic plasticity and...
Data
Knockdown of eNOS with lentiviral shRNA show the specificity of the eNOS antibody used in this study. (A) Epifluorescence microscopy of eNOS (right panels, green) and transduced cells (left panels, red) in hippocampal neurons. (B) eNOS mRNA expression (left panel) and nNOS mRNA expression (right panel) measured by quantitative PCR of hippocampal ne...
Data
eNOS co-distributes with the postsynaptic scaffolding protein PSD-95 and with the raft marker Thy-1. Confocal microscopy (left panels) and SR-SIM microscopy (right panels) of eNOS (green) and Thy-1 (red) (A) or PSD-95 (red) (B) in hippocampal neurons (left panels) or in hippocampal and cortical neurons (right). (C): Left panels show Mander’s coeffi...
Data
eNOS content in membranes of different tissues of eNOS and nNOS knock out mice reveal the specificity of the eNOS antibody used in this study. The same blots were reprobed with the nNOS and phospho-eNOS antibodies. Representative Western Blots after loading 20 μg of protein/per lane except in lane 1, in which 12.5% was loaded (∼2.5 μg). Lane 1 = po...
Article
Background: Mood disorders, consisting of unipolar and bipolar depression, are complex diseases characterized by depressed mood and anhedonia. These core symptoms are accompanied in a varying manner by anxiety, several neurovegetative symptoms and cognitive impairment. Mood disorders are characterized by decreases in neurogenesis, alteration in sy...
Article
Mesenchymal stem cells (MSCs) obtained from bone marrow have been shown to promote neuronal growth and survival. However, the comparative effects of MSCs of different sources, including menstrual MSCs (MenSCs), bone marrow, umbilical cord and chorion stem cells on neurite outgrowth have not yet been explored. Moreover, the modulatory effects of MSC...
Article
J. Neurochem. (2011) 118, 760–772. Nitric oxide (NO) has been proposed to down-regulate NMDA receptors (NMDA-Rs) in a homeostatic manner. However, NMDA-R-dependent NO synthesis also can cause excitotoxic cell death. Using bicuculline-stimulated hippocampal and cortical cell cultures, we have addressed the role of the brain-derived neurotrophic fact...

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