Anupam Dhasmana

Anupam Dhasmana
University of Texas Rio Grande Valley · Department of Immunology and Microbiology

Ph.D.

About

85
Publications
15,971
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
467
Citations
Citations since 2016
60 Research Items
449 Citations
2016201720182019202020212022050100150
2016201720182019202020212022050100150
2016201720182019202020212022050100150
2016201720182019202020212022050100150
Introduction
Currently I am working as an Assistant Scientist, at University of Texas, and also associated with Swami Rama Himalayan University as an Assistant Professor. My area of interest are systems molecular biology, drug designing, Nano-particles and natural compounds.

Publications

Publications (85)
Article
Full-text available
Curcumin is an important bioactive component of turmeric and also one of the important natural products, which has been investigated extensively. The precise mode of action of curcumin and its impact on system level protein networks are still not well studied. To identify the curcumin governed regulatory action on protein interaction network (PIN),...
Article
Full-text available
Several bioactive compounds are in use for the treatment of neurodegenerative disorders, such as Alzheimer’s and Parkinson’s disease. Historically, willow (salix sp.) bark has been an important source of salisylic acid and other natural compounds with anti-inflammatory, antipyretic and analgesic properties. Among these, picein isolated from hot wat...
Article
Full-text available
Cancer is the second deadliest disease listed by the WHO. One of the major causes of cancer disease is tobacco and consumption possibly due to its main component, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). A plethora of studies have been conducted in the past aiming to decipher the association of NNK with other diseases. However, it is s...
Article
Full-text available
Introduction Pulmonary emphysema characterized by alveolar wall destruction is resultant of persistent chronic inflammation. All-trans retinoic acid (ATRA) has been reported to reverse elastase-induced emphysema in rats. However, the underlying molecular mechanisms are so far unknown. Objective To investigate the therapeutic potential effect of AT...
Article
Full-text available
Polycyclic aromatic hydrocarbons (PAH), like Benzo[alpha]Pyrene (BaP) are known to cause a number of toxic manifestations including lung cancer. As Titanium dioxide Nanoparticles (TiO2 NPs) have recently been shown to adsorb a number of PAHs from soil and water, we investigated whether TiO2 NPs could provide protection against the BaP induced toxic...
Article
Background Amyotrophic Lateral Sclerosis (ALS) is a progressive and terminal neurodegenerative disorder. Mitochondrial dysfunction, imbalance of cellular bioenergetics, electron chain transportation and calcium homeostasis are deeply associated with the progression of this disease. Impaired mitochondrial functions are crucial in rapid neurodegenera...
Article
Background Curcumin, a polyphenolic compound present in turmeric plant (curcuma longa) is well known for its anti-aging, anti-tumor, anti-inflammative, anti-mutagenic and antioxidative properties due to which turmeric has been used as a medicinal plant from ages. Objective Our current study aims at finding the most potent targets of curcumin displ...
Article
Full-text available
Nonsmall-cell lung cancer (NSCLC) is the most common type of lung cancer, with a dismal prognosis. NSCLC is a highly vascularized tumor, and chemotherapy is often hampered by the development of angiogenesis. Therefore, suppression of angiogenesis is considered a potential treatment approach. Tannic acid (TA), a natural polyphenol, has been demonstr...
Article
Background: Pancreatic cancer remains 3rd deadliest disease, with less than 7-10% survival rate. Little progress has been seen in patient’s outcome due to high desmoplasia and chemo-resistance. Immunotherapy has shown promising results in cancers, except pancreatic cancer due to their characteristic fibrotic tumor microenvironment. The therapies ar...
Article
Background: The 3D crystal structure of a protein determines its overall function, and when the structure of a protein is known, small drug molecules can be designed to bind to it and inhibit its function. Target-based drug discovery, specifically for genetic products that cause a higher risk of disease (genetic targets), takes advantage of this fa...
