Ap Sugunan

Ap Sugunan
Indian Council of Medical Research | ICMR · Department of Epidemiology and Biostatistics

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120
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Publications

Publications (120)
Article
Temperature tolerance is an important factor limiting the distribution of arthropod vectors, with limited information on the ability of mosquitoes to evolve different temperature levels. Under laboratorial conditions effect of thermal stress in late third instar larvae of Aedes aegypti determined by subjecting them to temperature regimes such as 37...
Article
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We conducted a serosurvey of 155 healthcare workers and 124 household and community members who had close contact with 18 patients who had laboratory-confirmed Nipah virus infections in Kerala, India. We detected 3 sub-clinical infections; 2 persons had IgM and IgG and 1 only IgM against Nipah virus.
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Aedes albopictus (Skuse 1894) is prevalent in the urban/peri-urban Port Blair, posing a public health threat, during past outbreaks of chikungunya (2006) and dengue (2010). Despite its vector potential, information on the biology is scanty. Therefore, impact of temperature on survival of immature stages, under laboratory conditions, was studied on...
Article
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Seroprevalence of leptospirosis among a healthy population of the South Andaman Island was assessed through random sampling. Previous studies have high seroprevalences of up to 55% in general population and 65% in agricultural labourers. The study subjects (1,181 in total, 781 rural and 400 urban) were interviewed and tested for antibodies against...
Article
Onges, an indigenous vulnerable tribe, inhabit the Little Andaman Island. Study undertaken during 1997, recorded high prevalence of undernutrition among children. Subsequently, food rationing was modified by Andaman and Nicobar administration. In the present study, health and nutritional status of this tribe was assessed in 2013 after a gap of 15 y...
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The study was undertaken in South Andaman district, comprising three tehsils, viz. Port Blair, Ferrargunj and Little Andaman Tehsils, respectively. Intensive pupal infestation surveys were carried out along the National Highway (NH 223), the main passenger and trade route, referred to as Great Andaman Trunk Road. Sampling locations at every 3 km we...
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Objective: There is scarcity of information on the prevalence of female genital tuberculosis (FGTB) in the community. The present study was carried out to estimate the prevalence of FGTB, its risk factors and associated clinical features. Study design: Community-based cross-sectional survey. Methods: This study was carried during October 2011...
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The transmission cycle of leptospirosis can involve a broad range of mammalian species present in a particular geographical region. However, the factors that plays behind the emergence and resurgence of the disease after a time lag has remained matter of research. In prevailing background seropositivity to 11 Leptospira serogroups in cattle and goa...
Article
Background: Harmful use of alcohol is one of the globally recognized causes of health hazards. There are no data on alcohol consumption from Andaman and Nicobar Islands. Objective: The objective of the study was to assess the prevalence and pattern of alcohol use among the population of Andaman and Nicobar Islands, India. Methods: A representa...
Article
Acute childhood diarrhoea remains one of the leading causes of childhood morbidity and mortality in developing countries. The present study was conducted to estimate the prevalence of various intestinal parasitic infestation among children aged 5 years and less suffering from acute diarrhoea disease attending hospitals in Andaman Islands. During th...
Article
Corresponding author. Regional Medical Research Centre (ICMR), Post Bag: 13, Dollygunj, Port Blair - 744101, Andaman & Nicobar Islands, India. Tel.: +91 3192 251158, +91 3192 251164; fax: +91 3192 251163.
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Several researchers had carried out investigations on the possibility of existence of Weil's disease in Andaman Islands during early 20 th century. The first report of a series of confirmed cases of leptospirosis that occurred during1929 was published in 1931.There were several reports during 1995 to 2009 that described detailed account of leptospi...
Article
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Andaman and Nicobar Islands of India, home to six primitive tribes, constituting about 10 per cent of the total population of these Islands have been detected with high endemicity of hepatitis B infection. During 2000, a total of 936 individuals ≤ 45 yr, negative for hepatitis B surface antigen (HBsAg) and antibody anti-HBs were vaccinated with thr...
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Objective To identify the possible association of killer cell immunoglobulin like receptors (KIRs) gene polymorphisms in patients with dengue virus infection. Methods Seventeen known KIRs were determined in 30 dengue patients and 40 healthy individuals by the sequence specific primer polymerase chain reaction method. Associations with specific KIR...
Article
Drug resistance surveys have not yet conducted in these Islands and as such no data exists on drug resistance currently. the present study was initiated with the objective of isolation and assessment of Drug resistance patterns of Mycobacterium tuberculosis isolates from sputum specimens collected from different categories of Tribal, Non-Tribal pul...
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A disease outbreak of A (H1N1) PDM09 was reported in Andaman and Nicobar islands in 2009 with an attack rate of 33.5% among settler population and 26.3% among the aboriginal Nicobarese tribe. During the ongoing outbreak of A (H1N1) PDM09 disease in different parts of the world, a subject working in Dubai city of Saudi Arabia, came to Port Blair, fo...
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The long-lasting persistence of hepatitis B virus (HBV) genomes in the liver (with or without detectable HBV DNA) of individuals with negative for HBV surface antigen (HBsAg) is termed occult HBV infection (OBI). The present study is a part of the follow up on efficacy of vaccination, 10 years post inception, and was designed to understand the prev...
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SUMMARY This study is a part of the surveillance study on childhood diarrhoea in the Andaman and Nicobar Islands; here we report the drug resistance pattern of recent isolates of Shigella spp. (2006-2011) obtained as part of that study and compare it with that of Shigella isolates obtained earlier during 2000-2005. During 2006-2011, stool samples f...
