Anuraj Nayarisseri

Anuraj Nayarisseri
EMINENT BIOSCIENCES · Department of Bioinformatics

PhD.
Healthcare Data Analysis, Machine Learning, Artificial Intelligence, Clinical Bioinformatics, Drug Discovery

About

175
Publications
90,436
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Introduction
Principal Scientist and Director of Eminent Biosciences Indore, Madhya Pradesh, India. , Leads a team of 28 researchers including Bioinformaticians, Biotechnologists, Microbiologists, Biostatistician etc. Specialize in Clinical Bioinformatics, Clinical research data analysis, Epidemiological Data Analysis, Next Generation Sequencing Data analysis, Machine Learning, Deep Learning, Artificial Neural Network , RT-PCR, Q-PCR Data analysis, Structural and Computational Biology and Drug Discovery
Additional affiliations
November 2008 - present
Eminent Biosciences, Indore
Position
  • Bioinformatics Scientist
Description
  • - Functional Genomics, Transcriptome Analysis, Next Generation Sequencing Data Analysis. - Application of R, Bioconductor for Microarray Data, Chip-Chip Data and NGS data analysis.
November 2008 - present
EMINENT BIOSCIENCES
Position
  • Principal Investigator
Description
  • Specialize in Clinical Bioinformatics, Next Generation Sequencing Data Analysis, Transcriptome analysis.
November 2008 - April 2019
EMINENT BIOSCIENCES
Position
  • Managing Director

Publications

Publications (175)
Chapter
Disordered proteins serve a crucial part in many biological processes that go beyond the capabilities of ordered proteins. A large number of virus-encoded proteins have extremely condensed proteomes and genomes, which results in highly disordered proteins. The presence of these IDPs allows them to rapidly adapt to changes in their biological enviro...
Article
Full-text available
Colorectal cancer is the third most frequent cause of cancer worldwide and is more prevalent in older individuals of all ages. The recent statistics from World Health Organisation (WHO) on cancer accounted for 1.93 million new cases of colorectal cancer alone, in 2020[1]. The exact cause of this disease is still unknown; however, obesity, sedentary...
Article
Full-text available
The antipsychotic drug Olanzapine was crystallized with aromatic acid, 2,5-dihydroxybenzoic acid in isopropyl alcohol by slow evaporation which led to the formation of olanzapinium 2,5-dihydroxybenzoate crystalline salt. The structure of the compound was characterized by 1H-NMR, 13C-NMR, and single-crystal X-ray diffraction analysis. The Hirshfeld...
Preprint
Glioblastoma (GBM) is a WHO Grade IV tumor with poor visibility, a high risk of comorbidity, and limited treatment options. Resurfacing from second-rate glioma was originally classified as either mandatory or optional. Recent interest in personalized medicine has motivated research toward biomarker stratification-based individualized illness therap...
Preprint
Full-text available
Glioblastoma (GBM) is a WHO Grade IV tumor with poor visibility, a high risk of comorbidity, and limited treatment options. Resurfacing from second-rate glioma was originally classi ed as either mandatory or optional. Recent interest in personalized medicine has motivated research toward biomarker strati cation-based individualized illness therapy....
Preprint
Glioblastoma (GBM) is a WHO Grade IV tumor with poor visibility, a high risk of comorbidity, and limited treatment options. Resurfacing from second-rate glioma was originally classified as either mandatory or optional. Recent interest in personalized medicine has motivated research toward biomarker stratification-based individualized illness therap...
Article
Full-text available
Vascular endothelial growth factor (VEGF) and its receptor play an important role both in physiologic and pathologic angio-genesis, which is identified in ovarian cancer progression and metastasis development. The aim of the present investigation is to identify a potential vascular endothelial growth factor inhibitor which is playing a crucial role...
Preprint
Full-text available
Estrogen receptor alpha (ERα), a nuclear receptor proteinencoded by the estrogen receptor1 (ESR1) gene,is an important biomarker in breast cancer diagnosis. Any dysregulation in its expression can actively implicate the development and progression of the disease. ERα is abnormally expressed in around 60% of the active cases, making it animportant t...
Preprint
Estrogen receptor alpha (ERα), a nuclear receptor protein encoded by the estrogen receptor1 (ESR1) gene, is an important biomarker in breast cancer diagnosis. Any dysregulation in its expression can actively implicate the development and progression of the disease. ERα is abnormally expressed in around 60% of the active cases, making it an importan...
Preprint
Full-text available
VEGF and its receptor play an important role both in physiologic and pathologic angiogenesis, which is identi ed in ovarian cancer progression and metastasis development. The aim of the present investigation is to identify a potential VEGF inhibitor which is playing a crucial role in stimulating the immunosuppressive microenvironment in tumour cell...
