
Ardalan PasdaranShiraz University of Medical Sciences | SUMS
Ardalan Pasdaran
Doctor of Pharmacy (Pharm.D) and Doctor of Philosophy Pharmacognosy (Ph.D.)
About
90
Publications
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Introduction
I am a professor of pharmacognosy and expert in processing techniques including extraction methods, natural compounds isolation, purification and structure elucidation of them by 1DNMR & 2DNMR and MS techniques, and running clinical and laboratory trial for natural compounds.
Additional affiliations
January 2013 - present
January 2014 - January 2016
Education
January 2000 - December 2012
Publications
Publications (90)
The objective of this study was to examine phytochemical compounds and the cellular effects of the essential oil of Iphiona aucheri. The essential oil of the dried aerial parts of the plant with the recovery rate of 0.1% (v/w) was extracted through hydrodistillation by a Clavenger apparatus, and the chemical compounds were identified based on gas c...
The global decline of pollinators and particularly the decline of bumblebees is a well-proven fact. Their conservation is a leading task in searching for new biopesticides. Amorpha fruticosa L. (Fabaceae) is alien invasive plant in all parts of the world. This way it is a hazard to the local biodiversity. On the other hand, it is an inexpensive pot...
The Orobanche genus (broomrapes) is well-known as an herbaceous parasitic plant with a long
history in traditional Asian medicine and folklore foods. The volatile components of two Orobanche species, O. laxissima and O. ramosa (branched broomrape), from two different areas, East Azerbaijan and
Fars provinces, were analyzed in this study using hydro...
In 2021, the World Health Organization released the fifth edition of the central nervous system (CNS) tumor classification. This classification uses histopathology and molecular pathogenesis to group tumors into more biologically and molecularly defined entities. The prognosis of brain cancer, particularly malignant tumors, has remained poor worldw...
A comprehensive literature search was conducted in PubMed, Cochrane Library, Web of Science, Scopus, the National Library of Medicine (NLM) catalog, and Google Scholar from January 1980 up until October 2023 on plants in the Gundelia genus. Gundelia L. (Asteraceae) has been treated as a monospecific genus with G. tournefortii L. (1753: 814) in most...
Pyrus boissieriana is a rich source of arbutin and has been used in herbal medicine to treat infectious diseases. This study aimed to investigate the effect of the arbutin-rich fraction of Pyrus boissieriana aerial parts on Toxoplasma gondii In Vitro and In Vivo.
An arbutin-rich fraction of P. boissieriana was prepared beforehand. Flow cytometry wa...
Ten sesquiterpene lactones isolated from Anvillea garcinii (Burm.f.) DC ethanolic extract were assessed for their anti-inflammatory potential by myeloperoxidase (MPO) activity assignment, and mice paw swelling model. 3α,4α-10β-trihydroxy-8α-acetyloxyguaian-12,6α-olide (1), epi-vulgarin (3), 9a-hydroxyparthenolide (4), garcinamine C (7), garcinamine...
s u m m a r y Fruits, flowers, leaves, essential oils, hydrosols, and juices of citrus spp. Are utilized to prepare various forms of food products. Along with their nutritional values, in the health industry, different parts of the plants of the citrus genus have been used as supplements or remedies to prevent or control diseases. This review focus...
Natural pigments are important sources for the screening of bioactive lead compounds. This article reviewed the chemistry and therapeutic potentials of over 570 colored molecules from plants, fungi, bacteria, insects, algae, and marine sources. Moreover, related biological activities, advanced extraction, and identification approaches were reviewed...
Natural pigments are important sources for the screening of bioactive lead compounds. This article reviewed the chemistry and therapeutic potentials of over 570 colored molecules from plants, fungi, bacteria, insects, algae, and marine sources. Moreover, related biological activities, advanced extraction, and identification approaches were reviewed...
The Latin word lupus, meaning wolf, was in the medical literature prior to the 1200s to describe skin lesions that devour flesh, and the resources available to physicians to help people were limited. The present text reviews the ethnobotanical and pharmacological aspects of medicinal plants and purified molecules from natural sources with efficacy...
Wound care will always be among the main tasks in all surgical specialties. Several medicinal plants have proven efficacy to cure wounds. Ethnobotanical research and ethnopharmacological research have virtually endless potential to find new lead compounds. The aim of this research review is to assess the potential of some Gentiana species as source...
