Antonio Ciampi

Antonio Ciampi
McGill University | McGill · Department of Epidemiology, Biostatistics and Occupational Health

About

321
Publications
30,166
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
10,829
Citations
Citations since 2017
33 Research Items
4245 Citations
20172018201920202021202220230200400600
20172018201920202021202220230200400600
20172018201920202021202220230200400600
20172018201920202021202220230200400600
Additional affiliations
April 2006 - present
Saint Mary's Hospital Center
Saint Mary's Hospital Center
Position
  • senior biostatistician
July 1985 - present
McGill University
Position
  • Professor (Associate)

Publications

Publications (321)
Article
Full-text available
Background: Psychometrically sound measures of chronic disease self-management tasks are needed to improve identification of patient needs and to tailor self-management programs. This study aimed to develop and conduct a preliminary psychometric analysis of the CanSMART questionnaire among a diverse, multimorbid Canadian population. Methods: The...
Article
5‐hydroxymethylcytosine (5hmC) is a methylation state linked with gene regulation, commonly found in cells of the central nervous system. 5hmC is associated with demethylation of cytosines from 5‐methylcytosine (5mC) to the unmethylated state. The presence of 5hmC can be inferred by a paired experiment involving bisulfite and oxidation‐bisulfite tr...
Article
Objectives Identify the key effective components of a depression self-care intervention. Methods Secondary analysis of data from 3 studies that demonstrated effectiveness of a similar depression self-care intervention (n=275): 2 studies among patients with chronic physical conditions and 1 among cancer survivors. The studies used similar tools, an...
Article
Ownership of cats in childhood has been inconsistently associated with psychosis in adulthood. Parasitic exposure, the putative mechanism of this association, may be more common with rodent-hunting cats, and its association with psychosis may depend on other environmental exposures. We examined the conditional associations between childhood cat own...
Article
Full-text available
Background Delirium is a significant cause of morbidity and mortality among older people admitted to both acute and long-term care facilities (LTCFs). Multicomponent interventions have been shown to reduce delirium incidence in the acute care setting (30–73%) by acting on modifiable risk factors. Little work, however, has focused on using this appr...
Article
Introduction Geriatric emergency department (ED) care has gained increasing importance and interest due to increasing visits in seniors. Aim Among ED front-line nurses and physicians, to assess and compare ratings of elder-friendly care process indicators, variability in ratings, and concurrent validity of ratings. Methods Four Quebec EDs’ full-t...
Preprint
Background: Maternal distress influences her own wellbeing and shapes her offspring’s psychosocial adjustment and neurodevelopment across childhood. The aim of this study was to analyze multivariate trajectories of maternal postpartum distress using a latent class modeling approach and to find genetic and psychosocial factors that predict membershi...
Article
PURPOSE Depression in post-treatment cancer survivors is common and can impair quality of life. CanDirect is a novel, telephone-delivered depression self-care intervention for cancer survivors. We conducted a randomized controlled superiority trial to compare CanDirect with usual care (UC) in this population. METHODS Participants completing cancer...
Article
Objective To review the effectiveness of health education interventions adapted for culturally and linguistically diverse (CALD) populations with a chronic illness. Methods A systematic review and meta-analysis were conducted. Eligible studies were identified across six databases. Data were extracted and intervention effect was summarized using st...
Article
Full-text available
In this article, we introduce a novel bioinformatics program, Spore-associated Symbiotic Microbes Position-Specific Function (SeSaMe PS Function), for position-specific functional analysis of short sequences derived from metagenome sequencing data of the arbuscular mycorrhizal fungi. The unique advantage of the program lies in databases created bas...
Article
Full-text available
Arbuscular mycorrhizal fungi (AMF) are plant root symbionts that play key roles in plant growth and soil fertility. They are obligate biotrophic fungi that form coenocytic multinucleated hyphae and spores. Numerous studies have shown that diverse microorganisms live on the surface of and inside their mycelia, resulting in a metagenome when whole-ge...
