Anwar-ul Hassan Gilani

Anwar-ul Hassan Gilani
Higher Education Commission of Pakistan | HEC

PhD
Member, Executive Council, Pakistan Academy of Sciences and Honorary Advisor, Higher Education Commission

About

505
Publications
243,535
Reads
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20,881
Citations
Introduction
Prof. Gilani is a distinguished Pharmacologist who made break through discoveries in natural medicine and occupied multiple leadership positions. He has over 25,000 citation with h-index of 84 (google scholar). He is co-editor of two WHO books on Essential Medicine and recipient of Distinguished National Professorship and Life-Time Academic Achievement Award in addition to 3 civil awards including Hilal-i-Imtiaz. He is member of 10 int journals including Phytotherapy Research.
Additional affiliations
March 2022 - March 2022
The University of Haripur
Position
  • Vice Chancellor
Description
  • CEO of University of Haripur and Pattern in Chief of Public Health & Nutrition Department of this University
January 2015 - present
Pakistan Council for Science and Technology
Position
  • CEO
Description
  • Policy making and advisory role to the Government of Pakistan on Science and Technology
January 2013 - December 2014
Mekelle University
Position
  • Tandem Dean
Description
  • was on sabbatical leave from Aga Khan University Karachi
Education
April 1981 - April 1985
The University of Sydney
Field of study
  • Pharmacology
January 1976 - July 1978
University of Agriculture Faisalabad
Field of study
  • Physiology and Pharmacology
September 1972 - December 1975
University of Agriculture Faisalabad
Field of study
  • Animal Sciences, Agriculture and Nutrition

Publications

Publications (505)
Article
Full-text available
Alzheimer's disease (AD) is the most common form of dementia. There is limited choice in modern therapeutics, and drugs available have limited success with multiple side effects in addition to high cost. Hence, newer and alternate treatment options are being explored for effective and safer therapeutic targets to address AD. Turmeric possesses mult...
Article
Full-text available
The use of plants, plant extracts or plant-derived pure chemicals to treat disease is a therapeutic modality, which has stood the test of time. Indeed today many pharmacological classes of drugs include a natural product prototype. Aspirin, atropine, ephedrine, digoxin, morphine, quinine, reserpine and tubocurarine are a few examples of drugs, whic...
Article
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Moringa oleifera Lam (Moringaceae) is a highly valued plant, distributed in many countries of the tropics and subtropics. It has an impressive range of medicinal uses with high nutritional value. Different parts of this plant contain a profile of important minerals, and are a good source of protein, vitamins, beta-carotene, amino acids and various...
Article
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Alzheimer's disease (AD) is the common type of dementia and is currently incurable. Existing FDA-approved AD drugs may not be effective for everyone, they cannot cure the disease nor stop its progression and their effects diminish over time. Therefore, the present review aimed to explore the role of natural alternatives in the treatment of AD. A sy...
Article
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Acetylcholinesterase (AChE) inhibitors and calcium channel blockers are considered effective therapies for Alzheimer’s disease. AChE plays an essential role in the nervous system by catalyzing the hydrolysis of the neurotransmitter acetylcholine. In this study, the inhibition of the enzyme AChE by Sarcorucinine-D, a pregnane type steroidal alkaloid...
Article
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Results: When tested on the baseline of isolated tissues, Tfg.Cr was devoid of any activity (stimulant or relaxant) till 10 mg/ml. This is an interesting finding, keeping in mind that the fenugreek seeds are used to alleviate constipation and diarrhoea. When Tfg.Cr was tried for any potential AChE inhibitory activity, it did show an inhibitory eff...
Article
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Background: Metabolic syndrome (MetS) is a multifactorial disease, whose main stay of prevention and management is life-style modification which is difficult to attain. Combination of herbs have proven more efficacious in multi-targeted diseases, as compared to individual herbs owing to the “effect enhancing and side-effect neutralizing” properties...
Article
Linum usitatissimum (Flaxseed) is known to be traditionally used for managing hypertension. In this study, we aim to provide a mechanistic basis for the medicinal use of Flaxseed in hypertension. The high-performance liquid chromatography (HPLC) analysis that we carried out during our study showed the presence of polar compounds (quercetin, nicotin...
