Archana R Juvekar

Archana R Juvekar
Institute of Chemical Technology, Mumbai | ICT

About

132
Publications
19,482
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2,304
Citations
Citations since 2017
16 Research Items
1482 Citations
2017201820192020202120222023050100150200250300
2017201820192020202120222023050100150200250300
2017201820192020202120222023050100150200250300
2017201820192020202120222023050100150200250300

Publications

Publications (132)
Article
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Hydrogen sulfide (H2S) is reported to have a neuroprotective activity; however, the role of H2S in neuroinflammation-induced neuronal damage is ambiguous. Here, we aimed to evaluate the underlying mechanisms for the neuroprotective effect of NaHS, a known H2S donor, against lipopolysaccharide (LPS)-induced memory impairment (MI). All the treatments...
Article
Background: Alzheimer’s disease (AD), a progressive neuropsychiatric disorder, is characterized by neuroinflammation, β-amyloid plaques and neurofibrillary tangles. It has been demonstrated that systemic inflammation and neuroinflammation caused by lipopolysaccharide (LPS) injections in rodents leads to elevation in Aβ levels and neuronal cell deat...
Article
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Oxidative stress plays a pivotal part in the manifestation of neuroinflammation, which further leads to neurodegenerative diseases like Alzheimer’s disease (AD). Systemic administration of lipopolysaccharide (LPS) induces neuroinflammation resulting in memory impairment (MI) and cognitive decline. In this study, we evaluated whether prophylactic ad...
Article
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Recent evidence suggests that Alzheimer's disease (AD) is closely linked with insulin resistance, as seen in type 2 diabetes mellitus (T2DM). Insulin signaling is impaired in AD brains due to insulin resistance, ultimately resulting in the formation of neurofibrillary tangles (NFTs). AD and T2DM are connected at molecular, clinical, and epidemiolog...
Article
Alzheimer’s disease (AD) is a major neurodegenerative disorder characterized by Aβ‐plaque deposition, formation of neurofibrillary tangles, neuroinflammation, and neurodegeneration. Although not the initiator of the disease, neuroinflammation has been known to play a pivotal role in the pathogenesis of AD. Neuroinflammation was induced by systemic...
Article
The aim of this study is to test the hypothesis that feeding trans fatty acids (TFA) (5%) along with fructose exacerbates obesity and non-alcoholic fatty liver disease (NAFLD) in rats. Male Wistar rats were randomized into four groups, i.e., standard diet, 5% TFA + standard diet, fructose + standard diet, and TFA + fructose + standard diet. All the...
Article
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Nonalcoholic fatty liver disease (NAFLD) is regarded as the hepatic manifestation of the metabolic syndrome. It begins with the accumulation of fat in the liver (simple steatosis), which if untreated can progress to nonalcoholic steatohepatitis, cirrhosis, and hepatocellular carcinoma. Chrysin is a flavonoid present in bee propolis and many other p...
Article
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Background and aim Chrysin is a flavonoid found in plant extracts from Passiflora species, honey and propolis. It has demonstrated anti-adipogenic activity in vitro but there are no studies substantiating the anti-obesity activity of chrysin in vivo. Experimental procedure The pancreatic lipase (PL) inhibitory potential of chrysin was determined b...
Article
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Background Chronic consumption of fructose causes obesity and nonalcoholic fatty liver disease (NAFLD). Currently available therapies have limitations; hence there is a need to screen new molecules. Plumbagin is a naphthoquinone present in the roots of Plumbago species which has hypolipidemic and hepatoprotective activities. Methods Rats were divi...
Article
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Neuroinflammation is said to play a pivotal role in the pathogenesis of neurodegenerative disorders such as Alzheimer’s disease (AD). Trigonelline (TRG) is a naturally occurring alkaloid, commonly isolated from fenugreek and coffee beans. In the present study, we investigated whether TRG exerts neuroprotective action against LPS mediated cognitive...
Article
Background: Lipopolysaccharide (LPS), an endotoxin from the outer membrane of Gram negative bacteria has been reported to cause neuroinflammation and learning and memory deficits. There are reports describing the beneficial effects of Imperatorin (IMP), a naturally occurring furanocoumarin in central nervous system (CNS) disorders such as anxiety...
Article
Plumbagin is a naphthoquinone found in the roots of Plumbago zeylanica. Here, we report an investigation to evaluate its antiobesity activity. The preliminary binding affinity of plumbagin to human pancreatic lipase (PL) was determined using molecular docking simulation. The in vitro PL inhibitory potential and the kinetics of inhibition were studi...