Article
It is challenging to estimate the phenotypic impact of the structural genome changes known as copy‐number variations (CNVs), since there are many unique CNVs which are nonrecurrent, and most are too rare to be studied individually. In recent work, we found that CNV‐aggregated genomic annotations, that is, specifically the intolerance to mutation as...
Preprint
Full-text available
In this article, we introduce a novel bioinformatics program- SeSaMe PS Function (Spore associated Symbiotic Microbes Position Specific Function) - for position-specific functional analysis of short sequences derived from metagenome sequencing data of the arbuscular mycorrhizal fungi. The unique advantage of the program lies in databases created ba...
Preprint
Full-text available
Arbuscular mycorrhizal fungi (AMF) are plant root symbionts that play key roles in plant growth and soil fertility. They are obligate biotrophic fungi that form coenocytic multinucleated hyphae and spores. Numerous studies have shown that diverse microorganisms live on the surface and inside their mycelia, resulting in a metagenome when whole genom...
Article
Full-text available
Identifying disease‐associated changes in DNA methylation can help us gain a better understanding of disease etiology. Bisulfite sequencing allows the generation of high‐throughput methylation profiles at single‐base resolution of DNA. However, optimally modeling and analyzing these sparse and discrete sequencing data is still very challenging due...
Article
Full-text available
Purpose: Wide-awake local anesthesia hand surgery has many advantages over other forms of anesthesia, including faster recovery, lower cost, and improved patient safety; however, few studies compare postoperative pain and analgesic consumption after long- and short-acting anesthetics. This is important because surgeons seek to minimize opioid cons...
Article
Objectives: Among Canadian adults with chronic disease: 1) to identify groups that differ in self-management task frequency and self-efficacy; 2) to compare group characteristics and preferences for self-management support. Methods: Using data from an online survey, cluster analysis was used to identify groups that differed in self-management ta...
Article
Full-text available
In Mendelian randomization (MR), inference about causal relationship between a phenotype of interest and a response or disease outcome can be obtained by constructing instrumental variables from genetic variants. However, MR inference requires three assumptions, one of which is that the genetic variants only influence the outcome through phenotype...
Article
Objectives To examine: 1) whether patient characteristics predict perceived self-management support (usefulness of information and collaborative care planning) by primary care providers after six months, and 2) the association between perceived self-management support and patient activation at 6 months Methods We conducted a secondary analysis amo...
Article
Background: A large recent study analyzed the relationship between multiple factors and neonatal outcome and in preterm births. Study variables included reason for admission, indication for delivery, optimal steroid use, gestational age and other potentially prognostic factors. Using stepwise multivariable analysis, the only two variables independe...
Article
Objective: Caregiver research has relied on composite measures (e.g., count) of unmet supportive care needs to determine relationships with anxiety and depression. Such composite measures assume that all unmet needs have a similar impact on outcomes. The purpose of this study is to identify individual unmet needs most associated with caregivers' a...
Article
Study objective: This study aims to develop and validate measures of experiences of an emergency department (ED) visit suitable for use by older adults or their family members. Methods: A cohort of patients aged 75 years and older who were discharged home was recruited at 4 EDs. At 1 week after the visit, patients or family members were intervie...
Preprint
In Mendelian randomization (MR), genetic variants are used to construct instrumental variables, which enable inference about the causal relationship between a phenotype of interest and a response or disease outcome. However, standard MR inference requires several assumptions, including the assumption that the genetic variants only influence the res...
Article
Objectives: To develop and validate a comprehensive quality assessment tool for emergency department (ED) geriatric care. Design: Four-step study: (1) Content development of tool by a multidisciplinary panel, (2) survey of ED lead physicians and nurses, (3) development of subscales using principal component analysis and clinical judgment, (4) re...
Article
Objectives To validate 2 new patient-reported measures of self-management support from health professionals for mood and emotional problems. Methods The sample comprised primary care patients with chronic physical conditions and co-morbid depressive symptoms enrolled in a randomized trial of telephone coaching of a depression self-care interventio...
Article
Objective Recruiting participants in clinical research is challenging. Certain groups, such as older adults, rural residents, and individuals with lower socio-economic status, are typically underrepresented. Here, we explore perceived motivators and barriers among potential participants in a diagnostic study of ovarian cancer. Methods Women aged 5...
