Anuraj Nayarisseri

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Verified

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• PhD.
• Principal Scientist at EMINENT BIOSCIENCES

Petroleum is a vital and strategic energy resource for boosting a country’s GDP. Despite its high economic value, it is considered a primary factor in environmental deterioration. Bioremediation strategies employ indigenous microbial strains to propose an economical and sustainable alternative to conventional remediation practices. The current stud...

Azo dyes are highly recalcitrant, persistent, and toxic compounds, extensively used in the textile industry. The untreated discharge of dye effluents from the textile industry poses severe environmental and health risks. This research aimed to isolate and identify bacterial strains from textile wastewater that can decolorize azo dyes. After the sub...

Introduction Biosurfactants are the surface-active reagents produced by microorgan-isms, which exhibit the non-toxic and augmented bioavailability potential for the decomposition of petro-based pollutants and performing microbial-enhanced oil recovery (MEOR). Methods Thus, the present study entails the isolation of a novel biosurfactant-producing...

Background/Objectives: Leishmaniasis is one of the 20 Neglected Tropical Diseases according to the WHO, affecting approximately 12 million people in four continents, generating serious public health problems. The lack of therapeutic options, associated with toxicity and the emergence of resistance to the few available drugs, makes it urgent to deve...

The transition in clinical laboratory genomics from analog methods to modern digital technologies is ushering in a new era of big data that is not only faster and more reliable for human use but also amenable to analysis through both traditional and advanced computational techniques. This shift necessitates the use of deep learning (DL)—a cutting-e...

Phthalic acid esters are pivotal plasticizers in various applications, including cosmetics, packaging materials, and medical devices. They have garnered significant attention from the scientific community due to their persistence in ecosystems. The multifaceted aspects of PAEs, encompassing leaching, transformation, and toxicity, underscore their p...

Soil microorganisms have the potential to significantly increase soil fertility since they function as natural regulators and catalysts in the soil, transforming nutrients into easily absorbed inorganic forms. Microorganisms are an essential and fundamental part of living soil, contributing to various biogeochemical cycles of key nutrients such as...

Zanthoxylum leprieurii is a medicinal plant widely studied due to its great phytochemical diversity, especially its acrinonic alkaloids, which have shown to be promising anticancer candidates. The aim of this work was to promote the isolation of acridonic alkaloids from fruits of Z. leprieurii and carried out absorption and fluorescence spectroscop...

The advent of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of the coronavirus disease 2019 (COVID-19) pandemic, has promoted physical and mental health worldwide. Due to the unavailability of effective antiviral drugs, there is an unmet demand for a robust therapeutic approach for the development of anti-SARS-...

Oral squamous cell carcinoma (OSCC) is a major contributor to disease burden and mortality, particularly in rural India. This study aims to identify genes associated with OSCC through differential expression analysis utilizing datasets (BioProject: PRJNA853478) obtained from middle-aged Indian males. Differential expression analysis, transcript ass...

Phthalic acid esters are pivotalplasticizers in various applications, including cosmetics, packaging materials, and medical devices. They have garnered significant attention from the scientific community due to their persistence in ecosystems. The multifaceted aspects of PAEs, encompassing leaching, transformation, and toxicity, underscore their pr...

Natural products (NPs) are secondary metabolites that exert their biological effects within organisms and on other organisms. Among the microbial consortia, bacteria have been demonstrated to be potent microbial producers of bioactive natural therapeutic products due to their versatile biocatalytic activity. Therefore, the present study encompasses...

Natural products (NPs), also known as secondary metabolites, have biological effects on organisms and other organisms. Among the microbial consortia, bacteria have been demonstrated to be potent microbial producers of bioactive natural therapeutic products due to their versatile biocatalytic activity. The present study encompasses the isolation, id...

Azo dyes are highly recalcitrant, persistent, and toxic compounds, extensively used in the textile industry. The untreated discharge of dye effluents from the textile industry poses severe environmental and health risks. The objective of this research was to identify and characterize bacterial strains that effectively decolorize and degrade azo dye...

