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Introduction
Antonio Pose-Reino currently works at the Internal Medicine, Conselleria de Sanidade. Antonio does research in Artificial Intelligence, Data Mining and Algorithms. Their current project is 'retinal microcirculation analysis.'
Skills and Expertise
Current institution
Additional affiliations
January 1980 - December 2018
Publications
Publications (251)
Copper is a trace element whose electronic configuration provides it with essential structural and catalytic functions. However, in excess, both its high protein affinity and redox-catalyzing properties can lead to hazardous consequences. In addition to promoting oxidative stress, copper is gaining interest for its effects on neurotransmission thro...
High lipoprotein(a) (Lp(a)) levels are associated with an increased risk of arterial hypertension (AHT) and atherosclerotic cardiovascular disease. However, little is known about the detailed profile of AHT based on Lp(a) levels. This observational study focused on elucidating the relationship between Lp(a) concentrations and specific indices obtai...
Background:
Long-term effects of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) infection still under study. The objectives of this study were to identify persistent pulmonary lesions 1 year after coronavirus disease 2019 (COVID-19) hospitalization and assess whether it is possible to estimate the probability that a patient develops...
As in other fields, chronotherapy applied to arterial hypertension (AHT) may have implications on oxidative stress. We compared the levels of some redox markers between hypertensive patients with morning and bedtime use of renin-angiotensin-aldosterone system (RAAS) blockers. This was an observational study that included patients older than 18 year...
A collaborative project in different areas of Spain and Portugal was designed to find out the variables that influence the mortality after discharge and develop a prognostic model adapted to the current healthcare needs of chronic patients in an internal medicine ward. Inclusion criteria were being admitted to an Internal Medicine department and at...
To date, no model has jointly encompassed clinical, inflammatory, and redox markers with the risk of a non-dipper blood pressure (BP) profile. We aimed to evaluate the correlation between these features and the main twenty-four-hour ambulatory blood pressure monitoring (24-h ABPM) indices, as well as to establish a multivariate model including infl...
Background:
Inhaled ethanol in the early stages of SARS-CoV-2 infection may reduce the viral load, decreasing progression and improving prognosis. The ALCOVID-19 trial was designed to study the efficacy and safety of inhaled ethanol in older adults at initial phases of infection.
Methods:
Randomized, triple-blind, placebo-controlled phase II cli...
Objectives:
GALIPEMIAS is a study designed to establish the prevalence of familial dyslipidemia in the general population of Galicia. The objective of the present study was to assess the prevalence of atherogenic dyslipidemia (AD), its relationship with other cardiovascular risk (CVR) factors, and the degree of lipid control.
Methods:
Cross-sect...
Background
Cardiovascular (CV) polypills are a useful baseline treatment to prevent CV diseases by combining different drug classes in a single pill to simultaneously target more than one risk factor. The aim of the present trial was to determine whether the treatment with the CNIC-polypill was at least non-inferior to usual care in terms of low-de...
An impaired nocturnal decrease in diastolic blood pressure (DBP) increases the blood pressure (BP) load, which is a main factor in endothelial dysfunction, atherosclerosis, and arterial stiffness. We aimed to quantify some markers of oxidative stress in hypertensive patients, to compare their levels between individuals with dipper and non-dipper DB...
In recent decades, progressive population aging in developed countries has led to a significant increase in the number of people with at least one chronic medical condition. As a result, acquiring knowledge about chronicity in medical school is key for physicians to be able to provide proper management for these patients. However, the presence of c...
We aimed to evaluate the correlation of plasma levels of thiobarbituric acid reactive substances (TBARS) and reduced thiols with morbidity, mortality and immune response during and after SARS-CoV-2 infection. This was an observational study that included inpatients with SARS-CoV-2 infection older than 65 years. The individuals were followed up to t...
Infection with SARS-CoV-2 has highly variable clinical manifestations, ranging from asymptomatic infection through to life-threatening disease. Host whole blood transcriptomics can offer unique insights into the biological processes underpinning infection and disease, as well as severity. We performed whole blood RNA Sequencing of individuals with...
Background
Hospitalized COVID-19 patients are prone to develop persistent symptoms and to show reduced quality of life following hospital admission.
Methods
Prospective cohort study of COVID-19 patients admitted to a hospital from March 1 to April 30, 2020. The primary outcome was to compare health related quality of life and persistent symptoms s...
