Arie G. Nieuwenhuizen

Arie G. Nieuwenhuizen
Wageningen University & Research | WUR · Department of Human and Animal Physiology

Doctor of Medicine

About

77
Publications
12,380
Reads
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3,155
Citations
Introduction
Energy metabolism, mitochondrial function, muscle function, ageing, indirect calorimetry, near-infrared spectroscopy
Additional affiliations
March 2010 - present
Wageningen University & Research
Position
  • Professor (Assistant)
Description
  • Research interests: energy metabolism, physical activity, mitochondria, muscle function
March 2009 - February 2010
The Netherlands Nutrition Centre
Position
  • Knowledge expert Nutrition health & disease
Description
  • - Explaining the relevance of scientific knowledge - Translating it into easily understandable, balanced and practical guidelines and advice
October 2004 - March 2009
Maastricht University
Position
  • Professor (Assistant)
Description
  • Research interests: regulation of food intake and energy balance in humans.
Education
August 1987 - April 1993
University of Groningen
Field of study
  • Biology

Publications

Publications (77)
Article
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Energy metabolism at whole body and cellular, and even organelle (i [...]
Article
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Post‐translational protein modifications derived from metabolic intermediates, such as acyl‐CoAs, have been shown to regulate mitochondrial function. Patients with an inborn a genetic defect in the propionyl‐CoA carboxylase (PCC) gene clinically present symptoms related to mitochondrial disorders and are characterised by decreased mitochondrial res...
Article
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This study tested the hypothesis that in human aging, a decreased intramuscular acylcarnitine status is associated with (pre‐)frailty, reduced physical performance, and altered mitochondrial function. We used a cross‐sectional study design with well‐matched fit and (pre‐)frail old males and females, using young males and females as healthy controls...
Article
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Fructose consumption has been linked to obesity and increased hepatic de novo lipogenesis (DNL). Excessive caloric intake often confounds the results of fructose studies, and experimental diets are generally low-fat diets, not representative for westernized diets. Here, we compared the effects of dietary fructose with those of dietary glucose, in a...
Article
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Mitochondrial capacity is pivotal to skeletal muscle function and is suggested to decline with age. However, there is large heterogeneity in current data, possibly due to effect modifiers such as physical activity, sex and muscle group. Yet, few studies have compared multiple muscle groups in different age groups with comparable physical activity l...
Article
Mol. Nutr. Food Res. 2019, 63, 1900189 DOI: 10.1002/mnfr.201900189 Exhaled air contains volatile organic compounds (VOCs) that are partly derived from the body's internal metabolism. Despite substantial within‐ and between‐subject variation, differences in VOC profiles among drinks could be identified, indicating that analysis of exhaled VOCs might...
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Purpose: The recovery of muscle oxygen consumption (m[Formula: see text]O2) after exercise provides a measure of skeletal muscle mitochondrial capacity, as more and better-functioning mitochondria will be able to restore m[Formula: see text]O2 faster to the pre-exercise state. The aim was to measure muscle mitochondrial capacity using near-infrare...
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Scope: Exhaled volatile organic compounds (VOCs) are a possible relevant target for non-invasive assessment of metabolic responses. Using a breathomics approach, we aimed to explore whether lipid intake influences VOC profiles in exhaled air, and to obtain insight in intra- and inter-individual variations. Methods and results: Three human interv...
Article
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Correction for ‘Free fatty acid release from vegetable and bovine milk fat-based infant formulas and human milk during two-phase in vitro digestion’ by Jeske H. J. Hageman et al. , Food Funct. , 2019, 10 , 2102–2113.
Article
Fat is an important component of human milk and infant formula (IF), delivering half of the energy a baby needs. Nowadays, mostly vegetable fats are used in IFs; however, the use of bovine milk fat in formulas is currently increasing. Bovine milk fat contains a composition of fatty acids and lipid components different from those of vegetable fats....
Article
Background: Bovine milk fat is increasingly used in infant formula (IF). The triacylglycerol (TAG) structure of bovine milk fat might be beneficial for digestion and absorption. We investigated the release of fatty acids (FAs) of IF containing different fat blends and compared this to human milk. Methods: Fresh human milk was sampled and two IFs we...
