Ardalan Pasdaran

Ardalan Pasdaran
Shiraz University of Medical Sciences | SUMS

Doctor of Pharmacy (Pharm.D) and Doctor of Philosophy Pharmacognosy (Ph.D.)

About

68
Publications
19,283
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630
Citations
Introduction
I am a professor of pharmacognosy and expert in processing techniques including extraction methods, natural compounds isolation, purification and structure elucidation of them by 1DNMR & 2DNMR and MS techniques, and running clinical and laboratory trial for natural compounds.
Additional affiliations
January 2016 - present
January 2014 - January 2016
Guilan University of Medical Sciences
Position
  • Head of Department
January 2013 - present
Guilan University of Medical Sciences
Position
  • Head of Department
Education
January 2000 - December 2012
Tabriz University of Medical Sciences
Field of study
  • Pharmacutical

Publications

Publications (68)
Article
Full-text available
The extensive use of pesticides may negatively affect human health. Additionally, it is one of the main reasons for the decline of pollinators and is thus a hazard for most crops and biodiversity as a whole. Good candidates for the replacement of pesticides with ones less toxic to humans and pollinators are natural products (bioactive compounds ext...
Article
Full-text available
Plants are reservoirs of naturally occurring chemical constituents with a wide range of structural diversity. These biological compounds can be derived from different parts of plants such as leaves, barks, seeds, seed coats, flowers, and roots. A broad array of secondary metabolic compounds is present in the plants such as antibiotics, alkaloids, a...
Article
Full-text available
Plants are reservoirs of naturally occurring chemical constituents with a wide range of structural diversity. ese biological compounds can be derived from different parts of plants such as leaves, barks, seeds, seed coats, flowers, and roots. A broad array of secondary metabolic compounds is present in the plants such as antibiotics, alkaloids, ant...
Article
Full-text available
Since ancient times, herbal medicines (HM) have played a vital role in worldwide healthcare systems. It is therefore critical that a thorough evaluation of the quality and control of its complicated chemical makeup be conducted, in order to ensure its efficacy and safety. The notion of HM chemical prints, which aim to acquire a full characterizatio...
Article
Full-text available
Halophytic plants growing in harsh desert environments are rich reservoirs of unique endophytic microorganisms. Here, healthy fresh plants of the families Tamaricaceae and Amarantaceae at three saline locations in Iran were investigated for their bioactive endophytic fungi. Among a vast number of isolates, eight isolates were identified as Humicola...
Article
Different gentian preparations are used as traditional remedies for internal pain control in: Persian traditional medicine (PTM), Chinese traditional medicine (CTM) and Ancient Greek medicine (AGM) from the time of the Roman Empire. Objective: To present a survey of the ethnopharmacological applications of gentians recorded as being used in Eastern...
Article
Introduction: Fibroblasts and fibroblast-like cells (FLCs) are highly distributed in the dermis layer of the skin and gastrointestinal tract. A few studies have investigated the effects of color additives of cosmetic products on human fibroblasts. Therefore, this in vitro study was conducted to investigate the effects of 9 synthetic and natural dy...
Article
A new guaianolide sesquiterpene lactone with cytotoxic properties was isolated from Euphorbia microsphaera Boiss. To determine the highest active fraction and isolate bioactive compounds, a bioassay guided fractionation approach was used. The general toxicity properties of the plant's extracts and fractions (fr1-10) were assessed against Artemia sa...
Article
Full-text available
Oriental plane hydrosol (distillate), as a remedy for weight gain and asthma treatment, is popular in ethnomedicine. Phytochemicals of medicinal plants could have side effects or serious damages. In this study, the oriental plane hydrosol was prepared by steam distillation. Also, tree oriental plane hydrosol samples from different companies were pu...
Article
Monitoring of toxic heavy metals in fish samples is a matter of a great importance from the nutritional and toxicological points of view. A dispersive micro solid phase extraction (dµSPE) for preconcentration of trace Pb, Cd, Hg, Co, Ni ions using pectin coated magnetic graphene oxide (pectin/Fe3O4/GO) is presented. Inductively coupled plasma optic...
Article
Full-text available
Aromatic herbal remedies, hydrosols, and essential oils are widely used for women’s hormonal health. Scientific investigation of their major constituents may prevent unwanted infertility cases, fetal abnormalities, and drug-herb interactions. It also may lead to development of new medications. A list of 265 volatile molecules (mainly monoterpenes a...
Article
Full-text available
Background: In Persian food culture, Citrus aurantium L. (bitter orange) flowers and essential oil are consumed as jams or plant distillate in high doses. Some concerns were mentioned in Persian traditional literature about their effects on the liver. This study aimed to investigate the effect of the essential oil from C. aurantium L. flowers on li...