Objective:
Carotid intima-media thickness (IMT) and pulse wave velocity (PWV) are the two most widely recognized methods for the assessment of arterial stiffness. The aim of this study was to verify whether there is a correlation between them and some blood parameters in dipper and non-dipper hypertensive patients.
Design and method:
This was a...
The aim of the study was to evaluate the correlation of plasma levels of thiobarbituric acid reactive substances (TBARS) and reduced thiols with morbidity, mortality and immune response in SARS-CoV-2 infection. This was an observational study that included inpatients with SARS-CoV-2 infection greater than 65 years old. Individuals were followed up...
In this article, the name of the GLORIA-AF investigator Anastasios Kollias was given incorrectly as Athanasios Kollias in the Acknowledgements. The original article has been corrected.
We aimed to explore the influence that the circadian blood pressure (BP) profile could exert on the correlation between some inflammatory markers and hypertension-mediated organ damage (HMOD). This was a cross-sectional study that included patients with primary arterial hypertension older than 18 years old. We included some parameters of 24 h ambul...
COVID-19 symptoms range from mild to severe illness; the cause for this differential response to infection remains unknown. Unravelling the immune mechanisms acting at different levels of the colonization process might be key to understand these differences. We carried out a multi-tissue (nasal, buccal and blood; n = 156) gene expression analysis o...
Background
Low dose dexamethasone demonstrated clinical improvement in patients with coronavirus disease 2019 (COVID-19) needing oxygen therapy; however, evidence on the efficacy of high dose of dexamethasone is limited.
Methods
We performed a randomised, open-label, controlled trial involving hospitalised patients with confirmed COVID-19 pneumoni...
Background
Non-convulsive status epilepticus (NCSE) often goes unnoticed and is not easily detected in patients with a decreased level of consciousness, especially in older patients. In this sense, lack of data in this population is available.
Aims
The aim of the present study was to examine daily clinical practice and evaluate factors that may in...
Introduction: Aortitis is seen in a wide variety of diseases. It was rarely found in the past but this is changing because of new imaging techniques.
Case description: We present the case of a 45-year-old man who was found on thyroid ultrasound to have infrarenal aortitis and pathological lymphadenopathies in different locations. After an exhausti...
Resumen
Antecedentes/Contexto
Existe una tendencia en los pacientes hospitalizados por COVID-19 a desarrollar síntomas persistentes y a presentar una disminución en su calidad de vida tras el ingreso hospitalario.
Métodos
Estudio de cohorte prospectivo de pacientes COVID-19 con ingreso hospitalario entre el 1 de marzo al 30 de abril de 2020. El o...
Inhaled administration of ethanol in the early stages of COVID‐19 would favor its location
on the initial replication sites, being able to reduce the progression of the disease and improving its prognosis. Before evaluating the efficacy and safety of this novel therapeutic strategy in humans, its characterization is required. The developed 65° etha...
Introduction
COVID-19 have been a challenge for healthcare, mainly in elderly patients in Nursing Homes (NHs) and Long-Term Care Facilities (LTCFs). We present a pioneering novel experience in addressing healthcare of very elderly patients with COVID-19 in these facilities by a reconversion of a NH in a medicalized NH.
Methods
All patients admitte...
IntroductionThe syndrome of inappropriate antidiuretic hormone secretion (SIADH) is the most common cause of hyponatraemia in hospital inpatients. We present data on treatment setting, patient characteristics, and outcomes for patients treated with tolvaptan for SIADH across a range of real-world settings in Germany and Spain.Methods
This was a non...
Aim
The SAMe-TT2R2 score helps identify patients with atrial fibrillation (AF) likely to have poor anticoagulation control during anticoagulation with vitamin K antagonists (VKA), and those with scores >2 might be better managed with a target-specific oral anticoagulant (NOAC). We hypothesized that in clinical practice, VKAs may be prescribed less...
Objectives
To determine whether nutritional risk is associated with the mortality of elderly patients hospitalized with nonvalvular atrial fibrillation (NVAF).DesignProspective, multicenter cohort study.SettingInternal medicine departments in Spain.ParticipantsInpatients >75 years with NVAF.MeasurementsWe measured the thrombotic and hemorrhagic ris...
Background
Pleural effusion occurs as a response of the pleura to aggressions. The pleura reacts differently according to the type of injury. However, pleural reactions have not yet been characterized. The objective of this study was to identify homogeneous clusters of patients based on the analytical characteristics of their pleural fluid and iden...