Article
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Background: Gentamicin is widely used as an antibiotic for the treatment of gram negative infections. Evidences indicates that oxidative stress is involved in gentamicin-induced nephrotoxicity. In Ayurvedic medicine, Punica granatum Linn. is considered as 'a pharmacy unto itself". It has been claimed in traditional literature, to treat various kid...
Poster
Alzheimer's disease is a progressive neurodegenerative disorder and the most common cause of dementia worldwide. It mainly affects older individuals. It is characterized by the presence of beta-amyloid plaques and neurofibrillary tangles within the brain and patients presenting with the memory defects including impairment in learning and memory. Al...
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Objective: To elucidate the mechanism of action of methanolic extract of Carissa carandas fruits (MCCF) in attenuation of diabetic nephropathy using gentamicin induced nephrotoxicity model. Methods: Extract was daily administered to Sprague Dawley rats at doses of 100, 200 and 400 mg/kg for 8 days along with intramuscular injection of gentamicin (8...
Article
Introduction Pithecellobium dulce (Roxb.) Benth (Mimosaceae) commonly known as Manila tamarind, has been traditionally used for the treatment of diabetes mellitus. The present study investigated the attenuating effects of methanolic extract of Pithecellobium dulce seeds (PDM) on hyperglycemia, oxidative stress and hyperlipidemia in streptozotocin (...
Article
Objective: Achyranthes aspera Linn. is used as a traditional remedy for the treatment of various inflammatory conditions in India. The present study was designed to investigate the anti-inflammatory activity of methanolic extract of Achyranthes aspera (AA) and its active fraction using bioassay guided fractionation. Methods: The dry whole plant of...
Article
Objective: The present study was done to evaluate repeated-dose 90-day oral toxicity studies of l-dopa and hyoscine hydrbromide combination in rats. Methods: Repeated-dose 90-day oral toxicity study was performed according to the Organisation for Economic Co-operation and Development (OECD) guidelines 408. In the present study, combination of L-dop...
Article
The present study was carried out to evaluate the antidepressant potential of Vernonia anthelmintica willd seed extracts in experimental animals. Methanolic and aqueous extract of Vernonia anthelmintica seeds were carried out by soxhlet extraction and maceration technique respectively. The extracts were administered at dose levels of 125, 250 and 5...
Article
Objective: The present study was undertaken to evaluate the antidepressant and nootropic potential of aqueous extract of Indigofera tinctoria (ITAE).
Article
Objective: The present study was done to find out the anti-diabetic effect of Indigofera cordifolia seeds and leaves extract on intestinal α-glucosidase, α-amylase enzymes In-vitro.
Article
In the present study the anti-inflammatory potential of Methanolic and Aqueous extracts of Leaves of Mimusops elengi L. was evaluated for their in-vitro and in-vivo antiinflammatory activity. In-vitro anti-inflammatory activity was evaluated by using membrane stabilization assay, proteinase inhibitory activity and immunomodulatory activity using ma...
Article
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Arzanol is a novel phloroglucinol α -pyrone, isolated from a Mediterranean plant Helichrysum italicum (Roth) Don ssp. microphyllum which belongs to the family Asteraceae. Arzanol has been reported to possess a variety of pharmacological activities. However, anti-inflammatory, anti-HIV, and antioxidant activities have been studied in some detail. Ar...
Article
This study sought to asses and characterizes the inhibitory action of methanolic extract of Pithecellobium dulce (P. dulce) seeds on α-amylase and α-glucosidase enzymes as well as to characterize compounds responsible for these activities. The methanolic extract was assessed for total phenolic, flavanoid and triterpenoids content by using Folin-Cio...
Article
Despite the traditional use of Couroupita guianensis (CG) to treat various ailments, it had been less exploited from ethnopharmacological perspective. The aim of the present study was to evaluate aqueous and methanolic extract of CG for its anxiolytic activity in mice.Swiss albino male mice were orally administered both aqueous and methanolic extra...
Article
In present study, we investigated the in vitro antioxidant and free radical scavenging activities of crude methanolic and aqueous extract of Indigofera cordifolia (Fabaceae) seeds. The antioxidant and free radical-scavenging activities of Indigofera cordifolia seed extracts were evaluated using different tests involving inhibition of DPPH, ABTS, TB...
