Antonio Barone

Università di Pisa | UNIPI · Department of Surgical, Medical, Molecular, and Critical Area Pathology

This study aimed to describe a case of simultaneous guided bone regeneration (GBR) and implant placement in a patient with prior aesthetic implant failure, focusing on achieving optimal aesthetic and functional outcomes, and to perform a literature review of the current evidence. A 38-year-old male presented with an improperly positioned implant at...

The aim of the present study was to assess the occurrence of intra-, peri-, and post-operative bleeding following tooth extractions in patients treated with direct oral anticoagulants (DOACs). Consecutive patients requiring at least one dental extraction were enrolled. The DOAC regimen was either maintained or suspended. Patients were classified in...

Objectives: This retrospective study compared the outcomes of implants placed in alveolar ridge preservation (ARP) treated sites with those in spontaneously healed (SH) sites. Materials and methods: The study included patients presenting with one implant placed in an ARP-treated socket and one in an SH site. The primary outcome was the compariso...

Purpose: Immediate implant placement is a reliable solution to replace hopeless teeth, but this procedure may be associated to an increased risk of soft tissue complications in case of thin biotype. The use of tissue-level implants with a convergent transmucosal profile has been advocated to increase space for soft tissue, contributing to improve t...

Background: The present systematic review evaluated clinical and radiographic features and treatment outcomes of peri-implantitis-induced medication-related osteonecrosis of the jaws (Pi-MRONJ). Materials and methods: Literature search was performed in PubMed/MEDLINE, Cochrane CENTRAL, Web of Science, and Scopus databases. Studies reporting Pi-M...

Oxidative stress and high levels of reactive oxygen species (ROS) are linked to various age-related diseases and chronic conditions, including damage to oral tissues. Dexamethasone (DEX), a widely used glucocorticoid in dentistry, can have side effects like increased ROS production and delayed wound healing. Resveratrol (RSV) is known for its antio...

Background Maxillary sinus augmentation is one of the most performed procedures to increase the bone quantity of the atrophic maxilla to allow implant placement. The aim of the present case series was to describe a surgical protocol to perform maxillary sinus augmentation with the “bone lid technique,” and its outcomes in a cohort of patients eligi...

Additive manufacturing (AM), also known as additive printing, is increasing its importance in every field of dentistry. There are different methods of AM, one of these being digital light processing (DLP). Several factors can influence the accuracy of printed crowns, and one of them is the building or printing orientation. Therefore, the aim of thi...

Organs-on-a-chip (OoCs) are microfluidic devices constituted by PDMS or hydrogel in which different layers of cells are separated by a semipermeable membrane. This technology can set many parameters, like fluid shear stress, chemical concentration gradient, tissue–organ interface, and cell interaction. The use of these devices in medical research p...

Introduction: Tooth extractions can result in alveolar bone dimensional changes, necessitating additional bone grafting for implant placement. Alveolar Ridge Preservation (ARP) aims to counteract post-extraction changes. This study evaluates the bone regenerative properties of a freeze-dried bone allograft (FDBA) and the clinical outcomes of impla...

Background: Tooth extractions leads to alveolar bone resorption which may complicate or reduce the possibility to rehabilitate the edentulous area with dental implants. Alveolar Ridge Preservation (ARP) procedures have been introduced to minimize the dimensional changes following tooth extractions: the main feature of ARP is toperform a tooth extra...

This study aims to test a photodynamic protocol based on a gel containing aminolevulinic acid followed by red-LED (ALAD-PDT) irradiation on human gingival fibroblasts (hGFs) and osteoblasts (hOBs) cultured on a porcine acellular dermal matrix membrane (PADMM). In the previous literature, ALAD-PDT showed solid antibacterial activity and proliferativ...

Adequate implant primary stability is a key factor to obtain osseointegration and can be measured at insertion by insertion torque (IT) and at different timepoints with resonance frequency analysis (RFA), expressed as an implant stability quotient (ISQ). This retrospective study investigated the correlation between ISQ and IT at implant insertion....