Article
The Scrophularia genus is a rich source of phenylethanoid glycosides, with diverse biological activities including anti-diabetic properties. This study investigated anti-type 2 diabetic potential and active component of Scrophularia flava Grau. A new phenylethanoid glycoside was isolated from aerial parts of the plant and identified as 2-(4-hydroxy...
Article
Full-text available
In this study, methoxylated flavonoids and volatile constitutions of Agrostis gigantea Roth (Poaceae) were investigated for the first time. The flavonoids were identified by spectroscopic methods (1H-NMR, 13C-NMR, COSY, NOSEY, TCOSY, and HMBC). The volatile constitutions of aerial parts and seeds were analyzed by gas chromatography-mass spectrometr...
Article
Full-text available
Tricholoma is one of the famous genera of Basidiomycota division. Although some species of this genus have been used as culinary mushrooms, very negligible investigations have been conducted on Tricholoma genus phenolic contents and their biological activities. In the present study, the antioxidant, antimicrobial, and DNA protection properties of t...
Article
Full-text available
Three iridoid glycosides included 6-O-methyl, 1-glucopyranosyl catalpol (Compound 1), 6-O-α-L (3"-O-trans, 4"-O-trans cinnamoyl)-rhamnopyranosyl catalpol (Compound 2) and scropolioside D (Compound 3) were isolated from aerial parts of S. amplexicaulis using chromatographic methods. The structures were determined by different spectroscopic data. The...
Article
Full-text available
Halophytic plants growing in harsh desert environments are rich reservoirs of unique endophytic microorganisms. Here, healthy fresh plants of the families Tamaricaceae and Amarantaceae at three saline locations in Iran were investigated for their bioactive endophytic fungi. Among a vast number of isolates, eight isolates were identified as Humicola...
Article
Lately, it has been proved that yeast exopolysaccharides (EPS) are potentially applicable biopolymers, a fact that has led to incremental needs for their assessment. The current study is based on the biochemical and molecular level identification of the novel cold-adapted yeast Rhodotorula mucilaginosa sp. GUMS16. Possible antioxidant and antiproli...
Article
Full-text available
The present investigation was carried out to evaluate the pharmacognostic properties of Citrus aurantium seeds as well as its anti-inflammatory activities. The n-hexane fraction of seed oil extracted via a Soxhlet extractor and subjected to pharmacognostic assays, HPTLC and GC-MS analysis for determination of fatty acids and sterols. The possible a...
Article
Full-text available
Background: Different endemic species of Apiaceae that widely grow in Hyrcanian region have long been used as spices and herbal remedies. Chemical compositions and bioactivity of many of these plants have not been studied scientifically. The volatile constituents and antimicrobial activity of four edible Apiaceae plants—Elaeosticta glaucescens Bois...
Article
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25 ‫ﺷﻤﺎره‬ ،‫ﻫﻔﺘﻢ‬ ‫ﺳﺎل‬ ، 1 ‫ﺑﻬﺎر‬ ، 1398 ‫آﻧﺘﯽ‬ ،‫ﻓﯿﺘﻮﺷﯿﻤﯿﺎﯾﯽ‬ ‫ﺑﺮرﺳﯽ‬ ‫اﺳﺘﺮول‬ ‫ﺿﺪاﻟﺘﻬﺎﺑﯽ‬ ‫و‬ ‫اﮐﺴﯿﺪاﻧﯽ‬ ‫داروﯾﯽ‬ ‫ﮔﻮﻧﻪ‬ ‫دو‬ ‫ﭼﺮب‬ ‫اﺳﯿﺪﻫﺎي‬ ‫و‬ ‫ﻫﺎ‬) Eryngium caucasicum Trautv.) ‫و‬ (Caucalis platycarpos L. ‫ﮔﯿﻼن‬ ‫اﺳﺘﺎن‬ ‫در‬ (‫ﺳﺤﺮ‬ ‫ﻣﺤﻤﺪي‬ ‫ﭘﻮر‬ 1 ‫ﻋﺒﺪاﻟ‬ ، ‫ﺣﺎﺗﻤﺰاده‬ ‫ﻪ‬ 2 ‫ﺑﺨﺸﯽ‬ ‫داود‬ ، 3 ‫ﭘﺎﺳﺪاران‬ ‫اردﻻن‬ ، 4 * 1 ‫اﯾﺮان‬ ،‫رﺷﺖ‬ ،‫ﮔﯿﻼن...
Article
Ethnopharmacological relevance: As a significant health issue, Functional Constipation (FC) has a high prevalence of 0.7%-29% worldwide. In Persian ethnomedicine, several formulations of sugarcane extracts including faniz, shekar-e- sorkh and black strap molasses have been used to treat pediatric constipation. Aim of the study: To evaluate effic...
