Arba Pramundita Ramadani

• Lecturer at Islamic University of Indonesia

Curcuma xanthorrhiza has an active component xanthorrhizol that is poorly soluble in water, resulting in limited absorption and bioavailability. Liquid Self Nano Emulsifying Drug Delivery System (SNEDDS) dosage formulations can improve its solubility and absorption due to its small particle size. Solid SNEDDS technology significantly overcomes some...

Purpose: To investigate the activity of self-nanoemulsifying drug delivery system (SNEDDS) containing B. medicinalis and M. oleifera ethanolic extracts. Method: The SNEDDS was prepared using propylene glycol (40 %), Tween 80 (50 %), and isopropyl myristate (10 %). Transmittance percentage, particle size, polydispersity index, and zeta potential wer...

A BSTRACT Context The chronic diabetes mellitus (DM) condition may lead to diabetic wounds that increase morbidity in patients. Ipomoea reptans Poir leaves have been widely reported to possess anti-diabetic activity due to their flavonoid contents. To enhance drug penetration, a nanoemulgel preparation was formulated. Aims This study aimed to eva...

Background: The kidneys are the main organ for drug excretion, and it is critical to assess kidney functionwhendesigning dosage regimens for drugs that undergo renal elimination. Various formulae have beenused to estimate kidney function andsafely adjust doses. Objective: This research reviewedstudies that assessed patients' kidney function with va...

A total of twelve pentacyclic triterpenoid derivatives based on betulin (1) and lupeol (2) scaffolds isolated from Diospyros foxworthyi were hemisynthesized by acylation or acetylation reactions with appropriate acid chloride or acetic anhydride. The structures of the hemisynthesised compounds were characterised by means of FT-IR, 1D- and 2D-NMR, a...

Background: Moringa leaves (Moringa oleifera Lamk.) are plants from the Moringaceae family that have many properties and are often used empirically as traditional medicine. One of the benefits of M. oleifera leaves is immunomodulator, which functions to modulate the human immune system in both immunostimulants and immunosuppressants. Objectives: To...

Pegagan (Centella asiatica L.) is a herbal plant used in dermatology that has activity in treating skin diseases and skin lesions such as excoriations, burns, hypertrophic scars, antioxidants, anti-aging, skin whitening, and as a cosmetic ingredient. This review aims to collect data regarding the activity of Centella asiatica herb extracts in derma...

In this study, we examined the cytotoxic activity of Eriocaulon cinereum R.Br. against breast cancer T47D cells and normal Vero cells. The plant material of E. cinereum was extracted with n-hexane followed by a series of extraction with ethyl acetate and finally with methanol. The ethyl acetate extract was then fractionated with dichloromethane and...

The objective structured clinical examination (OSCE) has been implemented as an assessment of pharmacist education. It can measure the ability of pharmacist students both structurally and objectively. But since the pandemic of Covid-19, the implementation of OSCE must be switched into an online method. Therefore, this study was aimed to evaluate th...

Propolis memiliki efek imunostimulan yang tinggi namun tidak larut air dan memiliki bioavailabilitas yang rendah. Formulasi propolis dalam bentuk SNEDDS terbukti mampu meningkatkan aktivitas imunostimulannya, namun juga memberikan potensi ketoksikan dikarenakan kecilnya ukuran partikel nano dan akumulasi nya di dalam tubuh. Penelitian ini bertujuan...

Objectives: To evaluate the effect of extract and its fraction (n-hexane, ethyl acetate, and water) of the mulberry leaf (Morus australis Poir.) in reducing triglyceride and total cholesterol levels on HFD and PTU induced rats. Methods: In this study, mulberry leaves were collected from East Nusa Tenggara-Indonesia, extracted using maceration metho...

Gastric ulcer can be affected people at any age. One cause of this disease is NSAID usage. The aim of this study is to determine Muntingia calabura L. fruit activity for prevent ulcer using aspirin-induced gastric ulcer in rat model. Thirty male Wistar rats were divided become six groups: normal (CMC 0.5%), negative control (CMC 0.5%), positive con...

The current development of antimalarial drug resistance encourages researchers to discover and develop novel antimalarials. One of its alternatives for antimalarial discovery is using medicinal plants remembering the success of artemisinin. Sterculia quardrifida R. Br. bark, locally name as faloak, is an endemic medicinal plant from East Nusa Tengg...

