Antonio E Nardi

Federal University of Rio de Janeiro | UFRJ · Departamento de Psiquiatria e Medicina Legal

É apresentado o caso de um indivíduo com diagnóstico de esquizofrenia que cometeu um delito sexual e foi submetido a perícia psiquiátrica para avaliação de responsabilidade penal, sendo considerado inimputável. São discutidos fatores que podem contribuir para delitos dessa natureza, em indivíduos com transtornos psicóticos. Parecer CEP: Instituto d...

Ninety years after his death in 1934, the artistic beauty of the innovative brain images created by physician and histologist Santiago Ramón y Cajal, as well as his revolutionary neuroanatomical theory, remains relevant today. As a scientist who isolated brain nerve cells, he visualized them as physically distinct entities, answering one of the mos...

In recent years, the availability and quality of virtual reality (VR) technology have significantly increased. This has accelerated research on the use of VR in psychiatric settings. Notably, one of the key advantages of VR technology is its ability to create virtual environments that trigger the same feelings, thoughts, and physiological reactions...

Background Many pharmacological treatments are considered effective in the treatment of panic disorder (PD), however, about 20 to 40% of the patients have treatment-resistant PD. Pharmacogenetics could explain why some patients are treatment-resistant. Objective Our objective was to gather preliminary data on the clinical usefulness of pharmacogen...

Introduction With the growing older adult population, the European Union emphasizes the need to promote research in healthy aging trough multidisciplinary and innovative approaches, including the integration of advanced technologies like virtual reality (VR) in cognitive rehabilitation. This reflects the increasing awareness of the importance of ad...

José Leme Lopes is a distinguished figure in research on psychiatric diagnosis, alongside Emil Kraepelin, Kurt Schneider, Adolf Meyer, and Henry Ey. He was a lifetime member of the Society for Personality Assessment in New York, a member of the International Rorschach Society in Switzerland, a founding member and President of the International Cath...

Introduction: Social anxiety disorder (SAD) is one of the most prevalent anxiety disorders, often not well recognized. In most of the cases, SAD follows an unremitted and chronic course, affecting several areas of the individual functioning (i.e.: relationship, academic, work). Due to its relevance, there is a need for guideline-based treatments f...

Human sexuality knows no boundaries, yet our methods for researching, understanding, and treating it must be as diverse as the individuals that it affects, given how deep that it intertwines with the sociocultural factors that shape our lives. In the domain of sexual health within the Middle East and Arabic-speaking countries, developing and using...

Background The acquisition of health information via the internet has emerged as a prevalent approach within the general population and is likely to exert an influence on health decision-making processes. This study aims to evaluate the comprehensive quality of online information about anxiety treatment and management comparing websites in English,...

Introduction: This research describes incorporating the principles of the United Nations Convention on the Rights of Persons with Disabilities (CRPD) in training students at an Italian university. It also describes the perception of students on the rights of people with disabilities and the quality of services using the questionnaire the Well-Being...

The search for the biological substrate of mental disorders is a prerequisite for the development of more effective therapies and, above all, for preventive strategies through early diagnosis. Experimental attempts to identify specific markers for the different disorders remain unsuccessful. These negative results result, at least in part, from a p...

Introduction Adiponectin and leptin play important roles in the central nervous system. During the postpartum period, there is a need for a better understanding of the relationship between these cytokines and the neurological development of the infant, as well as their influence on preventing maternal depressive symptoms. Objectives To assess the...

Background: Alexithymia, a predictor in chronic illnesses, like cardiovascular and bipolar disorder (CD–BD), could be improved with a virtual reality (VR) cognitive remediation program. This secondary analysis of a previous randomized controlled trial (RCT) evaluates alexithymia improvement and its factors in an experimental group versus a control...

Background: Major Depressive Disorder is a global health issue that affects more than 300 million people worldwide, which is about 4.4% of the global population. Treatment usually consists of a combination of antidepressant medication and therapy. However, approximately 30% of individuals with Major Depressive Disorder experience a Treatment-Resist...

Just think about how episodes of sub-threshold hyperactivity were found to be higher in samples of Sardinian emigrants in Latin America than in Sardinians who remained in Sardinia. In emigrants, the difficulties of adaptation, the weight of the loss of affections was evidently less pressing (towards those who remained) compared to the pressure to l...