Article
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Background: Grewia asiatica Linn, or phalsa, is a commonly consumed fruit in Pakistan. The fruit is employed in the traditional medicine practice of Pakistan as a smooth muscle relaxant in different gastrointestinal (GI) and cardiovascular diseases. In this investigation, we show the antispasmodic and vasorelaxant actions of Grewia asiatica fruit...
Article
Objective: To compare the effect of Pakistani and American almonds on serum concentration of liver enzymes in coronary artery disease patients. Methods: The randomised controlled trial was conducted at the Cardiology Clinics of Aga Khan University Hospital, Karachi, from February to July, 2012, and comprised patients who were randomised into int...
Article
Full-text available
Polyherbal formulation (POL-4) is popularly used by traditional practitioners to treat diabetes in district Badin, Sindh, Pakistan. This study validates the folk claim of POL-4 in diabetes and associated dysfunctions (hyperlipidaemia, endothelial dysfunction, hypertension) using OGTT and alloxan-challenged diabetic assays. Administration of POL-4 e...
Article
Nuts hold prime significance throughout the world as they offer multiple health benefits owing to their highly nutritious profile. A number of scientific studies have demonstrated their actions against inflammation, oxidative damage, the aging process, as well as dementia or memory loss. However, only walnuts, followed by almonds, hazelnuts and pis...
Article
Full-text available
Materials and methods: Aqueous-methanolic crude extracts of Flaxseed (Fs.Cr) and Flaxseed oil were tested against 6% acetic acid- (AA-) induced colitis in BALB/c mice. Microscopic damage parameters of the hematoxylin and eosin-stained and periodic acid-Schiff-alcian blue-stained sections of the colon were scored to be assessed. Possible antispasmo...
Article
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Background: Euphorbia hirta (Linn) family Euphorbiaceae has been used in indigenous system of medicine for the treatment of gastrointestinal disorders. This study was designed to determine the pharmacological basis for the medicinal use of E. hirta in diarrhea and constipation. Methods: The aqueous-methanol extract of whole herb of E. hirta (EH....
Article
This study elicits the underlying mechanism(s) of Capparis decidua when used for different gut disorders. HPLC chromatogram of C. decidua extract (CD.Cr) and its respective fractions showed a variety of phytochemicals of which, kaempferol being in a high proportion. In mice, CD.Cr at doses of 70 and 150 mg/kg enhanced the wet feces output to 33 and...
Article
Full-text available
Alcea rosea L. also known as Althea rosea belongs to the Malvaceae family. This medicinal herb, traditionally used to treat several conditions including airway disorders like asthma and chronic bronchitis. This study evaluated the bronchodilatory effects and possible mechanism of A. rosea on guinea-pig tracheal tissues. Moreover lipophilic profilin...
Article
Hippophae rhamnoides (Family; Elaeagnaceae) fruit extract was investigated for prokinetic and gut excitatory effects to rationalize its therapeutic utility in gastrointestinal complaints like delayed gastric emptying and constipation. The fruit extract of Hippophae rhamnoides (Hr.Cr) prepared in hydro-methanol (30:70) was verified for flavonoids, t...
Chapter
Full-text available
National policy on essential medicines is one of the main pillars of global health agenda. The Nairobi Conference on the Rational Use of Drugs, held in 1985, was the first international conference on policies on essential medicines. Over the years, World Health Organization has widely supported most low- and middle-income countries (LMICs) in the d...
Article
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Objective: FTY720, an immunomodulator derived from sphingosine-1-phosphate, has recently demonstrated its immunomodulatory, anti-inflammatory, anti-oxidant, anti-apoptotic and anti-inflammatory properties. Furthermore, FTY720 might be a key pharmacological target for preconditioning. In this preclinical model, we have investigated the effects of FT...
Article
The genus Mentha comprises several aromatic species, which are cultivated world‐over due to their distinct aroma and commercial value. In addition to traditional food flavoring uses, Mentha are well recognized for their folk medicinal uses, especially to treat cold, fever, and digestive and cardiovascular disorders. A number of biological activitie...
Article
Madam, prevalence of male infertility with its associated social and health problems calls for an insight for its elucidation.1 Over the past few decades, there have been many experimental and clinical studies on the pathophysiology of oxidative stress and its impact on fertility disorders, both in men and women. Oxidative stress impairs sperm func...