Article
Introduction Maternal mental well being influences offspring development. Research suggests that an interplay between genetic and environmental factors underlies this familial transmission of mental disorders. Objectives To explore an interaction between genetic and environmental factors to predict trajectories of maternal mental well being, and t...
Article
Background/objectives: To describe changes in geriatric emergency department (ED) services from 2006 (T1) to 2013/14 (T2), associated factors, and outcomes. Design: Two-wave survey design. Setting: Province of Quebec, Canada. Participants: Lead nurses and physicians at 57 EDs that participated in both the T1 and T2 surveys. Intervention: C...
Article
Full-text available
Primary patterns in adult brain connectivity are established during development by coordinated networks of transiently expressed genes; however, neural networks remain malleable throughout life. The present study hypothesizes that structural connectivity from key seed regions may induce effects on their connected targets, which are reflected in gen...
Article
Background A few studies examine the time evolution of delirium in long-term care (LTC) settings. In this work, we analyze the multivariate Delirium Index (DI) time evolution in LTC settings. Methods The multivariate DI was measured weekly for six months in seven LTC facilities, located in Montreal and Quebec City. Data were analyzed using a hidde...
Article
Objectives To describe unmet needs of caregivers of hospitalized older adults during the transition from hospital back home, and identify subgroups with different needs. Methods Patients and family caregivers were recruited from an acute care hospital in Montreal, Canada. Measures included Instrumental Activities of Daily Living (IADL), Hospital A...
Conference Paper
Full-text available
Pulse transit time (PTT) is a simple, non-invasive measurement and an appropriate parameter for stress measurement, but few quantitative data are available describing the factors which influence PTT. Objective: The aim of this study was to investigate beat-to-beat the relationship between time-frequency heart rate variability, the cardiac interval (...
Article
Full-text available
IntroductionLarge-scale sequencing studies often measure many related phenotypes in addition to the genetic variants. Joint analysis of multiple phenotypes in genetic association studies may increase power to detect disease-associated loci. Methods We apply a recently developed multivariate rare-variant association test to the Genetic Analysis Work...
Conference Paper
In studies involving genetic data, the correlations between X and Y scores obtained from PLS regression models can be used as measures of association between genome-level measurements, X, and phenotype-level measurements, Y. These correlations may be overestimated due to potential overfitting (i.e., they may be vulnerable to optimism bias). We eval...
Conference Paper
In this paper we propose an extension to the PATHMOX segmentation algorithm to detect which endogenous latent variables and predictors are responsible for heterogeneity. We also address the problem of factor invariance in the terminal nodes of PATHMOX. We demonstrate the utility of such methodology on real mental health data by investigating the re...
Article
Full-text available
Diagnostic testing is recommended in women with “ovarian cancer symptoms.” However, these symptoms are nonspecific. The ongoing Diagnosing Ovarian Cancer Early (DOVE) Study in Montreal, Quebec, Canada, provides diagnostic testing to women aged 50 years or older with symptoms lasting for more than 2 weeks and less than 1 year. The prevalence of ovar...
Article
Background the implications of partial and no recovery from delirium after hospital discharge are not clear. We sought to explore whether partial and no recovery from delirium among recently discharged patients predicted increased adverse events (emergency room visits, hospitalisations, death) during the subsequent 3 months. Method prospective stu...
Article
Background: The delirium index (DI) is a valid measure of delirium severity. We proposed to describe longitudinal patterns of severity scores in older long-term care (LTC) residents. Methods: A prospective cohort study of 280 residents in seven LTC facilities in Montreal and Quebec City, Canada, was conducted. DI, Barthel Index, Mini-Mental Stat...
Article
The genomics era has led to an increase in the dimensionality of data collected in the investigation of biological questions. In this context, dimension-reduction techniques can be used to summarise high-dimensional signals into low-dimensional ones, to further test for association with one or more covariates of interest. This paper revisits one su...
Article
Full-text available
Sperm DNA damage is prevalent among infertile men and is known to influence natural reproduction. However, the impact of sperm DNA damage on assisted reproduction outcomes remains controversial. Here, we conducted a meta-analysis of studies on sperm DNA damage (assessed by SCSA, TUNEL, SCD, or Comet assay) and clinical pregnancy after IVF and/or IC...