Background Receptive vaginal penetration skills have been implicated in the etiology, explanatory models, and treatment of genito-pelvic pain penetration disorder (GPPPD). However, there are no psychometric skills measures designed to screen, assess, and stratify GPPPD. Aim We aimed to develop and psychometrically evaluate a new scale—the Vaginal...

Introduction Female sexual dysfunction (FSD) remains a silent problem, especially in Arabic-speaking countries and the Middle East and most of the data are from Western countries. Sociocultural determinants haven’t been getting the same attention as biological and psychological factors when studying sexual health. Objectives To assess the prevalen...

The Brazilian Academy of Sciences commissioned a report on mental health to develop strategies for addressing mental health challenges in the post-pandemic world. These strategies should be evidence-based, culturally sensitive, resourceefficient, and promote equity, while being tailored to specific contexts. The report's proposals are meant for dis...

Background Major Depressive Disorder (MDD) is a global health issue, and a significant portion of individuals with MDD experience Treatment-Resistant Depression (TRD), characterized by the lack of response to adequately trialed antidepressant medication and therapy. This systematic review aims to investigate the effectiveness of Mindfulness-Based C...

António Egas Moniz, born in 1874, was a pioneer in neurology, neurosurgery and psychiatry who brought about important changes in the 1920s using groundbreaking brain imaging techniques, such as cerebral angiography. This innovative procedure allowed the visualization of brain structures, leading to many advances in neurology and neurosurgery. Moniz...

The mental health crisis related to climate change is causing numerous concerns, prompting studies to explore the associations of multiple variables, including air pollution, heat exposure, loss of biodiversity, climate change, and mental health 15–18. There is a growing body of evidence showing how climate change significantly impacts mental healt...

Introduction: The development of depression after myocardial infarction is associated with a 2- to 2.5-fold increased risk of all-cause mortality, cardiovascular mortality, and cardiovascular events. The objective of this study was to investigate, through a broad search of the literature, whether major depression is associated with worse psychiatri...

Background This study aimed to measure differences among informal caregivers, users, and mental healthcare workers (MHW) regarding job/organizational satisfaction and perceptions of respect for rights in the mental health services of one region of Italy. Methods A sample of 100 caregivers, 240 MHW, and 200 users completed the “Well-Being at Work a...

Objective: The association between childhood separation anxiety disorder (CSAD) and panic disorder (PD) has been demonstrated, although some findings are contradictory. The separation anxiety hypothesis postulates that both CSAD and PD encompass a heightened sensitivity to carbon dioxide (CO2). Patients with the respiratory subtype (RS) of PD are k...

Predicting the trajectory of psychiatric conditions is a crucial area of clinical research. There is increasing emphasis on how early intervention for mental disorders can reduce the severity and subsequent burden of mental disorders and, in some cases, delay the development of full-threshold disorders. Since childhood trauma is a risk factor for s...

Introduction: Impairments in social cognition and cognitive deficits in Bipolar Disorder 17 (BD) offer insights into the disorder's progression. Understanding how interventions impact both 18 cognitive and emotional aspects of social cognition is essential. This study examines the effects of 19 Virtual Reality (VR) cognitive remediation on cognitiv...

In the online version of the article, a change was madein the title of an article titled “Mood DisorderQuestionnaire Positivity in Systemic LupusErythematosus and Other Chronic Diseases includingScreen Bipolar Disorders or Rhythm and EnergyDysregulation Syndromes (DYMERS)” which has beenupdated in “Clinical Practice and Epidemiology inMental Health...

Abstract: Background: A wide range of conditions, including mixed depressive symptoms, hyperac-tivity, cognitive impairment (CI) might be expressions of Bipolar Spectrum Disorder (BSD) according to the neo-Kraepelinian perspective, even in advanced age. CI, which has a high prevalence in the elderly population, when it occurs in comorbidity with de...

The floods in Southern Brazil serve as another unfortunate reminder that climate change is not merely a future concern; it is an existing reality. While the El Niño phenomenon played a key role in the emergence of heavy rains in Rio Grande do Sul, human-induced climate change has also been implicated in this recent disaster. In addition, more publi...

Introduction This study explores the issue of paper-and-pencil screening tests for bipolar disorder, often leading to false positives. It discusses hypotheses that connect MDQ positivity with sleep disorders, a decline in health-related quality of life, and the impact of the COVID-19 pandemic on mood disorders. The study proposes that MDQ identifie...