Article
This study explores the pharmacological basis for the folk use of Fagonia indica in constipation using in vivo and in vitro assays. The crude extract of F. indica contained tannins, saponins, anthraquinones, alkaloids, flavonoids, glyco-sides and phenols. The administration of F. indica extract (100 and 300 mg/kg) to mice caused a partially atropin...
Article
Full-text available
Purpose: To determine the mechanism of vasorelaxant effect of 1-trifluoromethoxyphenyl – 3-(1-propionylpiperidin–4-yl) urea (TPPU) in cardiovascular diseases, including hypertension. Methods: Isolated rat thoracic aortic tissue preparations were mounted in an organ bath set up integrated with isometric transducer and a Power Lab assembly. TPPU (0.3...
Article
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Background and Objective: Several species of Conyza bonariensis (C. bonariensis) and related species are used traditionally in the management of pain and inflammatory conditions. The current study was aimed to evaluate the analgesic and anti-inflammatory activities of C. bonariensis in animal models of pain and inflammation. Methodology: For the an...
Article
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Introduction: Diabetes mellitus is amongst the top five risk factors for cardiovascular deaths all over the world and is a major public concern. In 2010, 285 million people in the world have diabetes mellitus, and the incidence of this disease will increase to 7.7% by 2030. This study planned to evaluate the usefulness of an indigenous poly herbal...
Article
Achyranthes aspera L. is traditionally used to relieve constipation, diarrhea, and asthma. Its crude extract (Aa.Cr) was evaluated through in vivo and ex vivo experiments to rationalize these medicinal uses of A. aspera and to provide their scientific basis. Aa.Cr, at 3 and 10 mg/kg, increased fecal output, similar to castor oil, whereas at 30, 100...
Article
Background: Metal-based antimicrobial agents have recently been identified as an alternate therapy for the treatment of infectious diseases. This investigation relates to one-pot solvent-free preparation of some new transition metal complexes of omeprazole (OMP), followed by their characterization and in vitro applications as anti-Helicobacter pylo...
Article
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BackgroundA compound herbal formulation (POL4) has been used in the indigenous system of medicine to treat cardiometabolic disorders like diabetes and associated hypertension. POL4 and most of its constituents have not been studied widely for its therapeutic use in hypertension. This study is aimed to determine the efficacy and possible insight int...
Article
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Background The present research was carried out to investigate pharmacological properties of Buxus papillosa C.K. Schneid. (Buxaceae). Methods Buxus papillosa extracts of leaves (BpL), stem (BpS), roots (BpR) and BpL fractions: hexane (BpL-H), aqueous (BpL-A) also plant constituent, cyclomicrobuxine effect were studied in jejunum, atria, aorta and...
Article
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Fever or Pyrexia means abnormal rise in body temperature above the usual range of normal in response to a variety of infectious, immunological and neoplastic stimuli. To normalize these febrile conditions, several synthetic agents are in clinical practice such as acetaminophen, ibuprofen, and aspirin. However, they are having many side effects whic...
Chapter
Full-text available
Alzheimer's disease (AD) is the most common form of dementia, and it has only a limited treatment choice in modern therapeutics. Hence, newer and alternate treatment options with high efficacy and good safety profiles are being explored. Turmeric possesses multiple medicinal uses in a variety of diseases, including AD. Curcuminoids, a mixture of cu...
Article
Full-text available
Objective: The objective of study was to assess the variation of volatiles and biological activities (antioxidant, antimicrobial, cytotoxic and thrombolytic) of essential oils from aerial parts of Mentha longifolia harvested from five regions of Saudi Arabia such as Al-Kharj, Al-Qassim, Dammam, Abha and Al-Madinah. Methodology: Within the regions,...
Chapter
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Nutmeg (Myristica fragrans Houtt.), belonging to the family Myristicaceae, is a spice seed from the fruit of a tropical evergreen tree. It is a well-known aromatic perennial plant with a characteristic scent that possesses multiple medicinal applications, being used to treat stomach ulcers, indigestion, liver disorders, and as emmenagogue, nervine,...
Article
Full-text available
This study was aimed to investigate the effect of the extract of Mentha longifolia on blood pressure and the possible mechanisms. In anesthetized rats, the crude extract of M. longifolia and aqueous and chloroform fractions caused a dosedependent fall in mean arterial pressure. Atropine pretreatment abolished the effect of extract and aqueous fract...
