Antonio Luiz Martins Maia Filho

• Universidade Estadual do Piauí

Background: The wound healing process presents notable challenges for nursing teams, requiring extensive knowledge of wound care materials. A nanoparticle-free, bioabsorbable pol-yvinyl alcohol (PVA) with citric acid (CA) dressing produced by simple electrospin-ning was evaluated to treat acute wound healing in rats. This PVA-CA combination promote...

Diabetes mellitus is characterized by elevated blood glucose levels causing sometimes impairment of the body’s ability to repair itself. Promising treatments for tissue repair have included photobiomodulation therapy and heterologous fibrin biopolymer (HFB). This study aimed to evaluate the impact of photobiomodulation therapy by LED, both as a sta...

Sodium alginate is used in wound care because of its hydrogel‐forming properties and ability to protect the wound. Copper nanoparticles have properties that inhibit the growth of microorganisms and mediate the production of essential biomolecules for the healing process, making them an excellent choice for constructing nanocomposites for wound trea...

This study aimed to evaluate the effect of LED photobiomodulation therapy associated or not with heterologous fibrin biopolymer to repair skin wounds in rats. Full-thickness skin wounds were induced on the back of 84 Wistar rats and they were randomly divided into 4 groups: control group (CG), LED group (LED), heterologous fibrin biopolymer group (...

The marmeleiro (Croton blanchetianus Baill) is a native plant of the Brazilian semiarid region with wide distribution in the Northeast and Southeast regions of the country. This integrative review study addresses the biological activity and phytochemical composition of the marmeleiro, highlighting its therapeutic and agronomic properties. Twenty-fi...

The development of new drugs through studies of candidate molecules is a complex undertaking; however, computational or in silico approaches aimed at optimizing molecules with greater development potential are being utilized for predictions of pharmacokinetic properties such as absorption, distribution, metabolism and excretion (ADME) as well as to...

PurposeThe skin is a complex organ that covers the entire surface of the body. Any situation that interrupts the integrity of the skin, whether by accidents, trauma, disease, or surgery, is defined as a skin wound. This study aimed to evaluate the effect of LED photobiomodulation therapy associated or not with heterologous fibrin biopolymer to repa...

Inicialmente pensada para ser uma composição nacional, a coleção se expandiu e, além de autores das cinco regiões brasileiras, conta também com autores de outras nacionalidades, caracterizando-a, portanto, como internacional. Sinaliza-se ainda, seu enfoque multidisciplinar, uma vez que, os distintos autores possuem níveis e formações bastante disti...

Wound healing is a dynamic process that depends on external factors, such as the possibility of infection in the lesion area by different bacteria. In addition to synthetic drugs, other alternative substances have been proposed for healing purposes, such as medicinal plants, herbs, and bactericidal nanomaterials. In this research, we evaluated the...

Croton heliotropiifolius Kunth, popularly known as “quince” and “velame,” contains a high concentration of volatile oils in the leaves, and widely used in folk medicine as an antiseptic, analgesic, sedative, anti-inflammatory, spasmolytic and local anesthetic. The objectives of this investigation were to (1) identify the phytochemical compounds and...

Os extratos das folhas do cajueiro têm se mostrado eficazes no tratamento de doenças e também não permite a proliferação de micro-organismos, como fungos e bactérias. Porém, no Brasil as folhas não têm tido seu destaque merecido, uma vez que a maioria dos produtores agrícolas consideram as podas das árvores como um rejeito, já que a indústria, de m...

Cecropia pachystachya Tréc., popularly known as embaúba, belongs to the Cecropiaceae family and is used by the native population in the treatment of bronchitis, asthma, high blood pressure, fever, and as a diuretic. The pharmacological actions including anti-inflammatory, antioxidant, cardiotonic and sedative were previously reported. The objective...

The present study aimed to evaluate the new heterologous fibrin biopolymer associated, or not, with photobiomodulation therapy for application in tendon injuries, considered a serious and common orthopedic problem. Thus, 84 Rattus norvegicus had partial transection of the calcaneus tendon (PTCT) and were randomly divided into: control (CG); heterol...

This study aimed to evaluate the effect of LED photobiomodulation therapy associated or not with heterologous fibrin biopolymer to repair skin wounds in rats. Full-thickness skin wounds were induced on the back of 84 Wistar rats and they were randomly divided into 4 groups: control group (CG), LED group (LED), heterologous fibrin biopolymer group (...

Essa pesquisa tem como objetivo observar a influência do exercício aeróbico associado ao uso de corticoide e extrato aquoso das cascas do caule de Ximenia americana L. no tratamento da Doença Pulmonar Obstrutiva Crônica. Utilizaram-se três doses de papaína via nasal em sete grupos de ratos Wistar machos a fim de induzir resposta inflamatória pulmon...

