Anuradhani Kasturiratne

Anuradhani Kasturiratne
University of Kelaniya · Faculty of Medicine

MBBS, MSc, MD

About

207
Publications
33,044
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4,765
Citations
Additional affiliations
October 2008 - present
University of Kelaniya
Position
  • Professor (Associate)
August 2008 - August 2009
Queen Mary, University of London
Position
  • Visiting Research Fellow

Publications

Publications (207)
Preprint
Background Data on alcoholic fatty liver (AFL) is limited. We investigated patterns of alcohol use and AFL, among urban, adult, Sri Lankans. Methods The study population (selected by age-stratified random sampling) was screened in 2007 (35–64 years) and re-evaluated in 2014. On both occasions they were assessed by structured-interview, anthropometr...
Preprint
Background Snakebite envenoming is a neglected tropical disease. Data from the worst affected countries are limited because conducting epidemiological surveys is challenging. We assessed the utility of inhibitory geostatistical design with close pairs (ICP) to estimate snakebite incidence. Methods The National Snakebite Survey (NSS) in Sri Lanka a...
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Background The global epidemic of type 2 diabetes mellitus (T2DM) renders its prevention a major public health priority. A key risk factor of diabetes is obesity and poor diets. Food environments have been found to influence people’s diets and obesity, positing they may play a role in the prevalence of diabetes. Yet, there is scant evidence on the...
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South Asians are at high risk of developing type 2 diabetes (T2D). We carried out a genome-wide association meta-analysis with South Asian T2D cases (n = 16,677) and controls (n = 33,856), followed by combined analyses with Europeans (neff = 231,420). We identify 21 novel genetic loci for significant association with T2D (P = 4.7 × 10−8 to 5.2 × 10...
Article
Air pollution is a multifaceted environmental toxin affecting the Central Nervous System (CNS) through diverse pathways. The CNS of young children is particularly susceptible to the detrimental effects of toxins, as brain development continues postnatally with the formation of interneuronal connections, glial cell proliferation and myelination of a...
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Introduction: In low-middle income countries (LMICs) the role of food environments on obesity has been understudied. We address this gap by 1) examining the effect of food environments on adults' body size (BMI, waist circumference) and obesity; 2) measuring the heterogeneity of such effects by income and sex. Methods: This cross-sectional study...
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Background: People from South Asia are at increased risk of type 2 diabetes (T2D). There is an urgent need to develop approaches for the prevention of T2D in South Asians that are cost-effective, generalisable and scalable across settings. Hypothesis: Compared to usual care, the risk of T2D can be reduced amongst South Asians with central obesit...
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Introduction South Asians are at high risk of type 2 diabetes (T2D). We assessed whether intensive family-based lifestyle intervention leads to significant weight loss, improved glycaemia and blood pressure in adults at elevated risk for T2D. Methods This cluster randomised controlled trial (iHealth-T2D) was conducted at 120 locations across India...
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Despite important implications for human health, distribution, abundance and behaviour of most medically‐relevant snakes remain poorly understood. Such data deficiencies hamper efforts to characterise the causal pathways of snakebite envenoming and to prioritise management options in the areas at greatest risk. We estimated the spatial patterns of...
Conference Paper
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Introduction & Objectives Chronic kidney disease (CKD) affects 700 million people worldwide. In 2017, deaths due to CKD accounted for 4.6% of mortality globally. Prevalence of CKD is increasing worldwide, with increasing diabetes and hypertension in aging populations. Our objective was to determine prevalence of CKD in an urban, adult cohort, since...
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Background: Postpartum hemorrhage (PPH) is the leading cause of maternal death worldwide. When PPH occurs, early identification of bleeding and prompt management using evidence-based guidelines, can avert most PPH-related severe morbidities and deaths. However, adherence to the World Health Organization recommended practices remains a critical cha...
