Arata Horii

Arata Horii
Niigata University · Division of Otolaryngology Head and Neck Surgery

MD/PhD

About

339
Publications
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5,575
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Introduction
Skills and Expertise
Additional affiliations
April 2013 - March 2015
Independent Researcher
Independent Researcher
Position
  • Managing Director

Publications

Publications (339)
Article
Organized hematoma is a non-neoplastic mass lesion consisting mainly of hematoma and connective tissue, that rarely occurs in the sphenoid sinus. In this study, we present a case of organized hematoma of the sphenoid sinus causing diplopia and visual loss. A 75-year-old woman who was diagnosed as having cerebral infarction presented with a history...
Article
Objective To compare the feasibility and outcomes of vestibular rehabilitation (VR) for persistent postural-perceptual dizziness (PPPD) with those for chronic unilateral vestibular hypofunction (UVH). Study Design Prospective study. Setting Tertiary referral center. Patients Nineteen consecutive patients with chronic UVH lasting for >3 months an...
Preprint
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Speech sounds are acoustically composed of two main components: spectral and temporal. The spectral component or carrier frequency is important to detect pitch and perceived through activity at specific locations on the tonotopic map in the auditory cortex. The temporal envelope—the dynamic changes in sound wave amplitude over time—plays an essenti...
Article
In July 2023, Niigata Prefecture became the first prefecture in Japan to launch a subsidy program for the purchase of adult hearing aids in all municipalities of the prefecture. In this study, factors related to the purchase/return of hearing aids were examined in order to understand the actual situation of hearing aid trials in Niigata City. The s...
Article
Dizziness is a commonly reported symptom that often becomes chronic. This article describes the basic concepts of cognitive behavioral therapy (CBT) and the clinical presentation of patients with dizziness from a CBT perspective, followed by a report on the practice of CBT for patients with chronic dizziness at our department. Finally, we discuss t...
Article
The Niigata PPPD Questionnaire (NPQ) is a useful tool for screening and assessing the severity of Persistent Postural-Perceptual Dizziness (PPPD), the most common form of chronic dizziness encountered in practice. The NPQ is primarily a screening tool that allows PPPD to be suspected at the initial visit. A total score of ≥27 and/or a visual stimul...
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Background Persistent postural-perceptual dizziness (PPPD) is a chronic vestibular syndrome often triggered by acute or episodic vestibular syndromes, such as Meniere’s disease (MD). According to the diagnostic criteria, PPPD may coexist with other structural diseases, and the evidence of another active illness does not necessarily exclude PPPD dia...
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Background In view of improving biomarkers predicting the efficacy of immunotherapy for head and neck squamous cell carcinoma (R/M HNSCC), this multicenter retrospective study aimed to identify clinical, tumor microenvironmental, and genomic factors that are related to therapeutic response to the anti- Programmed cell death protein 1 (PD-1) antibod...
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We conducted a non-randomized, open-label, parallel-group study on patients with persistent postural-perceptual dizziness (PPPD) to compare cognitive-behavioral therapy ([CBT] group, n = 20) received a 6-session CBT program with pharmacotherapy ([PT] group, n = 22) received serotonin-related antidepressants. Outcomes were assessed using the Dizzine...
Article
As a substantial waiting time is usually required for radical surgery, safe and effective preoperative neoadjuvant chemotherapy (NAC) is desired for the treatment of locally advanced head and neck squamous cell carcinoma (HNSCC). However, the significance of NAC in advanced HNSCC is still unclear. This study aimed to assess the safety and efficacy...
Article
Eosinophilic chronic rhinosinusitis (ECRS) is a refractory form of sinusitis characterized by type 2 inflammation. Recently, biologics targeting type 2 inflammation have been developed, and dupilumab, an anti-IL-4/13 receptor antibody, is now indicated for management of chronic sinusitis with nasal polyps. Dupilumab exhibits profound efficacy and s...
Article
Objective To assess the location/number of otic capsule demineralization and hearing outcomes of stapes surgery (SS) for osteogenesis imperfecta (OI) compared with otosclerosis (OS). Patients This study included 11 and 181 consecutive ears from 6 and 152 patients with OI and OS, respectively. Interventions Demineralization loci observed as hypode...