Article
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Cognitive impairment is a leading cause of dysfunction in the elderly. When mild cognitive impairment (MCI) occurs in elderly, it is frequently a prodromal condition to dementia. The Montreal Cognitive Assessment (MoCA) is a commonly used tool to screen for MCI. However, this test requires a face-to-face administration and is composed of an assortm...
Article
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Body weight stability may imply active regulation towards a certain physiological condition, a body weight setpoint. This interpretation is ill at odds with the world-wide increase in overweight and obesity. Until now, a body weight setpoint has remained elusive and the setpoint theory did not provide practical clues for body weight reduction inter...
Article
The relationship between hypothalamus/pituitary/adrenal (HPA) axis functioning and (visceral) obesity may be explained by single-nucleotide polymorphisms (SNPs) of the HPA axis. Objective  To investigate the relationship between the HPA axis SNP's 'BclI' in the glucocorticoid receptor gene and C8246T in the POMC gene and anthropometric measurements...
Article
The influence of single nucleotide polymorphisms (SNP) of the FTO gene has been shown to change over time. The aim was to investigate the relationship between a SNP of the FTO gene (rs9939609) and obesity-related characteristics longitudinally during childhood and puberty. From 101 children (58 boys and 43 girls), the FTO (rs9939609) genotype and y...
Article
Short sleep duration is associated with obesity during childhood and adulthood. The objective of our study was to investigate the relationship between sleep duration and body mass index (BMI) from Tanner stages 1 to 5 in a Dutch children cohort. In 98 children, anthropometric measurements and leptin concentrations were measured from age 7 to 16 yea...
Article
Growth hormone (GH), a hormone originating from the anterior pituitary gland, is an important regulator of metabolism and body composition. Low GH secretion is associated with features of the metabolic syndrome, in particular increased visceral body fat and decreased lean body mass. It has been shown that GH release can be promoted by ingestion of...
Article
Acute psychological stress is associated with eating in the absence of hunger. To investigate if BclI and FTO polymorphisms are associated with eating in the absence of hunger as a result of acute psychological stress. FTO (rs9939609) and BclI were genotyped in 98 subjects (BMI=23.9+/-3.3kg/m(2)). In a randomized crossover design, the 'eating in ab...
Article
Growth hormone (GH) is an important regulator of growth and body composition. It has been shown that GH release can be promoted by administration of various amino acids (AAs), such as arginine and lysine, that are present in soy protein. We previously showed that oral ingestion of soy protein stimulates the GH release, it is not known however to wh...
Article
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Background: Stress results in eating in the absence of hunger, possibly related to food reward perception. Hypothesis: Stress decreases food reward perception. Aim: Determine the effect of acute stress on food choice and food choice reward-related brain activity. Subjects: Nine females (BMI ¼ 21.5 ± 2.2 kg/m 2 , age ¼ 24.3 ± 3.5 years). Procedure:...
Chapter
The monoamine neurotransmitter serotonin plays a role in the regulation of human appetite and food intake, as it is supported by the anorectic effects of various serotonergic drugs. Serotonin is synthesized from its precursor, the amino acid L-tryptophan. Studies in laboratory animals and humans have shown that supplementation with L-tryptophan, th...
Article
Background & aims Increasing the protein content of a diet results in increased satiety and energy expenditure. It is unknown to what extent gelatin has such effects. We compared satiety and energy expenditure in subjects on 2 single-protein diets with either 25% or 10% of energy (En%) from gelatin. Methods During 36 h in a respiration chamber, 24...
Article
Growth hormone (GH) is an important regulator of growth and body composition. It has been shown that GH release can be promoted by administration of various amino acids, such as arginine and lysine, that are present in soyprotein. Soyprotein ingestion increases GH secretion more than the ingestion of a combination of arginine and lysine. The GH pro...
Article
Full-text available
Stress results in eating in the absence of hunger, possibly related to food reward perception. Stress decreases food reward perception. Determine the effect of acute stress on food choice and food choice reward-related brain activity. Nine females (BMI = 21.5 + or - 2.2 kg/m(2), age = 24.3 + or - 3.5 years). Fasted subjects came twice to randomly c...
