Antonio Lavazza

Antonio Lavazza
Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna · Unit of Virology

Doctor Veterinary Medicine

About

480
Publications
50,746
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
7,151
Citations

Publications

Publications (480)
Article
Full-text available
This pilot study tested an on-farm protocol based on resource, management, and animal-based measures to evaluate the on-farm health and welfare of rabbits kept in four different housing systems. In detail, the four housing systems were (1) standard breeding cages for reproducing does (3,300 cm2) with their litters associated with bicellular cages f...
Article
Full-text available
This study described a SARS-CoV-2 infection in minks on an Italian farm. Surveillance was performed based on clinical examination and a collection of 1879 swabs and 74 sera from dead and live animals. The farm was placed under surveillance for 4.5 months, from the end of July 2020, when a man working on the farm tested positive by RT-PCR, till mid-...
Article
To genetically assess the Australian distribution and frequency of Eimeria species in wild rabbits, with a primary focus on Eimeria intestinalis and Eimeria flavescens as possible additional agents of rabbit biocontrol, the distal colon and faecal samples from wild rabbits sourced from 26 Australian locations with mean annual rainfalls of between 2...
Poster
Hepatitis E virus (HEV) is the agent of the hepatitis E disease that in Europe is mainly transmitted foodborne. Human cases in EU have increased in the last years and are linked to the consumption of raw or undercooked pork product or wild boar meat infected by the zoonotic HEV-3 genotype. Rabbit HEV (HEV-3ra) is a recent genotype of HEV detected i...
Conference Paper
Full-text available
Since the 1960s, Lepus europaeus populations have suffered a widespread density decline. In addition to habitat changes and inadequate hunting management, other causes influencing regional hare population decline are diseases. Our study aims to investigate Trepone-ma paraluisleporidarum ecovar Lepus (TPeL) seroprevalence in North-Italy. The infecti...
Article
Full-text available
In-vitro viral studies are still fundamental for biomedical research since studying the virus kinetics on cells is crucial for the determination of the biological properties of viruses and for screening the inhibitors of infections. Moreover, testing potential viral contaminants is often mandatory for safety evaluation. Nowadays, viral cytopathic e...
Conference Paper
Full-text available
Varieties of pathological conditions in domestic and wild animals have been attributed to coronavirus (CoV) infections. Since 2002, three highly virulent strains classified in two subgenera (Sarbecovirus and Merbecovirus) of the genus Beta-Coronavirus (BetaCoV) have caused severe respiratory diseases causing thousands of infections and deaths world...
Article
Full-text available
This study investigated the species composition and density of sand flies in the Lombardy region (Northern Italy). Sand flies were collected using CDC traps baited with CO2 (CO2–CDC traps) between June and August 2021. A total of 670 sand flies were collected. The specimens were identified as seven species belonging to two genera, Phlebotomus and S...
Article
Full-text available
In Italy, the West Nile Virus surveillance plan considers a multidisciplinary approach to identify the presence of the virus in the environment (entomological, ornithological, and equine surveillance) and to determine the risk of infections through potentially infected donors (blood and organ donors). The costs associated with the surveillance prog...
Article
Until the early 1980s, it was totally unknown that lagomorphs were the hosts of several caliciviruses, which were included in the genus Lagovirus by the International Committee on Taxonomy of Viruses (ICTV) in 2000. In those years, two new diseases appeared, with very similar clinical and pathological profiles and associated high mortality rates: r...
Article
Full-text available
Background Phlebotomine sand flies are known as vectors of various pathogens such as Leishmania sp parasite and Toscana virus (TOSV). Leishmaniasis is endemic in Morocco, and TOSV is increasingly reported. Our objective is to analyze the specific composition of the natural population of sand flies in endemic and non endemic area of leishmaniasis in...
Article
Full-text available
Due to the SARS-CoV-2 pandemic renewed attention has been directed towards viral neutralization assays and neutralizing antibodies quantification, for vaccine pre-clinical trials and determining vaccine efficacy over time. The gold standard to assess antibody titer is the plaque reduction neutralization test, an end-point assay which evaluates the...