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Introduction Immune-related adverse events (irAEs) due to immune checkpoint inhibitors may lead to discontinuation and treatment-related death. Acute aortitis is a rare but severe irAE. Case presentation A 67-year-old man with recurrent lower gingival carcinoma received nivolumab therapy. Twenty-three months later, he experienced chest compression...
Article
Re-entering the workforce by veteran physicians is expected to address the shortage and maldistribution of physicians. The Working Group on the Training and Utilization of Specialists in Otolaryngology and Head and Neck Surgery plans to establish a senior doctors bank through the Society. To obtain basic information on veteran physicians' intention...
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Purpose Removal of the current calcium alginate packing materials to the middle meatus in endoscopic sinus surgery (ESS) is usually accompanied by discomfort or pain owing to the hard and brittle nature of these materials. Plus moist HS-W® is a new calcium alginate packing material released in 2022 developed to overcome this issue by changing the u...
Article
The sarcopenia index (SI), calculated as [(serum creatinine/serum cystatin C) × 100], maybe a simpler alternative for measuring muscle mass than computed tomography (CT) and bioelectrical impedance analysis (BIA). We enrolled 112 patients with head and neck cancers (HNC). The correlation of the SI with muscle surface area measured by CT (CTMSA, n =...
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Introduction Immune‐related adverse events (irAEs) are prognostic factors for patients on nivolumab. However, predictors of irAEs have not yet been identified. We aimed to investigate the predictors of irAEs occurrence and nivolumab discontinuation due to irAEs. Methods Sixty‐two patients with recurrent/metastatic head and neck squamous cell carci...
Article
Posterior glottic stenosis (PGS) is caused by trauma or inflammation, such as occurs in endotracheal intubation. Although curable, PGS is often misdiagnosed as bilateral vocal fold paralysis and left without surgical interventions. In this report, we discuss two cases of PGS. Patient 1 is a 44-year-old woman who had an endoscopic finding of a bridg...
Article
The optimal chemotherapy regimen in concurrent chemoradiotherapy (CCRT) for cisplatin-ineligible head and neck squamous cell carcinoma (HNSCC) has not been established. We aimed to evaluate the feasibility, efficacy, and safety of CCRT with weekly low-dose carboplatin for the treatment of advanced HNSCC in patients who are cisplatin-ineligible. Thi...
Article
Objective Recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) treatment has changed dramatically with the introduction of immune checkpoint inhibitors (ICIs). However, there are few reports of treatment outcomes on HNSCC with distant metastasis (M1) at initial diagnosis, and its treatment strategy has not been standardized. We aimed...
Article
Nasal packing is commonly used to control bleeding and has the effect of a wet dressing following endoscopic sinus surgery (ESS). From the 2000's, calcium alginate dressings have been used to pack the middle meatus following ESS. Calcium alginate is a flocculent non-absorbable packing that shows a potent hemostatic effect, and acts as a wet dressin...
Preprint
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Background The optimal chemotherapy regimen in concurrent chemoradiotherapy (CCRT) for cisplatin-ineligible head and neck squamous cell carcinoma (HNSCC) has not been established. We aimed to evaluate the feasibility, efficacy, and safety of CCRT with weekly low-dose carboplatin for the treatment of advanced HNSCC in patients who are cisplatin-inel...
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Introduction Persistent postural-perceptual dizziness (PPPD) is a functional chronic vestibular syndrome with symptom exacerbation by upright posture, motion, and complex visual stimuli. Among these exacerbating factors, visual exacerbation is the most specific characteristic of PPPD requiring further investigation. We hypothesized that stimulus-in...
Article
Persistent Postural-Perceptual Dizziness (PPPD) is often secondary to vestibular disorders such as Benign Paroxysmal Positional Vertigo (BPPV) and Meniere's disease. However, PPPD secondary to vestibular disorders is often not correctly diagnosed. The Niigata PPPD Questionnaire (NPQ) was created for to screen for PPPD, but its usefulness for evalua...
Article
NRF2 is a transcription factor responsible for antioxidant stress responses that is usually regulated in a redox-dependent manner. p62 bodies formed by liquid-liquid phase separation contain Ser349-phosphorylated p62, which participates in the redox-independent activation of NRF2. However, the regulatory mechanism and physiological significance of...