Article
This study was designed to evaluate the anti-inflammatory activity of aqueous and 70% methanolic extracts of pollen grains of Typha angustifolia. Female Sprague Dawley rats were used for the study. The acute anti-inflammatory activity of pollen grains of T. angustifolia was studied using the carrageenan as phlogistic agent, whereas its chronic anti...
Article
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In the present study, effects of the methanolic extract of Couroupita guianensis (Family: Lecythidaceae) were studied on spontaneous motor activity, rota-rod performance and Phenobarbital sleeping time in mice. Preliminary phytochemicals analysis of extract revealed the presence of alkaloids, glycosides, tannins and flavonoids. The extract (100, 25...
Article
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Introduction: Oxidative stress resulted from free radicals and reactive oxygen species are associated with many diseases. Several studies are going on worldwide directed towards finding natural antioxidants of plant origin. Plants containing phenolic compounds have been reported to possess strong antioxidant activity. The aim of the present study w...
Article
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The objective of the present study was to investigate the antiulcer activity of methanol extract of Oxalis corniculata (whole plant) using pylorus ligation and indomethacin-induced gastric ulceration in Wistar rats. The extract was preliminary evaluated for acute oral toxicity test using Organisation for Economic Co-operation and Development guidel...
Article
Depression is a most serious stress related mental disorder affecting 450 million people worldwide. Due to clinical limitations and adverse effects researchers have focussed on novel pharmacotherapy for safe and efficient treatment of depression. The aim of present study was to evaluate the aqueous and methanolic extracts of Couroupita guianensis A...
Article
In the present in vitro study, 5 homeopathic drugs namely, Acid phos, Ignatia amara, Nux vomica, Phosphorus and Zincum metallicum with 4 different concentrations of each were subjected to evaluation of their antioxidant potential using reducing power assay. The highest activity was exhibited by Nux vomica (30c). In general, the reduction ability wa...
Article
The objective of the present work is to study the antidiabetic and antihyperlipidemic effect of aqueous extract of Alstonia scholaris Linn bark in streptozotocin (STZ) induced diabetes in rats. The diabetes was induced by single dose of STZ (65 mg/kg) in citrate buffer, while the normal control group was given the vehicle (citrate buffer) only. Aft...
Article
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To evaluate the antidiabetic effects of the aqueous extract of Elaeocarpus ganitrus (EAG) in experimental animals. The hypoglycemic activity of the EGA was evaluated in normoglycemic rats by single dose at three graded dose levels, viz. 250, 500 and 1000 mg/kg of body weight. Antihyperglycemic activity of the extract was also evaluated at the same...
Article
Traditionally different parts of Dillenia indica have been used for the relief of abdominal pain and the plant is a good source of flavonoids which are reported to possess the analgesic activity, hence the present study was aimed to screen analgesic activity of methanolic extract of leaves using in vivo animal models for pain. Central analgesic act...
Article
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Cardio protective potential of aqueous extract of Moringa oleifera Lam. (Family-Moringaceae) stem bark on serum lipids profiles, myocardial marker enzymes in serum and heart homogenate, antioxidant parameters in heart homogenate and histopathological findings in isoproterenol (ISO)-induced cardiotoxicity in rats was evaluated. Subcutaneous injectio...
Article
Woodfordia fruticosa Kurz. (Lythraceae), a non-rasayana immunomodulatory Indian medicinal plant, used traditionally as an anthelmintic, in dysentery, leprosy, blood diseases, leucorrhea, and menorrhagia. To investigate the effect of ethanol extract of W. fruticosa flowers on non-specific immune responses in mice. In vitro immunomodulatory activity...
Article
Mental disorders contribute significantly to the global burden of diseases. Projections towards the year 2020 show that the neuropsychiatric illness will increase their share from about 10.5% of the total burden of disease in 1990 to 15% in 2020 [1]. Mentha arvensis is an indigenous plant of the Lamiaceae family commonly known as ‘Pudina’ and ‘Mint...
Article
The present study was designed to investigate anti-inflammatory potential of flavonoid fraction of Tamarindus indica Linn (seeds) in rodents. The flavonoid fraction was prepared from methanol extract (successive) of T. indica seeds (Family: Caesalpiniaceae) by the method of Shinoda [1]. Anti-inflammatory activity was studied by carrageenan, histami...