Article
Background: Hepatocellular carcinoma (HCC) is the most frequent type of primary liver cancer with approximately 41,000 new diagnosis and 29,000 fatalities every year only in the U.S. Severe toxicity and poor response to available chemotherapeutic agents make HCC clinical management extremely difficult. Aberrant β-catenin signaling is found to play...
Article
Pancreatic cancer is the fourth leading cause of cancer-related deaths in the United States with limited therapeutic approaches. Dysregulation of the ribosome biogenesis process was observed in various cancer including pancreatic cancer. Therefore, strategically targeting ribosome biogenesis could be a novel approach for pancreatic cancer treatment...
Article
Background: Pancreatic cancer (PanCa) is expected to be the second leading cause of cancer-related death by 2030. The treatment of PanCa is highly challenging due to the extremely poor response to existing therapeutic options. Highly desmoplastic tumor microenvironment in pancreatic tumor causes suboptimal delivery of therapeutic agents in tumors t...
Chapter
Stem cells are very promising for the treatment of a plethora of human diseases. Numerous clinical studies have been conducted to assess the safety and efficacy of various stem cell types. Factors that ensure successful therapeutic outcomes in patients are cell-based parameters such as source, viability, and number, as well as frequency and timing...
Article
Full-text available
Piperlongumine (PL, piplartine) is an alkaloid derived from the Piper longum L. (long pepper) roots. Originally discovered in 1961, the biological activities of this molecule against some cancer types was reported during the last decade. Whether PL can synergize with doxorubicin and the underlying mechanism in breast cancer remains elusive. Herein,...
Article
Full-text available
Chemotherapy is one of the prime treatment options for cancer. However, the key issues with traditional chemotherapy are recurrence of cancer, development of resistance to chemotherapeutic agents, affordability, late-stage detection, serious health consequences, and inaccessibility. Hence, there is an urgent need to find innovative and cost-effecti...
Article
Tumor heterogeneity is a predominant feature of hepatocellular carcinoma (HCC) that plays a crucial role in chemoresistance and limits the efficacy of available chemo/immunotherapy regimens. Thus, a better understanding regarding the molecular determinants of tumor heterogeneity will help in developing newer strategies for effective HCC management....
Article
Marburg, a RNA virus (MRV), is responsible for causing hemorrhagic fever that affects humans and non-human primates. World Health Organization (WHO), National Institutes of Health (NIH) and Centre of Disease Control and Prevention (CDC) considered this as an extremely dangerous virus, thus categorised as risk group 4, category A priority pathogen a...
Article
Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurological disease affecting both upper and lower motor neurons. In the United States alone, there are 16,000–20,000 established cases of ALS. The early disease diagnosis is challenging due to many overlapping pathophysiologies with other neurological diseases. The etiology of ALS is...
Article
Gastrointestinal (GI) cancers are one of the leading causes of death worldwide. Although various approaches are implemented to improve the health condition of GI patients, none of the treatment protocols promise for eradicating cancer. However, a treatment mechanism against any kind of disease condition is already existing executing inside the huma...
Article
Since green revolution, the food systems in most of the countries have dramatically changed but undernourishment still remains an inflammable problem. This alarming condition is even increasing due to the marginal supply of nutri-enriched food to eat. Under such chronically undernourished condition, dietary deficiencies of iron and zinc lead to com...
Article
Full-text available
Background: Human health issues caused by cigarette smoke carcinogens (CSC) are increasing rapidly every day and challenging the scientific community to provide a better understanding in order to avoid impact on communities. Cigarette smoke also contains tobacco-based chemical compounds harmful to human beings either smokers or non-smokers. Objecti...
Article
Novel strategies modulating the immune system yielded enhanced anticancer responses and improved cancer survival. Nevertheless, the success rate of immunotherapy in cancer treatment has been below expectation(s) due to unpredictable efficacy and off-target effects from systemic dosing of immunotherapeutic. As a result, there is an unmet clinical ne...
Article
Cystic fibrosis (CF) is an autosomal recessive disease which involves the mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. CF involves the inflammatory processes and is considered as a multisystem disorder that is not confined to lungs, but it also affects other vital organs that leads to numerous co-morbidities. Th...