Crimes of parricide, murder of children against their parents, usually shock society and provoke discussions about possible motivations and legal and therapeutic interventions in cases of the existence of mental illness. The aim of this article is to conduct a narrative review of the relationship between parricide and mental illness, as well as the...

This article commemorates the 65th anniversary of the synthesis of the first benzodiazepine, chlordiazepoxide, and the 60th anniversary of the FDA approval of diazepam. The review highlights the importance of Leo Sternbach's legacy as the chemist who was responsible for the development of benzodiazepines. This was a major milestone in the pharmacol...

Generalized anxiety disorder (GAD) is a highly prevalent mental disorder. Previous data indicate more than 18 million Brazilians suffer from that condition. Traditionally, GAD has been considered a mild mental health disorder, despite its close link to decrease life expectancy, cardiovascular disease, and suicide. Objective: To combine elements of...

This systematic review addresses the complex nature of Panic Disorder (PD), characterized by recurrent episodes of acute fear, with a focus on updating and consolidating knowledge regarding neurochemical, genetic, and epigenetic factors associated with PD. Utilizing the PRISMA methodology, 33 original peer-reviewed studies were identified, comprisi...

Otto Loewi’s life journeys bear witness to the powers of talent, wisdom, curiosity, intellectual honesty, perseverance, resilience, hope, friendship, tolerance, loyalty, and family love to help overcome unusually tough hurdles and to lead to astonishing accomplishments. In the sesquicentennial of his birth, certainly a strange time to be living in,...

Background This study has investigated perceptions of respect for users' rights among informal caregivers in mental healthcare settings, aligning with the guidelines outlined in the United Nations Convention on the Rights of Persons with Disabilities (CRPD) and the World Health Organization QualityRights initiative. The study has employed the quest...

Background: Fibromyalgia syndrome (FMs) is a chronic condition characterized by widespread musculoskeletal pain and a range of complex symptoms, with chronic fatigue being a central feature significantly impacting daily life. The aim of this study was to analyze the secondary outcomes, specifically those related to perceived energy and fatigue symp...

Cognitive-behavioral coaching (CCC) is a structured process of goal setting and achievement that is based on the cognitive-behavioral principle, which assumes that it is not the events themselves that trigger emotional and behavioral responses, but rather the interpretation that individuals present about them. In this sense, CCC is a process of ide...

Mental health has no borders, yet the methodologies employed to understand and address it must be as diverse and personalized as the individuals it affects since it is intricately interwoven with the sociocultural determinants that shape our lives. In the context of Middle Eastern mental health, a call for culturally-sensitive approaches is not a m...

Introduction Treatment-resistant depression (TRD) presents a significant challenge, affecting approximately 30% of individuals diagnosed with major depressive disorder and leading to poor treatment responses. Innovations in digital mental health, especially online mindfulness-based cognitive therapy (eMBCT), offer promising avenues for enhancing ac...

Introduction: Rehabilitative interventions employing technology play a crucial role in bipolar disorder (BD) treatment. The study aims to appraise the virtual reality (VR)-based cognitive remediation (CR) and the interpersonal rhythm approaches to treatment outcomes of BD across different age groups. Methods: Post-hoc analysis of a 12-week randomiz...

Background: Social rhythm dysregulation has been identified as a determining factor in bipolar disorder (BD) relapses. It directly impacts individuals’ quality of life (QoL). This study aims to present preliminary data on the efficacy of an e-health psychoeducational intervention for BD for improving clinical outcomes. Methods: This study used an o...

Gender is one of the main social markers that build subjectivity and is culturally shaped by the meanings and representations associated with sexual anatomic char-acteristics of an individual since birth. Despite the perceived advances in women’s rights in the last few decades, sexism toward women has been conceptualized as a pervasive, chronic soc...

In this new moment, our goal, shared between the editors-in-chief, is to build upon these foundations while steering the BJP towards pioneering frontiers in psychiatric research.We remain steadfast in our vision to establish the BJP as a flagship psychiatry journal, both nationally and internationally. Honoring the legacy of the past while looking...

This is the second part of the Brazilian S20 mental health report. The mental health working group is dedicated to leveraging scientific insights to foster innovation and propose actionable recommendations for implementation in Brazil and participating countries. In addressing the heightened mental health challenges in a post-pandemic world, strate...

