Aregitu Mekuriaw Arega- Doctor of Philosophy
- Researcher II at National Veterinary Institute Ethiopia
Aregitu Mekuriaw Arega
- Doctor of Philosophy
- Researcher II at National Veterinary Institute Ethiopia
I am working in a Molecular Biology laboratory on different vaccines and biological development and manufacturing
About
11
Publications
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Introduction
I finished my P.h.D. study in Biotechnology at Kalinga Institute of Industrial Technology, Deemed to Be University, Bhubaneswar on September 2022. My Ph.D. dissertation is titled “Discovery of Potent Subunit Vaccine and Therapeutic Candidates against Tuberculosis: In-silico Approach and its Preliminary Validation in Ex-vivo Model”. My previous research work experiences focus on infectious diseases (tuberculosis on human and livestock, IBD on poultry, Camel Viral disease), food-borne diseases and
Current institution
National Veterinary Institute Ethiopia
Current position
- Researcher II
Additional affiliations
September 2012 - November 2017
National Veterinary Insitute Ethiopia
Position
- Vaccine Quality control and assurance Seniour Technologiest and Case team
Description
- Prepare different viral vaccine master and working seeds, test and assured different viral and bacterial vaccines produced by the vaccine production section of the institute, prepared (cultured, subcultured), maintained and preserved different continuous cell lines and primary cells; different vaccine input raw materials quality control and assurance tests; perform produced vaccines as well as vaccine working seeds safety, potency tests on lab animals and target animals. Coordinate and mobilize
Education
December 2017 - September 2022
KIIT University
Field of study
- Biotechnology
Publications
Publications (11)
BACKGROUND ANDMETHODS: Brucellosis is a dreadful zoonotic disease affecting humans and all domestic animals including camels worldwide. Serological evidence for Brucella infection in camels has been reported from all pastoralist and agro-pastoralist regions of Ethiopia. Investigations have shown that antibody concentrations are lower in camels than...
Background
Brucellosis is an economically devastating animal disease and has public health concern. Serological methods such as Rose Bengal Plate Test (RBPT), Complement Fixation Test (CFT), and Indirect-Enzyme-Linked Immunosorbent Assay (I-ELISA) have been used to detect brucellosis. However, there is limited comparative evaluation studies and lac...
Mycobacterium tuberculosis (Mtb) is the pathogen that causes tuberculosis and develops resistance to many of the existing drugs. The sole licensed TB vaccine, BCG, is unable to provide a comprehensive defense. So, it is crucial to maintain the immunological response to eliminate tuberculosis. Our previous in silico study reported five uncharacteriz...
Mycobacterium tuberculosis (Mtb) is the pathogen that causes tuberculosis and develops resistance to many of the existing drugs. The sole licensed TB vaccine, BCG, is unable to provide a comprehensive defence. So, it is crucial to maintain the immunological response to eliminate tuberculosis. Our previous in silico study reported five uncharacteriz...
Method: Brucella is an intracellular bacterium that affects both animals and humans. The aim of this study was to compare brucellosis diagnostic methods such as RBPT, I-ELISA, CFT and PCR detection of Brucella species. A total of (552) Sheep, (1345) Goats, and (420) Cattle sera samples were collected with no history of vaccination from brucellosis...
Tuberculosis caused by Mycobacterium tuberculosis (Mtb) is responsible for the highest global health problem, with the deaths of millions of people. With prevalence of multiple drug resistance (MDR) strains and extended therapeutic times, it is important to discover small molecule inhibitors against novel hypothetical proteins of the pathogen. In t...
With the emergence of multidrug‐resistant bacteria, insufficiency of the established chemotherapy, and the existing vaccine BCG, tuberculosis (TB) subsists as the chief cause of death in different parts of the world. Thus, identification of novel target proteins is urgently required to develop more effective TB interventions. However, the novel vac...
Tuberculosis (TB) is a complex infectious bacterial disease, which has evolved with highly successful mechanisms to interfere with host defences and existing classes of antibiotics to resist eradication. The single obtainable TB vaccine, Bacille Calmette-Guerin (BCG) has failed to provide regular defence for respiratory TB in adults. In this study,...
Abstract
Infectious bursal disease (IBDV) is an acute, highly contagious, immuno- suppressive and socio-economically important disease of chickens characterized by dysfunction of the immune system, with a suboptimal response either by the humoral or the cellular compartments caused by an infectious bursal disease virus (IBDV) belonging to the genus...
The study was conducted with the objective of isolation and molecular characterization of infectious bursal disease virus (IBDV) circulating in Ethiopia and to assess the immunogenicity of different commercially available live attenuated IBD vaccines and finally to select the appropriate vaccine strain for the existing IBDV. Outbreak samples collec...