Preprint
Full-text available
The bio-surfactants produced by microorganisms have high demand from microbial-enhanced oil recovery (MEOR) and they have focused on a chemical surfactant for the past few decades for degrading petro-based pollutants and oil spills due to its non-toxicity and increasing bioavailability. These microorganisms can survive over the different oil specie...
Preprint
The biosurfactants produced by microorganisms have high demand from microbial-enhanced oil recovery (MEOR) and they have focused on a chemical surfactant for the past few decades for degrading petro-based pollutants and oil spills due to its non-toxicity and increasing bioavailability. The study aims to identify and screen potential lipopeptide bio...
Preprint
The biosurfactants produced by microorganisms have high demand from microbial-enhanced oil recovery (MEOR) and they have focused on a chemical surfactant for the past few decades for degrading petro-based pollutants and oil spills due to its non-toxicity and increasing bioavailability. The study aims to identify and screen potential lipopeptide bio...
Preprint
Full-text available
VEGF and its receptor play an important role both in physiologic and pathologic angiogenesis, which is identified in ovarian cancer progression and metastasis development. The aim of the present investigation is to identify a potential VEGF inhibitor which is playing a crucial role in stimulating the immunosuppressive microenvironment in tumour cel...
Article
Full-text available
Mantle cell lymphoma (MCL) is a type of non-Hodgkin lymphoma characterized by the mutation and overexpression of the cyclin D1 protein by the reciprocal chromosomal translocation t(11;14)(q13:q32).The Present study aims to identify a potential inhibition of MMP9, Proteasome, BTK, and TAK1 and also determine the most suitable and effective protein t...
Article
Full-text available
Background Mantle cell lymphoma (MCL) is a type of non-Hodgkin lymphoma characterized by the mutation and overexpression of the cyclin D1 protein by the reciprocal chromosomal translocation t(11;14)(q13:q32). Aim The Present study aims to identify a potential inhibition of MMP9, Proteasome, BTK, and TAK1 and also determine the most suitable and ef...
Article
Full-text available
Artificial Intelligence revolutionizes the drug development process that can quickly identify potential biologically active compounds from millions of candidate within a short span of time. The present review is an overview based on some applications of Machine Learning based tools such as GOLD, DeepPVP, LIBSVM, etc and the algorithms involved such...
Conference Paper
Full-text available
Traditional agriculture research programs have used classical breeding and molecular biology approaches for crop improvement. Besides, they are proved inadequate to deal collectively with a major number of problems. High throughput sequencing has shown a way towards overcoming those barriers along with storing and evaluating various big scale datas...
Preprint
Full-text available
We announce the complete genome sequence of Bacillus tequilensis , a biosurfactant producing bacterium isolated from Chilika lake, Odisha, India(latitude and longitude: 19.8450 N 85.4788 E). The genome sequence is 4.47 MB consisting of 4,478,749 base pairs forming a circular chromosome with 528 scaffolds, 4492 protein-encoding genes(ORFs), 81 tRNA...
Preprint
Background: Bioremediation is crucial for recuperate polluted water and soil. By expanding the surface area of substrates, biosurfactants play a vital role in bioremediation. Bioremediation is crucial for recuperate polluted water and soil. By expanding the surface area of substrates, biosurfactants play a vital role in bioremediation. Biosurfactan...
Article
Full-text available
Multidrug resistance in microbes poses a major health crisis and demands for the discovery of novel antimicrobial agents. The recent pandemic of SARS-CoV-2 has raised a public health emergency in almost all the countries of the world. Unlike viruses, a bacterium plays a significant role in various environmental issues such as bioremediation. Furthe...
Article
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Liver cancers are one of the leading fatal diseases among malignant neoplasms. Current chemotherapeutic treatments used to fight these illnesses have become less efficient in terms of both efficacy and safety. Therefore, there is a great need of search for new anti-liver cancer agents and this can be accelerated by using computer-aided drug discove...
Article
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Background The vast geographical expansion of novel coronavirus and an increasing number of COVID-19 affected cases has overwhelmed health and public health services. AI and ML algorithms have extended its major role in tracking the disease patterns, and in identifying possible treatment of disease. Objective To identify potential COVID-19 proteas...
Research
Full-text available
Background: The vast geographical expansion of novel coronavirus and an increasing number of COVID-19 affected cases has overwhelmed health and public health services. AI and ML algorithms have extended its major role in tracking the disease patterns, and in identifying possible treatment of disease. Objective: To identify potential COVID-19 prote...