Article
Background: During oral and head and neck surgery, oral vestibular incisions may require a transverse incision on the upper lip mucosa, resulting in possible sensory disturbances in the area innervated by infraorbital nerve (ION) branches. Although sensory disturbances are attributed to nerve injuries, anatomy textbooks have not showed the precise...
Article
Ectopic parathyroid lesions can be difficult to detect. In the present study, we used near-infrared autofluorescence imaging (NIFI) in three cases of ectopic parathyroid lesions. Our results suggest that NIFI may be a confirmation tool for parathyroid pathology and an intraoperative navigation tool in vivo and ex vivo. Laryngoscope, 2023.
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On-site monitoring of plasma drug concentrations is required for effective therapies. Recently developed handy biosensors are not yet popular owing to insufficient evaluation of accuracy on clinical samples and the necessity of complicated costly fabrication processes. Here, we approached these bottlenecks via a strategy involving engineeringly unm...
Article
We report two patients with Persistent Postural- Perceptual Dizziness (PPPD) who were successfully treated by Cognitive Behavioral Therapy (CBT) after initially showing limited responses to vestibular rehabilitation and pharmacotherapy. The vestibular symptoms and psychiatric status were evaluated by the Dizziness Handicap Inventory (DHI) and Hospi...
Article
Patients frequently use the internet to gain information and make decisions about their health condition. This study was aimed at investigating the characteristics of viewers and their viewing trends of the otolaryngology-head and neck surgery (ORLHN) channel on YouTube, which is a popular video-sharing platform. We established a YouTube channel an...
Article
In 1986, the Niigata Registration Committee of Head and Neck Malignant Tumors was established by head and neck surgeons to register new cases of head and neck malignancies in Niigata prefecture. Between 1986 and 2018, 12,443 cases, including 8,619 male (69.3%) and 3,824 female (30.7%) patients, were registered. Epidemiological changes in the regist...
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Background Head and neck mucosal melanoma (HNMM) is a rare and aggressive subtype of melanoma. HNMM often develops as a recurrent or metastatic disease, and its prognosis is worse than that of cutaneous melanoma. Recent large-scale clinical studies have reported favorable outcomes with immune checkpoint inhibitors (ICIs) for melanoma. However, thes...
Preprint
Full-text available
NRF2 is a transcription factor responsible for antioxidant stress responses that is usually regulated in a redox-dependent manner. p62 bodies formed by liquid-liquid phase separation contain Ser349-phosphorylated p62, which participates in the redox-independent activation of NRF2. However, the regulatory mechanism and physiological significance of...
Article
Full-text available
Objective The global standard for chemoradiation therapy (CCRT) for head and neck squamous cell carcinoma is cisplatin 100 mg/m ² administered once every three weeks, although cisplatin 80 mg/m ² is also widely used as an alternative treatment to reduce adverse events in Japan. We aimed to assess the long-term survival outcomes and late adverse eve...
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Objective Basal information of head and neck small-cell carcinoma (HNSmCC) including epidemiology, primary site, treatment, and prognosis remains sparse due to its rarity. We report here a multicenter retrospective study on the diagnosis, treatment, and outcomes of patients with HNSmCC. Materials and methods This study involved 47 patients with HN...
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Introduction Persistent postural-perceptual dizziness (PPPD) is a chronic vestibular syndrome lasting more than 3 months. The core vestibular symptoms are dizziness, unsteadiness, and non-spinning vertigo, which are exacerbated by upright posture or walking, active or passive motion, and exposure to moving or complex visual stimuli. Among these, vi...
Article
Perilymphatic fistula is a rare complication of traumatic tympanic membrane perforation. We reviewed the clinical presentation and prognosis of three cases of direct traumatic perilymphatic fistulas. Vestibular symptoms were seen in three patients: one patient had severe paralytic nystagmus, while two patients had only suspected nystagmus. Two pati...
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Posture and gait are maintained by sensory inputs from the vestibular, visual, and somatosensory systems and motor outputs. Upon vestibular damage, the visual and/or somatosensory systems functionally substitute by cortical mechanisms called “sensory reweighting”. We investigated the cerebrocortical mechanisms underlying sensory reweighting after u...