Context: Andrographolide (AND) is an active compound of well-known medicinal plant Andrographis paniculata. It has been widely published for various activities. AND is difficult to develop into dosage form due to its poor solubility and bioavailability. This problem could be solved by using self-nanoemulsifying drug delivery system (SNEDDS) for it...

The use of medicinal plants in treating various disease has been reported since long time ago, including for hepatic disease. Corn silk contains phytochemicals of medical benefit such as flavonoids compounds which act as antioxidant agents and has been widely reported possess hepatoprotective effect. Using a model of carbon tetrachloride (CCl4)-ind...

Andrographis paniculata Ness is one of the plants that is under explored and could contain potentially active substances to serve as an antimalarial. Structure investigation of major compounds that have responsibility for the antimalarial activity of Andrographis paniculata Ness ’s n-hexane extract is very important so that it is known whether the...

Obat antiinflamasi non steroid (AINS), terutama yang dapat diperoleh tanpa resep, telah banyak digunakan oleh masyarakat untuk meredakan rasa sakit dan gejala inflamasi pada penyakit yang diderita. Namun, efek samping berupa ulkus lambung yang banyak dialami oleh pengguna AINS. Penelitian ini bertujuan untuk meneliti efek ekstrak etanol daun pepaya...

Because of the ring stage quiescence-based mechanism of artemisinin resistance, the standard IC50 methods measuring parasite growth inhibition to schizonte stage are irrelevant for the assessment of artemisinin resistance. Data on the in vitro artemisinin sensitivity of adapted Plasmodium falciparum field isolates from Africa using assays that take...

We assessed the ex vivo/in vitro sensitivity of 54 Malian Plasmodium falciparum isolates to artemisinin for the monitoring of drug resistance in this area. The artemisinin sensitivity of parasites was evaluated using 1) the ex vivo and in vitro parasite recrudescence detection after treatment of the ring stage with 1-200 nM artemisinin for 48 hours...

Malaria remains a global public health problem and worsening with the resistance of Plasmodium falciparum to Artemisinin-based Combination Therapies (ACTs), the latest and most effective antimalarial drugs. My project aimed to provide insight into malaria elimination in Indonesia. The first part was to look for new antimalarial drugs based on Indon...

Tithonia diversifolia, Cyclea barbata, Tinospora crispa, Arcangelisia flava, Pycnarrhena cauliflora are plants used in Indonesia for the traditional treatment of malaria. In the search for new antiparasitic drugs, the parts traditionally used of these 5 plants were extracted with ethanol and then fractionated with various solvents and evaluated in...

A series of twenty five molecules, including imidazolium salts functionalized by N-, O- or S-containing groups and their corresponding cationic, neutral or anionic gold(I) complexes were evaluated on Plasmodium falciparum in vitro and then on Vero cells to determine their selectivity. Among them, eight new compounds were synthesized and fully chara...

Plasmodium falciparum resistance to artemisinins, the most potent and fastest acting anti-malarials, threatens malaria elimination strategies. Artemisinin resistance is due to mutation of the PfK13 propeller domain and involves an unconventional mechanism based on a quiescence state leading to parasite recrudescence as soon as drug pressure is remo...

Technical Appendix. Additional information regarding induction of multidrug tolerance in Plasmodium falciparum by extended artemisinin pressure.

Plasmodium falciparum resistance to artemisinin derivatives in Southeast Asia threatens global malaria control strategies. Whether delayed parasite clearance, which exposes larger parasite numbers to artemisinins for longer times, selects higher-grade resistance remains unexplored. We investigated whether long-lasting artemisinin pressure selects a...

Preparations of Pseudelephantopus spiralis (Less.) Cronquist (Asteraceae) are traditionally used for the treatment of various diseases including fever, malaria, and spleen or liver inflammations in Latin America. Aerial parts of P. spiralis were extracted with either ethanol or distilled water. Seven hirsutinolide-type sesquiterpenoids were isolate...

The emergence of artemisinin resistance in Southeast Asia imperils efforts to reduce the global malaria burden. We genetically modified the Plasmodium falciparum K13 locus using zinc-finger nucleases, and measured ring-stage survival rates following drug exposure in vitro; these rates correlate with parasite clearance half-lives in artemisinin-trea...