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The burden of disability among survivors and the socio-economic impact of snakebite have not been adequately researched. We reviewed original research articles, case reports and small case series relating to chronic physical, mental and psycho-social disability and economic burden of snakebite. Both physical and psychological health problems seem c...
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Solid fuel combustion is an important risk factor of morbidity. This study was conducted to determine the effect of indoor air pollution (IAP) due to solid fuel combustion on physical growth in 262 Sri Lankan children under five. Exposure was defined by the type of fuel used for cooking. Pollutant levels were measured in a subsample of households....
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Background Inadequate treatment of hypertension is a widespread problem, especially in South Asian countries where cardiovascular disease mortality rates are high. We aimed to explore the effect of a multicomponent intervention (MCI) on antihypertensive medication intensification among rural South Asians with hypertension. Methods A post-hoc analy...
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Background COBRA-BPS (Control of Blood Pressure and Risk Attenuation-Bangladesh, Pakistan, Sri Lanka), a multi-component hypertension management programme that is led by community health workers, has been shown to be efficacious at reducing systolic blood pressure in rural communities in Bangladesh, Pakistan, and Sri Lanka. In this study, we aimed...
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Background The term “metabolic (dysfunction)-associated fatty liver disease” (MAFLD) is suggested alternative for “non-alcoholic fatty liver disease” (NAFLD), as it better reflects metabolic dysfunction. No study has compared outcomes of the two diagnostic criteria. Methods In an ongoing, community-based, cohort-study in suburban Sri Lanka, partic...
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Background: South Asia has become a major epicentre of the COVID-19 pandemic. Understanding South Asians' awareness, attitudes and experiences of early measures for the prevention of COVID-19 is key to improving the effectiveness and mitigating the social and economic impacts of pandemic responses at a critical time for the Region. Methods: We a...
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Snakebite causes more than 1.8 million envenoming cases annually and is a major cause of death in the tropics especially for poor farmers. While both social and ecological factors influence the chance encounter between snakes and people, the spatio-temporal processes underlying snakebites remain poorly explored. Previous research has heavily focuse...
Article
Objectives Despite its widespread use there is no consensus on ultrasound criteria to diagnose fatty liver. Method In an ongoing, cohort-study, participants were initially screened in 2007 and reassessed in 2014 by interview, anthropometric measurements, liver ultrasonography, and blood tests. We evaluated utility of increased hepatic echogenicity...
Preprint
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Background South Asians are at high risk of type 2 diabetes (T2D). Lifestyle modification is effective at preventing T2D amongst South Asians, but the approaches to screening and intervention are limited by high-costs, poor scalability and thus low impact on T2D burden. An intensive family-based lifestyle modification programme for prevention of T2...
Preprint
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Background There is limited data on prevalence and outcome of prediabetes (PDM) and incidence of type 2 diabetes mellitus (T2DM) from South Asia. We investigated this in an urban, adult population in Sri Lanka that was followed-up for seven years. Methods The study population (selected by age-stratified random sampling from the community) was initi...
Preprint
Full-text available
Background People from South Asia are at increased risk of type 2 diabetes (T2D). There is an urgent need to develop approaches for prevention of T2D in South Asians, that are cost-effective, generalisable and scalable across settings. Hypothesis Compared to usual care, risk of T2D can be reduced amongst South Asians with central obesity or raised...
Preprint
Full-text available
Background South Asia has become a major epicentre of the COVID-19 pandemic. Understanding South Asians’ awareness, attitudes and experiences of early measures for the prevention of COVID-19 is key to improving the effectiveness and mitigating the social and economic impacts of pandemic responses at a critical time for the Region. Methods We asses...
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Objective: To describe patterns and predictors of mortality in a semi-urban population in Sri Lanka. Design: A prospective population-based cohort study. Setting: Ragama Medical Officer of Health area in the Gampaha district, Sri Lanka. Participants: Adults between 35 and 64 years of age were recruited using an age stratified random sampling...