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Objective The management for malodour of malignant fungating wounds (MFWs) in head and neck cancer (HNC) is unestablished. We evaluated the effects of a novel odour transferrer on malodour generated by MFWs in patients with HNC. Methods A spray-type odour transferrer approved by the Japanese government for safe use in humans produces a good scent...
Article
Objective: To determine the locations and predictive factors of hypertrophic pachymeningitis (HP), a serious central complication of otitis media with antineutrophil cytoplasmic antigen-associated vasculitis (OMAAV). Study design: Retrospective study. Setting: University hospital. Patients: Thirty-six patients with OMAAV underwent contrast-e...
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Purpose Persistent hypoparathyroidism (hypoPT) is a major complication of total thyroidectomy. Nonetheless, previous reports may have underestimated the prevalence of hypoPT due to patient selection bias. We aimed to estimate the actual prevalence of persistent hypoPT after total thyroidectomy and to find predictive factors for postoperative hypoPT...
Article
Rarely, fungal rhinosinusitis is of the invasive type, with a poor prognosis. The invasive type can cause cranial nerve symptoms depending on the site of fungal infiltration. In this study, we investigated clinical features, diagnosis, treatment, and prognostic markers for infection control in four cases of invasive fungal rhinosinusitis. The patie...
Article
The cribriform variant of papillary thyroid carcinoma is a rare form accounting for less than 0.5% of all thyroid carcinomas. It is classified into the sporadic type and familial adenomatous polyposis (FAP)-associated type. Since the FAP-associated type manifests as synchronous or metachronous multiple tumors, total thyroidectomy is recommended eve...
Article
Background: Biomarkers predicting therapeutic response to immunotherapy have been widely explored via monitoring the liquid and tissue-derived components. Increasing treatment options for recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) mandates prediction of the therapeutic response of anti-PD-1 antibody alone as well as opti...
Article
Objective Diagnostic criteria for otogenic skull base osteomyelitis (SBO) have been conflicting among researchers. We aimed to propose clinically useful diagnostic criteria and a staging system for otogenic SBO that is associated with infection control and mortality. Design The present study is designed as a retrospective one. Setting This study wa...
Article
Histamine H1 receptors are involved in the development of the symptoms and signs of motion sickness and vertigo-induced vomiting. In the development of motion sickness and vertigo-induced vomiting, a neural mismatch signal encoding spatial disorientation activates the histaminergic neuron system in the hypothalamus, and the histaminergic descending...
Article
The neural mismatch hypothesis is widely accepted to explain the development of motion sickness. Essential to the neural mismatch hypothesis of motion sickness is the neural mismatch signal encoding spatial disorientation. We examined the neurochemical response to caloric stimulation with hot or cold water in the rat brain. Caloric stimulation with...
Preprint
Full-text available
Monitoring of plasma drug concentrations is required for effective and safe pharmacotherapies. Recent technical advances gave rise to various portable or wearable biosensors for rapid on-site monitoring. These devices are not yet popular owing to not only insufficient evaluation of accuracy on clinical samples and sensor-to-sensor variability but a...
Article
Full-text available
Despite the recent progression of treatments, the 5-year survival rate of patients with oral squamous cell carcinoma (OSCC) is still poor. One of the most critical factors affecting prognosis is tumor metastasis. Developing novel molecular targeted therapies by analyzing the molecular pathway of OSCC metastasis is an urgent issue. The present study...
Article
Paget's disease causes progressive sensorineural or mixed hearing loss. However, reports of cochlear implantation for hearing loss in patients with Paget's disease is rare. We encountered a case of Paget's disease of the bone with severe hearing loss in whom we performed cochlear implant surgery. The patient was a 66-year-old man who had suffered f...
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Background Early detection of head and neck carcinoma (HNC) as superficial HNC (SHNC) identified using recently developed optical techniques, such as magnifying endoscopy and narrow-band imaging (NBI), in combination with endoscopic surgeries enables minimally invasive treatment with favorable outcomes for HNC. This study aimed to identify the pred...
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Tinnitus therapies have been combined with the use of varieties of sound/noise. For masking external sounds, location of the masker in space is important; however, effects of the spatial location of the masker on tinnitus are less understood. We aimed to test whether a masking sound location would affect the perception level of simulated tinnitus....
