Antonio Olry de Labry

• PhD, MPH
• Technician at Andalusian School of Public Health

RESUMEN Fundamentos Se estima que un 80% de la población mundial está en riesgo de contraer una enfermedad de transmisión vectorial, siendo los mosquitos los responsables de una mayor carga de enfermedad. Dado que el control biológico es una opción más natural que otras intervenciones disponibles y que el uso de peces está muy extendido, el objeti...

Objective Given that vector control represents the primary strategy for preventing these diseases, the objective of this systematic review is to ascertain the efficacy of chemical interventions in reducing their burden. Methods The PRISMA guidelines were followed to search for experimental studies published between 1987 and 2024 in English, Portug...

Objective: To synthesize the available evidence on antipsychotic gradual dose reduction or abrupt deprescription in the older people population with dementia. Methods: A systematic review of intervention studies. PubMed, Embase, Web of Science-Core Collection, Cochrane Library, Scopus, MEDLINE(Ovid), and PsycINFO databases were consulted. Articles...

Dado el crecimiento exponencial de la producción científica, resulta imprescindible que profesionales y la comunidad universitaria dispongan de herramientas y competencias para hacer eficiente la búsqueda de información relevante. Las necesidades de información requieren ser trabajadas y transformadas en preguntas susceptibles de ser contestadas, p...

Background The incidence of self-harm and suicidal behaviour in adolescents is increasing. Considering the great impact in this population, an actualization of the evidence of those psychological treatment’s excellence for suicidal behaviour. Thus, the aim of this paper is to compile the available evidence on the effectiveness of cognitive behaviou...

Introduction Abemaciclib is an oral inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6). Data from the clinical trial monarchE (2023) showed improved survival from invasive disease. The aim of the present article was to conduct an economic assessment of adjuvant treatment with abemaciclib in women with luminal, HER2- and node-positive breast can...

Objective: To evaluate the value of the provision of contracted versus hospital dialysis services for the treatment of chronic kidney disease in Spain using the multicriteria decision analysis methodology. Method: The EVIDEM (Evidence and Value: Impact on Decision Making) evaluation framework was used to calculate the estimated value of both dia...

Background Patients provide a unique, irreplaceable, and essential perspective in evaluating patient safety. The suite of Patient Reported Experiences and Outcomes of Safety in Primary Care (PREOS-PC) tools are a notable exception to the scarcity of patient-reported patient safety measures. Full evaluation of their performance has only been attempt...

Purpose The ADAURA trial demonstrated the superiority of osimertinib over a placebo with regard to disease-free survival, showing it to be indicated as an adjuvant therapy for treatment of non–small cell lung cancer with mutated epidermal growth factor receptor (EGFR). The aim of the present study was to conduct a cost-utility analysis and an analy...

Background The use of health surveys has been key in the scientific community to promptly communicate results about the health impact of COVID-19. But what information was collected, where, when and how, and who was the study population? Objective To describe the methodological characteristics used in large health surveys conducted in Spain early...

Background INES (INteractive model for Extrapolation of Survival and cost) provides an open-access tool powered by R that implements three-state partitioned survival models (PSM). This article describes the properties of the tool, and the situations where INES may or may not be suitable. Methods INES is designed to be used by investigators or heal...

The shortage of physicians in rural and underserved areas is an obstacle to the implementation of Universal Health Coverage (UHC). We carried out a systematic review to analyze the effectiveness of initiatives in medical education aimed to increase the supply of physicians in rural or underserved areas. We searched for studies published between 199...

Background INES (INteractive model for Extrapolation of Survival and cost) provides an open-access tool powered by R that implements partitioned survival models (PSM). This article describes the properties of the tool, and the situations where INES may or may not be suitable. Methods INES is designed to be used by investigators or healthcare profes...

Introduction: Chronic kidney disease represents an important health problem, due to its high incidence and prevalence, as well as its significant morbidity and mortality and socioeconomic cost. Aims: compare the effectiveness and economic consequences of outsourcing versus hospital dialysis. Method: A scoping review, for which different databa...