The primary aim of this study was to assess the histomorphometric outcomes of extraction sockets grafted with freeze-dried bone allograft (FDBA) and sealed with a collagen membrane after 3 months of healing in the ROI (region of interest) areas. The secondary aims were to analyze the biomaterial resorption rate, the bone to biomaterial contact and...

Objectives: Alveolar ridge preservation (ARP) is a procedure with the aim to reduce bone resorption that occurs after tooth extraction, facilitating the following implant placement. The aim of this cross-sectional study was to evaluate the prevalence of mucositis and peri-implantitis around implants inserted in sites treated with ARP and to invest...

The success of implant-supported fixed complete dental prostheses (ISFCDPs) depends on multiple factors: some are related to the fixtures, such as fixture material, surface characteristics, positioning, and type of connection to prosthetic components; others are related to the prostheses, such as design and materials used. Zirconia is a material wi...

Guided bone regeneration (GBR) comprehends the application of membranes to drive bone healing and to exclude non-osteogenic tissues from interfering with bone regeneration. However, the membranes may be exposed to bacterial attack, with the risk of failure of the GBR. Recently, an antibacterial photodynamic protocol (ALAD-PDT) based on a gel with 5...

The use of collagen membranes has remained the gold standard in GTR/GBR. In this study, the features and the biological activities of an acellular porcine dermis collagen matrix membrane applicable during dental surgery were investigated, and also by applying hydration with NaCl. Thus, two tested membranes were distinguished, the H-Membrane and Mem...

Background: In order to minimize the remodeling process observed after tooth extraction, alveolar ridge preservation (ARP), has been widely used with the aims to reduce the amount of dimensional changes, maintain the integrity and shape of the alveolar crest and allow an easier implant placement without additional bone graft. Although several studi...

The basis for dental implant success comes not only with the titanium implant osseointegration but also depends on other factors such as the development of a soft tissue barrier, which protects the peri-implant bone from the oral environment. The characteristics of surfaces in contact with peri-implant soft tissues may affect the capacity of peri-i...

Purpose: The present systematic review and meta-analysis aimed to investigate the available evidence in the literature to answer the following focused question: In partially edentulous arches with reduced bone width, do implants placed after horizontal bone augmentation exhibit differences in survival and success rate compared to narrow-diameter i...

Hereditary Angioedema (HAE) is a rare disease characterized by a deficiency or a reduced function of the plasma protein C1 esterase inhibitor (C1-INH), which is involved in the downregulation of several inflammatory pathways. Patients affected by HAE suffer from episodic swellings of subcutaneous or submucosal tissues. Swellings can be caused by st...

Aim: Long-term studies addressing the outcomes of single immediate implantation and provisionalization at the maxillary esthetic zone are needed. The current study aimed to assess such outcomes along a follow-up period of up to 18 years. Materials and methods: The current study is a continuation follow-up of our previously published up to 6-year...

Tooth autotransplantation is a procedure which provides the extraction of an erupted or impacted tooth and its repositioning to another site in the oral cavity. This Case Report describes a successful case of two autotransplantations of open-apex mandibular third molars in place of the hopeless first mandibular molars with the use of L-PRF in a gro...

Background: Lateral maxillary sinus augmentation (MSA) is a predictable bone regeneration technique in case of atrophy of the posterior-upper maxilla. Aimed at obtaining quantity and quality of bone suitable for receiving osseointegrated implants, its success is largely due to the skill of the surgeon, but also to the characteristics of the biomate...

Purpose: To systematically review the literature comparing marginal bone loss (MBL) and pink esthetic scores of implants with convergent or concave transmucosal profiles vs divergent or parallel profiles. Materials and methods: A PICO question was defined, and an electronic search was carried out in the MEDLINE/PubMed and Cochrane Oral Health Gr...

Objectives A controlled, single‐blind, randomized clinical trial was performed to evaluate usefulness of antibiotics in preventing pain and complications after tooth extractions and benefits of probiotics in reducing gastro‐intestinal symptoms associated with antibiotic therapy Materials and methods 159 patients were enrolled in this trial. After...