Article
A straightforward and efficient method was developed by ultrasound assisted emulsification microextraction (USAEME) combined with inductively coupled plasma optical emission spectroscopy (ICP/OES) to trace some toxic heavy metal ions in eight select farmed and four select imported rice samples. In this study, carbon tetrachloride (CCl 4 ) and 1-(2-...
Article
Introduction In addition to the development of analytical equipment, another movement has also appeared in the field of computer assisted techniques for metabolite assessment. Although, some studies can be found in the literature there is still not available reliable and user‐friendly software which is coupled with a simple chromatography method fo...
Article
Background: The essential oils from the plants of the genus Acantholimon have been an integral part of the traditional food additive in Middle East. Most of the plants in Acantholimon genus have not been studied scientifically. The aim of this study is to investigate the chemical composition, antibacterial, insecticidal and anti-oxidant activities...
Article
Full-text available
Herbs are ancient medicines rich in various phenolic and aromatic compounds, although used only in culinary applications. The influence of regular consumption of spring herbs from plant foods rich in naturally occurring antioxidants from plant foods, oxidative stress, cardiovascular risk and gaining in health effect was studied. The dietary fibers...
Article
Caucalis platycarpos L. and Eryngium caucasicum belong to Umbelliferae and are well represented in the flora of Iran by about 120 genera, 3500 species, and 100 endemic plants. This family is really valuable from economic and medicinal points of view and some species of this family are well known either because they have medicinal properties or beca...
Article
The objective of this study was to identify the bioactive compounds of essential oil and evaluate the antibacterial activity of the essential oil extracted from Chenopodium album subsp. striatum against multidrug-resistant bacterial strains (MDR) which were isolated from clinical specimens by conventional methods. Furthermore, eight different Gram-...
Article
Full-text available
Chemical compounds of the hydrophobic extracts (n-hexane-ether extract) of the aerial parts of Scrophularia amplexicaulis and Scrophularia oxysepala were analyzed for the first time by the Gas Chromatography-Mass Spectrometry (GC-MS) and Gas Chromatography-Flame Ionization Detection (GC-FID). Total 36 compounds were identified which were 84.7% and...
Article
Full-text available
The aerial parts of Acantholimon gilliati was extracted by n-hexane, dichloromethane and methanol. Methanolic extract tested for hepatoprotective effects on formaldehyde liver injury in mice. The maximum effect that the methanolic extract showed protective effect on this experiment against formaldehyde observed in 5 and 10 mg. Also other concentrat...
Article
Full-text available
Context: Scrophularia genus (Scrophulariaceae) includes about 350 species commonly known as figwort. Many species of this genus grow wild in nature and have not been cultivated yet. However, some species are in danger of extinction. Objective: This paper reviews the chemical compounds, biological activities and the ethnopharmacology of some Scrophu...
Article
Full-text available
Chenopodium album (sub sp. striatum) is a folk and nutritious medicine belongs to Chenopodiaceae family and widely used as antimicrobial agent. The aim of this study is to evaluate the in vitro antibacterial potential against multidrug-resistance (MDR) bacteria isolated from clinical spicemens, antioxidant activity, total phenolic and total flavono...
Poster
Full-text available
In this study, a cold-adapted yeast was isolated and identified from fallen leaf debris in Deylaman Forest, Guilan, North of Iran.
Article
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Syrian rue (Peganum harmala L., Zygophyllaceae) has been used in traditional medicine of Central Asia, the Middle East, and Caucasus areas (Azerbaijan) for centuries, mainly as ritual and psychedelic plant. At full growth, this erect, dichotomously branched shrub is about 1 m in height with a dense foliage consisting of narrow, linear, pinnate leav...
Article
Full-text available
Background: This study investigates fatty acids and sterol contents of some seeds used in Asian nutrition culture to prepare functional beverages, foods or fatty acids and sterols source. Objective: Current study presents an overview about some seeds as a valuable source for fatty acids and sterols extraction. Methods: Gas chromatography-mass spect...
Article
Full-text available
In Persian nutrition culture, drinking aromatic waters (hydrosols, distillate) has a long history as functional beverages or therapeutic remedies. The co-distilled water with essential oils, which contains partial amounts of more water-soluble volatile compounds are diluted and used as beverages. Since the solubility of volatile components is diffe...
Article
Full-text available
Isolated five known iridoids glycosides (Scrophuloside A, Harpagoside B, 5-hydroxyloganin, 8-O-acetylharpagide and 6-O-methyl,1-glucopyranosyl catalpol), one phenyl ethanoid glycoside (Verbascoside) and a phenyl ethanol amine (2-(4-Chlorobenzyl amino) ethanol) compound from the methanolic extract of aerial parts of Scrophularia oxysepala using by h...
Article
Full-text available
The aerial parts of Acantholimon gilliati was extracted with n-hexane, dichloromethane, and methanol. Methanolic extract tested for hepatoprotective effects on formaldehyde liver injury in mice. The maximum effect that the methanolic extract showed a protective effect on this experiment against formaldehyde observed in 5 and 10 mg. Also, other conc...
