Anwar Zeb

University of Malakand · Department of Pharmacy

Based on the ethnomedicinal use of Isodon rugosus the current study was designed to evaluate its crude saponins (Ir.Sp), and subsequent fractions for anti-angiogenic and anti-tumor potentials. Chorioallantoic membrane (CAM) assay was used in anti-angiogenic potentials with Dexamethasone as positive control. The antitumor activity was evaluated with...

Objective: To investigate saponins and various solvent extracts from Atriplex laciniata (A. laciniata) against human parasites and various pests. Methods: The samples from A. laciniata used in the activities were crude saponins (Al.SpF) and solvent samples including methanolic extract (Al.MeF), ethyl acetate (Al.EaF), choloroform (Al.CfF), n-hex...

Abstract Background Since long, natural sources have been explored for possible managements of various diseases. In this context, the study is designed to evaluate Isodon rugosus Wall. ex Benth for biological potentials including antibacterial, anthelmintic, insecticidal, anti-termites and anti-Pharaoh activities followed by GC-MS analysis of activ...

Background Herbal medicines have long been used for various ailments in various societies and natural bioactive compounds are gaining more and more importance due to various factors. In this context, three plant species i.e., Eryngium caeruleum, Notholirion thomsonianum and Allium consanguineum have been aimed for the scientific verification of the...

Background The emergence of multidrug resistant (MDR) pathogens is of great concern to the global health community. Our ability to effectively treat diseases is based on the discovery of potent drugs for the treatment of these challenging diseases. Traditional medicines are one of the major sources for the discovery of safe, effective and economica...

Background The importance of Rumex genus and the renowned ethnopharmacological and biological potentials of Rumex hastatus is evident from the previous reports. Recently the R. hastatus has been evaluated for anticancer potential against HepG2, MCF7 or LNCaP cell lines with considerable cytotoxicity. We also reported the anti-tumor and anti-angioge...

Isodon rugosus Wall. ex Benth. is extensively used as traditional medicine for the management of various types of pain including tooth ache, gastric pain, abdominal pain, ear ache and generalized body pain. The current study is designed to scientifically verify the purported uses of I. rugosus as analgesic agent and to figure out its possible mecha...

Background: Cancer, being the foremost challenge of the modern era and the focus of world-class investigators, gargantuan research is in progress worldwide to explore novel therapeutic for its management. The exploitation of natural sources has been proven to be an excellent approach to treat or minify the excessive angiogenesis and proliferation...

Background Ethnomedicinally Rumex hastatus D. Don has been used since long for various ailments especially in neurological disorders. The reported data and the importance of Rumex genus demonstrate the vital medicinal value of R. hastatus. Methods In the current investigational study, isolation of essential oil and its antioxidant and anticholines...

In the present study the crude saponins, crude methanolic extract and subsequent fractions of Rumex hastatus have been evaluated for the cytotoxic potential against brine shrimps and phytotoxic potential against radish. In addition, the antibacterial activity has been evaluated for crude flavonoids (Rh.Fl), saponins (Rh.Sp), crude methanolic extrac...

This study was designed to investigate antioxidant and anticholinesterase potential of Iris germanica var; florentina. Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory potential of plant samples were investigated by Ellman's assay. Antioxidant activity was performed using DPPH, H2O2 and ABTS free radical scavenging assays. To...

Due to the biodegradable and non-hazardous nature of majority of natural bioactive compounds, the current study was designed to evaluate crude saponins (Rh.Sp), crude methanolic extract (Rh.Cr) and the resultant fractions (n-hexane (Rh.Hex), chloroform (Rh. Chf), ethyl acetate (Rh.EtAc), aqueous (Rh.Aq)) of Rumex hastatus for insecticidal activity...

Background: Atriplex laciniata L. was investigated for phenolic, flavonoid contents, antioxidant, anticholinesterase activities, in an attempt to explore its effectiveness in Alzheimer's and other neurological disorders. Plant crude methanolic extract (Al.MeF), subsequent fractions; n-hexane (Al.HxF), chloroform (Al.CfF), ethyl acetate (Al.EaF), a...

This Provisional PDF corresponds to the article as it appeared upon acceptance. Fully formatted PDF and full text (HTML) versions will be made available soon. Anticholinesterse and antioxidant investigations of crude extracts, subsequent fractions, saponins and flavonoids of atriplex laciniata L.: potential effectiveness in Alzheimer's and other ne...

Background Based on the ethnomedicinal uses and the effective outcomes of natural products in various diseases, this study was designed to evaluate Isodon rugosus as possible remedy in oxidative stress, alzheimer's and other neurodegenerative diseases. Acetylecholinestrase (AChE) and butyrylcholinesterase (BChE) inhibitory activities of crude metha...

Nonea micrantha Boiss. & Reut. (N. micrantha) crude methanolic extract (CME), subsequent fractions and crude saponins (CSP) were investigated for antibacterial, antifungal, anthelmintic potentials and total phenolic contents. Chloroform fraction (CHF) exhibited the highest antibacterial activity against Pseudomonas aeruginosa (P. aeruginosa), Salmo...

Nonea micrantha Boiss. & Reut. (N. micrantha) crude methanolic extract (CME), subsequent fractions and crude saponins (CSP) were investigated for antibacterial, antifungal, anthelmintic potentials and total phenolic contents. Chloroform fraction (CHF) exhibited the highest antibacterial activity against Pseudomonas aeruginosa (P. aeruginosa), Salmo...

Background Isodon rugosus is used traditionally in the management of hypertension, rheumatism, tooth-ache and pyrexia. Present study was arranged to investigate I. rugosus for phytoconstituents, phytotoxic and cytotoxic activities to explore its toxicological, pharmacological potentials and to rationalize its ethnomedicinal uses. Briefly, qualitati...