Article
Full-text available
The head and neck squamous cell carcinoma (HNSCC) constitute about 90% of all head and neck cancers. HNSCC falls in the top 10 cancers in men globally. Epoxyazadiradione (EPA) and Azadiradione (AZA) are the limonoids derived from the medicinal plant Azadirachta indica (popularly known as Neem). Whether or not the limonoids exhibit activities agains...
Article
Biosurfactants are surface-active biomolecules, produced by various microbes and play an imperative role in different fields. A lot of research work is going on including media optimization strategies by using the low-cost substrates for their production in a promising amount. The commercial uses of biosurfactants in various industries like food, c...
Article
Full-text available
The coronavirus disease 2019 (COVID-19) pandemic, an infection caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2), has led to more than 771,000 deaths worldwide. Tobacco smoking is a major known risk factor for severe illness and even death from many respiratory infections. The effects of smoking on COVID-19 are currently cont...
Article
Full-text available
microRNAs (miRNAs) are a class of small non-coding RNAs that regulate the expression of their target mRNAs post transcriptionally. miRNAs are known to regulate not just a gene but the whole gene network (signaling pathways). Accumulating evidence(s) suggests that miRNAs can work either as oncogenes or tumor suppressors, but some miRNAs have a dual...
Article
Background Previously human society has faced various unprecedented pandemics in the history and viruses have majorly held the responsibilities of those outbreaks. Furthermore, due to amplified global connection and speedy modernization, epidemic outbreaks caused by novel and re-emerging viruses signify potential risk to community health. Despite g...
Article
Cancer cells exhibit distinct energy metabolic pathways due to multiple oncogenic events. In normoxia condition, the anaerobic glycolysis (Warburg effect) is highly observed in head and neck squamous cell carcinoma (HNSCC). HNSCC is associated with smoking, chewing tobacco, consumption of alcohol or Human Papillomavirus (HPV) infection primarily HP...
Article
Full-text available
The sesquiterpene lactones, Isodeoxyelephantopin (IDET) and Deoxyelephantopin (DET) are known to exhibit activities against some cancer types. The activities of these lactones against breast cancer and the molecular bases is not known. We examined the efficacy of lactones in breast cancer preclinical model. Although both lactones exhibited drug lik...
Article
A series of novel β‐carboline‐peptide (5 a‐5 f)/ tetrahydro‐β‐carbolines‐peptide (10 a‐10 f) has been synthesized via natural product inspired molecular hybridization approach. All the hybrids were examined for their anti‐leishmanial potential. Most of the screened derivatives exhibited significant in vitro anti‐leishmanial activity against promast...
Chapter
Due to rapid industrialization and urbanization, huge amount of production as well as accumulation of toxic and organic contaminants can lead to serious environmental problems. Unwanted buildup of untreated effluents and their discharge into water bodies negatively affects the stability and wholesomeness of natural aquatic ecosystems and may also b...
Chapter
Nanotechnology, a science dealing with particles at nano scale, is currently used in many fields including environmental management and medicine for welfare of human being. The economic development and quality of life have been improved through nanotechnology. The Polycyclic aromatic hydrocarbons (PAHs) and other toxicants have higher affinity to s...
Chapter
Ecological studies showed the association of exposure to carcinogens present surroundings an indoor and outdoor environment. The International Agency for Research on Cancer (IARC) has classified arsenic, asbestos, benzene, radon gas etc. into group 1 carcinogens. In many countries, pollution is rising due to trend of increasing industrialization an...
Chapter
Mutagenesis is the alteration of the genetic material by the help of mutagens. Mutations that are capable of inducing any diseases have a large impact on the biological systems. Whenever mutation occurs, it not only affects any particular gene or protein, but also affects the whole system related to that gene. Changes in one system will further bri...
Article
Full-text available
Breast cancer is the leading cause of death among women worldwide. It is a multi-factorial disease caused by genetic and environmental factors. Vitamin D has been hypothesized to lower the risk of breast cancer via the nuclear vitamin D receptor (VDR). Genetic variants of these vitamin D metabolizing genes may alter the bioavailability of vitamin D...
