Anuj Malik

Maharishi Markandeshwar University, Mullana | MM University Trust, Mullana ·  College of Pharmacy

Objective: The objective of this study was to elucidate the effects of regular exercise, smoking and consumption of alcohol on pre diabetic condition. Methods: It is a prospective-observational study in the period of Six month in local society of barara in Ambala district, India. Among 1000 volunteers were included and ethical approval was also obt...

Prevalent as a major phenolic ingredient of soy and soy products, genistein is recognized as an eminent phytoestrogen owing to its interacting ability with estrogen receptors (ERs). The metabolic conversion of plant-derived genistin to genistein by gut microbes and intestinal enzymes enhances its absorption at intestinal pH of ~7.5-7.8. Genistein i...

Antimicrobial resistance (AMR) is a serious global warning to social wellbeing. Antimicrobial stewardship Intervention is evident to provide a good effect on AMR. Antimicrobial Stewardship Programs (ASPs) have been established to minimize the usage of antibiotics, antibiotic resistance, and healthcare expenditure. Prospective audits with feedback,...

Antibiotics are those drugs which are commonly used for therapeutic management of variety of bacterial infections. Nowadays, bacteria seem to have developed antibiotic resistance due to inappropriate use of medications. Pseudomonas aeruginosa is a nosocomial gram-negative pathogen which causes most fatal infections in humans. This species of pseudo...

Background Immune dysregulation associated with COVID-19 includes immune cell activation, inflammatory cytokine release, and neutrophil extracellular trap release (NETosis), which are mediated by spleen tyrosine kinase (SYK) (Fig 1). Fostamatinib, an oral spleen tyrosine kinase (SYK) inhibitor, was approved for immune thrombocytopenia (ITP) in 2018...

Antibiotics are drugs which are commonly used for therapeutic management of variety of bacterial infections. Nowadays, bacteria seem to have developed antibiotic resistance due to inappropriate use of medications. Pseudomonas aeruginosa is a nosocomial gram-negative pathogen which causes most fatal infections in humans. This species of pseudomonas...

Background: Irrational antibiotic usage major cause of spreading antimicrobial resistance therefore goal of this research was to refine prescribing patterns and may aid in addressing issues related to irrational antibiotic usage. Method: This prospective observational research was conducted at Maharishi Markandeshwar Institute of Medical Sciences &...

Superfluity drug delivery system (SFDDS) is an auspicious conception to obtain adequate oral bioavailability of poorly soluble drugs especially those drugs which are belongs to Biopharmaceutical Classification System II. The drug is in the form of high energy or otherwise swiftly dissolving form such that generated the drug in intraluminal concentr...

This article will provide information about pharmaceutical robots used in industry, as well as assemble and analyse data from previous years on the market's deploy only few micro or nanotechnology robots are now available for distribution of medicines. These robots have use in sterile production, laboratories, packaging, 3D printing, and other area...

Artificial Intelligence (AI) aims to create intelligent modelling that aids in imagining information, solving problems, and making decisions. In recent years, AI has become increasingly relevant in areas of pharmacy such as drug discovery, drug delivery formulation development, polypharmacology, hospital pharmacy, and so on. Artificial Neural Netwo...

Superfluity drug delivery system (SFDDS) is an auspicious conception to obtain adequate oral bioavailability of poorly soluble drugs especially those drugs which are belongs to Biopharmaceutical Classification System II. The drug is in the form of high energy or otherwise swiftly dissolving form such that generated the drug in intraluminal concentr...

The process of prescribing a set of standards or inherent characteristics, constant parameters, definitive qualitative and quantitative values that carry an assurance of quality, efficacy, safety, and reproducibility is known as standardization of herbal medicine.Since many factors affect bio efficacy and a consistent therapeutic impact, standardiz...

Background Key pathologies in severe COVID-19 include immune cell activation, inflammatory cytokine release, and neutrophil extracellular trap release (NETosis), which are mediated by spleen tyrosine kinase (SYK) (Figure 1). Fostamatinib, an oral SYK inhibitor approved for chronic immune thrombocytopenia, has shown activity in vitro using plasma fr...