The trajectory of healthcare has evolved from ancient holistic practices to the present biomedical model, reflecting the dynamic interplay between scientific progress, technological advancements, and the integration of humanistic values. While biomedical advancements have revolutionized medical treatments, there is an emerging recognition of the im...

Introduction: Despite its milder severity, the chronic nature of dysthymia leads to significant impairments and functional limitations. The treatment of dysthymia has received considerably less research attention compared to major depressive disorder (MDD). Areas Covered: The authors have conducted a comprehensive review on the treatment of dysthym...

Background Major Depressive Disorder is a long-term, recurring, and very common illness that is associated with a significant decline in functional ability. The gold-standard method of treating depression is pharmacotherapy, which involves the use of antidepressant medications either alone or in various combinations. However, approximately 30% of M...

Introduction The following work aims to compare the types and magnitude of risk events in patients with Schizophrenia and Bipolar Disorder and each of those groups with of a group of healthy siblings, exploring differences and similarities of the two psychotic disorders. Methods Retrospective interviews were conducted with 20 families to investiga...

A syndrome centered on the dysregulation of behavioral rhythms (DBR) is discussed. Recent pandemic brought to observe: (1) Having a DBR affecting sleep patterns, eating habits, and social interactions, before the lockdown period, was a determinant for depressive episodes during the lockdown; (2) In tighter lockdowns, DBR triggered depressive episod...

This editorial explores the role of hyperactivity and social rhythm dysregulation in bipolar disorder (BD) and related syndromes. Social Rhythm Dysregulation Syndrome (DYMERS) is proposed as a common vulnerability across various disorders, including panic disorder (PD), attention deficit hyperactivity disorder, and post-traumatic stress disorder. A...

Os autores fazem uma revisão narrativa sobre a definição de crime, de violência e seus tipos, bem como as consequências para as vítimas. O relatório anual do Fórum Brasileiro de Segurança Pública mostra que o país registrou 47.503 mortes violentas intencionais no ano de 2021. São também abordadas questões sobre comportamento violento perpetrado por...

Background: The disruption of social rhythms was found to be associated with depressive disor-ders during the COVID-19 pandemic; lower rates of these disorders were surprisingly found in old adults. The present study aims to verify the stability of social rhythms during lockdown in a sam-ple of elderly people. Methods: Controlled cohort study (seco...

Background: The disruption of social rhythms was found to be associated with depressive disorders during the COVID-19 pandemic; lower rates of these disorders were surprisingly found in old adults. The present study aims to verify the stability of social rhythms during lockdown in a sample of elderly people. Methods: Controlled cohort study (second...

Introduction Major Depressive Disorder (MDD) is a chronic, recurrent, and highly prevalent disease that is associated with significant functional disability. During pregnancy, the prevalence of the disease is approximately 20%, with 12% of these, requiring treatment to avoid important negative consequences for the mother-baby binomial. Risk-benefit...

Ugo Cerletti, with determination and perseverance, revolutionized the theoretical and therapeutic approaches of his era by successfully integrating safety and effectiveness in convulsive therapy. He was the pioneer who introduced the concept of using electricity in the treatment of mental illnesses, conducting tests and validating its application....

Objective: To evaluate traditional versus guided cognitive-behavioral therapy (CBT) with the use of applications and technological innovations. Data Sources: A systematic search was conducted in the MEDLINE/PubMed, SciELO, and Cochrane Library databases and included randomized controlled trials (RCTs) from inception to March 30, 2023, with no langu...

Objective: To adapt the Scale of Perception of Respect for and Maintenance of the Dignity of the Inpatient (CuPDPH) to the Brazilian language and culture and to assess its psychometric properties. Results: The scale was evaluated by 15 experts, and 239 patients from three tertiary hospitals in Rio de Janeiro. All participants signed a consent form....

Heinz Lehmann was a member of the generation of pioneers of psychopharmacology who “did it all,” combined astute clinical observations with using objective tools, worked on developing new tools and medications, conducted clinical trials, and moved the nascent field of clinical psychopharmacology forward. It is of great interest to catch the attenti...