Article
Objectives: In a sample of primary care participants with chronic physical conditions and comorbid depressive symptoms: to describe the cross-sectional and longitudinal associations of activation and self-efficacy with demographic, physical and mental health status, health behaviors, depression self-care, health care utilization, and use of self-c...
Article
Full-text available
Objective: To explore the effects of baseline psychological and antidepressant medication treatment in a trial of lay telephone coaching in a low-intensity, supported depression self-care intervention. Method: A single blind, individually randomised, pragmatic trial was conducted among primary care adults with chronic physical conditions and com...
Article
Objective: The objective of this study is to explore whether the use of medications that antagonize mediators of inflammatory responses reduces the risk of delirium in older adults. Methods: A nested case-control study was conducted using data from a prospective study of delirium in older long-term care residents from 7 long-term care facilities...
Article
Full-text available
For region-based sequencing data, power to detect genetic associations can be improved through analysis of multiple related phenotypes. With this motivation, we propose a novel test to detect association simultaneously between a set of rare variants, such as those obtained by sequencing in a small genomic region, and multiple continuous phenotypes....
Article
Objective Among primary care patients with chronic physical conditions and comorbid depressive symptoms, to assess (1) the effect of lay telephone coaching on adherence to a psycho-educational intervention for depression, (2) demographic characteristics that predict adherence and (3) the association between adherence and 6-month outcomes. Design S...
Preprint
Full-text available
The genomics era has led to an increase in the dimensionality of the data collected to investigate biological questions. In this context, dimension-reduction techniques can be used to summarize high-dimensional signals into low-dimensional ones, to further test for association with one or more covariates of interest. This paper revisits one such ap...
Article
Objectives: To determine the frequencies of full, partial and no recovery from subsyndromal delirium (SSD) in older hospital inpatients. A secondary objective was to compare the recovery status of patients with SSD or delirium. Methods: SSD was defined as acute onset of one or more Confusion Assessment Method core symptoms of delirium (fluctuati...
Article
Objectives To determine the frequency and baseline risk factors for partial and no recovery from delirium in older hospitalized adults. DesignCohort study with assessment of recovery status approximately 1 and 3months after enrollment. SettingUniversity-affiliated, primary, acute-care hospital. ParticipantsMedical or surgical inpatients aged 65 and...
Article
Full-text available
Motivation: DNA methylation patterns are well known to vary substantially across cell types or tissues. Hence, existing normalization methods may not be optimal if they do not take this into account. We therefore present a new R package for normalization of data from the Illumina Infinium Human Methylation450 BeadChip (Illumina 450K) built on the...
Article
Full-text available
Supplementary Methods funtooNorm normalization method: Let í µí±‹ (í µí±xí µí° ¶) represent a matrix of summary control-probe data for í µí± samples and í µí° ¶ control probe signals, where there is a column for the average log signal from each control probe type and each colour (red, green). We create a larger matrix, í µí±‹ * , by adding additi...
Article
Background: High station at specific points in the first stage of labor, such as a floating head on admission, or at 4 cm dilation or when arrest of dilation occurs, is associated with higher rates of failure to deliver vaginally. Therefore it could be useful to know if station is within an expected range at a given dilation during first stage. Ar...
Article
The contribution of rare and low-frequency variants to human traits is largely unexplored. Here we describe insights from sequencing whole genomes (low read depth, 7×) or exomes (high read depth, 80×) of nearly 10,000 individuals from population-based and disease collections. In extensively phenotyped cohorts we characterize over 24 million novel s...
Article
Full-text available
Imputing genotypes from reference panels created by whole-genome sequencing (WGS) provides a cost-effective strategy for augmenting the single-nucleotide polymorphism (SNP) content of genome-wide arrays. The UK10K Cohorts project has generated a data set of 3,781 whole genomes sequenced at low depth (average 7x), aiming to exhaustively characterize...