Article
The present study has been undertaken to evaluate the antidiabetic activity of aqueous extract of Withania coagulans fruits in normal as well as in streptozotocin induced diabetes model in rats. In this single dose study, aqueous extract of Withania coagulans fruits was given once orally in three different doses (150 mg/kg, 250 mg/kg and 500 mg/kg)...
Article
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Initiation of acetaminophen (APAP) toxicities is believed to be promoted by oxidative stress during the event of overdosage.The aim of the present study was to evaluate the hepatoregenerative effect of Nyctanthes arbortristis (NAT) was evaluated by intoxicating the rats with 1g/kg of acetaminophen(APAP) p.o. for seven days. The Methanolic extract o...
Article
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The present study was designed to investigate the antioxidant activity of aqueous and methanol extracts of Erythrina indica Lam leaves by in vitro methods viz. 1, 1-Diphenyl-2-Picrylhydrazyl, nitric oxide radical scavenging activity, and inhibition of lipid peroxidation by thiobarbituric acid reactive substances (TBARS) method on isolated rat liver...
Article
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The present study examined the hepatoprotective activity of methanolic extract of Averrhoa bilimbi (leaves) in carbon tetrachloride intoxicated rats. Liver toxicity was induced by intraperitoneal administration of carbon tetrachloride (CCl 4) at the dose of 1 ml/kg with a gap of 72 hrs for 10 days in wistar rats. The hepatoprotective activity of me...
Article
The seeds of Rudraksha (Elaeocarpus ganitrus) have been traditionally used in India and other Asian countries. The methanolic extract of Elaeocarpus ganitrus (EGM) seeds were evaluated for immunomodulatory activity using in vitro and in vivo methodologies. Effect of the extract at various concentrations (832 - 6.5 μg/ml) on secretion of mediators l...
Article
The anti-stress activity of aqueous extract of Tylophora indica (Burm.f.) (100, 250 and 500 mg/kg) was evaluated using chronic cold restraint stress model in Wistar rats. Standard behavioural paradigms such as elevated plus maze model and light-dark model were employed to study the anxiolytic potential of the test extract in Swiss Albino mice. Stim...
Article
The present study was designed to investigate anti-inflammatory potential of aqueous extract of Grewia tiliaefolia Vahl leaves in rodents using carrageenan, histamine and serotonin induced paw edema, prostaglandin inhibitory activity, acetic acid induced capillary permeability, sodium CMC induced leukocytes emigration and cotton pellets induced gra...
Article
Leaves of Murraya koenigii (Linn.) Spreng. (Curry patta) are reported to possess antidiabetic, antimicrobial, cytotoxic and anti-inflammatory activity. In the present study immunomodulatory potential of aqueous extract of its leaves on specific (humoral and cell mediated) and non specific (macrophage) immunity in mice was investigated. Oral adminis...
Article
The saponin rich fraction (SRF) of Bacopa monnieri were prepared and evaluated for in vitro immune response using murine immune cells. Thioglycollate medium elicited peritoneal exudates cells (PEC) were used to study in vitro effects of the fraction (SRF) on release of immune mediators. SRF was evaluated at different concentrations (832 - 6.5μg/ml)...
Article
Erythrina indica Lam (Family: Febaceae) is used in Indian folk medicine for rheumatism, itching, burning sensation, fever, asthma, leprosy and inflammation. Traditionally, it is widely used in the treatment of inflammation and related disorders. However there is no scientific report available on its anti-inflammatory activity. Hence, the present st...
Article
Couroupita guianensis Aubl. a member of the Lecythidaceae family, vernacularly known as cannon ball, locally Kailashpati, grows in tropical areas of the India, South America and the Caribbean. The plant has rich source of triterpenoids which have been concerned with anxiolytic activity. Therefore the present research was aimed to evaluate the poten...
Article
Full-text available
Aqueous extract of Elaeocarpus ganitrus Roxb. seeds powder (Family: Elaeocarpaceae) was evaluated for its antihypertensive activity in renal artery occluded hypertensive rats. Male Wistar rats (180-200g) were pretreated with aqueous extract of E. ganitrus for 6 weeks. Hypertension was induced in animals by clamping the renal artery with renal bulld...
Article
Barleria cristata Linn (family Acanthaceae) has been used traditionally for the treatment of variety of diseases including anemia, toothache and inflammatory disorders [1]. Due to lack of sufficient scientific evidence indicating the utility of this plant in the treatment of inflammation, the present study was aimed at investigating the potential a...
