Aras Emre Canda

KRC Private Clinic for Colorectal Surgery and Peritoneal Carcinomatosis · Surgery

Deterioration of anorectal function after long-course preoperative chemoradiotherapy combined with surgery for rectal cancer is poorly defined. We conducted a prospective study to evaluate the acute and long term effects of preoperative chemoradiotherapy on anorectal function and quality of life of the patients. There were 26 patients in surgery gr...

Transanal single-port access microsurgery (TSPAM) is an emerging and feasible minimally invasive method for the transanal excision of large sessile adenomas and early-stage carcinomas of the rectum. Here we present our TSPAM experience on rectal adenomas (high-grade rectal adenomas in 5 cases and carcinoma in situ in 1 case). TSPAM is an innovative...

Introduction: The purpose of our study was to evaluate the perioperative complications, toxicity, mortality rates after cytoreductive surgery (CRS), and effects of hyperthermic intraperitoneal chemotherapy (HIPEC) used in the treatment of peritoneal surface malignancies. Methods: Between September 2007 and March 2012, we performed 118 CRS and HI...

Purpose: Parastomal hernia is a frequent complication of an abdominal wall stoma. Surgical repairs have high complication and recurrence rates. Several different techniques have been suggested to prevent parastomal hernia during stoma creation. The aim of the present case-control study was to evaluate the efficacy of modified Stapled Mesh stomA Re...

Background: Diagnosis of peritoneal carcinomatosis (PC) may be missed by preoperative imaging. We are presenting our experience with incidentally detected PC of colorectal origin treated with cytoreductive surgery (CRS) and intraperitoneal chemotherapy (IPC) at the same operation. Methods: Between January 2010 and September 2016, 19 patients und...

Aim Our study aimed to establish a mouse model with colorectal cancer-induced peritoneal metastasis(PM) and to compare the efficacy of hyperthermic intraperitoneal chemotherapeutic agents, mitomycin C and oxaliplatin. Materials and Methods The peritoneal metastasis model was established in nude mice using the CC531 colon carcinoma cell line. Model...

Background Sacral neuromodulation (SNM) has emerged as an effective treatment option for patients with fecal incontinence. The efficacy of SNM in the treatment of low anterior resection syndrome (LARS) following rectal cancer surgery is encouraging. The aim of this study is to review the long-term outcomes of patients treated with SNM for LARS. Me...

PURPOSE This paper aims to investigate the diagnostic performance of magnetic resonance imaging (MRI) in predicting the pathologic stage of locally advanced rectal cancer (LARC) after neoadjuvant chemoradiotherapy (CRT) and the role of MRI in selecting patients with a pathologic complete response (ypCR). METHODS Restaging MRI (yMRI) examinations of...

Purpose: We aimed to determine the long-term oncologic outcome for patients with rectal cancer treated with preoperative Chemoradiotherapy (CRT) followed by total mesorectal excision (TME). In addition, we attempted to identify prognostic factors and the oncologic significance of a pathological complete response (pCR) on the patient's oncologic out...

Metastatic spread of prostate cancer to the peritoneum is rare but may be either due to an iatrogenic cause or a sign of a more aggressive disease. We present a patient with peritoneal carcinomatosis who survived prostate and colon cancer. A 72-year-old male presented with abdominal pain, weight loss, and abdominal distension. He was treated surgic...

Metastatic spread of prostate cancer to the peritoneum is rare but may be either due to an iatrogenic cause or a sign of a more aggressive disease. We present a patient with peritoneal carcinomatosis who survived prostate and colon cancer. A 72-year-old male presented with abdominal pain, weight loss, and abdominal distension. He was treated surgic...

Background: Investigation for research on the cellular biology and physiology of colon cancer tissues requires viable dissociation of single cells. The amount of tissue and dissociation methods can affect the amount of single cell viability. Inadequate initial tissue has negative effects on data quality by resulting in insufficient quality and the...

Purpose Preparing a patient cognitively, psychosocially and emotionally for an operation is important for the healing process. The purpose of this study is to investigate the psycholinguistic and psychometric properties of the Turkish version of The Preparedness for Colorectal Cancer Surgery Questionnaire (PCSQ-TR). Design Methodological study. M...