Poster
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Looking at phytochemicals and antioxidant activities of medicinal plants
Poster
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Hepatic and vacualr protection in high-fat diet rat model and in-vitro antioxidatice activity and phenolic composition of Viola odorata and Wrightia tinctoria
Poster
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Looking at phytochemicals and antioxidant activities of medicinal plants
Article
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Background: Dengue, a vector borne disease has become a crucial health concern globally. The search for a suitable dengue vaccine has been going on for the last few decades due to unavailability of any effective treatment. An efficient medication strategy is required to overcome the devastating effects of dengue. Now, computational biology has emer...
Article
Morus nigra Linn. (black mulberry) is used in gastrointestinal ailments. This study demonstrates gut modulatory properties of M. nigra. The prokinetic, laxative, and antidiarrheal activities of M. nigra were assessed in mice, while isolated rabbit jejunum and guinea-pig ileum were used to explore insight into mechanism(s). At 30 and 70 mg/kg, the c...
Article
Full-text available
Nepeta suavis is used in traditional medicine for treatment of abdominal spasm (colic). The tricyclic clerodane type diterpene, nepetolide, isolated for the first time from Nepeta suavis. was evaluated for Ca⁺⁺ antagonist and antispasmodic activities. When studied in isolated rabbit jejunum, nepetolide caused concentration-dependent (0.03–100 μM) r...
Article
Nepeta suavis is used in traditional medicine for treatment of abdominal spasm (colic). The tricyclic clerodane type diterpene, nepetolide, isolated for the first time from Nepeta suavis, was evaluated for Ca++ antagonist and antispasmodic activities. When studied in isolated rabbit jejunum, nepetolide caused concentration-dependent (0.03-100 μM) r...
Article
The crude ethanolic extract of Chrozophora prostrata (Cp.Cr) was tested using in vivo and ex vivo assays for its possible bronchodilatory effects in order to validate its medicinal use in respiratory disorders, like asthma and cough. Cp.Cr exhibited dose-dependent inhibition of carbachol (CCh)-induced bronchospasm in anesthetized rats, similar to a...
Article
Full-text available
Caper (Capparis spinosaL.), a drought tolerant plant belonging to genus Capparis of the family Capparidaceae is mainly distributed in arid and semi-arid regions of the tropical and subtropical world. The plant, as a potential source of valuable nutrients such as vitamins (especially vitamin C), digestible protein, reducing sugars and essential mine...
Article
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Background Buddleja crispa Benth (Buddlejaceae) is a dense shrub; several species of genus Buddleja have been used in the management of various health conditions including pain and inflammation. The present study was aimed to investigate the analgesic, anti-inflammatory and anti-platelet properties of B. crispa. Methods Male rats (220–270 gm,) and...
Article
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Background: Obesity is a global epidemic, which is a risk factor for cardiovascular diseases and metabolic abnormalities. It is measured by body mass index (BMI), waist circumference (WC), waist-hip ratio (WHR), body fat (BF) distribution and abdominal fat mass, each having its own merits and limitations. Variability in body composition between et...
Article
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Objective Elevated serum uric acid (UA), a biomarker of renal insufficiency, is also an independent prognostic marker for morbidity in coronary artery disease (CAD) and poses serious health risks. This study reports the effect of almond consumption on UA in CAD patients. Study designA randomized controlled clinical trial was conducted with three gr...
Article
Full-text available
This study was aimed to rationalize medicinal use of M. nagi in gut, airways and cardiovascular disorders. The crude extract of M. nagi bark (Mn.Cr), its aqueous (Mn.Aq) and ethyl acetate (Mn.EtAc) fractions were prepared. Antidiarrheal activity of M. nagi was carried out in mice, while its gut modulatory, bronchodilatory and vasodilatory activitie...
Article
Full-text available
Several Buddleja species were the target of phytochemical and biological studies; however, nothing was reported concerning the chemistry of Buddleja polystachya Fresen. growing in Saudi Arabia. Sixteen constituents were isolated from the aerial parts of B. polystachya using various chromatographic techniques and were identified by the help of diffe...
Article
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More than one-half of coronary artery disease (CAD) patients have low HDL cholesterol despite having well-managed LDL cholesterol. Almond supplementation has not been shown to elevate circulating HDL cholesterol concentrations in clinical trials, perhaps because the baseline HDL cholesterol of trial subjects was not low. This clinical trial was des...