Chapter
The requirement and need of novel techniques to speed up the sanitization of polluted and adulterated sites and reduction in the expenses of these methods is a growing concern. The application of nanoparticles, predominantly the iron nanoparticles, as a pioneering and inventive technique to decontaminate the adulterated sites has received attention...
Article
The role of niacin’s metabolite, nicotinamide adenine dinucleotide (NAD), in DNA repair via base‐excision repair pathway is well documented. We evaluated if niacin deficiency results in genetic instability in normal human fetal lung fibroblasts (MRC‐5), and further, does it leads to enhanced accumulation of cigarette smoke–induced genetic damage? M...
Article
Purpose: The linkage of human T-cell leukemia virus type 1 (HTLV-1) to fatal diseases is a well known fact for many years. However, there has been no significant progress in the field of the treatment that can lead to the development of a successful vaccine. Furthermore, there are no means of assessing the risk of disease and its prognosis in the...
Article
β-carbolines have been assessed in osteoclastogenesis. However, their effect on osteoblast during estrogen deficiency is still unclear. Here, a series of novel piperazine and tetrazole tag β-carbolines has been synthesized and examined for osteoblast differentiation in vitro. In vitro data suggest that compound 8g is the most promising osteoblast d...
Article
Nanotechnology is a promptly growing field in this century, and it have been extensively used in several solicitations. Reactive oxygen species (ROS) generation is one of the important mechanism of action of nanoparticles. The excess ROS generation can induce oxidative stress, so the cells are unable to sustain the normal biological redox-regulated...
Article
Objective: At present, toxicological tests are resource-intensive, time-consuming and require a large pool of animal models for toxicity assessment. To speed up the toxicity evaluation and to reduce animal suffering during toxicity assessment, the use of alternative methods including computational models is in high demand. The computational toxicit...
Article
The immune signalling genes during challenge of bovine macrophages with bacterial products derived from disease causing bacteria in cattle were investigated. An in-vitro cell culture model were challenged to Mycobacterium bovis of bovine monocyte derived macrophages. Macrophages from healthy and already infected animals can both be fully activated...
Article
Full-text available
Zika virus (ZIKV) is a mosquito-borne flavivirus distributed all over Africa, South America and Asia. The infection with the virus may cause acute febrile sickness that clinically resembles dengue fever, yet there is no vaccine, no satisfactory treatment, and no means of evaluating the risk of the disease or prognosis in the infected people. In the...
Article
Goals: Fullerenes have tremendous potential for human biological studies which may further lead to their therapeutic applications. Hence, it has become necessary to explore the possibility of their interference with various important cellular processes. The current study was designed to explore how the presence of fullerenes can affect the binding...
Article
Full-text available
Expression of various cytochrome P450s (CYPs) in mammalian brain cells is well documented. However, such studies are hampered in neural/glial cells of human origin due to nonavailability of human brain cells. To address this issue, we investigated the expression and inducibility of CYP2C8 and CYP3A4 and their responsiveness against cyclophosphamide...
Chapter
We have performed the interaction analysis of cigarette smoke carcinogens with the enzymes involved in DNA repair mechanisms. Cigarette smoke’s derivatives like 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) are well known carcinogens. The binding efficiency of carcinogens with enzymes...
Chapter
It is widely accepted that non-ionizing electromagnetic fields are present in the environment and are alarming as a major pollutant or electro-pollutant for health risk. The present study aimed to investigate the protective measures of melatonin against exposure of microwave radiations. Study also explored the mechanistic correlation among microwav...
Chapter
Nanotechnology has a global socioeconomic significance. On the brighter side, Nanoparticles (NPs) offer extraordinary technical competencies which allow them to perform enormously novel developments in science and industries. Whereas, on the darker side, just the same novel qualities of nanoparticles can concurrently evoke undesired features, which...
Article
Clostridium difficile is an enteric pathogen that causes approximately 20% to 30% of antibiotic-associated diarrhea. In recent years, there has been a substantial rise in the rate of C. difficile infections as well as the emergence of virulent and antibiotic resistant C. difficile strains. So, there is an urgent need for the identification of thera...