A Doença Pulmonar Obstrutiva Crônica (DPOC) é considerada um conjunto de doenças respiratórias como a bronquite crônica e enfisema pulmonar que são caracterizadas principalmente por inflamação progressiva e redução do fluxo de ar nas vias aéreas. Se desenvolvi sobretudo pelo tabagismo ativo ou passivo, inalação de gases ou partículas tóxicas. Seu t...

Himatanthus obovatus, conhecida como janaguba, é encontrada no Nordeste brasileiro. As suas folhas são usadas para hipertensão, manchas na pele e como antitumoral, no entanto ainda são incipientes os estudos quanto à ação cicatrizante. O estudo teve como objetivo analisar o perfil fitoquímico e o efeito cicatrizante do extrato etanólico das folhas...

Purpose The aim of this work was to analyze the effect of fibrin biopolymer sealant (FS) associated or not to aquatic exercise (AE) on the calcaneal tendon repair. Methods Forty-four female Wistar rats were randomly divided into four experimental groups: Lesion control (L), Lesion and FS (LS), Lesion and AE (LE) and Lesion and FS associated to AE...

Introdução: As infecções sexualmente transmissíveis (ISTs) são um importante problema de saúde pública, trazendo muitas consequências para a população mundial. A sífilis é uma IST causada pela bactéria Treponema pallidum e constitui uma importante doença no contexto da saúde brasileira pelo aumento de casos nos últimos anos. Objetivo: Descrever as...

O objetivo foi produzir extrato em gel de Chenopodium ambrosioides e analisar os efeitos do uso tópico no reparo ósseo de ratas osteoporóticas, realizando triagem fitoquímica para identificação de taninos e saponinas, verificando microscopicamente o processo inflamatório durante a reparação e neoformação óssea pós-lesão. Para produzir o extrato de...

Biomaterials used in tissue regeneration processes represent a promising option for the versatility of its physical and chemical characteristics, allowing for assisting or speeding up the repair process stages. This research has characterized a polyurethane produced from castor oil monoacylglyceride ( Ricinus communis L) and tested its effect on re...

Rose oxide (RO) is a monoterpene found in rose oil fragrances. This monoterpene has been reported to possess anti-inflammatory activity, however, little is known regarding its pharmacological activity. The present study was carried out to evaluate its antidepressant action and possible mechanisms of action. Analysis of ADMET pharmacokinetic propert...

Objetivo: Avaliar os efeitos de cicatrização da Moringa oleifera em ratos Wistar. Metodologia: Folhas da moringa foram coletadas, secas, trituradas, misturadas com solvente hexano e filtrada. Após remoção do solvente e da umidade, combinou concentrado resultante ao gel natrosol, alcançando concentrações de 5% e 10%. Dividiu-se 60 ratos machos em 4...

Objective: In this scientific study, we aimed to evaluate genotoxic effects in rats (Rattus norvegicus), related to different periods of exposures to the LED curing light. Methodology: For the genotoxicity evaluation, the rats received lights from the LED photopolymerizer for 40 sec, 10 min and 7-and-a-half minutes, while the negative and positive...

In the face of controversies about the treatment of tendon injuries, non-surgical treatment using photobiomodulation therapy has been shown to be effective in repair. Objective was to evaluate the effects of photobiomodulation therapy on the tendon repair process. 42 Rattus norvegicus belonging to the wistar lineage were used, which were randomly d...

Purpose To synthesize and characterize poly(hydroxybutyrate) (PHB) and norbixin membranes to evaluate them for genotoxicity in rats and wound healing in mice by histological staining. Methods For the evaluation of genotoxicity, male rats ( Rattus novegicus ) were divided into three groups (n= 5): 5% PHB/Norbixin membrane introduced into the perito...

O objetivo do presente trabalho foi analisar a ação do gel enriquecido com α-terpineol associado ao ultrassom terapêutico no processo inflamatório. A tendinite foi induzida mediante a compressão transversal durante 10s com pinça Halstead na segunda cremalheira, assim como dez escarificações, usando 72 ratos da espécie Rattus norvegicus, variedade W...

Purpose: To evaluate the in vivo response of photobiomodulation therapy associated with norbixin-based poly(hydroxybutyrate) membrane (PHB) in tenotomized calcaneal tendon. Methods: Thirty rats were randomly allocated to six groups (n=5 each): LED groups (L1, L2 and L3) and membrane + LED groups (ML1, ML2 and ML3). The right calcaneal tendons of a...

Purpose: To determine the efficacy of norbixin-based poly(hydroxybutyrate) (PHB) membranes for Achilles tendon repair. Methods: Thirty rats were submitted to total tenotomy surgery of the right Achilles tendon and divided into two groups (control and membrane; n = 15 each), which were further subdivided into three subgroups (days 7, 14, and 21; n...

O estudo teve por objetivo avaliar a qualidade das informações das embalagens e das características físicas dos fios de Nylon monofilamentares empregados nas suturas em um hospital de uma capital do Nordeste. Foi realizado um estudo experimental com caráter qualitativo analisando fios do tipo nylon monofilamentar 2-0 agulhado sertix (Shalon e Super...