Background Self-perceived minor ailments might conceal other health conditions if patients are not appropriately assisted by health care professionals. The aim of the study was to evaluate the patient-related outcomes of a community pharmacy Minor Ailment Service (MAS) compared to usual pharmacist care (UC). Methods A cluster randomised controlled...

Background: There has been a steadily growing trend in prescribing benzodiazepines over last decade. Spain is one of the countries where this class of drugs is most extensively prescribed by primary healthcare physicians. The aim of this study is to identify factors that might be acting as barriers and enablers for benzodiazepine (de)prescription...

Objectives Advanced therapy medicinal products (ATMPs) are drugs for human use for the treatment of chronic, degenerative, or life-threatening diseases that are based on genes, tissues, or cells. This article aimed to identify and critically review published economic analyses of ATMPs. Methods A systematic review of economic analyses of ATMPs was...

Resumen Objetivo: evaluar el valor de la prestación de servicios de diálisis concertada frente a la hospitalaria para el tratamiento de la enfermedad renal crónica en España mediante la metodología de análisis de decisión multicriterio. Método: se utilizó el marco de evaluación EVIDEM (Evidence and Value: Impact on Decision Making), para el cálculo...

Introduction: Non-adherence to medications is one of the challenges health systems faces. Patients with poor adherence to treatment fail to benefit from effective medication, and this is associated with reductions in quality of life, poorer outcomes, increased hospitalisations, deaths, and, consequently, higher healthcare costs. Community pharmacie...

Several studies have shown how energy poverty (EP) increases morbidity and mortality, being a growing problem worldwide. We conducted a scoping review to synthesize the state of knowledge on the relationship between energy poverty (EP) and health, analysing the results according to different axes of inequality (gender, age, ethnicity/country of bir...

Vector-borne diseases are a major public health problem. Among them, dengue, Zika and chikungunya illnesses are increasing their incidence and geographical expansion. Since vector control is the main measure to prevent these diseases, this systematic review aims to determine the effectiveness of environmental interventions for the prevention of the...

Introduction Costs are one of the critical factors for the transferability of the results in health technology assessment and economic evaluation. The objective is to develop a cost database at the European level to facilitate cross-border cost comparisons in different settings and explains the factors that lead to differences in healthcare costs i...

Aim: The primary aim was to examine the feasibility of intervention delivery and of trial procedures. Secondary aims were to study the intervention uptake; its acceptability and perceived utility; and its potential to improve safety culture and avoidable hospital admissions. Methods: We conducted a 3-month, single-arm feasibility study in 10 pri...

Background The lack of transparency in the methodology of unit cost estimation and the usage of confidential or undisclosed information prevents cost comparisons and makes the transferability of the results across countries difficult. The objective of this article is to compare the methodologies used in the estimation of the cost of a day case cata...

Objective: To determine the baseline characteristics associated with higher mortality at 42 days in patients hospitalized for COVID-19 in Spain. Method: The study analyzed a prospective cohort of hospitalized COVID-19 patients. The dependent variable was 42-day mortality. Data on the subjects' demographic and clinical characteristics, comorbidit...

Resumen Introducción La enfermedad renal crónica representa un importante problema de salud, tanto por su elevada incidencia y prevalencia, como por su importante morbimortalidad y coste socioeconómico. Objetivo Comparar la efectividad y consecuencias económicas de la diálisis concertada frente a la diálisis hospitalaria. Metodología Revisión de...

Introduction The global health emergency caused by the current COVID-19 pandemic is resulting in a huge challenge at all levels. The use of masks may reduce the spread of the infection by minimising the excretion of Flügge droplets. The objective of this study was to compile the evidence available on the use of masks in relation to respiratory infe...

A correction to this paper has been published: https://doi.org/10.1007/s10198-021-01313-0

Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most widely used drugs worldwide. This makes it necessary to carry out a comprehensive synthesis of the available evidence on the safe and adequate prescription of NSAIDs in patients with cardiovascular disease, chronic kidney disease, hypertension, heart failure or liver cirrhosis and in...

BACKGROUND Developing new strategies to support the provision of safer primary care (PC) is a major priority both internationally and in Spain, where around 3 million adverse events occur each year in the PC setting. OBJECTIVE The primary aims of this mixed-methods feasibility study were to examine the feasibility and to explore the acceptability...