Article
Full-text available
Drug discovery is one of the most complicated processes and establishment of a single drug may require multidisciplinary attempts to design efficient and commercially viable drugs. The main purpose of drug design is to identify a chemical compound or inhibitor that can bind to an active site of a specific cavity on a target protein. The traditional...
Article
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Background Bioremediation has taken its call for removing pollutants for years. The oil-contaminated surroundings are majorly hazardous for sustaining life but there has been a great contribution of nature in the form of microorganisms. The complex carbon-hydrogen chain has served as classic raw material to chemical industries, which has perked up...
Article
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Background Bluetongue disease currently noticeable to the World Organization for Animal Health (OIE); causes enormous economic losses due to rapid deteriorate trade associated with bluetongue outbreaks and high mortality and morbidity.The capsid coat protein of Bluetongue virus(BTV)VP2 is responsible for BTV transmission by the Culicoides vector to...
Article
Full-text available
BACKGROUND The Non-Small Cell Lung Cancer (NSCLC) alone is responsible for the sovereignty of demises worldwide related to the other cancers.ROS1 is a receptor tyrosine kinase (RTK), eminently recognized as the stereotyped oncogenic driver. These RTKs trigger an array of physiological regulations via cellular signal transduction pathways which are...
Conference Paper
Full-text available
Polycystic Ovary Syndrome (PCOS) is extremely prevalent and diverse. It is the most commonly encountered heterogeneous endocrine disorder in premenopausal (reproductive age) women worldwide. Studies shows that it affects 5-10% of this population. It is a characteristic syndrome of ovarian dysfunction associated with hyperandrogenism, chronic anovul...
Article
Full-text available
Aims The In silico approach provides a platform for determination and establishing a potential inhibitor against GD2 in Pediatric neuroblastoma. Background Originating from the abnormal growth of neuroblasts, pediatric neuroblastoma affects the age group below 15 years. It is an aggressive heterogenous cancer with a high morbidity rate. Biological...
Conference Paper
Full-text available
Cancer stands as major cause of mortality in the world, and it's the morbidity has significantly increased in both developing and developed nations. In spite of the recent advancement in cancer therapies, the clinical follow-up still lags far behind.Recent studies show that, stem cells are bestowed with distinctive functions, like tumor cells reloc...
Conference Paper
Full-text available
Cancer forms second-most cause of death in the USA next to cardio vascular diseases, contributing to significant economic and social burden. WHO reports suggest that, almost 18 millions cancer cases and 60 lakhs deaths from cancer is expected in the US in 2019 alone. The most common types such as lung, breast, prostate, and colorectal cancer are mo...
Article
Full-text available
Vascular endothelial growth factor (VEGF) expression could be found in all glioblastomas. VEGF takes part in numerous changes including the endothelial cell proliferation, the vasculature of solid tumor: its survival invasion, and migration, chemotaxis of bone marrow-derived progenitor cells, vasodilation and vascular permeability. VEGF inhibition...
Article
Full-text available
Background: Multicentric Castleman Disease (MCD) is a confrontational lymphoproliferative disorder described by symptoms such as lymph node proliferation, unwarranted secretion of inflammatory cytokines, hyperactive immune system, and in severe cases, multiple organs dysfunction. Interleukin-6 (IL-6) is a pleiotropic cytokine which is involved in...
Article
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Acute myeloid leukemia (AML) is symbolized by an increase in the number of myeloid cells in the bone marrow and an arrest in their maturation, frequently resulting in hematopoietic insufficiency (granulocytopenia, thrombocytopenia, or anemia) with or without leukocytosis either by a predominance of immature forms or a loss of normal hematopoiesis....
Article
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Background: Alzheimers Disease (AD) is a neurodegenerative disease which is characterized by the deposition of amyloid plaques in the brain- a concept supported by most of the researchers worldwide. The main component of the plaques being amyloid-beta (Aβ42) results from the sequential cleavage of Amyloid precursor protein (APP) by beta and gamma...
Conference Paper
Full-text available
Background Tay Sachs is a very rare neurodegenerative disorder and the second most common lipid storage disorder. The testimony of TSD in infants is marked by the gradual loss in vision, hearing impairment, increased muscle stiffness and cherry red retinal spot. These symptoms progress to paralysis, dementia, seizures, neuro-regression leading to...
Article
Full-text available
BACKGROUND Lung cancer is the most common among all the cancer worldwide with 1.8 million people diagnosed every year, leading to 1.6 million death each year according to American cancer society. Involvement of mutated Anaplasic Lymphoma Kinase (ALK)positive fusion protein in progression of NSCLC has made itself a propitious target to inhibit and t...