Adherence has been defined as the “voluntary, active, and collaborative involvement of the patients in mutually acceptable courses of behaviour to produce desired therapeutic effects”. Medication adherence generally illustrates the term as to whether the patients take their medicines as per prescription instruction and either they keep on to take a...

Adherence has been defined as the "voluntary, active, and collaborative involvement of the patients in mutually acceptable courses of behaviour to produce desired therapeutic effects". Medication adherence generally illustrates the term as to whether the patients take their medicines as per prescription instruction and either they keep on to take a...

UV-spectrophotometric method has been developed in different mediums simultaneously for the assessment of Dextromethorphan hydrobromide (as model drug) with their analytical investigation from bulk. There was no report for the method validation of drug in Simulated Gastrointestinal fluid without enzymes. The equilibrium solubility of crystalline De...

Though the oral controlled drug delivery systems (DDS) offer a very attractive strategy for drug delivery, their efficiency is complicated by a number of physiological adversities. These include impulsive gastric emptying times (GET) and little gastric residence time (GRT). These, in turn, present a significant problem in complete release and absor...

ABSTRACT: Cancer is a genetic disorder that results from genetic or epigenetic alterations in the somatic cells and has abnormal cell growth which may be spread to other body parts. In 2018, 18 million cancer was recorded globally in which 9.5 million cancer cases in men, 8.5 million cases in women, and 9.6 deaths were also recorded in the same yea...

The novel virus such as corona virus 2019 is the main cause of the disease that is declared by the WHO (World Health Origination). Some other virus similar to this virus were also discovered in initial year of 21th century such as SARS-CoV in 2003, HCoV NL63 in 2004, HKU1 in 2005, MERS-CoV in 2012, and SARS-CoV-2 in 2019. The first few cases of cov...

Ulcers are lesions which is a discontinuity of gastrointestinal mucosa. A variety of medications are used to treat mild to reasonable ulcers. Drugs used to treat ulcers are called anti-ulcer drugs. Floating microspheres organized by solvent-evaporation method using polymers and solvents whose particle size analysis, encapsulation efficiency, scanni...

In targeted drug delivery systems, there is one of the most important drug delivery systems is colon targeting drug delivery system. This system is mainly used in the treatment of diseases like colonic cancer, ulcerative colitis, Crohn's disease. For local treatment of various bowel diseases colon is highly desirable. For the systemic action of non...

Nutraceuticals are merged from two words i.e., nutrition and pharmaceutical in which nutrition means a nourishing food component like vitamins, minerals, fibres, fats, carbohydrates etc which are essentials for maintaining human health and pharmaceutical means a medical drug. Nutraceuticals known as the food component or dietary supplement which pr...

Objectives: Fast dispersible tablets (FDTs) get dispersed very fast due to which the discrimination of in vitro drug release and their evaluation is difficult. Hence in the present study a new in vitro discriminatory dissolution method was developed and validated for FDTs of domperidone of BCS class II. Materials and methods: FDTs of domperidone...

Introduction Solid Lipid nanoparticles (SLN) are comprising of a solid lipid core with a mean diameter between 50 and 1000 nm. SLN is an advanced carrier system to traditional colloidal carriers such as emulsion, liposomes, and polymeric microparticles. Objective The objective of this study was to formulate SLN of Itraconazole (ITZ) for intranasal...

Thiamine (vitamin B1) was the primary water-soluble vitamin to possess been distinguished. It fills in as a substance for variety of chemicals associated with vitality digestion. The thiamine-subordinate compounds are vital for the amalgamation of neurotransmitters and for the formation of diminishing substances used in oxidizing operator stress pr...

The combination tablets dosage form of Telmisartan and Nebivolol hydrochloride dissolution method was developed by UV spectrophotometer and validated was according to the ICH guidelines. The any official method of this combination drugs was not available. In this proposed method two commercial brands of drug was used. The simultaneous estimation of...

The aim of the present study was to fabricate a thermosensitive gel containing chlorpheniramine maleate (CPM)–loaded nanoparticles following intranasal administration for effective treatment of allergic rhinitis. Chitosan-based nanoparticles were prepared by a precipitation method followed by the addition of developed NPs within the poloxamer 407–...