Z Giriş: Peritoneal karsinomatozis (PK) hastalarında sitoredüktif cerrah için optimal hasta seçimi ve cerrahinin planlanması açısından preoperative evreleme çok önemlidir. Bu çalışmanın amacı preoperatif BT ile intraoperatif bulguları karşılaştırmak ve iki radyolog arasındaki korelasyonu ve uyumu araştırmaktır. Gereç ve Yöntem: İki radyolog 48 PK h...

Purpose To evaluate the trophic changes in rectus abdominis and psoas muscles in patients who underwent open or laparoscopic rectum resection for rectal cancer. Methods We retrospectively analyzed preoperative staging computerized tomographies (CT) and postoperative first oncological follow-up CTs of the patients who underwent low anterior resecti...

Background The aim of this study was to evaluate the prognostic value of preoperative sarcopenia with regard to postoperative morbidity and long-term survival in patients with peritoneal metastasis from colorectal cancer treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC).MethodsA longitudinal cohort study...

Objective: Recently, the development of technologies to culture intestinal epithelial cells in vitro as different forms of intestinal organoids causes drawing attention in this area. The isolation and culture of colorectal crypts were first demonstrated in the very recent decade with the identification of stem cell marker Lgr5. The growth of crypts...

Aim: To compare the pathologic complete response (pCR) rate at 8 compared to 12 weeks interval between completion of neoadjuvant chemoradiotherapy (CRT) and surgery in patients with locally advanced rectal cancer. Method: This was a randomized trial which included a total of 330 patients from two institutions. Patients with locally advanced (T3-...

Background/aims: Patients with colorectal cancer continue to present with relatively advanced tumors that are associated with poor oncological outcomes. The aim of the present study was to assess the association between localization, symptom duration, and tumor stage. Materials and methods: A prospective, multicenter cohort study was conducted o...

Purpose: Colon mucinous carcinomas (MUCs) have two morphological patterns: (i) glands lined by mucinous epithelium with direct contact to the stroma (FIX) and (ii) carcinoma cells floating in mucin (FLO). In this study, we evaluated the prognostic value of these patterns. Methods: Digital images were captured from the 38 MUC's tissue sections. A...

Purpose: The purpose of this study was to assess the feasibility and safety of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in elderly patients with peritoneal carcinomatosis of colorectal cancer. Methods: Patients who underwent curative complete CRS and HIPEC for peritoneal carcinomatosis of colorectal cance...

Background: Individuals who have undergone stoma surgery take time to adjust to the stoma, and their quality of life is decreasing. Objective: The aim of this study was to examine the effects of home-based nursing interventions informed by the Health Belief Model on patient care outcomes for individuals having a stoma. Methods: This pretest, p...

Background: The aim of this study was to investigate the effect of irrigating the surgical site with 0.05% chlorhexidine gluconate (CHG) on surgical site infection (SSI) in temporary loop ileostomy closure. Methods: In this observational cohort, patients who underwent diverting loop ileostomy and elective ileostomy closure for any reason between...

Background: Primary closure of the fistula tract using energy emitted by a radial fiber connected to a diode laser is a novel procedure for treating perianal fistulas. Objective: The aim of this study was to determine the long-term effectiveness of this new technique. Design: The surgical objective was to seal the fistula tract using laser ene...

Locally advanced right colon cancer may invade adjacent tissue and organs. Direct invasion of the duodenum and pancreas necessitates an en bloc resection. Previously, this challenging procedure was associated with high morbidity and mortality; however, today, this procedure can be done more safely in experienced centers. The aim of this study is to...

Background: The aim of this study was to review the post-operative and infectious complications and determine the risk factors associated with infections in cytoreductive surgery (CRS) and hyperthermic intra-peritoneal chemotherapy (HIPEC). Patients and methods: Between October 2007 and December 2013, patients who underwent CRS and HIPEC with a...

Fekal inkontinans barsak içeriğinin anal kanaldan çıkışının kontrol edilememesi olarak ta-nımlanmaktadır. Özellikle ileri yaş grubunda sıklığı %55'e kadar ulaşabilmektedir. En sık nedeni obstetrik travmalar ve perianal girişimler olarak görülmekle birlikte doğumsal, nörojenik ve intestinal hastalıklar da fekal inkontinansa yol açabilmektedir. Bu de...

Introduction . We discuss a rare gastrointestinal stromal tumor (GIST) case detected at the 10th postpartum week and we want to pay attention to the challenges and improvements in the diagnosis, surgery, chemotherapy, and follow-up of this rare tumor accompanied with the review of the current literature. Case Presentation . A 32-year-old multiparou...