Conference Paper
Full-text available
Hemophilia can be defined as a genetic disorder in which the body loses its capability to clot blood, and hence can’t stop blood flow. It is an X- linked recessive disease, hence mostly seen in males, with its severity significantly reduced in females. In India, hemophilia has an occurrence of 1 per 10,000 births, which generally progresses to a ch...
Article
Full-text available
Neurodegenerative diseases (NDs) constitute a large group of pathological conditions, characterized by a progressive loss of neuronal cells, which compromise motor and/or cognitive functions. The most common NDs are Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), Parkinson’s disease (PD), and Huntington’s disease (HD). The causes of...
Article
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Breast cancer is the most frequent malignancy among women. It is a heterogeneous disease with different subtypes defined by its hormone receptor. A hormone receptor is mainly concerned with the progression of the PI3K/AKT/ mTOR pathway which is often dysregulated in breast cancer. This is a major signaling pathway that controls the activities such...
Article
Full-text available
Juvenile idiopathic arthritis (JIA) is a heterogeneous disease characterized by the arthritis of unknown origin and IL6 is a known target for JIA. 20 known inhibitors towards IL-6 were screened and Methotrexate (MTX) having PubChem ID: 126941 showed high binding capacity with the receptor IL-6. The similarity searching with this compound gave 269 v...
Article
Full-text available
Acute Myeloid Leukaemia (AML) is a blood cancer, which affects the red blood cells in the bone marrow. Of the possible proteins that are affected in AML, fms-like tyrosine kinase 3 (FLT3) has long been recognized as a potential therapeutic target as it affects the other signaling pathways and leads to a cascade of events. First-generation inhibitor...
Article
Full-text available
Multiple cytokines play a pivotal role in the pathogenesis of Rheumatoid Arthritis by inducing intracellular signaling and it is known that the members of the Janus kinase (JAK) family are essential for such signal transduction. Janus kinase 3 is a tyrosine kinase that belongs to the Janus family of kinases. Drugs targeting JAK 3 is known as an eff...
Article
Full-text available
The progression of lung cancer is associated with inactivation of Programmed cell death protein 1, abbreviated as PD-1 which regulates the suppression of the body’s immune system by suppressing T- cell inflammatory activity and is responsible for preventing cancer cell growth. It is of interest to identify inhibitors for PD-L1 dimeric structure thr...
Research
Full-text available
Juvenile idiopathic arthritis (JIA) is a heterogeneous disease characterized by the arthritis of unknown origin and IL6 is a known target for JIA. 20 known inhibitors towards IL-6 were screened and Methotrexate (MTX) having PubChem ID: 126941 showed high binding capacity with the receptor IL-6. The similarity searching with this compound gave 269 v...
Article
Full-text available
Neurodegenerative diseases, such as Parkinson’s and Alzheimer’s, are understood as occurring through genetic, cellular, and multifactor pathophysiological mechanisms. Several natural products such as flavonoids have been reported in the literature for having the capacity to cross the blood-brain barrier and slow the progression of such diseases. Th...
Article
Full-text available
Neurodegenerative diseases, such as Parkinson's and Alzheimer's, are understood as occurring through genetic, cellular, and multifactor pathophysiological mechanisms. Several natural products such as flavonoids have been reported in the literature for having the capacity to cross the blood-brain barrier and slow the progression of such diseases. Th...
Article
Full-text available
Neurodegenerative diseases, such as Parkinson's and Alzheimer's, are understood as occurring through genetic, cellular, and multifactor pathophysiological mechanisms. Several natural products such as flavonoids have been reported in the literature for having the capacity to cross the blood-brain barrier and slow the progression of such diseases. Th...
Article
Full-text available
Background: Chronic lymphocytic leukemia (CLL) is a B-lineage lymphoid malignancy of self-reactive cells that are focused to produce polyreactive natural autoantibodies. Its surface protein marker CD20 plays an important role in the humoral immune response targeting which has emerged as an attractive therapeutic option for the treatment of CLL. Th...
Article
Full-text available
Background: Plant protease Inhibitors (PIs) play key roles in regulation of many biological activities and being less toxic, more potent and specific in comparision to chemical inhibitors. Methods: A new proteinaceous trypsin inhibitor was isolated and purified from Macrotyloma uniflorum seeds with a molecular mass of 25 KDa was purified to homo...
Article
Full-text available
Introduction: Renal Cell Carcinoma is a common type of renal cancer-causing deaths worldwide which is characterized by sustained angiogenesis. VEGF and its receptors play a major role in physiologic and pathologic angiogenesis, which is marked in tumour progression and metastasis development. Induction of VEGF genes occur due to hypoxic condition...