As a major public health issue, cutaneous leishmaniasis (CL) has a number of complications, including drug resistance and poor response to conventional treatments. Over the last decade, research on natural sources for finding new anti-leishmanial agents has been a critical part of tropical disease research. Natural products also should be regarded...
Fruits, flowers, leaves, essential oils, hydrosols, and juices of citrus spp. Are utilized to prepare various
forms of food products. Along with their nutritional values, in the health industry, different parts of the
plants of the citrus genus have been used as supplements or remedies to prevent or control diseases. This
review focused on reported...
The disease of COVID-19 is generated by the SARS-COV-2 virus and principally
attacks the lung tissue. In addition, other tissues are also attacked by the virus.
Reports have shown that the clinical symptoms of this disease vary from no sign to acute respiratory symptoms in the lungs and the occurrence of septic shock with an effect on the immune...
Ten sesquiterpene lactones isolated from Anvillea garcinii (Burm.f.) DC ethanolic extract were assessed for their anti-inflammatory potential by myeloperoxidase (MPO) activity assignment, and mice paw swelling model. 3α,4α-10β-trihydroxy-8α-acetyloxyguaian-12,6α-olide (1), epi -vulgarin (3), 9a-hydroxyparthenolide (4), garcinamine C (7), garcinami...
Background and aims
Coronary artery bypass graft surgery (CABG) is a primary treatment in coronary artery disease (CAD). Patients experience pain after CABG. Pain may increase postoperative complications and decrease quality of life (QoL). This study aims to determine the lavandula aromatherapy effect on patients' pain after CABG.
Methods
98 patie...
The extensive use of pesticides may negatively affect human health. Additionally, it is one
of the main reasons for the decline of pollinators and is thus a hazard for most crops and biodiversity
as a whole. Good candidates for the replacement of pesticides with ones less toxic to humans and
pollinators are natural products (bioactive compounds ext...
Plants are reservoirs of naturally occurring chemical constituents with a wide range of structural diversity. These biological compounds can be derived from different parts of plants such as leaves, barks, seeds, seed coats, flowers, and roots. A broad array of secondary metabolic compounds is present in the plants such as antibiotics, alkaloids, a...
Plants are reservoirs of naturally occurring chemical constituents with a wide range of structural diversity. ese biological compounds can be derived from different parts of plants such as leaves, barks, seeds, seed coats, flowers, and roots. A broad array of secondary metabolic compounds is present in the plants such as antibiotics, alkaloids, ant...
Since ancient times, herbal medicines (HM) have played a vital role in worldwide healthcare systems. It is therefore critical that a thorough evaluation of the quality and control of its complicated chemical makeup be conducted, in order to ensure its efficacy and safety. The notion of HM chemical prints, which aim to acquire a full characterizatio...
Halophytic plants growing in harsh desert environments are rich reservoirs of unique endophytic microorganisms. Here, healthy fresh plants of the families Tamaricaceae and Amarantaceae at three saline locations in Iran were investigated for their bioactive endophytic fungi. Among a vast number of isolates, eight isolates were identified as Humicola...
Different gentian preparations are used as traditional remedies for internal pain control in: Persian traditional medicine (PTM), Chinese traditional medicine (CTM) and Ancient Greek medicine (AGM) from the time of the Roman Empire. Objective: To present a survey of the ethnopharmacological applications of gentians recorded as being used in Eastern...
Introduction:
Fibroblasts and fibroblast-like cells (FLCs) are highly distributed in the dermis layer of the skin and gastrointestinal tract. A few studies have investigated the effects of color additives of cosmetic products on human fibroblasts. Therefore, this in vitro study was conducted to investigate the effects of 9 synthetic and natural dy...
Background and objectives: There is growing interest in introducing safe and bioactive natural red pigments to the pharmaceutical and cosmetic industries. This study was designed to determine the phytochemical content and potential cytotoxicity of red pigment from Callistemon citrinus (Curtis) Skeels (syn. Melaleuca citrina (Curtis) Dum.Cours.) flo...
A new guaianolide sesquiterpene lactone with cytotoxic properties was isolated from Euphorbia microsphaera Boiss. To determine the highest active fraction and isolate bioactive compounds, a bioassay guided fractionation approach was used. The general toxicity properties of the plant's extracts and fractions (fr1-10) were assessed against Artemia sa...