Preprint
Introduction Metabolic (dysfunction)-associated fatty liver disease (MAFLD) is a recently suggested alternative to Non-alcoholic fatty liver disease (NAFLD). We compared baseline metabolic traits and outcomes of NAFLD and MAFLD. Methods In an ongoing, community-based, cohort study, participants were first screened in 2007 by structured-interview, a...
Preprint
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Background and aims: This paper describes the data resource profile of South Asia Biobank (SAB), which was set up in South Asia from November 2018 to March 2020, to identify the risk factors and their complex interactions underlying the development of type-2 diabetes mellitus, cardiovascular disease and other chronic diseases in South Asians. Data...
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Background: The burden of hypertension is escalating, and control rates are poor in low- and middle-income countries. Cardiovascular mortality is high in rural areas. Methods: We conducted a cluster-randomized, controlled trial in rural districts in Bangladesh, Pakistan, and Sri Lanka. A total of 30 communities were randomly assigned to either a...
Article
Background: Data on outcomes of non-alcoholic fatty liver disease (NAFLD) from South Asia are lacking. We compared mortality, among those with- and without-NAFLD, after 10-years follow-up among urban, adult Sri Lankans. Method: Participants (aged 35-64 years), selected by age-stratified random sampling, were screened by structured-interview in 2007...
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Background There are few studies investigating the natural course of non-alcoholic fatty liver disease (NAFLD) in the community. We assessed resolution of NAFLD in a general population cohort of urban Sri Lankans adults. Methods Participants were selected by age-stratified random sampling from electoral lists. They were initially screened in 2007...
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Introduction Uncontrolled hypertension is the leading risk factor for mortality globally, including low-income and middle-income countries (LMICs). However, pathways for seeking hypertension care and patients’ experience with the utilisation of health services for hypertension in LMICs are not well understood. Objectives This study aimed to explor...
Article
Abstract Introduction: Uncontrolled hypertension is the leading risk factor for mortality globally, including low-income and middle-income countries (LMICs). However, pathways for seeking hypertension care and patients’ experience with the utilisation of health services for hypertension in LMICs are not well understood. Objectives: This study aim...
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Background Health outcomes and causality are usually assessed with individual level sociodemographic variables. Studies that consider only individual-level variables can suffer from residual confounding. This can result in individual variables that are unrelated to risk behaving as proxies for uncaptured information. There is a scarcity of literatu...
Conference Paper
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Background: Modulation of the gut microbiome may help in the management of metabolic disorders such as type-2 diabetes mellitus (T2DM). The use of antibiotics in animals and prebiotics/probiotics in humans has shown to improve glycaemic control (GC) by altering the gut microbiota. However, the use of rifaximin for better GC in T2DM has not been st...
Conference Paper
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Introduction and Objectives There is limited data on incidence of type-2 diabetes mellitus (T2DM) from South Asia. We investigated incidence and predictors of T2DM in an urban, adult population, after seven-years of follow-up. Methods The study population, selected by age-stratified random sampling from the Ragama MOH area, was initially screened...
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Background: Household air pollution from combustion of solid fuels for cooking and space heating is one of the most important risk factors of the global burden of disease. This study was aimed to determine the association between household air pollution due to combustion of biomass fuel in Sri Lankan households and self-reported respiratory sympto...
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Objective To determinate the prevalence and correlates of cardiometabolic multimorbidity (CMM), and their cross-country variation among individuals with hypertension residing in rural communities in South Asia. Design A cross-sectional study. Setting Rural communities in Bangladesh, Pakistan and Sri Lanka. Participants A total of 2288 individual...
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Background: The metabolic syndrome (MetS) is a clustering of abdominal obesity, diabetes and prediabetes, high cholesterol and high blood pressure, that confers an increased risk of cardiovascular disease. There is limited data on incidence of MetS from South Asia. This study investigated incidence and risk factors for new onset MetS in an urban a...