Article
Full-text available
Torque teno sus virus (TTSuV) is a non-enveloped circular ssDNA virus which frequently infects swine and has been associated with hepatic, respiratory, and autoimmune disorders. TTSuV’s pathogenic role is still uncertain, and clear data in the literature on virus reservoirs are lacking. The aims of this study were to investigate the presence of pot...
Article
European wild rabbit (Oryctolagus cuniculus) populations are severely affected by rabbit haemorrhagic disease (RHD), currently aggravated by the spread of the new lagovirus serotype RHDV2 that replaced the classical RHDV strains (RHDV/RHDVa). This virus causes high mortality in both adult and young rabbits and to date, there is no management tool t...
Conference Paper
Full-text available
A standardised protocol was used to evaluate health and welfare of lactating does and their litters on 12 commercial farms of the North of Italy in 36 visits (three per farm) during three productive cycles (autumn, winter, and summer) over one year. Farms used four different housing systems (standard breeding cages, dual-purpose breeding cages, enr...
Conference Paper
Equid and asinine gammaherpesviruses (GHVs, genus Percavirus) are members of the family Herpesviridae. Differently from horse populations, a limited number of studies on gammaherpesviral infections in donkeys is available. This study reports the co-infection with two different GHVs in endangered Pantesco breed donkeys.
Article
Full-text available
Treponema paraluisleporidarum infects both rabbits (ecovar Cuniculus) and hares (ecovar Lepus). While the occurrence of the bacterium has previously been reported for European brown hares ( Lepus europaeus ) and domestic rabbits ( Oryctolagus cuniculus f. domestica ), there are no data available that report infection in the European context. We tes...
Article
Full-text available
Wild birds play an important role in the circulation and spread of pathogens that are potentially zoonotic or of high economic impact on zootechnical production. They include, for example, West Nile virus (WNV), Usutu virus (USUV), avian influenza virus (AIV), and Newcastle disease virus (NDV), which, despite having mostly an asymptomatic course in...
Article
Rabbit hemorrhagic disease virus type 2 (RHDV2) causes a severe systemic disease with hepatic necrosis. Differently from classic RHDV, which affects only European rabbits (Oryctolagus cuniculus), RHDV2 can affect many leporid species, including hares (Lepus spp) and cottontail rabbits (Sylvilagus spp). RHDV2 emerged in Europe in 2010 and spread wor...
Conference Paper
Full-text available
Western European hedgehog (Erinaceus europaeus) is a common synanthropic mammal. It could be involved in maintenance and transmission of potentially zoonotic pathogens. In Ferrara province (Emilia Romagna region–North Italy), since the end of 2019, an increase of hedgehog’s mortality was recorded. Necropsy was carried out on 88 hedgehogs. In most c...
Article
Full-text available
Whilst multiple countries in Europe have wildlife health surveillance (WHS) programmes, they vary in scope. In many countries, coordinated general surveillance at a national scale is not conducted and the knowledge of wildlife health status in Europe remains limited. Learning lessons from countries with established systems may help others to effect...
Article
Full-text available
Phleboviruses are arboviruses transmitted by sand flies, mosquitoes and ticks. Some sand fly-borne phleboviruses cause illnesses in humans, such as the summer fevers caused by the Sicilian and Naples viruses or meningitis caused by the Toscana virus. Indeed, traces of several phleboviral infections have been serologically detected in domestic anima...
Article
Full-text available
Honeybee and general pollinator decline is extensively reported in many countries, adding new concern to the general biodiversity loss. Many studies were addressed to assess the causes of pollinator decline, concluding that in most cases multi-stress effects were the most probable ones. In this research, the combined effects of two possible stress...