Bipolar disorder (BD) and schizophrenia (SCZ) may exhibit functional abnormalities in several brain areas, including the medial temporal and prefrontal cortex and hippocampus; however, a less explored topic is how brain connectivity is linked to premorbid trauma experiences and clinical features in non-Caucasian samples of SCZ and BD. Methods: Sixt...

Introduction: The history of psychiatry encompasses the evolving concepts about the relationship between body and mind and also of the definiton of normality, which depend on the knowledge and customs of different times and places. For a better understanding of this journey, this study privileged the presentation of the main influential figures on...

Introduction: The history of psychiatry encompasses the evolving concepts about the relationship between body and mind and also of the definition of normality, which depend on the knowledge and customs of different times and places. For a better understanding of this journey, this study privileged the presentation of the influential figures on the...

Background: Extensive research has explored SLE's impact on health-related quality of 12 life (H-QoL), especially its connection with mental well-being. Recent evidence indicates that de-13 pressive syndromes significantly affect H-QoL in SLE. This study aims to quantify SLE's impact on 14 H-QoL, accounting for comorbid depressive episodes through...

Anxiety disorders are very prevalent and often persistent mental disorders, with a considerable rate of treatment resistance which requires regulatory clinical trials of innovative therapeutic interventions. However, an explicit definition of treatment‐resistant anxiety disorders (TR‐AD) informing such trials is currently lacking. We used a Delphi...

Medicine shortages are a lethal problem, quite literally. Pharmaceuticals are essential health products, subject to health regulations, and cannot be treated as mere commodities in the lucrative financial system. On November 8, 2023, psychiatrists in Brazil were alarmed by the news, confirmed by the Brazilian national health surveillance agency, An...

Objective: To perform a meta-analysis and comparison between developed and developing countries postpartum depression symptoms prevalences. Methods: PubMed, Embase, Virtual Health Library, Scopus, Web of Science, PsycINFO and CINAHL databases were searched until October 2022 for studies that collected data during the pandemic. The metaprop command...

Suicide is among the main causes of death among Brazilian adolescents. Using machine learning to calculate predictive models is important as it can help us create predictive calculators and transfer knowledge to society. This work compared machine learning algorithms to suicide risk in Brazilian adolescents using nationally representative community...

Digital technologies are popular means of exchanging, communicating, and accessing information, and their use has been increasing in recent years. Studies of changes in society's behavior are observed because of the new way of communicating and relating. To evaluate the sexual behavior of couples during the period of social isolation imposed by the...

Objective: Cancer-related diseases pose a substantial public health challenge; however, recent treatments have enhanced patient outcomes. Adherence to therapy is crucial, and research focuses on elucidating the factors that influence it. Limited information exists on medication adherence in cancer patients. This study aims to identify risk factors...

Violence against children is a very important concern in the public health system. Filicide is a deliberate act of a mother or father killing his own child. The aim of this study is to describe a case of filicide associated with the presence of borderline personality disorder, discussing the evaluation of criminal imputability related to this case,...

O objetivo desse artigo é realizar uma revisão narrative sobre o conceito de responsabilidade penal, aplicado aos principais transtornos do humor: transtorno bipolar e depressão. Casos graves desses transtornos podem tornar esses indivíduos não responsáveis criminalmente, no caso de afetar seu entendimento ou deteerminação, dessa forma recebendo me...

Crimes de parricídio, assassinato de filhos contra os pais, costumam chocar a sociedade e provocar discussões sobre as possíveis motivações e intervenções jurídicas e terapêuticas, nos casos de existência de doença mental. O objetivo desse artigo é realizar uma revisão narrativa sobre a relação entre parricídio e doença mental, bem como os fatores...

Objective: Medication non-adherence is frequently reported in patients with major depressive disorder (MDD). The objective of this review is to consolidate data on the prevalence of nonadherence to antidepressant in MDD. Methods: A systematic review with meta-analysis was performed according to the Preferred Reporting Items for Systematic Reviews a...

Objective: The demanding nature of oncological therapies may affect treatment motivation and adherence, leading to an increased risk of premature death. Exploring the interaction between depressive episodes and treatment adherence is essential, considering how depression may influence patients' willingness to continue treatment. This study aims to...

Objective: Cancer-related diseases pose a substantial public health challenge; however, recent treatments have enhanced patient outcomes. Adherence to therapy is crucial, and research focuses on elucidating the factors that influence it. Limited information exists on medication adherence in cancer patients. This study aims to identify risk factors...