Article
Depression is a common problem in long-term care (LTC) settings. We sought to characterize depression symptom trajectories over six months among older residents, and to identify resident characteristics at baseline that predict symptom trajectory. This study was a secondary analysis of data from a six-month prospective, observational, and multi-sit...
Conference Paper
The specification of a measurement model as reflective or formative is the object of a lively debate. Part of the existing literature focuses on measurement model misspecification. This means that a true model is assumed and the impact on the path coefficients of using a wrong model is investigated. The majority of these studies is restricted to St...
Article
The aim of this study was to compare outcomes of use of a depression self-care toolkit with and without lay telephone coaching among primary care patients 40 years and older with depressive symptoms and comorbid chronic physical conditions. A single blind, individually randomized, pragmatic trial of a depression self-care toolkit (Toolkit) with or...
Article
Full-text available
Normal thyroid function is essential for health, but its genetic architecture remains poorly understood. Here, for the heritable thyroid traits thyrotropin (TSH) and free thyroxine (FT4), we analyse whole-genome sequence data from the UK10K project (N=2,287). Using additional whole-genome sequence and deeply imputed data sets, we report meta-analys...
Article
Full-text available
Tuberculosis (TB) transmission may occur with exposure to an infectious contact often in the setting of household environments, but extra-domiciliary transmission also may happen. We evaluated if using buses and/or minibuses as public transportation was associated with acquiring TB in a high incidence urban district in Lima, Peru. Newly diagnosed T...
Article
Full-text available
Self-care programs for depression use educational and cognitive-behavioral techniques (e.g. written information, audiotapes, videotapes, computerized, or group courses) to assist patients in the management of depressive symptoms (Morgan and Jorm, 2008). In the UK, these interventions are recommended as step 1 in a stepped care program for treating...
Article
Full-text available
We assessed adherence to and predictors of two components of a telephone-supported self-care intervention for depression among primary care adults aged 40 and above with chronic physical illnesses and comorbid depressive symptoms. Participants received a “toolkit” containing six self-care tools. Trained lay self-care “coaches” negotiated a contact...
Article
With the advent of large-scale DNA sequencing studies, it is worth considering how to estimate the required significance threshold for tests of association between the resulting genetic variation and a phenotype of interest. Due to the rarity of most of the identified variants, standard analytic practice now includes, in addition to single-variant...
Article
Full-text available
The contribution of rare and low-frequency variants to human traits is largely unexplored. Here we describe insights from sequencing whole genomes (low read depth, 7x) or exomes (high read depth, 80x) of nearly 10,000 individuals from population-based and disease collections. In extensively phenotyped cohorts we characterize over 24 million novel s...
Article
To describe the 6-month outcomes of co-occurring delirium (full syndrome and subsyndromal symptoms), depression, and dementia in a long-term care (LTC) population. Observational, prospective cohort study with 6-month follow-up conducted from 2005 to 2009. Seven LTC facilities in the province of Quebec, Canada. Newly admitted and long-term residents...
Article
We model longitudinal data from a heterogeneous population as samples from a mixture of extended linear mixed-effects (ELME) models, and develop algorithms for maximum likelihood estimation based on the Expectation–Maximization (EM) method. The three EM algorithms to estimate ELME are: (A) A standard EM algorithm; (B) An EM algorithm for the partic...
Article
Full-text available
Behavioral and psychological symptoms of dementia (BPSD) affect approximately all residents in nursing homes at some point; however, the course of BPSD among this group is not well known. The goal of the current study was to describe the course of each measured BPSD over a period of 6 months. A secondary explorative objective was to identify which...
Article
Full-text available
SETTING: Peru reports among the highest multidrug-resistant tuberculosis (MDR-TB) rates in the Americas, with a growing proportion in previously untreated tuberculosis (TB) cases. The identification of clusters of primary MDR-TB compared with drug-susceptible TB (DS-TB) could help prioritize interventions. OBJECTIVE: To examine the clustering of pr...
Article
Objectives: The associations between emergency department (ED) crowding and patient outcomes have not been investigated comprehensively in different types of ED. The study objective was to examine the associations of changes over time in ED occupancy with patient outcomes in a sample of EDs that vary by size and location. A secondary objective was...