Ethnic diversity in breast cancer often results in overlapping genetic profiles, complicating prognosis despite evolving classification methods. The present study examines transcriptomic variations between Caucasian and Indian populations through a cross-population analysis to assess whether genes differentially expressed in breast cancer among Cau...

Cervical cancer stands as a prevalent gynaecologic malignancy affecting women globally, often linked to persistent human papillomavirus infection. Biomarkers associated with cervical cancer, including VEGF-A, VEGF-B, VEGF-C, VEGF-D, and VEGF-E, show upregulation and are linked to angiogenesis and lymphangiogenesis. This research aims to employ in-s...

Recent advances in genome-wide studies have revealed numerous epigenetic regulations brought about by genes involved in cellular metabolism. Isocitrate dehydrogenase (IDH), an essential enzyme, that converts isocitrate into -ketoglutarate (KG) predominantly in the tricarboxylic acid (TCA) cycle, has gained particular importance due to its cardinal...

The advent of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of the coronavirus disease 2019 (COVID-19) pandemic, has promoted physical and mental health worldwide. Due to the unavailability of effective antiviral drugs, there is an unmet demand for a robust therapeutic approach for the development of anti-COVID...

Background The current study recognizes the significance of estrogen receptor alpha (ERα) as a member of the nuclear receptor protein family, which holds a central role in the pathophysiology of breast cancer. ERα serves as a valuable prognostic marker, with its established relevance in predicting disease outcomes and treatment responses. Method I...

Cancer is a multifactorial disease that continues to increase. Lignans are known to be important anticancer agents. However, due to the structural diversity of lignans, it is difficult to associate anticancer activity with a particular subclass. Therefore, the present study sought to evaluate the association of lignan subclasses with antitumor acti...

Glioblastoma (GBM) is a WHO Grade IV tumor with poor visibility, a high risk of comor-bidity, and exhibit limited treatment options. Resurfacing from second-rate glioma was originally classified as either mandatory or optional. Recent interest in personalized medicine has motivated research toward biomarker stratification-based individualized illne...

Cancer is a multifactorial disease that continues to increase. Lignans are known to be important anticancer agents. However, due to the structural diversity of lignans, it is difficult to associate anticancer activity with a particular subclass. Therefore, the present study sought to evaluate the association of lignan subclasses with antitumor acti...

Bioremediation is crucial for recuperating polluted water and soil. By expanding the surface area of substrates, biosurfactants play a vital role in bioremediation. Biosurfactant-producing microbes release certain biosurfactant compounds, which are promoted for oil spill remediation. In the present investigation, a biosurfactant-producing bacterium...

Glioblastoma (GBM) is a WHO Grade IV tumor with poor visibility, a high risk of comorbidity, and exhibit limited treatment options. Resurfacing from second-rate glioma was originally classified as either mandatory or optional. Recent interest in personalized medicine has motivated research toward biomarker stratification-based individualized illnes...

Recycling, reclamation and valorization of colored industrial effluent may redeem to the constraints of prevailing water paucity. Before discharging, it must be appropriately treated for environment stability and public health protection. With this perspective, the current manuscript aims to scrutinize and fabricate a fast-paced, ecofriendly, and e...

Gene expression varies due to the intrinsic stochasticity of transcription or as a reaction to external perturbations that generate cellular mutations. Co-regulation, co-expression and functional similarity of substances have been employed for indoctrinating the process of the transcriptional paradigm. The difficult process of analysing complicated...

Disordered proteins serve a crucial part in many biological processes that go beyond the capabilities of ordered proteins. A large number of virus-encoded proteins have extremely condensed proteomes and genomes, which results in highly disordered proteins. The presence of these IDPs allows them to rapidly adapt to changes in their biological enviro...

https://www.ncbi.nlm.nih.gov/nuccore/KU529483 https://www.ebi.ac.uk/ena/browser/view/KU529483

https://www.ebi.ac.uk/ena/browser/view/KU179507 https://www.ncbi.nlm.nih.gov/nuccore/KU179507

Glioblastoma (GBM) is a WHO Grade IV tumor with poor visibility, a high risk of comorbidity, and limited treatment options. Resurfacing from second-rate glioma was originally classi ed as either mandatory or optional. Recent interest in personalized medicine has motivated research toward biomarker strati cation-based individualized illness therapy....