Article
Full-text available
Zika virus (ZIKV) is a mosquito-borne flavivirus distributed all over Africa, South America and Asia. The infection with the virus may cause acute febrile sickness that clinically resembles dengue fever, yet there is no vaccine, no satisfactory treatment, and no means of evaluating the risk of the disease or prognosis in the infected people. In the...
Article
Breast cancer is a leading cause of death among women, around the world. It is a multifactorial disease involving genetic and environmental factors. Vitamin D is known to modulate biological processes like immune response, bone metabolism, cell growth regulation. The protective actions of vitamin D in cancer development are only sparsely understood...
Chapter
Full-text available
Article
Full-text available
Of late, a consirable interest has grown in literature on early development of arsenicosis and untimely death in humans after exposure to iAs in drinking water in utero or during the childhood. The mechanism of this kind of intrauterine arsenic poisoning is not known; however it is often suggested to involve stem cells. We looked into this possibil...
Article
Full-text available
Recently, the venues of exposure to nanoparticles have increased significantly owing to their increased deliberate production. In this study the interaction of fullerenes with DNA was analyzed along with various factors affecting this interaction like mol. wt. of fullerenes (C20 to C180), the form of DNA i.e., A, B and Z, and sequences of DNA, and...
Article
Background: Cissus quadrangularis Linn. (CQ) commonly known as Hadjod (Family: Vitaceae) is usually distributed in India and Sri Lanka and contains several bioactive compounds responsible for various metabolic and physiologic effects. Objective: In this study, the biological effects of CQ ethanolic extract were evaluated by in vitro and supporte...
Article
Full-text available
Cigarette smoke derivatives like NNK (4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone) and NNAL (4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol) are well-known carcinogens. We analyzed the interaction of enzymes involved in the NER (nucleotide excision repair) pathway with ligands (NNK and NNAL). Binding was characterized for the enzymes sharing e...
Article
Full-text available
Metal ions are required for many critical functions in living systems. Scarcity of some metal ions can lead to disease. A characteristic of metals is that they easily lose electrons from the familiar elemental or metallic state to form positively charged ions which tend to be soluble in biological fluids. Role of zinc, calcium and copper ions in th...
Article
We examined the interaction of Polycyclic Hydrocarbons (PAHs) like Benzo-α-Pyrene (BaP), Chrysene and their metabolites 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene,9,10-oxide (BPDE) & Chrysene1,2-diol-3,4-epoxide-2 (CDE), with the enzymes involved in DNA repair. We investigated interaction of120 enzymes with PAHs and screened out 40 probable targets am...
Article
Full-text available
Fullerenes have attracted considerable attention due to their unique chemical structure and potential applications. In this study fullerenes (C20 to C180) were interacted with different forms of DNA i.e. A, B and Z-forms. And no such change in the binding score was observed with the change in the sequence of DNA. In fact, binding score increases wi...
Article
Full-text available
Interaction pattern for the complex of B-DNAFullerene compounds with a set of known replication proteins using docking study
Article
Full-text available
ullerenes have attracted considerable attention due to their unique chemical structure and potential applications which has opened wide venues for possible human exposure to various fullerene types. Therefore, in depth knowledge of how fullerene may interfere with various cellular processes becomes quite imperative. The present study was designed t...
Conference Paper
Full-text available
Nanotechnology, actually means the exploitation of the substances at their nano-meter size, is expected to enhance the quality of life and economic development on the global basis. Recently some of the nanoparticles have been employed in scavenging the high molecular weight polycyclic aromatic hydrocarbons (PAHs) from the contaminated soils. Amphip...
Conference Paper
Full-text available
Synthesis of nanoparticles is an expensive and time consuming process. In the current era of information technology many commercial, non commercial, online and downloadable tools are available to design, analyze nanoparticles three dimensional (3D) structures and perform molecular interaction between nanoparticles and bio macromolecules. Computatio...