Background The lack of transparency in the methodology of unit cost estimation and the usage of confidential or undisclosed information prevents cost comparison and makes the transferability of the results across countries difficult. The objective of this article is to compare the methodologies used in the estimation of the cost of a day case catar...

Background Hyperkalaemia (HK) is a common electrolyte disorder in patients with chronic kidney disease (CKD) and/or treated with inhibitors of the renin-angiotensin-aldosterone system (RAASi). The aim of this study is to determine the severity, current management and cost of chronic HK. Methods Retrospective cohort study of patients with chronic H...

Breast cancer is one of the most frequent malignancies. The aim of the article is to analyse the cost-utility ratio and budgetary impact of talazoparib treatment for patients with locally advanced or metastatic gBRCA+ breast cancer from the perspective of the Spanish National Health System. Analyses were based on the EMBRACA clinical trial and the...

Objective: This study aimed to cross-culturally adapt, validate, and pilot the Patient Reported Experiences and Outcomes of Safety in Primary Care questionnaire for its use in Spain. Methods: After setting up an expert panel to determine its content validity, the questionnaire was translated and back-translated, and subjected to cognitive testin...

Resumen Introducción La emergencia sanitaria global causada por la actual pandemia de COVID-19 está suponiendo un enorme desafío a todos los niveles. El uso de la mascarilla puede reducir la propagación de la infección al minimizar la excreción de las gotitas de Flügge. Así, el objetivo de este trabajo es realizar una recopilación de la evidencia...

Background: There is a high prevalence of potentially inappropriate prescriptions in primary care. This is associated with more frequent adverse events, lower quality of life and more frequent visits to hospital accident & emergency departments. The aim of the present study is to summarise available evidence on the effectiveness of deprescription...

According to the most traditional economic evaluation manuals, all “relevant” costs should be included in the economic analysis, taking into account factors such as the patient population, setting, location, year, perspective and time horizon. However, cost information may be designed for other purposes. Health care organisations may lack sophistic...

Environmental risks are responsible for one in five of all deaths worldwide. Persistent, bioaccumulative, and toxic substances are chemicals that can subsist for decades in human tissues and the environment. They include heavy metals, organochlorines, polychlorinated biphenyls, organobromines, organofluorines, and polycyclic aromatic hydrocarbons a...

Introduction Despite the enormous potential for adverse events in primary healthcare (PHC), the knowledge about how to improve patient safety in this context is still sparse. We describe the methods for the development and evaluation of an intervention targeted at PHC professionals to improve patient safety in Spanish PHC centres. Methods and anal...

The objective of this article is to analyze the ratio of cost-effectiveness and budgetary impact of lenalidomide treatment in patients with multiple myeloma who have undergone autologous transplant in Spain. The analyses were based on clinical trials CALGB 100104 and IFM 2005-02, from the perspective of the National Health System. The alternatives...

Objective To compare the survival among patients with chronic kidney disease who had optimal starts of renal replacement therapy, dialysis or hemodialysis, with patients who had suboptimal starts. Methods A retrospective cohort consisting of >18 year-old patients who started renal replacement therapy, using peritoneal dialysis or hemodialysis, in...

Background: To analyse trends in the rates of consumption of benzodiazepine (BZD) anxiolytics, BZD hypnotics and non-BZD hypnotics and the association with contextual factors. Methods: Descriptive time series study. Units of analysis were monthly dose per inhabitant per day (DID) and dose per medical card per day(DCD) of benzodiazepine(BZD anxio...

Background: The control of vector-borne diseases (VBD) is one of the greatest challenges on the global health agenda. Rapid and uncontrolled urbanization has heightened the interest in addressing these challenges through an integrated vector management (IVM) approach. The aim was to identify components related to impacts, economic evaluation, and...

En este documento se presenta una breve revisión, en español, de la evidencia que existe acerca de los tratamientos eficaces para el trastorno de ansiedad.

