Anuradha Venkatakrishnan Chimata

Anuradha Venkatakrishnan Chimata
University of Dayton | UD · Department of Biology

Master of Science (Human Genetics)

About

14
Publications
2,993
Reads
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27
Citations
Citations since 2016
13 Research Items
20 Citations
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20162017201820192020202120220246810
20162017201820192020202120220246810
20162017201820192020202120220246810
Additional affiliations
December 2017 - May 2019
Excelra Knowledge Solutions
Position
  • Analyst
Education
July 2015 - July 2017
Sri Ramachandra University
Field of study
  • Human Genetics
June 2011 - December 2014
Stella Maris College
Field of study
  • Plant Biology and Plant Biotechnology

Publications

Publications (14)
Article
During organogenesis, cell proliferation is followed by the differentiation of specific cell types to form an organ. Any aberration in differentiation can result in developmental defects, which can result in a partial to a near-complete loss of an organ. We employ the Drosophila eye model to understand the genetic and molecular mechanisms involved...
Article
Full-text available
During development, regulation of organ size requires a balance between cell proliferation, growth and cell death. Dysregulation of these fundamental processes can cause a variety of diseases. Excessive cell proliferation results in cancer whereas excessive cell death results in neurodegenerative disorders. Many signaling pathways known-to-date hav...
Article
Full-text available
The phenomenon of RNA polymerase II (Pol II) pausing at transcription start site (TSS) is one of the key rate-limiting steps in regulating genome-wide gene expression. In Drosophila embryo, Pol II pausing is known to regulate the developmental control genes expression, however, the functional implication of Pol II pausing during later developmental...
Article
Hematopoiesis is a continuous phenomenon involving the formation of hematopoietic stem cells (HSCs) giving rise to diverse functional blood cells. This developmental process of hematopoiesis is evolutionarily conserved, yet comparably different in various model organisms. Vertebrate HSCs give rise to all types of mature cells of both the myeloid an...
Preprint
Full-text available
A fundamental process of regeneration, which varies among animals, recruits conserved signaling pathways to restore missing parts. Only a few animals like newts can repeatedly regenerate lost body parts throughout their lifespan that can be attributed to strategic regulation of conserved signaling pathways by newt's regeneration tool-kit genes. Her...
Chapter
RNA is an important connecting link between DNA and proteins. Levels of RNA within a cell or a tissue serve as the unique genetic signatures, which can help in correlating gene expression to the resultant phenotype(s) during development and disease. Transcriptomics is the study of all RNAs expressed/available in cells or tissues that allow study of...
Article
Full-text available
Cell death maintains tissue homeostasis by eliminating dispensable cells. Misregulation of cell death is seen in diseases like cancer, neurodegeneration, etc. Therefore, cell death assays like TUNEL have become reliable tools, where fragmented DNA of dying cells gets fluorescently labeled and can be detected under microscope. We used TUNEL assay in...
Chapter
A hallmark of development, aging, represents the changes in the body over a period of time. At cellular level, the basic unit of organization in multicellular organism, aging is associated with deterioration of cellular function(s) and replicative ability. These changes include accumulation of genetic damage, shortening of telomere length, metaboli...
Article
Full-text available
Newts utilize their unique genes to restore missing parts by strategic regulation of conserved signaling pathways. Lack of genetic tools pose challenges to determine the function of such genes. Therefore, we used the Drosophila eye model to demonstrate the potential of 5 unique newt (Notophthalmus viridescens) gene(s), viropana1-viropana5 (vna1-vna...
Article
Full-text available
Numerous imaging modules are utilized to study changes that occur during cellular processes. Besides qualitative (immunohistochemical) or semiquantitative (Western blot) approaches, direct quantitation method(s) for detecting and analyzing signal intensities for disease(s) biomarkers are lacking. Thus, there is a need to develop method(s) to quanti...
Article
Pituitary adenylate cyclase-activating polypeptide (PACAP), a neu-roendocrine hormone of the secretin peptide superfamily, is mainlyproduced in hypothalamus. PACAP shows diverse effects on CNS, per-ipheral organs, and some hematopoietic cells by VPAC1 and 2 receptorsignaling [1]. Megakaryocytes (MKs) express the stimulatory G protein(Gs)-coupled PA...
Technical Report
Full-text available
Monoclonal antibodies produced by hybridoma technology are increasingly being used in therapeutics, diagnostics and research. Use of such antibodies and their products which are non-human in origin often leads to less efficient and unsafe results. This is overcome with the help of various other alternatives like antibody fragments, bispecifics, con...

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