Oriental plane hydrosol (distillate), as a remedy for weight gain and asthma treatment, is popular in ethnomedicine. Phytochemicals of medicinal plants could have side effects or serious damages. In this study, the oriental plane hydrosol was prepared by steam distillation. Also, tree oriental plane hydrosol samples from different companies were pu...
Monitoring of toxic heavy metals in fish samples is a matter of a great importance from the nutritional and toxicological points of view. A dispersive micro solid phase extraction (dµSPE) for preconcentration of trace Pb, Cd, Hg, Co, Ni ions using pectin coated magnetic graphene oxide (pectin/Fe3O4/GO) is presented. Inductively coupled plasma optic...
Aromatic herbal remedies, hydrosols, and essential oils are widely used for women’s hormonal health. Scientific investigation of their major constituents may prevent unwanted infertility cases, fetal abnormalities, and drug-herb interactions. It also may lead to development of new medications. A list of 265 volatile molecules (mainly monoterpenes a...
Background: In Persian food culture, Citrus aurantium L. (bitter orange) flowers and essential oil are consumed as jams or plant distillate in high doses. Some concerns were mentioned in Persian traditional literature about their effects on the liver. This study aimed to investigate the effect of the essential oil from C. aurantium L. flowers on li...
The Scrophularia genus is a rich source of phenylethanoid glycosides, with diverse biological activities including anti-diabetic properties. This study investigated anti-type 2 diabetic potential and active component of Scrophularia flava Grau.
A new phenylethanoid glycoside was isolated from aerial parts of the plant and identified as 2-(4-hydroxy...
In this study, methoxylated flavonoids and volatile constitutions of Agrostis gigantea Roth (Poaceae) were investigated for the first time. The flavonoids were identified by spectroscopic methods (¹H-NMR, ¹³C-NMR, COSY, NOSEY, TCOSY, and HMBC). The volatile constitutions of aerial parts and seeds were analyzed by gas chromatography–mass spectrometr...
Tricholoma is one of the famous genera of Basidiomycota division. Although some species of this genus have been used as culinary mushrooms, very negligible investigations have been conducted on Tricholoma genus phenolic contents and their biological activities. In the present study, the antioxidant, antimicrobial, and DNA protection properties of t...
Three iridoid glycosides included 6-O-methyl, 1-glucopyranosyl catalpol (Compound 1), 6-O-α-L (3"-O-trans, 4"-O-trans cinnamoyl)-rhamnopyranosyl catalpol (Compound 2) and scropolioside D (Compound 3) were isolated from aerial parts of S. amplexicaulis using chromatographic methods. The structures were determined by different spectroscopic data. The...
Halophytic plants growing in harsh desert environments are rich reservoirs of unique endophytic microorganisms. Here, healthy fresh plants of the families Tamaricaceae and Amarantaceae at three saline locations in Iran were investigated for their bioactive endophytic fungi. Among a vast number of isolates, eight isolates were identified as Humicola...
Lately, it has been proved that yeast exopolysaccharides (EPS) are potentially applicable biopolymers, a fact that has led to incremental needs for their assessment. The current study is based on the biochemical and molecular level identification of the novel cold-adapted yeast Rhodotorula mucilaginosa sp. GUMS16. Possible antioxidant and antiproli...
The present investigation was carried out to evaluate the pharmacognostic properties of Citrus aurantium seeds as well as its anti-inflammatory activities. The n-hexane fraction of seed oil extracted via a Soxhlet extractor and subjected to pharmacognostic assays, HPTLC and GC-MS analysis for determination of fatty acids and sterols. The possible a...
Background: Different endemic species of Apiaceae that widely grow in Hyrcanian region have long been used as spices and herbal remedies. Chemical compositions and bioactivity of many of these plants have not been studied scientifically. The volatile constituents and antimicrobial activity of four edible Apiaceae plants—Elaeosticta glaucescens Bois...