Article
Multiple myeloma accounts for 10-15% of all hematologic malignancies, and 20% of deaths related to cancers of the blood and bone marrow. Diagnosis is defined by the presence of a serum monoclonal spike (M-spike) of more than 3 g/dL or more than 10% clonal plasma cells in the bone marrow and at least one myeloma-defining event, such as hypercalcemia...
Article
Equid and asinine gammaherpesviruses (GHVs; genus Percavirus) are members of the Herpesviridae family. Though GHVs have been reported in horse populations, less studies are available on gammaherpesviral infections in donkeys. This study reports the co-infection with two GHVs in Pantesco breed donkeys, an endangered Italian donkey breed. Samples (n...
Poster
Full-text available
Aim: The aim of this study was to investigate the occurrence and distribution of Hepatitis E virus (HEV), Mammalian orthoreovirus (MRV), and Torque teno sus virus (TTSuV) in wild animals in Northern Italy to assess their potential role as zoonotic reservoirs, and to gain insight on the risk of their spreading to farm animals and possibly to humans....
Article
A comparative study was carried out on common and agile frogs ( Rana temporaria and R. dalmatina) naturally infected with ranid herpesvirus 3 (RaHV3) and common toads ( Bufo bufo) naturally infected with bufonid herpesvirus 1 (BfHV1) to investigate common pathogenetic pathways and molecular mechanisms based on macroscopic, microscopic, and ultrastr...
Article
Full-text available
Mammalian orthoreoviruses (MRVs) are emerging infectious agents that may affect wild animals. MRVs are usually associated with asymptomatic or mild respiratory and enteric infections. However, severe clinical manifestations have been occasionally reported in human and animal hosts. An insight into their circulation is essential to minimize the risk...
Article
Full-text available
Canine distemper (CD) is a fatal, highly contagious disease of wild and domestic carnivores. In the Alpine territory, several outbreaks have occurred in the past few decades within wild populations. This study investigated the presence of canine distemper virus (CDV) infections in wild carnivores in Lombardy, relating to the different circulating g...
Preprint
Full-text available
PREPRINT 2 Viraemic pigs entering the food chain are the most likely source of hepatitis E virus (HEV) in pork meat: modelling the fate of HEV during slaughtering of pigs. ABSTRACT Hepatitis E Virus (HEV) is an emerging foodborne pathogen and consumption of raw or undercooked pork products has been associated with increased risk of human infection....
Article
Hepatitis E Virus (HEV) is an emerging foodborne pathogen and consumption of raw or undercooked pork products has been associated with increased risk of human infection. This work represents the first attempt to evaluate the risk of HEV being present on pig carcasses and in meat at the end of the slaughtering process considering the steps of bleedi...
Article
Full-text available
Background . The occurrence of trans-placental transmission of severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) infection remains highly debated. Placental positivity for SARS-CoV-2 has been reported in selected cases, but infection or virus-associated disease of fetal tissues or newborns remains to be demonstrated. Methods We screene...
Article
Full-text available
Inactivated strain-specific vaccines have been successfully used to control rabbit haemorrhagic disease (RHD) caused by RHDV-2 in the rabbit industry. It is unknown whether and how vaccination of breeding does contributed to protect the population of young susceptible rabbit kits. The present study investigates whether the immunity against RHDV-2 p...
Article
Full-text available
We describe two cases of skin co-infections with epitheliotropic viruses, detected in two cattle during lumpy skin disease (LSD) surveillance in northern Italy. A diagnostic protocol including different molecular methods as well as negative staining electron microscopy was applied to detect the most common viral agents belonging to the family Papil...
Article
Full-text available
Introduction The aim of the study was to estimate the diagnostic sensitivity (DSe) and specificity (DSp) of an agar gel immunodiffusion (AGID) assay for detection of myxoma virus (MYXV) in the classical form of myxomatosis and to compare its diagnostic performance to that of molecular methods (IAC-PCR, OIE PCR, and OIE real-time PCR). Material and...