Introduction and objectives:
Coronavirus disease (COVID-19) has been designated a global pandemic by the World Health Organization. It is unclear whether previous treatment with angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) affects the prognosis of COVID-19 patients. The aim of this study was to evaluate t...
Objectives
To determine whether nutritional risk is associated with the mortality of elderly patients hospitalized with nonvalvular atrial fibrillation (NVAF).DesignProspective, multicenter cohort study.SettingInternal medicine departments in Spain.ParticipantsInpatients >75 years with NVAF.MeasurementsWe measured the thrombotic and hemorrhagic ris...
Introduction and objectives: Coronavirus disease (COVID-19) has been designated a global pandemic by the World Health Organization. It is unclear whether previous treatment with angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) affects the prognosis of COVID-19 patients. The aim of this study was to evaluate th...
Background:
Pleural effusion occurs as a response of the pleura to aggressions. The pleura reacts differently according to the type of injury. However, pleural reactions have not yet been characterized. The objective of this study was to identify homogeneous clusters of patients based on the analytical characteristics of their pleural fluid and id...
Objectives
To determine the prevalence of sarcopenia, frailty and cognitive impairment in elderly patients with nonvalvular atrial fibrillation (NVAF) and the factors’ influence on survival.
Methods
Prospective, multicentre cohort study of patients older than 75 years with NVAF hospitalised in internal medicine departments in Spain. For each patie...
Resumen
Objetivos
Determinar la prevalencia de la sarcopenia, la fragilidad y el deterioro cognitivo en pacientes ancianos con fibrilación auricular no valvular (FANV) y su influencia en la supervivencia.
Métodos
Estudio de cohortes, prospectivo y multicéntrico realizado con pacientes > 75 años con FANV hospitalizados en servicios de Medicina Int...
AimRenal insufficiency is associated with medical complications in patients with non-valvular atrial fibrillation (NVAF). However, data for elderly patients are scarce. Thus, the main objectives of the present study were to analyze the characteristics of elderly patients with NVAF and acute or chronic renal disease, describe their management in rea...
In the original publication, all the collaborator names were incorrectly tagged and published online. The correct given and family names for the collaborators names should list as follows.
Frailty is an important prognostic factor in older adults with cardiovascular diseases. We aim to describe the characteristics of elderly hospitalised frail patients with non-valvular atrial fibrillation (NVAF) and to assess the influence of frailty, along with other functional and health status variables on anticoagulation prescription, 1-year all...
Objective
To identify factors associated with poor anticoagulation control with vitamin K antagonists (VKA) among outpatients with nonvalvular atrial fibrillation (NVAF) attended in Neurology and Internal Medicine in Spain.
Methods
Cross-sectional and multicenter study, from the ALADIN database, of outpatients with NVAF treated with VKA and attend...
Introduction: Residual cardiovascular risk remains high in patients with atherosclerotic cardiovascular disease despite current antithrombotic therapy. On the other hand, patients with atrial fibrillation have an increased risk of myocardial infarction and cardiovascular death. As a result, a new antithrombotic approach appears necessary to reduce...
Objective:
To identify factors associated with poor anticoagulation control with vitaminK antagonists (VKA) among outpatients with nonvalvular atrial fibrillation (NVAF) attended in Neurology and Internal Medicine in Spain.
Methods:
Cross-sectional and multicenter study, from the ALADIN database, of outpatients with NVAF treated with VKA and att...
Aim
To determine the factors associated with discontinuing or not starting oral anticoagulation (OA) therapy in older patients with non‐valvular atrial fibrillation (NVAF).
Methods
A prospective, multicenter cohort study was carried out of patients aged >75 years with NVAF hospitalized in internal medicine departments in Spain. For each patient, w...
Objectives
To evaluate the degree of compliance with the current guidelines regarding venous thromboembolism (VTE) prophylaxis in medical patients during admission and to identify risk factors linked to complications of VTE prophylaxis.
Design
Prospective cohort study.
Setting
The Internal Medicine Department of the University Hospital of Santiag...
En los próximos 8 años se espera un cambio demográfico
poblacional similar al ocurrido en los últimos 40
años, donde el 30% de la población será mayor de 65
años.