25 ﺷﻤﺎره ،ﻫﻔﺘﻢ ﺳﺎل ، 1 ﺑﻬﺎر ، 1398 آﻧﺘﯽ ،ﻓﯿﺘﻮﺷﯿﻤﯿﺎﯾﯽ ﺑﺮرﺳﯽ اﺳﺘﺮول ﺿﺪاﻟﺘﻬﺎﺑﯽ و اﮐﺴﯿﺪاﻧﯽ داروﯾﯽ ﮔﻮﻧﻪ دو ﭼﺮب اﺳﯿﺪﻫﺎي و ﻫﺎ) Eryngium caucasicum Trautv.) و (Caucalis platycarpos L. ﮔﯿﻼن اﺳﺘﺎن در (ﺳﺤﺮ ﻣﺤﻤﺪي ﭘﻮر 1 ﻋﺒﺪاﻟ ، ﺣﺎﺗﻤﺰاده ﻪ 2 ﺑﺨﺸﯽ داود ، 3 ﭘﺎﺳﺪاران اردﻻن ، 4 * 1 اﯾﺮان ،رﺷﺖ ،ﮔﯿﻼن...
Ethnopharmacological relevance:
As a significant health issue, Functional Constipation (FC) has a high prevalence of 0.7%-29% worldwide. In Persian ethnomedicine, several formulations of sugarcane extracts including faniz, shekar-e- sorkh and black strap molasses have been used to treat pediatric constipation.
Aim of the study:
To evaluate effic...
A straightforward and efficient method was developed by ultrasound assisted emulsification microextraction (USAEME) combined with inductively coupled plasma optical emission spectroscopy (ICP/OES) to trace some toxic heavy metal ions in eight select farmed and four select imported rice samples. In this study, carbon tetrachloride (CCl 4 ) and 1-(2-...
Introduction
In addition to the development of analytical equipment, another movement has also appeared in the field of computer assisted techniques for metabolite assessment. Although, some studies can be found in the literature there is still not available reliable and user‐friendly software which is coupled with a simple chromatography method fo...
Background: The essential oils from the plants of the genus Acantholimon have been an integral part of the traditional food additive in Middle East. Most of the plants in Acantholimon genus have not been studied scientifically. The aim of this study is to investigate the chemical composition, antibacterial, insecticidal and anti-oxidant activities...
Herbs are ancient medicines rich in various phenolic and aromatic compounds, although used only in culinary applications. The influence of regular consumption of spring herbs from plant foods rich in naturally occurring antioxidants from plant foods, oxidative stress, cardiovascular risk and gaining in health effect was studied. The dietary fibers...
Caucalis platycarpos L. and Eryngium caucasicum belong to Umbelliferae and are well represented in the flora of Iran by about 120 genera, 3500 species, and 100 endemic plants. This family is really valuable from economic and medicinal points of view and some species of this family are well known either because they have medicinal properties or beca...
The objective of this study was to identify the bioactive compounds of essential oil and evaluate the antibacterial activity of the essential oil extracted from Chenopodium album subsp. striatum against multidrug-resistant bacterial strains (MDR) which were isolated from clinical specimens by conventional methods. Furthermore, eight different Gram-...
Chemical compounds of the hydrophobic extracts (n-hexane-ether extract) of the aerial parts of Scrophularia amplexicaulis and Scrophularia oxysepala were analyzed for the first time by the Gas Chromatography-Mass Spectrometry (GC-MS) and Gas Chromatography-Flame Ionization Detection (GC-FID). Total 36 compounds were identified which were 84.7% and...
The aerial parts of Acantholimon gilliati was extracted by n-hexane, dichloromethane and methanol. Methanolic extract tested for hepatoprotective effects on formaldehyde liver injury in mice. The maximum effect that the methanolic extract showed protective effect on this experiment against formaldehyde observed in 5 and 10 mg. Also other concentrat...
In Persian nutrition culture, drinking aromatic waters (hydrosols, distillate) has a long history as functional beverages or therapeutic remedies. The co-distilled water with essential oils, which contains partial amounts of more water-soluble volatile compounds are diluted and used as beverages. Since the solubility of volatile components is diffe...
Chenopodium album (sub sp. striatum) is a folk and nutritious medicine belongs to Chenopodiaceae family and widely used as antimicrobial agent. The aim of this study is to evaluate the in vitro antibacterial potential against multidrug-resistance (MDR) bacteria isolated from clinical spicemens, antioxidant activity, total phenolic and total flavono...