Amlodipine Besylate is used to treat hypertension and Coronary Artery Disease. It is a calcium channel blocker. Amlodipine Besylate blocks calcium movement into certain tissues and arteries which leads to the relaxation of arteries so that blood can flow more easily into our heart. Ramipril is also used to treat hypertension, prevent strokes, heart...

This is the advanced approach for development of pharmaceutical product with full range and specified limits of variables during procurements, storage and manufacturing process with a qualification, at desired level of quality within the limits of low and higher values of variables to ensures the Pharmaceutical product Quality by design (QbD) of ma...

Nutraceuticals are food of part of food material with the potential of maintaining health and may be characterized with physiological advantages or give assurance against perpetual maladies. Nutraceuticals play key role in maintaining the physiological variable in the normal range at cellular level or molecular level that's why, nutraceuticals migh...

Efficacy of pharmaceuticals dosage form generally depends on their formulation properties and manufacturing methods, hence it is likely that the quality of dosage form may vary. Renin acts on angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin-converting enzyme (ACE). Angiotensin II, a potent vasoconstrictor i...

Intellectual property rights (IPR) have been characterized as thoughts, developments, and imaginative articulations in view of which there is an open readiness to give the status of property. IPR give certain restrictive rights to the designers or makers of that property, so as to empower them to receive business rewards from their inventive endeav...

Pharmaceutical Analysis is the branch of chemistry involved in separating, identifying and determining the relative amounts of the components making up a sample of matter. It is mainly involved in the qualitative identification or detection of compounds and quantitative measurements of the substances present in bulk and pharmaceutical preparation....

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In vitro drug dissolution is important parameters in pharmaceutical discipline used to be checked the releases of drug product in standard conditions. Telmisartan includes in the classification system BCS class (II). The angiotensin II receptors blocker of Telmisartan freely used for hypertension. The aim of this proposed method was developed and v...

The aim of the current study was to formulate and optimize the formulation on the basis of in vitro performance of microsphere. Chromolyn Sodium Microspheres were prepared by o/w emulsification solvent diffusion technique using rate controlling polymers hydroxy propyl methyl cellulose and chitosan. The shape and surface morphology of prepared micro...

The safety and efficacy of a pharmaceutical dosage form can be guaranteed when its quality is reliable. The efficacy of pharmaceutical dosage forms generally depends on their formulation properties, and manufacturing methods, hence it is likely that the quality of dosage form may vary. The aim was to evaluate the quality of aceclofenac tablet marke...

The aim to develop a locally effective colon targeted therapeutic system in the form of a multiparticulate oral formulation that might provide an improved efficacy with a significant reduction in dose and systemic toxicity and improved quality of life for the treatment of Irritable Bowel Disease (IBD). The formulation of beads develops by inotropic...

The purpose of research work was to develop and optimize mucoadhesive microspheres of glibenclamide incorporated in in-situ gel for nasal delivery with the aim to enhance the residence time and improve therapeutic efficacy. Chitosan (mucoadhesive) based microspheres of glibenclamide were prepared by emulsification-crosslinking method. Glutaraldehyd...

Topical application of drugs to the eye is the most popular and well-accepted route of administration for the treatment of various eye disorders with various drugs like ACV (Acyclovir), an antiviral drug with a significant and highly specific activity against herpes viruses, particular, herpes simplex keratitis, with its poor water solubility (0.2...

Topical application of drugs to eye is the most popular and well-accepted route of administration for the treatment of various eye diseases. The anatomy, physiology and barrier function of the cornea decline the rapid absorption of drugs. Numerous strategies were developed to increase the bioavailability of ophthalmic drugs by prolonging the contac...

Coumarins, an old class of compounds, are naturally occurring benzopyrene derivatives. A lot of coumarins have been identified from natural sources, especially green plants. Coumarins have attracted intense interest in recent years because of their diverse pharmacological properties. Phytochemical investigation on the fruit of Aegle marmelos (Rutac...

Purpose: The objective of this study is preparation and evaluation of saquinavir mesylate oral suspension. Method: The suspensions were prepared by 2 3 factorial designed, dispersion method in which solid phase was sieved, wetted and dispersed by glycerol into the 2% solution of xanthrol 150. The suspensions were subjected to dissolution test and f...