Article
Present work focused on carrying out the phytochemical and pharmacological studies on the leaves of Couroupita guianensis Aubl. Fractionation of petroleum ether extract of these leaves yielded three compounds. Compound 1, m.p. 79-81°C was identified as aliphatic hydrocarbon, while compound 2, m.p. 95-97°C was obtained in small yields and further wo...
Article
Aqueous extract of Elaeocarpus ganitrus Roxb. seeds powder (Family: Elaeocarpaceae) was evaluated for its antihypertensive activity in renal artery occluded hypertensive rats. Male Wistar rats (180-200g) were pretreated with aqueous extract of E. ganitrus for 6 weeks. Hypertension was induced in animals by clamping the renal artery with renal bulld...
Article
Couroupita guianensis Aubl. (Family: Lecythidaceae) popularly known as "cannon ball tree" contains triterpenoids which have been implicated in antidepressant activity. Therefore the present research was aimed to evaluate the potential antidepressant activity of methanolic extract of Couroupita guianensis (CGM) root in mice. This extracts was admini...
Article
Methanol extract of whole plant of Oxalis corniculata Linn (Family: Oxalidaceae) was assessed for its antioxidant and anti-inflammatory activity by in-vitro methods. Antioxidant activity was studied using 1,1-Diphenyl-2- Picrylhydrazyl (DPPH) and nitric oxide radical scavenging activity. Inhibition of lipid peroxidation was studied by thiobarbituri...
Article
Methanolic leaf extract of Aegle marmelose L. was evaluated for its antihyperglycemic and antihyperlipidemic activity in Streptozotocin induced diabetes model in rats. The extract was given orally in two different doses (200mg/kg and 400 mg/kg) for 28 days and for comparison purpose, Glibenclamide (4 mg/kg), an oral hypoglycemic was used as a stand...
Article
The leaves of the indigenous plant Coleus amboinicus Lour (Lamiaceae) possess a characteristic aroma and are used in many food preparations to enhance the flavour. Apart from this, they also exhibit medicinal properties. Aqueous extracts of fresh leaves of C. amboinicus Lour. parent (CAP), as well as tissue culture-raised plants (CAT), showed a dos...
Article
The present study was designed to investigate the effect of aqueous extract of Nelumbo nucifera leaves on convulsive behaviour using various chemoconvulsants in mice. The anticonvulsant activity of the extract (100 mg/kg, 200 mg/kg p.o.) was studied against seizures induced by pentylenetetrazole, strychnine and 4-aminopyridine. An attempt was made...
Article
Full-text available
Effect of stress and its modulation by methanolic extract of bark of Alstonia scholaris was studied using acute restraint stress model in mice. The extract was also evaluated for nootropic and antioxidant potential to support anti-stress activity testing. Acute restraint stress resulted in significant increase of plasma corticosterone, glucose, pro...
Article
Full-text available
Neem (Azadirachta indica A. Juss) is one of the most useful traditional medicinal plants in India. Neem flowers are traditionally used as tonic and stomachic. Neem leaf, stem and seed oil has proved immunomodulatory activity along with the adverse effect on sperm count. Therefore, the aim of the present study was to evaluate immunomodulatory activi...
Article
The anti-inflammatory activities of the methanol extract of Dillenia indica Linnaeus (Family Dilleniaceae) leaves were observed in various experimental models related to inflammation to provide some evidence for its traditional use. Anti-inflammatory activity was observed in carrageenan-induced edema and acetic acid-induced capillary permeability....
Article
The present study investigated the protective effect of methanolic extract of pericarp of fruits of Punica granatum L. (PGM) on isoproterenol (ISO) induced myocardial infarction in rats. Wistar albino rats were fed two different doses of PGM (p.o.) for 28 days followed by s.c. injection of ISO for 2 days. ISO administration to rats showed a signifi...
Article
Full-text available
In the present study, the anti-anxiety activity of aqueous extract of leaves of Nelumbo nucifera was evaluated in four standard behavioral paradigms in mice. In elevated plus maze model, aqueous extract of Nelumbo nucifera at 100 mg/kg and 200 mg/kg increased the frequency and duration of occupancy of mice in open arm, suggesting its anxiolytic pot...
Article
The present work was designed to assess the potential of aqueous extract of Tylophora indica on cognitive functions in mice using elevated plus maze model and Morris water maze model. Piracetam (200 mg/kg) was used as a standard nootropic agent for comparison. The results of elevated plus maze model showed that, Tylophora indica extract treated mic...