Purpose: We aimed to evaluate preoperative T and N staging and retroperitoneal surgical margin (RSM) involvement in colon cancer using multidetector computed tomography (MDCT). Methods: In this retrospective study, preoperative MDCTs of 141 patients with colon adenocarcinoma were evaluated in terms of T and N staging and retroperitoneal surgical...

In this paper we present our initial natural orifice transluminal endoscopic surgery (NOTES) experience by video of a transvaginal appendectomy. Our experience demonstrated that pure NOTES appendectomy by transvaginal access is a safe and well tolerated procedure which can be performed also in emergency conditions.

Xanthogranulomatous inflammation (XGI) is a rare chronic inflammatory condition most commonly involving the kidneys and gallbladder. The condition is histopathologically characterized by the presence of foamy histiocytes, lymphocytes, and plasma cells. A few reports describing appendicitis caused by XGI have appeared in the English-language literat...

The peritoneal stromal tissue which provides a rich source of growth factors and chemokines is a favorable environment for tumor proliferation. The pathophysiological mechanism of peritoneal carcinomatosis is an individual sequence consisting of genetic and environmental factors and remains controversial. The natural history of the disease reveals...

Abstract Abdominal wall hernias are a common problem in the general population. A Western estimate reveals that the lifetime risk of developing a hernia is about 2%. (1 - 3) As a result, hernia repairs likely comprise the most frequent general surgery operations. More than 20 million hernias are estimated to be repaired every year around the world....

The association between systemic inflammatory response and tumor biology has been well documented over the last decade. The aim of this study is to investigate the prognostic role of neutrophilto- lymphocyte ratio (NLR) in gastrointestinal stromal tumors (GISTs). A prospectively recorded database of 67 patients who underwent surgical resection for...

Background: Colorectal cancer has a heterogeneous nature that is influenced by the tumour site. Many improvements have been made in identifying and characterizing the genetic alterations between colon and rectal cancers. However, there is not enough information about KRAS mutational differences between rectosigmoid and colon cancers arising elsewh...

AIM: The study aimed to investigate the prognostic impact of the log odds of positive lymph nodes (LODDS) in colon cancer. METHOD: Four hundred forty colon cancer patients were divided into three each groups according to the lymph node ratio (LNR) and LODDS. Survival analysis was performed. RESULTS: The five-year overall survival (OS) rate...

A small-bowel enteroatmospheric fistula (EAF) is an especially challenging complication for patients with open abdomens (OAs) and their surgeons. Manipulation of the bowel during treatment (e.g. dressing changes) is one of the risk factors for developing these openings between the atmosphere and the gastrointestinal tract. Unlike enterocutaneous fi...

The prognostic value of KRAS and BRAF mutation in colorectal cancer (CRC) is very consistent. Several studies have demonstrated an association between these gene mutations and resistance to anti-EGFR based therapies. Wild type KRAS and BRAF is required for a response to CRC therapy. The aim of this study is to identify the frequency of KRAS and BRA...

Abstract Background: Neoadjuvant radiotherapy in rectal cancer could interfere with anastomotic healing. We investigated the effects of preoperative oral administration of Benefiber on the healing irradiated colonic anastomosis. Methods: Forty male Wistar rats were divided into four groups. Group I (control group), Group II (Benefiber® pretreatment...

Objective: Colorectal mucinous carcinomas (MC) have a poor prognosis. The relationship of the cells to the stroma and extracellular mucin [percentage of tumour cells contacting surrounding stroma (PTCCSS)] was identified as a prognostic marker for salivary gland carcinomas. We evaluated the prognostic value of this feature in colorectal MC. Method:...

Antikanser Ajanların Farmakogenomik özellikleri: Anti-EGRF tedavisi verilecek kolorektal kanserli hastaların seçilmesinde prediktif biyomarkerlar

Carcinogenesis may involve overproduction of oxygen-derived species including free radicals, which are capable of damaging DNA and other biomolecules in vivo. Increased DNA damage contributes to genetic instability and promote the development of malignancy. We hypothesized that the repair of oxidatively induced DNA base damage may be modulated in c...

Molecular pathways that play a role in the development of colorectal cancer involve multiple genetic changes in cancer-related genes that may be caused by overproduction of reactive oxygen species (ROS) including free radicals. Various types of ROS are capable of damaging DNA and other biomolecules. Increased formation of ROS can contribute to gene...