Article
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Growth hormone (GH) affects linear growth and body composition, by increasing the secretion of insulin-like growth factor-I (IGF-I), muscle protein synthesis and lipolysis. The intake of protein (PROT) as well as the specific amino acids arginine (ARG) and lysine (LYS) stimulates GH/IGF-I secretion. The present paper aimed to investigate associatio...
Article
To relate hypothalamic-pituitary-adrenal (HPA) axis functioning and HPA feedback functioning to body fat distribution in normal weight to obese subjects. 91 men and 103 women [age 18-45 years, BMI 19-35 kg/m(2), waist-to-hip ratio (WHR) 0.6-1.1]. Anthropometry, body composition using hydrodensitometry and deuterium dilution method, cortisol variabi...
Article
Although the current use of growth hormone (GH) stimulation tests (GHSTs) is still subject to debate, the tests are widely used to diagnose GH deficiency. This literature review evaluates primarily the sensitivity, specificity and reliability of GHSTs and secondarily their convenience. Single pharmacological tests typically address only a single pa...
Article
Growth hormone (GH) affects body composition by a relatively reduced fat mass and increased fat free mass. The intake of protein as well as the specific amino acids arginine and lysine potently stimulate GH secretion. This study investigated associations between intakes of protein, arginine, lysine and subsequent 6-year change in body composition a...
Article
The role of dietary protein in weight loss and weight maintenance encompasses influences on crucial targets for body weight regulation, namely satiety, thermogenesis, energy efficiency, and body composition. Protein-induced satiety may be mainly due to oxidation of amino acids fed in excess, especially in diets with "incomplete" proteins. Protein-i...
Article
Dietary protein plays a role in body weight regulation, partly due to its effects on satiety. The objective was to compare the effects of casein-, soy-, whey-, whey without glycomacropeptide (GMP)-, alpha-lactalbumin-, gelatin-, or gelatin with tryptophan (TRP)-protein breakfasts at two concentrations on subsequent satiety and energy intake (EI). T...
Article
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To investigate the relationship between leptin concentrations, gonadotropic hormone concentrations, and body composition during puberty in a Dutch children cohort. In a cohort of 98 children, we determined anthropometric measurements, body composition, and concentrations of leptin, FSH, and LH. Sex differences were observed from Tanner stage 1 onwa...
Article
Dietary protein plays a role in body weight regulation, partly because of its effects on appetite. The objective was to compare the effects of high or normal casein-, soy-, or whey-protein breakfasts on appetite, specific hormones, amino acid responses and subsequent energy intake. Twenty-five healthy subjects (mean+/-SEMBMI:23.9+/-0.3 kg/m2; age:2...
Article
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The role of dietary protein in short term satiety is of interest with respect to body weight regulation. To compare the effects of a high versus a normal soyprotein breakfast on satiety and subsequent energy intake (EI), including 'satiety' hormones and plasma amino acid responses. Twenty-five healthy subjects (mean +/- SEM, BMI: 23.9 +/- 0.3 kg/m(...
Article
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An increase in the protein content of a diet results in an increase in satiety and energy expenditure. It is not clear to what extent a specific type of protein has such effects. The objective was to compare the effects of 2 diets with either 25% or 10% of energy from casein (25En% and 10En% casein diets), as the only protein source, on energy expe...
Article
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The present study compared the effects of a high- and normal-casein-protein breakfast on satiety, 'satiety' hormones, plasma amino acid responses and subsequent energy intake. Twenty-five healthy subjects (BMI 23.9 (SEM 0.3) kg/m2; age 22 (SEM 1) years) received a subject-specific standardised breakfast (20% of daily energy requirements): a custard...
Article
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Proteins are the most satiating macronutrients. Tryptophan (TRP) may contribute to the satiating effect, as it serves as a precursor for the anorexigenic neurotransmitter serotonin. To address the role of TRP in the satiating properties of dietary protein, we compared three different breakfasts, containing either alpha-lactalbumin (high in TRP), ge...
Article
To compare the effects of whey versus whey without glycomacropeptide (GMP) in a high and a normal amount of protein in a breakfast custard on satiety and energy intake (EI), taking concentrations of amino acids (AA), glucose, insulin, glucagon-like peptide 1 (GLP-1) and ghrelin into account. Twenty-five healthy subjects (mean+/-S.E.M., BMI: 23.9+/-...