Background: The aim of this study is to determine the effectiveness of non-pharmacological interventions for prevention of cardiovascular disease (CVD) events and mortality in healthy adults or those at high risk of CVD. Methods: An umbrella review about primary prevention of non-pharmacological interventions was undertaken in key databases as P...

It has been hypothesized that circadian disruption is related to higher cancer risk. Since the International Agency for Research on Cancer classified shift work involving circadian disruption as probably carcinogenic to humans (Group 2A), multiple studies have been conducted to test this hypothesis. The aim of this systematic review was to summariz...

Introduction and objectives: To analyze the cost-effectiveness ratio and budget impact of treatment with evolocumab (PCSK9 inhibitor) for patients in secondary prevention in the Spanish National Health System. Methods: A budget impact analysis, decision tree and Markov models were designed under the public health system perspective, based on the...

Aim: Analyze the relative risks of critical cardiovascular outcomes and mortality associated with adherence to statin treatment in a clinical setting in people with no history of prior cardiovascular disease (CVD). Methods: A systematic review of the literature was conducted up to December 2016. The outcomes of interest were cardiovascular fatal...

Introduction The aim was to assess the impact on economic costs and length of stay (LOS) of postoperative complications. Methods 5822 records from BMDS (2014–2015) are included. A descriptive, univariate and multivariate study evaluated the correlation between complications, Clavien-Dindo grade and vacation periods with LOS and economic costs, bas...

Introduction: The aim was to assess the impact on economic costs and length of stay (LOS) of postoperative complications. Methods: 5,822 records from BMDS (2014-2015) are included. A descriptive, univariate and multivariate study evaluated the correlation between complications, Clavien-Dindo grade and vacation periods with LOS and economic costs...

Objective: To identify good practices in order to develop and implement indicators of health outcomes for clinical and healthcare management, as well as the characteristics for an indicator to be considered adequate. Methodology: A scoping review was performed, with the following phases: 1) Search and identification of bibliography. 2) Selection...

Resumen Introducción y objetivos Analizar la razón de coste-efectividad y el impacto presupuestario del tratamiento con evolocumab (inhibidor de la PCSK9) para pacientes en prevención secundaria en el Sistema Nacional de Salud español. Métodos Se realizaron, desde la perspectiva del sistema sanitario público, análisis de impacto presupuestario, m...

Aim: Health technology assessment (HTA) is a tool to help the decision-making process. The aim is to describe methods and processes used in the reimbursement decision making for drug-eluting stents (DES) in four different settings. Methods: DES as a technology under study was selected according to different criteria, all of them agreed by a work...

Introduction: Outcome measures are being widely used by health services to assess the quality of health care. It is important to have a battery of useful performance indicators with high validity and feasibility. Thus, the objective of this study is to perform a review of reviews in order to identify outcome indicators for use in Primary Care. Me...

Background: The human papillomavirus (HPV) vaccine has recently attracted considerable attention in emerging countries, due to its potential to reduce the impact of HPV-related diseases. This case study sheds new light about the variety of HTA arrangements, methods and processes involved in the adoption and use of HPV vaccines in a selected sample...

Objective: To gain knowledge and insights on health technology assessment (HTA) and decision-making processes in Central, Eastern and South Eastern Europe (CESEE) countries. Methods: A cross-sectional study was performed. Based on the literature, a questionnaire was developed in a multi-stage process. The questionnaire was arranged according to...

Objective: This article describes a Health Technology Assessment (HTA) toolbox that aims to improve the decision-making processes by providing information on best practices, practical experiences and recommendations on HTA. The toolbox is targeted to emerging settings, with emphasis on Central, Eastern and South-Eastern Europe (CESEE) and Region of...

Objective: To determine whether an intervention based on patient-practitioner communication is more effective than usual care in improving diabetes self-management in patients with type 2 diabetes with low educational level. Methods: 12-month, pragmatic cluster randomised controlled trial. Nine physicians and 184 patients registered at two pract...

Aim: To describe processes for the adoption of trastuzumab in four countries in the use of health technology assessment (HTA): Poland, Albania, Brazil and Colombia. Materials & methods: Mixed methods were used for collection and triangulation of data. Data were examined following a conceptual framework connecting HTA process steps and key princi...