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Objective: We aimed to compare the outcomes and safety of chemoradiotherapy (CRT) between elderly and non-elderly patients with head and neck squamous cell carcinoma (HNSCC). It is difficult to assess the causal effect of age because of possible differences in general conditions among individuals. Therefore, we adjusted the background factors of el...
Article
We report a suspected case of mucosal contact point headache, which was alleviated by the use of a topical decongestant. A 19-year-old woman visited our hospital with severe headache, nasal obstruction, and nasal discharge on the left side. CT showed no evidence of either intracranial illness or rhinosinusitis, and there were no neurological findin...
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Objective: To develop a diagnostic algorithm for chronic vestibular syndromes by determining significant items that differ among diagnoses. Methods: Two hundred thirty-one patients with chronic vestibular syndromes lasting for >3 months were included. Full vestibular tests and questionnaire surveys were performed: bithermal caloric test, cervical a...
Article
Introduction: Psychological disorders, such as depression, are markedly prevalent in patients with airway diseases. In this study, we assessed the effect of treatment with dupilumab, an IL-4 receptor α chain antibody, on depressive symptoms in a cohort of patients with asthma with eosinophilic chronic rhinosinusitis (ECRS). Methods: The study pa...
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Lemierre's syndrome is characterized by internal jugular vein thrombosis and systemic septic embolism; it is a fatal complication of upper respiratory tract infections. To date, it has not been demonstrated how the upper respiratory tract inflammation spreads from the primary infection site to internal jugular vein and systemic thrombosis. We repor...
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Objective: To examine the validity of head roll-tilt subjective visual vertical (HT-SVV) in diagnosing persistent postural-perceptual dizziness (PPPD). Study design: Retrospective review. Setting: Tertiary referral center. Patients: Sixty-one patients with PPPD, 10 with unilateral vestibular hypofunction (UVH), and 11 with psychogenic dizzin...
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Excitable cochlear hair cells convert the mechanical energy of sounds into the electrical signals necessary for neurotransmission. The key process is cellular depolarization via K⁺ entry from K⁺‐enriched endolymph through hair cells’ mechanosensitive channels. Positive 80 mV potential in endolymph accelerates the K⁺ entry, thereby sensitizing heari...
Article
Vestibular diseases are sometimes associated with comorbid psychiatric conditions, such as anxiety and depression. These conditions often exacerbate the bodily symptoms of vestibular patients, e.g., dizziness and vertigo. In such cases, treatment not only for the organic vestibular diseases, but also for the comorbid psychiatric conditions is impor...
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We examined the role of lateral temporal bone resection (LTBR) in the treatment of external ear canal (EAC) carcinoma between 2007 and 2018. The estimated 3-year disease-free survival (DFS) and disease-specific survival (DSS) according to the tumor stage and treatments were investigated in 36 patients with EAC squamous cell carcinoma. T stage class...
Article
The diagnostic criteria for Persistent Postural-Perceptual Dizziness (PPPD) was defined by the Committee for the Classification of Vestibular Disorders of the Barany Society, and published in the Journal of Vestibular Research in 2017. PPPD is characterized by chronic vestibular syndrome persisting for >3 months, that is typically preceded by acute...
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PurposeSarcopenia, defined as a decrease in the skeletal muscle mass and its function, is associated with a poor clinical outcome in several malignancies. We aimed to examine whether sarcopenia can be a predictor of incompletion of concurrent chemoradiotherapy (CCRT) and survival for head and neck cancer (HNC) patients.Methods Forty-one male HNC pa...
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Hearing loss affects >5% of the global population and therefore, has a great social and clinical impact. Sensorineural hearing loss, which can be caused by different factors, such as acoustic trauma, aging, and administration of certain classes of drugs, stems primarily from a dysfunction of the cochlea in the inner ear. Few therapeutic strategies...
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Full-text available
Purpose To determine patients with abnormal sensation in the throat (AST) who would respond to potassium-competitive acid blocker (P-CAB) or serotonin noradrenaline reuptake inhibitor (SNRI) treatment. Methods AST patients were randomly divided into two groups. Thirty-one and 21 patients received P-CAB and SNRI treatment, respectively. GETS-J, the...