Article
Background & aims: Dietary protein plays a role in body weight regulation, partly due to its effects on satiety. The objective was to compare the effects of casein-, soy-, whey-, whey without glycomacropeptide (GMP)-, alpha-lactalbumin-, gelatin-, or gelatin with tryptophan (TRP)-protein breakfasts at two concentrations on subsequent satiety and en...
Article
Obesity results from chronic deregulation of energy balance, which may in part be caused by stress. Our objective was to investigate the effect of acute and psychological stress on food intake, using the eating in the absence of hunger paradigm, in normal and overweight men and women (while taking dietary restraint and disinhibition into account)....
Article
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The postprandial responses in (an)orexigenic hormones and feelings of hunger are characterized by large inter-individual differences. Food intake regulation was shown earlier to be partly under genetic control. This study aimed to determine whether the postprandial responses in (an)orexigenic hormones and parameters of food intake regulation are as...
Article
The objective of our study was to investigate the relationship between hypothalamus/pituitary/adrenal (HPA) axis functioning and dietary restraint in normal weight (BMI between 20 and 25 kg/m(2)) men and women. We therefore assessed in 38 men and 38 women HPA axis functioning, through measuring 5-hour cortisol exposure and cortisol feedback functio...
Article
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GH is an important regulator of growth and body composition. We previously showed that GH release can be promoted by oral ingestion of soy protein; it is not known, however, whether these somatotropic effects of soy protein are also present when soy protein is ingested as part of a complete meal. We compared the effects of oral ingestion of soy pro...
Article
Human (visceral) obesity is associated with alterations hypothalamus-pituitary-adrenal (HPA) axis functioning. It is however not completely clear whether the HPA axis is causally or co-incidentally related to (visceral) obesity. This review summarizes supporting data of an involvement of the HPA axis in the development of (visceral) obesity. First,...
Article
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The development of body weight is determined by different factors, namely genetic, behavioral, parental and physiological. To investigate whether genetic, behavioral, parental and physiological factors are involved and the extent of involvement in the development of body weight at ages 12 and 13 y in a Dutch children cohort. In a Dutch cohort of 94...
Article
Full-text available
GH is an important regulator of growth and body composition. It has been shown that GH release can be promoted by iv as well as oral administration of various amino acids (AAs), especially arginine (ARG) and lysine (LYS), which are amply present in soy protein. However, the effects of dietary protein on GH secretion are less well described. In an e...
Article
Dietary protein seems to play an important role in body weight regulation. The objective of the study was to compare the effects of high or normal casein-, soy-, or whey with or without glycomacropeptide (GMP)-protein breakfasts on satiety, ‘satiety’ hormones, and plasma amino acid responses. Twenty-five healthy subjects (mean+sem BMI:23.9+0.3 kg/m...
Article
Summary  Recent findings suggest that an elevated protein intake plays a key role in bodyweight management, through increased satiety (related to increased diet-induced thermogenesis), and its effect on thermogenesis, body composition and decreased energy efficiency. These factors are related to protein metabolism. Supported by these mechanisms, la...
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Body-weight management requires a multifactorial approach. Recent findings suggest that an elevated protein intake seems to play a key role herein, through (i) increased satiety related to increased diet-induced thermogenesis; (ii) its effect on thermogenesis; (iii) body composition; and (iv) decreased energy-efficiency, all of which are related to...
Article
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Studies on the effects of (-)-hydroxycitric acid (HCA) in humans are controversial. As differences in the HCA preparations may contribute to this apparent discrepancy, the aim of the current study is to compare different HCA-containing preparations in adult Wistar rats. The effects of 3 different HCA-containing preparations (Regulator, Citrin K, Su...
Article
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In this study, we investigated in rats if hydroxycitric acid (HCA) reduces the postprandial glucose response by affecting gastric emptying or intestinal glucose absorption. We compared the effect of regulator HCA (310 mg/kg) and vehicle (control) on the glucose response after an intragastric or intraduodenal glucose load to investigate the role of...