Colorectal cancer is the third most frequent cause of cancer worldwide and is more prevalent in older individuals of all ages. The recent statistics from World Health Organisation (WHO) on cancer accounted for 1.93 million new cases of colorectal cancer alone, in 2020[1]. The exact cause of this disease is still unknown; however, obesity, sedentary...

Colorectal cancer is the third most frequent cause of cancer worldwide and is more prevalent in older individuals of all ages. The recent statistics from World Health Organisation (WHO) on cancer accounted for 1.93 million new cases of colorectal cancer alone, in 2020[1]. The exact cause of this disease is still unknown; however, obesity, sedentary...

The antipsychotic drug Olanzapine was crystallized with aromatic acid, 2,5-dihydroxybenzoic acid in isopropyl alcohol by slow evaporation which led to the formation of olanzapinium 2,5-dihydroxybenzoate crystalline salt. The structure of the compound was characterized by ¹H-NMR, ¹³C-NMR, and single-crystal X-ray diffraction analysis. The Hirshfeld...

Glioblastoma (GBM) is a WHO Grade IV tumor with poor visibility, a high risk of comorbidity, and limited treatment options. Resurfacing from second-rate glioma was originally classified as either mandatory or optional. Recent interest in personalized medicine has motivated research toward biomarker stratification-based individualized illness therap...

Glioblastoma (GBM) is a WHO Grade IV tumor with poor visibility, a high risk of comorbidity, and limited treatment options. Resurfacing from second-rate glioma was originally classi ed as either mandatory or optional. Recent interest in personalized medicine has motivated research toward biomarker strati cation-based individualized illness therapy....

Glioblastoma (GBM) is a WHO Grade IV tumor with poor visibility, a high risk of comorbidity, and limited treatment options. Resurfacing from second-rate glioma was originally classified as either mandatory or optional. Recent interest in personalized medicine has motivated research toward biomarker stratification-based individualized illness therap...

Estrogen receptor alpha (ERα), a nuclear receptor protein encoded by the estrogen receptor1 (ESR1) gene, is an important biomarker in breast cancer diagnosis. Any dysregulation in its expression can actively implicate the development and progression of the disease. ERα is abnormally expressed in around 60% of the active cases, making it an importan...

Vascular endothelial growth factor (VEGF) and its receptor play an important role both in physiologic and pathologic angio-genesis, which is identified in ovarian cancer progression and metastasis development. The aim of the present investigation is to identify a potential vascular endothelial growth factor inhibitor which is playing a crucial role...

Estrogen receptor alpha (ERα), a nuclear receptor proteinencoded by the estrogen receptor1 (ESR1) gene,is an important biomarker in breast cancer diagnosis. Any dysregulation in its expression can actively implicate the development and progression of the disease. ERα is abnormally expressed in around 60% of the active cases, making it animportant t...

Estrogen receptor alpha (ERα), a nuclear receptor protein encoded by the estrogen receptor1 (ESR1) gene, is an important biomarker in breast cancer diagnosis. Any dysregulation in its expression can actively implicate the development and progression of the disease. ERα is abnormally expressed in around 60% of the active cases, making it an importan...

VEGF and its receptor play an important role both in physiologic and pathologic angiogenesis, which is identi ed in ovarian cancer progression and metastasis development. The aim of the present investigation is to identify a potential VEGF inhibitor which is playing a crucial role in stimulating the immunosuppressive microenvironment in tumour cell...

The bio-surfactants produced by microorganisms have high demand from microbial-enhanced oil recovery (MEOR) and they have focused on a chemical surfactant for the past few decades for degrading petro-based pollutants and oil spills due to its non-toxicity and increasing bioavailability. These microorganisms can survive over the different oil specie...