In this study, a cold-adapted yeast was isolated and identified from fallen leaf debris in Deylaman Forest, Guilan, North of Iran.
Syrian
rue (Peganum harmala L., Zygophyllaceae) has been used in
traditional medicine of Central Asia, the Middle East, and Caucasus areas
(Azerbaijan) for centuries, mainly as ritual and psychedelic plant. At full growth, this erect, dichotomously
branched shrub is about 1 m in height with a dense foliage consisting of
narrow, linear, pinnate leav...
Background: This study investigates fatty acids and sterol contents of some seeds used in Asian nutrition culture to prepare functional beverages, foods or fatty acids and sterols source. Objective: Current study presents an overview about some seeds as a valuable source for fatty acids and sterols extraction. Methods: Gas chromatography-mass spect...
Isolated five known iridoids glycosides (Scrophuloside A, Harpagoside B, 5-hydroxyloganin,
8-O-acetylharpagide and 6-O-methyl,1-glucopyranosyl catalpol), one phenyl ethanoid
glycoside (Verbascoside) and a phenyl ethanol amine (2-(4-Chlorobenzyl amino) ethanol)
compound from the methanolic extract of aerial parts of Scrophularia oxysepala using by h...
The aerial parts of Acantholimon gilliati was extracted with n-hexane, dichloromethane, and
methanol. Methanolic extract tested for hepatoprotective effects on formaldehyde liver injury
in mice. The maximum effect that the methanolic extract showed a protective effect on this
experiment against formaldehyde observed in 5 and 10 mg. Also, other conc...
Background
Burns are common event and associated with a high incidence of death, disability, and high costs. Centella asiatica (L.) is a medicinal herb, commonly growing in humid areas in several tropical countries that improve wound healing. On the basis of previous studies, we compared the efficacy of Centiderm versus silver sulfadiazine (SSD) in...
Background: Solanum sisymbriifolium Lam. is used as traditional remedy in
South America, recently this plant considered as a new edible source. Berries
and flower of S. sisymbriifolium have a characteristic fragrance. The pleasant
fragrance of the S. sisymbriifolium could be considered as a source of food
additive or preservative.
Methods: The esse...
6th Iranian national burning congressIntroduction: Burns are common event and associated with a high incidence of death, disability and high costs. Centella asiatica (L.) is a medicinal herb, commonly growing in humid areas in several tropical countries which improve wound healing. Based on previous studies, we compared the efficacy of Centiderm ve...
Context: Scrophularia genus (Scrophulariaceae) includes about 350 species commonly known as figwort. Many species of this genus grow wild in nature and have not been cultivated yet. However, some species are in danger of extinction.
Objective: This paper reviews the chemical compounds, biological activities and the ethnopharmacology of some Scrophu...
Scrophularia amplexicaulis Benth. is an Iranian endemic species of the genus Scrophularia, which comprises ca. 200 medicinally important herbaceous flowering plants. Phytochemical investigation of the methanol extract of the aerial parts of this species afforded two iridoid glycosides, scropolioside D (1) and scrophuloside B4 (2), and two phenylalk...
Many of the volatile oils showed important biological
and pharmacological activities, these compounds as part of the traditional
medicine in many cultures used as long time. Potencies of them caused these
natural products gained many scientific researches in felid of natural
products. The volatile oils of Actinotrichia
fragilis (Forsskål) Børgesen,...
Background and objectives: Acantholimon bracteatum (Girard) Boiss (Plumbaginaceae) is used in variety of diseases including hepatic ailments in the west regions of Iran. In the present study, the hepatoprotective effect of the methanol extract (ME) of A. bracteatum on formaldehyde (FA) induced liver injury has been investigated in adult male mice....
Background: Plumbaginaceae plants family is a valuable natural insecticidal compound. This research focused on contact toxicity and chemical composition of essential oil obtained from Acantholimon scorpus. Methods: The essential oil from the aerial parts of A. scorpius was extracted by hydrodistillation method and tested for their toxicity against...
Background: C.trinodisis brown algae of Oman Sea coast is used traditionally as a diuretic in Chabahar, Sistan and Baluchestan province of Iran. But no researches have been conducted on the distractive effects of this alga on the renal tissues until now. Methods: Forty-two adult male mice were divided into 6 groups. Control group received normal sa...
Herbs have played a positive role in medicine