Objectives During the months of March and April 2020, Italy saw an exponential outbreak of COVID‐19 epidemic. Dental practitioners were particularly limited in their routine activity, and the sole performance of urgent treatments was strongly encouraged during the peak of the epidemic. A survey among dental professionals was performed between 6th‐1...

The management of patients under treatment with Direct Oral Anticoagulants (DOACs) has led clinicians to deal with two clinical issues, such as the hemorrhagic risk in case of non-interruption or the risk of thromboembolism in case of suspension of the treatment. The primary aim of this retrospective study was to evaluate the incidence of periopera...

Purpose: Marginal bone loss (MBL) is an important clinical issue in implant therapy. One feature that has been cited as a contributing factor to this bone loss is peri-implant mucosal thickness. Therefore, in this report, we conducted a systematic review of the literature comparing bone remodeling around implants placed in areas with thick (≥2-mm)...

La elevación lateral del seno maxilar (ELSM) es una técnica regenerativa predecible en los casos de atrofia del maxilar posterior. Su objetivo es obtener un volumen óseo adecuado para la inserción de los implantes y su posterior rehabilitación prostodóncica. Pacientes y métodos. 24 pacientes fueron tratados con ELSM con diferentes biomaterials (hue...

Literature reviews are crucial in the choice of the best personalized material type and restauration type in restorative dentistry. We developed an IBM-Watson based system to support literature search for restorative dentistry, and compared its results to a literature search performed by a trained professional. We found that our system could assist...

Background: Dental implants placed in medically compromised patients have predictable outcomes and a high rate of survival, compared to those placed in healthy patients. The aims of this study were to observe and compare implant survival/success rates and soft tissue response to tissue-level implants placed in healthy and medically compromised pat...

OBJECTIVES. The aim of this multicentre randomised controlled trial was to evaluate the efficacy of a xenogeneic dermal matrix in widening keratinised peri-implant tissues du-ring second-stage surgery, and to compare it to both autologous connective tissue graft and a control group with no augmentation. MATERIAL AND METHODS. Patients requiring an i...

Many biomaterials have been proposed for ridge preservation techniques to counteract fresh extraction socket resorption. The primary aim of this prospective single cohort study was to evaluate the histomorphometric outcomes of a synthetic biphasic calcium phosphate (60% HA/40% β-TCP) and a synthetic poly-lactic acid membrane, used to graft fresh ex...

One of the most important aspects of bone remodeling is the constant turnover mainly driven by the mechanical loading stimulus. The remodeling process produces changes not only in the bone microarchitecture but also in the density distribution of the mineralized matrix - i.e. in calcium concentrations- and in the osteocyte lacunar network. Synchrot...

Objective: The purpose of this retrospective study was to assess the influence of antibiotics on the development of alveolitis after tooth extractions. Materials and methods: The study population consisted of patients who had erupted tooth extractions in 3 centres. The patients' medical records were collected for several parameters. Moreover, us...

Background/Purpose Blade implants account for one of the most debated dental implants design in scientific literature. They have been reconsidered by clinicians since their re-classification by Food and Drug Administration in 2014. Materials and methods The present study aimed to evaluate the outcome of newly manufactured extension implants in the...

Background: Immediate implants have shown risks of esthetic complications. The hypothesis was that a customized healing abutment could improve the peri-implant tissue healing. Purpose: To evaluate and compare the soft and hard tissue healing around immediate implants that received bone grafting and a customized vs a standard healing abutment. M...

Objective: This prospective clinical study evaluated the clinical performance of one-, two- and multi-surface composite resin inlays over a 12-year period on premolars and molars. Method and materials: One clinician placed 113 indirect composite resin inlays (Signum, Heraeus Kulzer) in 30 patients that were bonded using a three-step bonding syst...

Medication-related osteonecrosis of the jaw are bone exposures in the maxillofacial region that does not heal after 8 weeks from the observation of a health care provider in patients with history of the intake of antiresorptive agents and no previous irradiation of the craniofacial region. Initially attributed only to the intake of bisphosphonates...