The biosurfactants produced by microorganisms have high demand from microbial-enhanced oil recovery (MEOR) and they have focused on a chemical surfactant for the past few decades for degrading petro-based pollutants and oil spills due to its non-toxicity and increasing bioavailability. The study aims to identify and screen potential lipopeptide bio...

The biosurfactants produced by microorganisms have high demand from microbial-enhanced oil recovery (MEOR) and they have focused on a chemical surfactant for the past few decades for degrading petro-based pollutants and oil spills due to its non-toxicity and increasing bioavailability. The study aims to identify and screen potential lipopeptide bio...

The biosurfactants produced by microorganisms have high demand from microbial-enhanced oil recovery (MEOR) and they have focused on a chemical surfactant for the past few decades for degrading petro-based pollutants and oil spills due to its non-toxicity and increasing bioavailability. The study aims to identify and screen potential lipopeptide bio...

VEGF and its receptor play an important role both in physiologic and pathologic angiogenesis, which is identified in ovarian cancer progression and metastasis development. The aim of the present investigation is to identify a potential VEGF inhibitor which is playing a crucial role in stimulating the immunosuppressive microenvironment in tumour cel...

The user has requested enhancement of the downloaded file. F o r p e r s o n a l p r i v a t e u s e o n l y. N o t b e d i s t r i b u t e d o r u p l o a d e d t o a n y o n e o r a n y w h e r e. Abstract: Background: Mantle cell lymphoma (MCL) is a type of non-Hodgkin lymphoma characterized by the mutation and overexpression of the cyclin D1 pr...

The user has requested enhancement of the downloaded file. F o r p e r s o n a l p r i v a t e u s e o n l y. N o t b e d i s t r i b u t e d o r u p l o a d e d t o a n y o n e o r a n y w h e r e. Abstract: Artificial Intelligence revolutionizes the drug development process that can quickly identify potential biologically active compounds from mi...

Mantle cell lymphoma (MCL) is a type of non-Hodgkin lymphoma characterized by the mutation and overexpression of the cyclin D1 protein by the reciprocal chromosomal translocation t(11;14)(q13:q32).The Present study aims to identify a potential inhibition of MMP9, Proteasome, BTK, and TAK1 and also determine the most suitable and effective protein t...

Background Mantle cell lymphoma (MCL) is a type of non-Hodgkin lymphoma characterized by the mutation and overexpression of the cyclin D1 protein by the reciprocal chromosomal translocation t(11;14)(q13:q32). Aim The Present study aims to identify a potential inhibition of MMP9, Proteasome, BTK, and TAK1 and also determine the most suitable and ef...

Artificial Intelligence revolutionizes the drug development process that can quickly identify potential biologically active compounds from millions of candidate within a short span of time. The present review is an overview based on some applications of Machine Learning based tools such as GOLD, DeepPVP, LIBSVM, etc and the algorithms involved such...

Traditional agriculture research programs have used classical breeding and molecular biology approaches for crop improvement. Besides, they are proved inadequate to deal collectively with a major number of problems. High throughput sequencing has shown a way towards overcoming those barriers along with storing and evaluating various big scale datas...

We announce the complete genome sequence of Bacillus tequilensis , a biosurfactant producing bacterium isolated from Chilika lake, Odisha, India(latitude and longitude: 19.8450 N 85.4788 E). The genome sequence is 4.47 MB consisting of 4,478,749 base pairs forming a circular chromosome with 528 scaffolds, 4492 protein-encoding genes(ORFs), 81 tRNA...

Background: Bioremediation is crucial for recuperate polluted water and soil. By expanding the surface area of substrates, biosurfactants play a vital role in bioremediation. Bioremediation is crucial for recuperate polluted water and soil. By expanding the surface area of substrates, biosurfactants play a vital role in bioremediation. Biosurfactan...

Multidrug resistance in microbes poses a major health crisis and demands for the discovery of novel antimicrobial agents. The recent pandemic of SARS-CoV-2 has raised a public health emergency in almost all the countries of the world. Unlike viruses, a bacterium plays a significant role in various environmental issues such as bioremediation. Furthe...