Article
Full-text available
Background Burns are common event and associated with a high incidence of death, disability, and high costs. Centella asiatica (L.) is a medicinal herb, commonly growing in humid areas in several tropical countries that improve wound healing. On the basis of previous studies, we compared the efficacy of Centiderm versus silver sulfadiazine (SSD) in...
Article
Full-text available
Background: Solanum sisymbriifolium Lam. is used as traditional remedy in South America, recently this plant considered as a new edible source. Berries and flower of S. sisymbriifolium have a characteristic fragrance. The pleasant fragrance of the S. sisymbriifolium could be considered as a source of food additive or preservative. Methods: The esse...
Conference Paper
6th Iranian national burning congressIntroduction: Burns are common event and associated with a high incidence of death, disability and high costs. Centella asiatica (L.) is a medicinal herb, commonly growing in humid areas in several tropical countries which improve wound healing. Based on previous studies, we compared the efficacy of Centiderm ve...
Article
Full-text available
Scrophularia amplexicaulis Benth. is an Iranian endemic species of the genus Scrophularia, which comprises ca. 200 medicinally important herbaceous flowering plants. Phytochemical investigation of the methanol extract of the aerial parts of this species afforded two iridoid glycosides, scropolioside D (1) and scrophuloside B4 (2), and two phenylalk...
Article
Full-text available
Many of the volatile oils showed important biological and pharmacological activities, these compounds as part of the traditional medicine in many cultures used as long time. Potencies of them caused these natural products gained many scientific researches in felid of natural products. The volatile oils of Actinotrichia fragilis (Forsskål) Børgesen,...
Article
Full-text available
Background and objectives: Acantholimon bracteatum (Girard) Boiss (Plumbaginaceae) is used in variety of diseases including hepatic ailments in the west regions of Iran. In the present study, the hepatoprotective effect of the methanol extract (ME) of A. bracteatum on formaldehyde (FA) induced liver injury has been investigated in adult male mice....
Article
Full-text available
Background: Plumbaginaceae plants family is a valuable natural insecticidal compound. This research focused on contact toxicity and chemical composition of essential oil obtained from Acantholimon scorpus. Methods: The essential oil from the aerial parts of A. scorpius was extracted by hydrodistillation method and tested for their toxicity against...
Article
Full-text available
Background: C.trinodisis brown algae of Oman Sea coast is used traditionally as a diuretic in Chabahar, Sistan and Baluchestan province of Iran. But no researches have been conducted on the distractive effects of this alga on the renal tissues until now. Methods: Forty-two adult male mice were divided into 6 groups. Control group received normal sa...
Article
Full-text available
Herbs have played a positive role in medicine for thousands of years. In the current study, we investigated the cytotoxicity effects of Scrophularia oxysepala methanolic subfractions and the underlying mechanism responsible for cell death in human breast carcinoma (MCF-7 cells) and mouse fibrosarcoma (WEHI-164 cells). From 60% and 80% methanolic fr...
Patent
Full-text available
This ointment can improve the burning wound healing faster than other available drugs and can be introduced as a new drug for burning.
Article
Full-text available
Breast cancer is a prevalent malignancy among women, especially in developing countries. A large number of anticancer agents with herbal origins have been reported. Hence, herbals may play an essential role in prevention and treatment of cancers. We investigated cytotoxic effects of dichloromethane fractions of Scrophularia oxysepala extract on the...
Article
Full-text available
Background: Scrophularia oxysepala Boiss. is endemic to western and central regions of Iran, and belongs to the genus Scrophularia (family: Scrophulariaceae), which has long been used in traditional medicines. In the present work, chemical composition of the essential oil of the aerial parts of this species was analyzed. Methods: The air-dried grou...
Article
Background: Cancer is a major public health problem in both developed and developing countries. It is the second largest common disease spread world-wide. Drug toxicity and resistance to chemotherapeutic agents make a struggle to treat cancer. For this reason, initial research focuses on traditional medicines or herbal formulations. As we know, bre...
Article
Full-text available
Purpose: Breast cancer is the most common cause of cancer-related death in women worldwide. Therefore, there is an urgent need to identify and develop therapeutic strategies against this deadly disease. This study is the first to investigate the cytotoxic effects and the mechanism of cell death of Scrophularia oxysepala extracts in MCF-7 human bre...
Article
Full-text available
Chemical composition of the essential oil obtained from the aerial parts of Scrophularia amplexicaulis Benth. was analyzed, for the first time, by the gas chromatography/mass spectrometry (GC-MS) and gas chromatography/flame ionization detection (GC-FID). A total yield of 3 mg of essential oil per100 g of plant dry mass was obtained, and 27 compoun...