Article
Full-text available
Pestivirus A or bovine viral diarrhoea virus (BVDV) type 1 is responsible for cosmopolitan diseases affecting cattle and other ruminants, presenting a wide range of clinical manifestations, with relevant impact on zootechnic production. The objective of the present study was to verify whether animals immunised with four commercial vaccines also dev...
Article
Full-text available
The Lagovirus genus comprises both pathogenic viruses as European brown hare syndrome virus (EBHSV‐ GII.1) and rabbit hemorrhagic disease viruses (RHDV – GI.1 and RHDV2 – GI.2), that principally infect European brown hares (Lepus europeaus) and European rabbits (Oryctolagus cuniculus), respectively, causing severe necrotic hepatitis, spleen enlarge...
Article
Full-text available
A proliferative cauliflower lesion was excised from the udder of a sheep. Histological investigation confirmed the macroscopic classification of the lesion as a papilloma, without any fibroblastic proliferation. PCR revealed the presence of bovine papillomavirus (BPV), which was further confirmed by the identification of a Deltapapillomavirus 4 by...
Article
Full-text available
The mountain chain of the Alps, represents the habitat of alpine fauna where the red deer (Cervus elaphus) population is the outmost numerous, followed by the chamois (Rupicapra rupicapra) and the alpine ibex (Capra ibex) at higher altitudes. Previous reports showed the circulation of epitheliotropic viruses, belonging to the families Papillomaviri...
Article
Full-text available
The Respirovirus genus, family Paramamixoviridae, includes respiratory viral pathogens. Here we report the identification and genetic characterization of a respirovirus in an Alpine chamois showing interstitial pneumonia associated with catarrhal bronchopneumonia. The full-genome characterization of this respirovirus, named ChamoisRV/IT2014, reveal...
Article
Astroviruses (AstVs) have been identified in the stools of calves with enteritis and in the brain tissues of bovines with encephalitis but their pathogenic role has not been clarified. In this study, we report the detection and characterization of bovine and water buffalo AstV strains identified in young bovine and buffalo calves with enteritis in...
Article
This study describes an Aujeszky’s disease case in an adult male red fox found in an urban area in Central Italy, that exhibited a fatal infection with neurological lesions, but neither itching nor skin lesions. Diagnostic examinations included histology, and parasitological, bacteriological and virological analyses. Detection of parasitic enteric...
Article
Full-text available
The Western European Hedgehog (Erinaceus europaeus) is one of the four hedgehog species belonging to the genus Erinaceus. Among them, E. amurensis is extant in East Asia’s areas only, whereas E. europaeus, E. roumanicus and E. concolor are mainly found in Europe. E. europaeus is endemically distributed from western to central and southern Europe, i...
Article
The genus Pestivirus comprises globally distributed members of the family Flaviviridae, which cause severe losses in livestock. The most common species of the genus are bovine viral diarrhea virus type 1 (BVDV‐1) and type 2 (BVDV‐2), classical swine fever virus (CSFV), and border disease virus (BDV). Recently, a novel ovine pestivirus was repeatedl...
Article
Full-text available
Atypical porcine pestivirus (APPV) is a newly recognized member of the Flaviviridae family. This novel porcine pestivirus was first described in 2015 in the USA, where it has been associated with congenital tremor type A-II in new-born piglets. APPV is widely distributed in domestic pigs in Europe and Asia. In this study, a virological survey was p...
Conference Paper
Full-text available
European law, Reg. CE 852-853-854/2004, allow hunters to become primary producers of game meat aiming to create a controlled and sustainable production chain. The project 'Selvatici e buoni: una filiera alimentare da valorizzare' aims to provide adequate health status of wildlife, not only for final consumer, but also to protect the well-being of w...
Article
Full-text available
Melatonin, an indole produced by pineal and extrapineal tissues, but also taken with a vegetarian diet, has strong anti-oxidant, anti-inflammatory and anti-obesogenic potentials. Non-alcoholic fatty liver disease (NAFLD) is the hepatic side of the metabolic syndrome. NAFLD is a still reversible phase but may evolve into steatohepatitis (NASH), cirr...
