Anubha Khale

• Faculty Member at Institute of Chemical Technology

Analogue design forms one of the mainstays of new drug discovery. A fast-follow on approach is commonly used by modern day drug discoverers on the quest of the best in class. Monitoring close structural analogues of the pioneering drug by an algorithm such as docking is fraught with the risk of returning false positives. In this paper, we present t...

Sustained release polymeric microspheres of lornoxicam are prepared by using calcium chloride gelatin followed by amphiphilic HPMCAS (Hydroxypropyl Methylcellulose Acetate Succinate H grade) polymer by solvent evaporation method. Polyvinyl alcohol (PVA) is used as an emulsifier which was found to improve shape whereas HPMCAS increased surface smoot...

The Clinical Research industry is growing at an unparalleled rate and India is increasingly being recognized as a quality player and a preferred partner for globalclinical trials. India has several prized attributes for clinical trial development, making it the “hub for global clinical research”, hence the demand for Clinical Research professionals...

The main aim of the work was to study the solubility behaviour of the poorly soluble drug from BCS Class IV, Tadalafil. The solubility determination was done by Shake flask method in different solvent systems (Water, Methanol, Water: Methanol, Water: SLS, in buffers of pH 1 to 7.4). The time of shaking was varied between 30 minutes and 48 hours. Th...

Plants have important role in Indian medicinal systems as well others nature based systems. The ethno botanical pharmacology is old and passes from ancient time. The important of plants medicines are they do not shows side effects as such of chemical molecules. Present paper focus on one of the important Indian plant which shows no. of pharmacologi...

nsufficient drug delivery across the blood–brain barrier (BBB) has been a major challenge in the chemotherapy of brain pathologies.Various novel approaches have been developed for the accurate detection of early-stage of cancer like brain tumor and for its targeted therapies. Newly developed targeted therapies limits the unwanted toxicity to health...

Antibody drug conjugates (ADCs) is an emerging class of Biotherapeutics which represents a unique treatment strategy in the field of Oncology. The majority of anticancer agents developed to date have substantial side effect profiles and a narrow therapeutic index. Antibody-drug conjugates (ADCs) combine the specificity of monoclonal antibodies (mAb...

Aloe vera is a perennial, drought-resisting, succulent plant belonging to the Asphodelaceae family which, historically has been used for a variety of medicinal purposes. It has a vast traditional role in indigenous system of medicine like ayurveda, siddha, unani and homoeopathy. The present reviews the phytochemical, traditional and pharmacological...

Atrophic vaginitis is a condition that arises when there is insufficient estrogen, resulting in a failure of the maturation of the vaginal epithelium. This is seen in any condition in which there is a significant decrease in estrogen production. (E.g. breast-feeding, natural menopause, women younger than 50 who have had a bilateral salpingo-oophore...

Process Analytical Technology (PAT) is an initiative of US FDA to ensure for a better quality product with minimum cost, minimum wastage and defects by a constant check on the quality attributes throughout a process. The PAT concept proved beneficial in maintaining the quality of many of the pharmaceutical and biotechnological process. Yet for all...

Polycystic ovarian syndrome (PCOS) is a heterogeneous endocrine disorder that affects about one in 15 women worldwide. It is a major disorder characterized by elevated levels of male hormones (androgens), acne and hirsutism. It can even cause insulin resistance, anovulation and infertility on prolong incidence of cysts. Since PCOS is a curable diso...

In the present study attempts were made to prepare metered dose inhalation of salbutamol in solution form and compared it with the marketed metered dose inhalation in suspension form. Solution form of the drug was found better than marketed suspension formulation with respect to homogeneity and content uniformity. Propellant blend P-11 and P-12 in...

The present article reveals an important role and wide applications played by the resins. Herbal system is considered as a complimentary and alternative system of medicines plays a significant role in India. Resins being the natural products are the secondary metabolites which have therapeutic actions in humans and which can be refined to produce t...

In the present article attempt has been made to explain the basic ideas and the significance of Thin layer Chromatography (TLC) in different analytical methods. As TLC is less time consuming, low cost, and can be performed with less complicated technique it has a wide application in pharmaceutical analysis. If performed precisely 32 amino acids can...

Metered Dose Inhalers (MDI) are most commonly used type of inhalers mainly used in Asthma and chronic obstructive pulmonary diseases (COPD). In MDI the specicialized devices such as pressurized canisters are used for drug delivery and the therapeutic response totally depends upon optimum drug delivery. MDI are used in emergency such as asthma attac...

A rapid, sensitive and specific RP-HPLC method involving U.V detection was developed and validated for the estimation of Cefixime and Cloxacillin in tablet dosage form. The method was validated in terms of linearity, accuracy, precision, specificity, robustness, limit of detection and limit of quantitation. The mobile phase used acetonitrile: tetra...