Objectives We sought to validate a new method to detect the degree of correlation between simulated and real tilted blade implants as they appear on a single two-dimensional radiograph. Methods The angular correction factor (CF^) was defined as the coupling of two subsequent angle transformations, a set of five angular values describing the theore...

Immediate implant placement in fresh extraction sockets is considered a reliable procedure that offers several clinical advantages. A flapless surgery, the integrity of buccal bone plate and the adequate implant placement are key factors for ensuring favourable clinical outcomes. The use of biomaterials into peri-implant bone defect and the design...

Implant treatment became the standard of care for the rehabilitation of partial and total edentulisms. Healthy patients showed a very high success rate over a long-term follow-up, nevertheless implant failures could happen due to lack (early failure) or loss of osseointegration (late failure)1,2. The impact of several systemic diseases on the outco...

Implant placement immediately after tooth extraction has proven to be a predictable technique with a high success rate1. This procedure offers several advantages for the patient and for the clinician, including shorter treatment time and less surgical procedures2,3. The correct three-dimesional implant position and the management of peri-implant ga...

Background: Consistent bone changes occur after tooth removal, often compromising the suc- cess of implants placed within the socket left to natural healing The long-term effect of ridge preservation on implant outcomes is still unclear. Purpose: The aim of the study was to assess success and survival rates of implants placed in extraction sockets,...

Purpose: The purpose of the present cohort study was to investigate the 3-year efficacy and clinical performance of implant-supported rehabilitations in posterior mandibles augmented with the sandwich osteotomy technique. Materials and methods: Twenty-three partially edentulous patients who developed atrophy of the posterior mandible (residual r...

Objectives: The purpose of this study was to evaluate a nonsurgical approach toward peri-implantitis by means of mechanical debridement and local detoxification leaving granulation tissue into the peri-implant pockets. Materials and methods: An analysis was performed on the outcomes of 2 nonsurgical protocols: mechanical debridement plus chemica...

Background: Implant stability is commonly related to insertion torque. Recently, it has been suggested that higher insertion torque may lead to greater bone resorption. Purpose: The aim of the present randomized clinical study was to evaluate the role of different insertion torque values in terms of implant success, marginal bone loss, and facial...

Aim: To systematically review the literature comparing marginal bone loss around implants placed in areas with thick versus thin mucosa at 1 year after implant loading. Materials and Methods: A PICO question was defined and manual and electronic screenings on MEDLINE/PubMed and Cochrane Oral Health Group databases were performed. Prospective studie...

Conclusiones. Este estudio indica que la rehabilitación de la mandíbula atrófica mediante técnicas quirúrgicas complejas con injertos óseos e implantes constituye un tratamiento con una elevada tasa de éxito.

Gingival recessions have multifactorial etiology and are often associated with non-caries cervical lesions. Different surgical techniques have been proposed over the years for their treatment, according to the severity of the recession. A novel technique, called restoration guided creeping attachment (RGCA), for the treatment of combined gingival r...

Background: Patient-centred outcomes are being given great attention by the dental scientific community. The Oral Health Impact Profile -14 questionnaire (OHIP-14) has been introduced to address patients' success criteria when describing the impact of oral rehabilitations on quality of life (OHrQoL). Methods: Thirty-five patients wearing a full-...

The placement of implants immediately after tooth extraction has proven to be a predictable treatment strategy with a very high success rate. Nevertheless, the success of this surgery involves strict clinical criteria. A description is provided of a clinical orientation and scientific point of view based on our experience and available evidence of...

Background: Implant stability is commonly related to insertion torque. Recently, it has been suggested that higher insertion torque may lead to greater bone resorption. Purpose: The aim of the present randomized clinical study was to evaluate the role of different insertion torque values in terms of implant success, marginal bone loss, and facia...

Objectives: The present randomized double-blind clinical trial aimed to compare the efficacy in reducing dentin hypersensitivity of a dentifrice formulation containing nano-hydroxyapatite with a fluoride dentifrice and a placebo. Methods and materials: One hundred and five subjects were recruited to participate in the study. A computer-generated...