Objective:
To estimate the prevalence of orthostatic hypotension (OH) in patients 80 years old and over attending a primary care unit. To relate OH to the most prevalent pathologies and to the most used drugs.
Design:
Transversal observational study.
Location:
Primary care unit, Santiago de Compostela.
Participants:
Eighty one patients 80 ye...
Background
Although, by itself, atrial fibrillation is associated with an impairment of quality of life antithrombotic therapy may play a role.
Objective
To evaluate the satisfaction with anticoagulant treatment in patients with nonvalvular atrial fibrillation who attended internal medicine departments in Spain.
Methods
Patients from two differen...
Aim. To determine the clinical profile, management of anticoagulant treatment and satisfaction related to anticoagulation in outpatients with nonvalvular atrial fibrillation attended in Neurology or Internal Medicine departments of Spain. Patients and methods. Cross-sectional and multicenter study, in which 1,337 outpatients were included. Patients...
Objectives:
Atrial fibrillation (AF) has been associated with higher mortality. We aimed to identify the baseline predictors of in-hospital mortality among elderly patients with non-valvular AF (NVAF) hospitalised for any reason.
Methods:
Observational, prospective and multicentre study was carried out on patients with NVAF over the age of 75, w...
Objective:
The aim of our study is to analyse hospital readmissions due to asthma, as well as the factors associated with their increase.
Study design:
We carried out a retrospective study including all admissions of patients over 18 years old due to exacerbation of asthma occurring in our hospital between the years 2000 and 2010.
Methods:
The...
Heart failure (HF) is currently one of the most significant healthcare problems in Spain and has a continuously increasing prevalence. Advances in our understanding of the various biological responses that promote cardiac remodeling and pulmonary venous congestion constitute the basis of current treatment.
This article, prepared by members of the H...
Heart failure (HF) is currently one of the most significant healthcare problems in Spain and has a continuously increasing prevalence. Advances in our understanding of the various biological responses that promote cardiac remodelling and pulmonary venous congestion constitute the basis of current treatment. This article, prepared by members of the...
The prevalence of non-valvular atrial fibrillation (NVAF) increases with the patient's age and is associated with high morbi-mortality rates. The main goal of this study was to describe the characteristics of hospitalized elderly patients with NVAF and to identify the clinical and functional factors which determine the use of different antithrombot...
Background and objetives:
The prevalence of non-valvular atrial fibrillation (NVAF) increases with the patient's age and is associated with high morbi-mortality rates. The main goal of this study was to describe the characteristics of hospitalized elderly patients with NVAF and to identify the clinical and functional factors which determine the us...
Objective:
We have followed patients admitted to a Polypathology and Advanced Age Unit for two years in order to identify the variables that best define the mortality prognosis at medium-term (1-2years) for chronic and polypathological patients requiring admission at an Internal Medicine Department.
Methods:
This is an observational, prospective...
Background and objective
To validate the satisfaction questionnaire Anti-Clot-Treatment Scale (ACTS) in outpatients with nonvalvular atrial fibrillation (NVAF) treated with oral anticoagulants attended in Internal Medicine and Neurology departments in Spain.
Methods
In this cross-sectional and multicentrer study, 1337 outpatients aged ≥18 years, w...
A case of a patient admitted in the internal medicine unit with a clinical picture of rhabdomyolysis, hyponatraemia and convulsions. It was probably caused by a serotonin syndrome triggered by a drug interaction between venlafaxine and amoxicillin/clavulanic acid.
Europen Congress of Intrnal Medicine
The increase in serum urate concentrations (hyperuricemia, ≥7.0 mg/dL) creates crystals, which promote inflammation and joint lesions. Ultrasonography can reveal these urate deposits. The presence of crystals suggests that a patient with hyperuricemia is actually experiencing asymptomatic gout, and that a patient with gout without subcutaneous toph...
Background and objective:
To validate the satisfaction questionnaire Anti-Clot-Treatment Scale (ACTS) in outpatients with nonvalvular atrial fibrillation (NVAF) treated with oral anticoagulants attended in Internal Medicine and Neurology departments in Spain.
Methods:
In this cross-sectional and multicentrer study, 1,337 outpatients aged≥18 year...
Background:
Several studies suggest that there is a pathogenic link between chronic obstructive pulmonary disease (COPD) and cardiovascular diseases. On the other hand, increased sympathetic tone has been described in several respiratory diseases. Our objective was to determine whether hypertension mediated by sympathetic overactivity is a mechani...