Liver cancers are one of the leading fatal diseases among malignant neoplasms. Current chemotherapeutic treatments used to fight these illnesses have become less efficient in terms of both efficacy and safety. Therefore, there is a great need of search for new anti-liver cancer agents and this can be accelerated by using computer-aided drug discove...

Background The vast geographical expansion of novel coronavirus and an increasing number of COVID-19 affected cases has overwhelmed health and public health services. AI and ML algorithms have extended its major role in tracking the disease patterns, and in identifying possible treatment of disease. Objective To identify potential COVID-19 proteas...

Background: The vast geographical expansion of novel coronavirus and an increasing number of COVID-19 affected cases has overwhelmed health and public health services. AI and ML algorithms have extended its major role in tracking the disease patterns, and in identifying possible treatment of disease. Objective: To identify potential COVID-19 prote...

Drug discovery is one of the most complicated processes and establishment of a single drug may require multidisciplinary attempts to design efficient and commercially viable drugs. The main purpose of drug design is to identify a chemical compound or inhibitor that can bind to an active site of a specific cavity on a target protein. The traditional...

Background Bioremediation has taken its call for removing pollutants for years. The oil-contaminated surroundings are majorly hazardous for sustaining life but there has been a great contribution of nature in the form of microorganisms. The complex carbon-hydrogen chain has served as classic raw material to chemical industries, which has perked up...

Background Bluetongue disease currently noticeable to the World Organization for Animal Health (OIE); causes enormous economic losses due to rapid deteriorate trade associated with bluetongue outbreaks and high mortality and morbidity.The capsid coat protein of Bluetongue virus(BTV)VP2 is responsible for BTV transmission by the Culicoides vector to...

BACKGROUND The Non-Small Cell Lung Cancer (NSCLC) alone is responsible for the sovereignty of demises worldwide related to the other cancers.ROS1 is a receptor tyrosine kinase (RTK), eminently recognized as the stereotyped oncogenic driver. These RTKs trigger an array of physiological regulations via cellular signal transduction pathways which are...

Polycystic Ovary Syndrome (PCOS) is extremely prevalent and diverse. It is the most commonly encountered heterogeneous endocrine disorder in premenopausal (reproductive age) women worldwide. Studies shows that it affects 5-10% of this population. It is a characteristic syndrome of ovarian dysfunction associated with hyperandrogenism, chronic anovul...

Aims The In silico approach provides a platform for determination and establishing a potential inhibitor against GD2 in Pediatric neuroblastoma. Background Originating from the abnormal growth of neuroblasts, pediatric neuroblastoma affects the age group below 15 years. It is an aggressive heterogenous cancer with a high morbidity rate. Biological...

Cancer stands as major cause of mortality in the world, and it's the morbidity has significantly increased in both developing and developed nations. In spite of the recent advancement in cancer therapies, the clinical follow-up still lags far behind.Recent studies show that, stem cells are bestowed with distinctive functions, like tumor cells reloc...

Cancer forms second-most cause of death in the USA next to cardio vascular diseases, contributing to significant economic and social burden. WHO reports suggest that, almost 18 millions cancer cases and 60 lakhs deaths from cancer is expected in the US in 2019 alone. The most common types such as lung, breast, prostate, and colorectal cancer are mo...

Vascular endothelial growth factor (VEGF) expression could be found in all glioblastomas. VEGF takes part in numerous changes including the endothelial cell proliferation, the vasculature of solid tumor: its survival invasion, and migration, chemotaxis of bone marrow-derived progenitor cells, vasodilation and vascular permeability. VEGF inhibition...

Background: Multicentric Castleman Disease (MCD) is a confrontational lymphoproliferative disorder described by symptoms such as lymph node proliferation, unwarranted secretion of inflammatory cytokines, hyperactive immune system, and in severe cases, multiple organs dysfunction. Interleukin-6 (IL-6) is a pleiotropic cytokine which is involved in...