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Introduction: Carbapenems have long been the dependable last line of treatment for multidrugresistant Gram-negative bacteria. Case presentation: We report here two cases of enterotoxigenic Escherichia coli harbouring the New Delhi metallo-b-lactamase-1 (NDM-1) in childhood diarrhoea. Two paediatric patients aged 1.5 and 5 years were admitted to hos...
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Background & objectives: A total of 237 Nicobarese subjects who had received hepatitis B vaccination as part of mass vaccination project during 2000-2001 were screened for anti-HBsAg titres by quantitative ELISA five years after vaccination. Methods: Anti-HBsAg antibody was estimated using quantitative ELISA. Proportion of the subjects with protec...
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This study aims to determine the clinical features and seasonal patterns associated with shigellosis, the antimicrobial resistance frequencies of the isolates obtained during the period 2006-2012 for 22 antibiotics, and the molecular characterization of multidrug-resistant strains isolated from endemic cases of shigellosis in the remote islands of...
Article
Abstract The present study was undertaken to understand the distribution and the antimicrobial susceptibility patterns of the uropathogens in the remote islands of India. Patients' demographical data, urine culture results, and resistance rates were analyzed and multidrug resistant isolates were characterized. Significant bacteriuria was found in 1...
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Data on prevalence, pattern of tobacco use, proportion of population dependent on nicotine and their determinants are important for developing and implementing tobacco control strategies. The aim of the study was to estimate the prevalence and determinants of tobacco use and nicotine dependency. A cross-sectional survey among a representative sampl...
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Enteric fever, due to infection with Salmonella enterica serotype Typhi and Paratyphi A, is estimated to cause more than 27 million infections each year worldwide with 216,000 deaths 1,2 . Almost 80 per cent of cases and deaths occur in Asia. Annual incidence as high as 1,100 cases per 100,000 population has been documented in developing countries...
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Shigellosis is known to be a major cause of acute childhood diarrhoea in Andaman & Nicobar Islands, India. Rapid emergence of antibiotic resistance warrants continuous monitoring of sensitivity pattern of bacterial isolates. We report here the salient findings of an ongoing study on shigellosis in Andaman Islands, India, with regards to change in d...
Conference Paper
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Background / Purpose: This study was initiated to assess the proportion of childhood diarrhoeas attributable to Shigellosis, the drug resistance pattern in Shigellae, and the prevalence of various determinants of virulence and drug resistance among Shigellae. Main conclusion: The study showed that a substantial proportion of childhood diarrhoe...
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Chikungunya virus (CHIKV) has caused large outbreaks worldwide in recent years. Acute-phase CHIKV infection has been reported to cause mild to severe febrile illness, and in some patients, this may be followed by long-lasting polyarthritis. The mainstay of treatment includes nonsteroidal anti-inflammatory drugs and other disease-modifying agents, t...
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This study was carried out to find the prevalence of various plasmid-mediated quinolone-resistant (PMQR) determinants among the quinolone-resistant clinical isolates of Shigella sp. from paediatric patients in Andaman & Nicobar Islands. A total of 106 quinolone-resistant Shigella isolates obtained from paediatric patients during hospital-based surv...
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There are no composite estimates on prevalence of hypertension among indigenous tribes in India. The present study was carried out to estimate the prevalence of hypertension, its association with determinants, and to assess the hypertension related behaviour of the Nicobarese aborigines. This cross-sectional survey was carried during 2007 and 2009....
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Shigellosis is a major cause of diarrheal diseases among children in Andaman & Nicobar Islands, India, which have a population of 350,000 people, including settlers from mainland India and 6 indigenous tribes. From the last one-and-half decade, we have been monitoring the species distribution and emergence of antibiotic resistance among the isolate...
Article
Port Blair, the capital city of the Union Territory of Andaman and Nicobar Islands in the republic of India, witnessed an outbreak of chikungunya (CHIK) fever in 2006. Although no deaths attributable to CHIK fever were registered, thousands of people were affected. In view of evidence from other parts of the world indicating that CHIK fever does ca...
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The outbreak of chikungunya fever that surfaced in India during late 2005 has affected more than 1.56 million people, spread to more than 17 states/union territories, and is still ongoing. Many of these areas are dengue- and leptospirosis-endemic settings. We carried out a cross-sectional survey in one such chikungunya-affected location in Dakshina...
Article
The Andaman & Nicobar Islands, situated in the Bay of Bengal, is an Union Territory of India. Health care in these islands (population of about 3 50 000) is almost entirely provided by the Government. G.B. Pant Hospital, located at Port Blair, is the only referral hospital in the islands. Bacteriological surveillance carried out by the RMRC, Port B...
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This longitudinal follow-up study of 203 patients with serologically confirmed chikungunya (CHIK) virus infection describes the clinical features of CHIK fever during the first and tenth months of illness. During the acute stage CHIK fever presents with a wide array of symptoms. The foremost chronic symptoms at the end of a month were rheumatism (7...
Article
The genus Leptospira comprises pathogenic and saprophytic strains. Conventional methods for the identification of pathogenic leptospiral isolates are cumbersome and laborious. In view of these limitations, the search for alternative methods have been focused on DNA based techniques. In this study, we have developed an effective method for the rapid...
Article
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Leptospirosis outbreaks occur frequently in North and South Andaman Islands but not in Middle Andaman. In 2002, an outbreak appeared in Middle Andaman for the first time. Although a study on risk factors was conducted in North Andaman, it used seropositivity to define leptospirosis. Since seropositivity might not indicate current leptospiral infect...