El propósito de este Toolbox o “caja de herramientas” es el de mejorar el conocimiento sobre el proceso, las ventajas y el uso de la Evaluación de Tecnologías Sanitarias (ETS); acercar buenas prácticas, experiencias relevantes y recomendaciones para la mejora del proceso de toma de decisiones. Dirigido a responsables de políticas y profesionales, d...

Aim To provide insights into the capacity to conduct health technology assessment (HTA) in Central, Eastern, and South-Eastern Europe (CESEE), taking account of technical, financial, networking, and human resources. Methods An e-mail survey of 257 CESEE key informants involved in HTA was undertaken between March and April 2014. Contact e-mail addr...

To estimate the additional cost attributable to nosocomial infection (NI) in a pediatric intensive care unit (PICU) and related factors. A prospective cohort study was conducted in all children admitted to the PICU of a tertiary-care pediatric hospital between 2008 and 2009. Descriptive and bivariate analyses were conducted of total direct costs du...

Objective To estimate the cost, outcome and economic impact, of the use of a Blood Glucose Monitoring System (BGMS) with pattern alert technology compared with standard BGMS, for the prevention of severe hypoglycemia (SH) in the insulin-treated type 1 and type 2 diabetes populations. Material and methods A short term model has been constructed fro...

Realise a review of studies of economic evaluation about the ambulatory monitoring of capillary glucose (AMGC) in diabetic type II persons. A review of the literature was conducted, in MedLine, various websites, referenced paper and provided by expert's persons. Five studies concluded that the AMGC was a cost-effective strategic, of this papers use...

Background: In the last decades the presence of social inequalities in diabetes care has been observed in multiple countries, including Spain. These inequalities have been at least partially attributed to differences in diabetes self-management behaviours. Communication problems during medical consultations occur more frequently to patients with a...

Introduction and study objectives: To describe the development of biosimilars in 24 European Union (EU) Member States, plus Norway and Switzerland, and to identify the key parameters associated with biosimilars market dynamics across EU Member States. Methods: A quantitative analysis of the EU biosimilar market from 2007 to 2010 was conducted. Data...

Objective To estimate the difference between the consumption recommended by the Spanish Diabetes Society (SED) and the observed consumption of test strips for blood glucose level monitoring in people diagnosed with type 1 and 2 diabetes. Methods The dependent variable was the relative difference between the recommended test frequency according to S...

Introduccio´n: El ca´ncer de ce´rvix es un importante problema de salud pu´blica, ya que produce cerca del 10% de las defunciones femeninas por ca´ncer en el todo el mundo. Objetivo: Determinar el ratio coste-efectividad de la citologı´a de base lı´quida frente a la citologı´a convencional para la deteccio´n de lesiones precancerosas de ce´rvix. Me...

The aim of the paper is to compare the accuracy and effectiveness of liquid-based versus conventional cytology when used as part of a process of population screening to reduce the incidence of invasive cervical cancer. Data from split-sample studies were analysed by using a hierarchical Bayesian multiparameter evidence synthesis model. Predictions...

The aim of the paper is to compare the accuracy and effectiveness of liquid-based versus conventional cytology when used as part of a process of population screening to reduce the incidence of invasive cervical cancer. Data from split-sample studies were analysed by using a hierarchical Bayesian multiparameter evidence synthesis model. Predictions...

Objective: To carry out a systematic literature review to identify elements that either hinder or facilitate the entry of medicines in European countries characterized by small populations or low income levels. Methodology: We searched MedLine, Web pages, OECD Publications and PPRI reports, using key words and free terminology. We included studies...

The major increase in the prevalence of diabetes mellitus (DM) has led to the study of social inequalities in health-care. The aim of this study is to establish the possible existence of social inequalities in the prevention, diagnosis, treatment, control and monitoring of diabetes in Organisation for Economic Co-operation and Development (OECD) co...

Proper adherence is essential to obtain the desired results of antiretroviral therapy; thus, new interventional strategies for this purpose must be sought. Comparison of 2 interventions, one conducted by a health professional and the other by a peer (patient on antiretroviral therapy), to improve adherence to antiretroviral therapy. In 2003, a rand...