Acute myeloid leukemia (AML) is symbolized by an increase in the number of myeloid cells in the bone marrow and an arrest in their maturation, frequently resulting in hematopoietic insufficiency (granulocytopenia, thrombocytopenia, or anemia) with or without leukocytosis either by a predominance of immature forms or a loss of normal hematopoiesis....

Background: Alzheimers Disease (AD) is a neurodegenerative disease which is characterized by the deposition of amyloid plaques in the brain- a concept supported by most of the researchers worldwide. The main component of the plaques being amyloid-beta (Aβ42) results from the sequential cleavage of Amyloid precursor protein (APP) by beta and gamma...

Background Tay Sachs is a very rare neurodegenerative disorder and the second most common lipid storage disorder. The testimony of TSD in infants is marked by the gradual loss in vision, hearing impairment, increased muscle stiffness and cherry red retinal spot. These symptoms progress to paralysis, dementia, seizures, neuro-regression leading to...

BACKGROUND Lung cancer is the most common among all the cancer worldwide with 1.8 million people diagnosed every year, leading to 1.6 million death each year according to American cancer society. Involvement of mutated Anaplasic Lymphoma Kinase (ALK)positive fusion protein in progression of NSCLC has made itself a propitious target to inhibit and t...

Hemophilia can be defined as a genetic disorder in which the body loses its capability to clot blood, and hence can’t stop blood flow. It is an X- linked recessive disease, hence mostly seen in males, with its severity significantly reduced in females. In India, hemophilia has an occurrence of 1 per 10,000 births, which generally progresses to a ch...

Neurodegenerative diseases (NDs) constitute a large group of pathological conditions, characterized by a progressive loss of neuronal cells, which compromise motor and/or cognitive functions. The most common NDs are Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), Parkinson’s disease (PD), and Huntington’s disease (HD). The causes of...

Breast cancer is the most frequent malignancy among women. It is a heterogeneous disease with different subtypes defined by its hormone receptor. A hormone receptor is mainly concerned with the progression of the PI3K/AKT/ mTOR pathway which is often dysregulated in breast cancer. This is a major signaling pathway that controls the activities such...

Juvenile idiopathic arthritis (JIA) is a heterogeneous disease characterized by the arthritis of unknown origin and IL6 is a known target for JIA. 20 known inhibitors towards IL-6 were screened and Methotrexate (MTX) having PubChem ID: 126941 showed high binding capacity with the receptor IL-6. The similarity searching with this compound gave 269 v...

Acute Myeloid Leukaemia (AML) is a blood cancer, which affects the red blood cells in the bone marrow. Of the possible proteins that are affected in AML, fms-like tyrosine kinase 3 (FLT3) has long been recognized as a potential therapeutic target as it affects the other signaling pathways and leads to a cascade of events. First-generation inhibitor...

Multiple cytokines play a pivotal role in the pathogenesis of Rheumatoid Arthritis by inducing intracellular signaling and it is known that the members of the Janus kinase (JAK) family are essential for such signal transduction. Janus kinase 3 is a tyrosine kinase that belongs to the Janus family of kinases. Drugs targeting JAK 3 is known as an eff...

The progression of lung cancer is associated with inactivation of Programmed cell death protein 1, abbreviated as PD-1 which regulates the suppression of the body’s immune system by suppressing T- cell inflammatory activity and is responsible for preventing cancer cell growth. It is of interest to identify inhibitors for PD-L1 dimeric structure thr...

Juvenile idiopathic arthritis (JIA) is a heterogeneous disease characterized by the arthritis of unknown origin and IL6 is a known target for JIA. 20 known inhibitors towards IL-6 were screened and Methotrexate (MTX) having PubChem ID: 126941 showed high binding capacity with the receptor IL-6. The similarity searching with this compound gave 269 v...

Neurodegenerative diseases, such as Parkinson’s and Alzheimer’s, are understood as occurring through genetic, cellular, and multifactor pathophysiological mechanisms. Several natural products such as flavonoids have been reported in the literature for having the capacity to cross the blood-brain barrier and slow the progression of such diseases. Th...