Article
Full-text available
Pestiviruses are distributed worldwide and are responsible for a variety of economically important diseases. They are not very host-specific, and thus sheep can be infected by well-known pestiviruses like bovine viral diarrhea virus (BVDV) and border disease virus (BDV), as well as by other recently discovered pestivirus species. The aim of this st...
Article
Full-text available
Information concerning the pathogenic role of honey bee viruses in invasive species are still scarce. The aim of this investigation was to assess the presence of several honey bee viruses, such as Black Queen Cell Virus (BQCV), Kashmir Bee Virus (KBV), Slow Paralysis Virus (SPV), Sac Brood Virus (SBV), Israeli Acute Paralysis Virus (IAPV), Acute Be...
Article
Full-text available
In February 2019, following the annual taxon ratification vote, the order Mononegavirales was amended by the addition of four new subfamilies and 12 new genera and the creation of 28 novel species. This article presents the updated taxonomy of the order Mononegavirales as now accepted by the International Committee on Taxonomy of Viruses (ICTV). ©...
Article
Full-text available
Interest in bat-related viruses has increased considerably during the last decade, leading to the discovery of a rising number of new viruses in several bat species. Poxviridae are a large, diverse family of DNA viruses that can infect a wide range of vertebrates and invertebrates. To date, only a few documented detections of poxviruses have been d...
Conference Paper
Full-text available
An objective protocol of rabbit health and welfare assessment has been developed using animal-based and resource and management-based measurements. Time points selected to apply the protocol are the end of the lactation period for the reproducing sector and one week before slaughtering for the fattening sector. Currently, the protocol is under test...
Article
Full-text available
Adenoviruses are important pathogens of humans and animals. Bats have been recognized as potential reservoirs of novel viruses, with some viruses being regarded as a possible zoonotic threat to humans. In this study, we report the detection and analysis of adenoviruses from different bat species in northern Italy. Upon sequence and phylogenetic ana...
Poster
Full-text available
Sampling was carried out during hunting activity and depopulation plans in two periods in Western and Central Alps: 2013- 2015 and 2017-2018. In the first period, sera from 216 chamois (Rupicapra rupicapra), 254 red deer (Cervus elaphus) and 32 roe deer (Capreolus capreolus) were collected in different provinces of North Italy: Verbano-Cusio-ossola...
Article
Mammalian orthoreoviruses (MRV) type 3 have been recently identified in human and several animal hosts, highlighting the apparent lack of species barriers. Here we report the identification and genetic characterization of MRVs strains in alpine chamois, one of the most abundant wild ungulate in the Alps. Serological survey was also performed by MRV...
Article
Full-text available
During the last few decades native European hares (Lepus europaeus) have declined in Central and Northern Italy. Despite this trend having multiple causes, it was hypothesized that invasive Eastern cottontails (Sylvilagus floridanus) contributed to the decline through apparent competition and disease transmission. In this research we explored wheth...
Article
Full-text available
The interplay of mitochondria with the endoplasmic reticulum and their connections, called mitochondria-ER contacts (MERCs) or mitochondria-associated ER membranes (MAMs), are crucial hubs in cellular stress. These sites are essential for the passage of calcium ions, reactive oxygen species delivery, the sorting of lipids in whole-body metabolism....
Article
Full-text available
The interplay of mitochondria with the endoplasmic reticulum and their connections, called mitochondria-ER contacts (MERCs) or mitochondria-associated ER membranes (MAMs), are crucial hubs in cellular stress. These sites are essential for the passage of calcium ions, reactive oxygen species delivery, the sorting of lipids in whole-body metabolism....
Article
Full-text available
The importance of infectious diseases originating from or carried by wildlife is increasingly being recognised. An understanding of these diseases is based on knowledge of their epidemiology; thus, it is essential to gather pathogen data which are region-specific. The objective of this review was to provide an update on changes in the epidemiology...