Supplemental Tables A to F.
(DOC)
The increase in serum urate concentrations (hyperuricaemia, ≥7.0mg/dL) creates crystals, which promote inflammation and joint lesions. Ultrasonography can reveal these urate deposits. The presence of crystals suggests that a patient with hyperuricaemia is actually experiencing asymptomatic gout, and that a patient with gout without subcutaneous top...
Background and objective: With the development of image processing techniques, it has become possible to measure the changes in retinal vessels of hypertensive patients by means of eye fundus photographs. Patients and method: In this paper we aim to classify retinal vessels automatically into arterioles and venules. In order to do so, we have compa...
Aims
Hyponatraemia is an electrolyte disorder that occurs in advanced congestive heart failure (HF) and worsens prognosis. We explored the usefulness of tolvaptan, which has shown promising results in the treatment of this condition.
Methods and results
This study is based on a retrospective national registry (2011–15) of patients hospitalized wit...
Background: Atrial fibrillation (AF) in the elderly is a complex condition. It has a direct impact on the underuse of antithrombotic therapy reported in this population. Discussion: All patients aged ≥75years with AF have an individual yearly risk of stroke >4%. However, the risk of hemorrhage is also increased. Moreover, in this population it is c...
Resumen Objetivos: Presentar las características clínicas de los pacientes incluidos en el estudio CRONIGAL y conocer la mortalidad al año de seguimiento. Métodos: Se reclutan 698 pacientes ingresados en la planta de Medicina Interna entre junio de 2010 y julio de 2011. Se excluyen los pacientes con datos perdidos, aquellos que no firman el consent...
Resumen Objetivos: Determinar las características diferenciales pronósticas de supervivencia a 6 meses en los pacientes crónicos y pluripatológicos ingresados en un Servicio de Medicina Interna y Pluripatología. Evaluar y comparar la performance del índice PROFUND con el índice CRONIGAL en esos pacientes. Métodos: Estudio observacional, longitudina...
Resumen Objetivos: Comparar la utilidad de dos índices para predecir la mortalidad al cabo de un año en pacientes pluripatológicos (PP). Métodos: Se han incluido de forma prospectiva los PP dados de alta vivos tras un ingreso en una unidad de Medicina Interna de un hospital de segundo nivel. Para el diagnóstico se han utilizado los criterios de la...
Background
Atrial fibrillation (AF) in the elderly is a complex condition. It has a direct impact on the underuse of antithrombotic therapy reported in this population.
Discussion
All patients aged ≥75 years with AF have an individual yearly risk of stroke >4 %. However, the risk of hemorrhage is also increased. Moreover, in this population it is...
Asthma remains a major public health concern because of its high prevalence and the costs it generates. Near-fatal asthma (NFA) episodes represent the most severe forms of the disease after fatal asthma with significant variations in their incidence between different populations.
To analyze the episodes of NFA over a period of 11 years in the hospi...
Objective: The aim of this study was to assess circadian blood pressure pattern and nocturnal hypertension prevalence in those hypertensive subjects with mild-moderate chronic kidney disease. Design and method: A cross-sectional study was conducted among a cohort hypertensive subjects over 18 years old. BP was measured by ambulatory monitoring (ABP...
Objective: The aim of this study was to identify cardiovascular risk factors in a cohort of hypertensive subjects over 70 years. Design and method: We designed a retrospective cohort study. The study population included 72 hypertensive patients over 70 years and they all underwent a complete annual medical examination from January 2011 to December...
Atrial fibrillation (AF) in the elderly is a complex condition due to the high number of frequently associated comorbidities, such as cardiovascular and kidney disease, cognitive disorders, falls and polypharmacy. Except when contraindicated, anticoagulation is necessary for preventing thromboembolic events in this population. Both vitamin K antago...
Introduction:
The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is the most frequent cause of hyponatremia in a hospital setting. However, detailed protocols and algorithms for its management are lacking. Our objective was to develop 2 consensus algorithms for the therapy of hyponatremia due to SIADH in hospitalized patients.
M...
Background:
Patients with lung cancer usually present with symptoms at the time of diagnosis, but it is common that neither the doctor nor the patient initially associate them with the possibility of a malignant tumour.
Objectives:
The aim of our study is to analyse the symptoms of patients with lung cancer and the relationship with the personal...