Ethnopharmacological relevance: Ximenia americana L. is popularly known as yellow plum, brave plum or tallow wood. All the parts of this plant are used in popular medicine. Its reddish and smooth bark are used to treat skin infections, inflammation of the mucous membranes and in the wound healing process. Objective: Verification of phytochemical...

INTRODUÇÃO: Os recursos fisioterapêuticos influenciam positivamente no processo de cicatrização, acelerando as diferentes fases e reduzindo o tempo de lesão através da aplicação de recursos eletrofísicos, tais como ultrassom terapêutico (UST). A interação entre o UST e os tecidos biológicos, é capaz de gerar alterações celulares, por efeitos mecâni...

Here, butylene adipate-co-terephthalate/polypyrrole with nanohydroxyapatite (PBAT/PPy/nHAp) scaffolds were fabricated and characterized. The electrospinning process was carried out using 12 kV, a needle of 23 G, an infusion pump set at 0.3 mL/h, and 10 cm of distance. Afterwards, nHAp was directly electrodeposited onto PBAT/PPy scaffolds using a cl...

O Z. officinale é utilizado como condimento e erva medicinal desde a antiguidade, há mais de 3.000 anos, tendo sido usada para o tratamento de náuseas, dispepsias, vômito, diarreia e reumatismo. Apesar do uso corriqueiro de pela medicina popular, o gengibre não possui estudos acerca de sua genotoxicidade. O presente estudo teve como objetivo avalia...

Acidentes com animais peçonhentos estão relacionados à localização geográfica e hábitos de vida da população envolvida. O objetivo deste trabalho foi avaliar os aspectos epidemiológicos e clínicos dos acidentes com animais peçonhentos no estado do Piauí, no período de janeiro de 2007 a dezembro de 2011. Realizou-se um estudo descritivo e retrospect...

Biocompatible membranes are widely used in medicine to stimulate bone repair. Several studies have demonstrated that laser photobiomodulation (PBM) also stimulates osteoblast proliferation and osteogenesis at the fracture site, leading to a greater deposition of bone mass and accelerating the process of bone consolidation. This work assessed the th...

Introdução: A queimadura é uma injúria que altera a integridade da pele, decorrente de traumas térmicos. Dentre os compostos não convencionais utilizados na cicatrização de feridas estão a norbixina e as preparações com prata. Objetivo: avaliar a ação cicatrizante da nanopartícula de prata associada à norbixina em queimaduras de Mus musculus. Métod...

Introduction: Repeated overloads of a tendon may give rise to an inflammatory response, called tendinitis, which usually begins suddenly. Researches report that the Brazilian Northeast is common to use the pequi oil (Caryocar Coriaceum wittm) in the treatment of inflammation and other diseases. Objective: To evaluate the anti-inflammatory effect of...

Purpose: To evaluate in a macroscopic, histological and histomorphometric manner the healing process of cutaneous wounds in mice. Methods: The sample consisted of 40 male mice and was divided in four groups: 1st group (control, n=10), 2nd group (High Frequency Generator - HF, the maximum amplitude range, 120s, n=10), 3rd group (AlGaInP Laser 660...

Introduction: There are several studies on the use of Caryocar brasiliense in the scarring process; however, few studies have evaluated posttreatment skin tissue resistance to tension. Objective: To analyze the scar tension in skin incisions of rats after therapy Caryocar brasiliense . Method: Twenty Wistar rats were divided into two groups (placeb...

Recent studies have demonstrated the efficacy of coherent light therapy from the red region of the electromagnetic spectrum on the tissue-healing process. This study analysed the effect of non-coherent light therapy (light-emitting diode-LED) with or without silver sulfadiazine (sulpha) on the healing process of third-degree burns. In this study, 7...

Introduction: Mastruz (Chenopodium ambrosioides) is one of the most used plants in folk medicine. Objectives: To verify the healing of skin wounds treated with mastruz with and without cover. Methods: Forty-five Wistar rats, divided into three groups, were used. The wounds of the animals were treated as follow: in group 1, with a 0.9% saline soluti...

Studies have demonstrated the beneficial effects of topical application of fatty acids as healing agents. The lipid fraction of Ovis aries have an anti-inflammatory action that accelerates the healing process. Ultrasound increases blood flow and the extensibility of collagen structures and tendons. To assess the anti-inflammatory action of the Ovis...

The aim of our study was to compare topical use of Aloe vera gel, pulsed mode ultrasound (US) and Aloe vera phonophoresis on rat paw with collagenase-induced tendinitis. Edema size, tensile tendon strength, tendon elasticity, number of inflammatory cells and tissue histology were studied at 7 and 14 days after tendinitis induction. Pulse mode US pa...

Inflammation is a set of successive, active and complex biochemical, physiological and morphological phenomena which exteriorize through the vascular reaction of the living tissue to any aggression. The ultrasound therapy is an electro- physical resource used to control inflammation. To examine the action of anti-inflammatory sonophoresis in a tend...