The ionic gelatine method proved to be a simple, cost effective and extended the release of the metadoxine from prepared microbeads. The metadoxine is a water soluble drug, having the biological half life less than 1 hr. the microbeads prepared using sodium alginate and pectin as polymers formulation F4 showed 92% release up to 8 hrs. Among the var...

The objective of this work was to formulate and evaluate the floating tablets of atenolol. Tablets were prepared by direct compression method, where hydroxypropylmethylcellulose K-15M, sodium carboxymethylcellulose were used as swelling polymers, sodium bicarbonate as gas generating agent, dicalcium phosphate as diluent, magnesium stearate, talc as...

The antimicrobial activity of novel synthesized compounds was evaluated by Disc- Diffusion method. Compounds IVc, IVf and IVi showed better, while IVb, IVd and IVh showed moderate and rest showed poor antimicrobial activity. The Disc Diffusion method of assay of drug potency is based on the measurement of the zone of microbial growth inhibition sur...

The present study was designed to investigate the possible potential nephrocurative, and nephroprotective activity of 200mg/kg methanolic extract of Ficus religiosa L. latex was use to against cisplatin (5mg/kg, i.p.) induced acute renal failure. The experimental protocol designed as the animals were divided into four groups (n=6) like control, mod...

Scopoletin is a coumarin and a major component of Aegle Marmelos. In the present study, we determined the antioxidant activity of Scopoletin by employing various in vitro antioxidant assay such as 1, 1-diphenyl-2-picrul-hydrazil free radical (DPPH •) scavenging, Hydrogen peroxide scavenging, superoxide radical scavenging, Hydroxyl radical scavengin...

The objective of this work was to formulate and evaluate the floating tablets of atenolol. Tablets were prepared by direct compression method, where hydroxypropylmethylcellulose K-15M, sodium carboxymethylcellulose were used as swelling polymers, sodium bicarbonate as gas generating agent, dicalcium phosphate as diluent, magnesium stearate, talc as...

The ionic gelatine method proved to be a simple, cost effective and extended the release of the metadoxine from prepared microbeads. The metadoxine is a water soluble drug, having the biological half life less than 1 hr. the microbeads prepared using sodium alginate and pectin as polymers formulation F 4 showed 92% release up to 8 hrs. Among the va...

Spiro 1,2,4-trioxane are synthetic derivative of artemisinin (1,2,4-trioxane is supposed to be a pharmacophore of artemisinin) which is a well known antimalarial drug from leaves of Artemisia annua found in China. Spiro 1,2,4-trioxane substituted with admantane and its 4 different derivatives were synthesized using well standardized method. These c...

Defatted alcoholic extract of the oleo gum resin of Boswellia serrata was screened for antiinfianunatory activity in carrageenan induced rat paw edema at the dose level of 250 and 500 mg/kg and compared to the standard dnig diclofenac sodium. The result were found to be significant (p <0.001) when compared to the control.

Chemically metadoxine is pyridoxol L-2-pyrrolidone-5-carboxylate an ion pair that combines pyridoxine and Pyrrolidone carboxylate[1]. Metadoxine exerts several actions that are beneficial to patients with alcoholic liver diseases[2]. It increase the clearance of alcohol and acetaldehyde and decreases the damaging effect of free radicals, restores A...

Malaria is a major parasitic disease, affecting over 100 countries of the tropical and subtropical regions of the world.1 Around 300-500 million clinical cases of malaria are reported every year, of which more than a million die of severe and complicated cases of malaria.2 It is fatal for children below the age of 5 years. Every 40 seconds a child...

The nutraceuticals: food or part of food plays a significant role that modifies and maintains normal physiological function that maintaining healthy human beings. A number of nutraceuticals are available in the market that includes antioxidants, probiotics, prebiotics, omega-3 fatty acids and dietary fibers.IntroductionDrug and food from natural or...

A simple and sensitive spectroscopic method in ultraviolet region was developed and validated for the estimation of Metadoxine in pure and pharmaceutical dosage forms by derivative spectroscopy. The method is based on Metadoxine, showing absorbance at 292, 302, 270 and 314 nm for zero order, first order, second order and third order derivative spec...