Conference Paper
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INCIDENCE AND PREDICTORS OF DIABETES MELLITUS: A 7- YEAR COMMUNITY COHORT FOLLOW-UP OF URBAN, ADULT SRI LANKANS De Silva ST1,2, Ediriweera D1, Beddage T1, Kasturiratne A1, Niriella MA1,2, de Silva AP1,2, Dassanayake AS1, Pathmeswaran A1, Kato N3, Wickramasinghe AR1, de Silva HJ1,2 1Faculty of Medicine, University of Kelaniya 2University Medical U...
Conference Paper
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Introduction and Objectives There is limited knowledge on early predictors of mortality among Sri Lankans. We investigated predictors of mortality in the Ragama Health Study cohort 10 years after recruitment. Methods The study population (35-64-year-olds selected by age-stratified random sampling from the Ragama Medical Officer of Health area) was...
Conference Paper
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Background Some studies suggest increased mortality in patients with non-alcoholic fatty liver disease (NAFLD), but others do not. The stage of fibrosis, but not steatosis, seems related to overall mortality in patients with NAFLD. There are few data on long-term outcomes NAFLD from South Asia. In a community-based cohort study in an urban area in...
Article
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We aimed to explore the cross-country variation in the prevalence of comorbid prediabetes or diabetes and determine the sociodemographic, lifestyle, and clinical factors, especially body mass index (BMI) and waist circumference, associated with comorbid diabetes in individuals with hypertension in rural South Asia. We analyzed cross-sectional data...
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The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene–smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. C...
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Cataract is still the leading cause of blindness.Many government institutes and voluntary organizations in Sri Lanka are providing free treatment services to patients with cataract. Still people are not patronizing the available free services; thus they have to live with impaired vision or blindness. This paper describes the barriers for cataract t...
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Hypertension is the leading risk factor for cardiovascular disease and leading cause of premature death globally. In 2008, approximately 40% of adults were diagnosed with hypertension, with more than 1.5 billion people estimated to be affected globally by 2025. Hypertension disproportionally affects low- and middle-income countries, where the preva...
Article
Introduction While patients with non-alcoholic fatty liver disease (NAFLD) are mostly overweight or obese, some are lean. Methods In a community-based follow-up study (baseline and follow-up surveys performed in 2007 and 2014), we investigated and compared the clinical characteristics, body composition, metabolic associations and outcomes, and oth...
Preprint
Full-text available
Introduction Use of solid fuel for cooking is a major source of household air pollution in developing countries. Of the many pollutants emitted during solid fuel combustion, Particulate Matter (PM)is considered to be one of the most hazardous pollutants. We monitored PM fractions emitted during solid fuel and Liquefied Petroleum Gas(LPG) combustion...
Preprint
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Background: Nearly 74% of the Sri Lankan population use biomass in the form of unprocessed wood as the primary cooking fuel. Growing evidence for meta-analyses and individual studies have reported increased risk of adverse birth outcomes associated with prenatal exposure to household air pollution (HAP) from cooking with biomass fuel. We thus estab...
Preprint
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Background and aims: The Neonatal Behavior Assessment Scale (NBAS) was introduced by Brazelton is a useful tool to assess neurodevelopment in newborn in research setting. However, it is complex, time-consuming and requires specialized training for administration and is therefore difficult tool to use in routine clinical settings. The Alberta Infant...
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Background: Snakebite is a neglected tropical disease that has been overlooked by healthcare decision makers in many countries. Previous studies have reported seasonal variation in hospital admission rates due to snakebites in endemic countries including Sri Lanka, but seasonal patterns have not been investigated in detail. Methods: A national c...
Conference Paper
Introduction and objectives Chronic kidney disease is a major non communicable disease in Sri Lanka with a rising prevalence. We studied the prevalence and associations of chronic kidney disease among patients with hypertension in a rural Sri Lankan population. Methods A community-based study was conducted in selected Grama Niladhari divisions in...