Introduction. Carcinoid tumors are low-grade tumors originating from endoderm and mostly involving the gastrointestinal system. However; they may be seen in any site within the gastrointestinal system. Case Presentation. A 69-year-old female patient. The results of blood tests were observed to be consistent with obstructive jaundice. A mass appeara...

Cutaneous metastases from well-differentiated thyroid carcinomas are rare and usually identified in patients with widely disseminated disease. Fine-needle aspiration biopsy (FNAB) has become an acceptable method for the assessment of thyroid nodules. Very rarely needle track dissemination of tumor cells in the thyroid nodule occurs, but, when this...

A 64-year-old man with a locally advanced rectum adenocarcinoma was referred for 18-fluoro-2-deoxyglucose (F-18 FDG) imaging for the purpose of restaging and tumor response. Circumferentially increased perirectal F-18 FDG uptake was seen. Three days after the first F-18 FDG positron emission tomography clinically Fournier gangrene was diagnosed and...

Ectopic thyroid gland with no orthotopic thyroid tissue is extremely rare. The authors present a case of a follicular variant of papillary carcinoma developed from an ectopic thyroid gland with no orthotopic thyroid tissue.

Solitary fibrous tumor is an uncommon neoplasm. We present a case of solitary fibrous tumor of the perithyroidal soft tissue mimicking a substernal goiter.

Short bowel syndrome (SBS) is characterized by the malabsorption of nutrients and fluids that occurs after major intestinal resection, resulting from an adaptation process that begins immediately to increase the mucosal surface area and absorption. Certain nutrients and trophic factors are widely used to increase intestinal adaptation following mas...

Aim: We planned a trial to establish the realities on the suggestion which included the idea that there is loss of interest to General Surgery residency or it is not among the top choices. Material and Method: We performed a questionairre on 202 residents who studied general surgery residency in 9 state universities in Ankara, Istanbul, Izmir and B...

Laparoscopic splenectomy (LS) is becoming the "gold standard" technique for splenectomy. The aim of this study was to evaluate the hospital experience, body image, and cosmesis after LS or open splenectomy (OS). Patients who underwent LS or OS were invited to fill out questionnaires evaluating their hospital experience, body image, and cosmetic res...

The aim of this study was to evaluate the role of matrix metalloproteinases (MMPs), their tissue inhibitors [tissue inhibitors of metalloproteinases (TIMPs)] and activators [membrane-type MMPs (MT1-MMPs)], vascular endothelial growth factor (VEGF) and endostatin on clinicopathological variables and prognosis in patients with rectal cancer. Paired s...

Minimally invasive techniques, such as laparoscopic appendectomy (LA), are thought to produce better cosmetic results. The aim of this study was to evaluate the body image and cosmesis of patients after both LA and open appendectomy (OA). Between August 2007 and June 2008, patients who underwent LA or OA with the diagnosis of acute appendicitis wer...

In this paper, we describe our experience in the successful use of vacuum-assisted closure (VAC) and porcine dermal collagen (PDC) mesh reconstruction of a complicated contaminated abdominal wall defect resulting from a strangulated incisional hernia with late jejunal perforation in a 57-year-old obese and diabetic woman.

Echinococcus infestation is endemic in certain parts of the world. Extrahepatic dissemination of the disease is rare. Successful management of these patients and possible routes for abdominopelvic dissemination of the disease are discussed.

Today laparoscopic splenectomy (LS) is considered the gold standard for the treatment of hematologic disorders of the spleen with the aid of advancements in laparoscopy technique and modern electrosurgical devices. LigaSure vessel sealing system permanently fuses vessels up to 7 mm in diameter by applying a precise amount of pressure and bipolar en...

Lymph node (LN) metastasis of gastrointestinal stromal tumors (GIST) is unusual. Unlike gastric adenocarcinomas, routine lymphadenectomy is not recommended unless there is no suspicion for LN metastasis. Herein, we report a case of GIST of the stomach with LN metastasis treated with distal gastrectomy with perigastric LN dissection followed by adju...

We aimed to evaluate the efficacy of treatment with partially hydrolyzed guar gum (PHGG) using a rat model of ileal pouch-anal anastomosis and pouchitis. In the J pouch groups, tissue myeloperoxidase activities were significantly higher than native myeloperoxidase activities (P = 0.020; P = 0.015; P = 0.004, respectively). A statistically significa...