Antonio Arnaiz-Villena

Antonio Arnaiz-Villena
Complutense University of Madrid | UCM · Department of Immunology

Professor

About

490
Publications
86,866
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Introduction
RESEARCH INTERESTS https://www.ucm.es/microbiologia-1/antonio-arnaiz-villena Prof. Dr. Antonio Arnaiz-Villena He studied Medicine and Biology at Complutense University (Madrid, Spain) and got his PhD in Medicine. He spent 9 years at the London Hospital Medical College and the Middlesex Hospital Medical School (London, UK) training in Immunology and Genetics. He came back to Spain and set up the Immunology departments of Hospital Ramon y Cajal and Hospital 12 de Octubre (Madrid);
Additional affiliations
April 1990 - January 2017
Complutense University of Madrid
Position
  • Chairman,Research Director,Head Department
January 1990 - January 2017
Complutense University of Madrid
Position
  • Chairman,Head Dept

Publications

Publications (490)
Article
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Kurds are living at Middle East region comprising several countries (38 million people) and also have emi- grated to Asia, Europe and America. Kurds from Iran have been HLA typed in the present work from Saqqez and Baneh towns, Kordestan province, Iran. Origin of Kurds is considered autochthonous from Anatolia and surrounding mountains :they have b...
Article
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Classical HLA (Human Leukocyte Antigen) is the Major Histocompatibility Complex (MHC) in man. HLA genes and disease association has been studied at least since 1967 and no firm pathogenic mechanisms have been established yet. HLA-G immune modulation gene (and also -E and -F) are starting the same arduous way: statistics and allele association are t...
Article
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Paleolithic/Neolithic (Megalithic) Lineal Scripts have been found in big or small rocks with or without megalithic context. Huelva (South West Spain) megalithic rocks presented engraved signs apparently contained in the Iberian-Tartessian semi-syllabary and this region is in the core of Tartessian civilization. Iberian-Tartessian scripts have been...
Article
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A big megalithic complex has been described at Cumbres Mayores (Huelva, Spain): it is composed of menhirs, a cromlech and some other not yet fully studied structures. Lineal Megalithic Scripts are present both on the rocks and the menhirs which also contain figure engravings. Iberian signs included within Iberian-Tartessian semi-syllabary are also...
Conference Paper
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Iberia.Nithology.Basque Iberism
Article
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Desert Finch is the genetic ancestor of all Greenfinches Spacies.Classification should be taken out from Genus Rhodopechys and changed to Genus Carduelis (Spinus).A TRNASLATIONAL PAPER.
Article
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Spain was invaded in 711 CE by mostly Berber North Africans carrying Muslim religion to a mostly Christian/Catholic Kingdom. A fight to expel Muslims soon started and were apparently driven out of Iberia (Spain) starting in 1492 CE. However, many of these expelled people were of Iberian old ancestry that had become Muslims at Las Alpujarras Mts. (S...
Article
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Azeri people are at present day mainly living in an area which comprises North (Azerbaijan) and South (Azeri Iran provinces) parts, living the biggest population in Azeri Iran provinces with about 17–20 million people. They were studied HLA-A, -B, -DRB1 and -DQB1 allele and extended haplotype frequencies in unrelated Iranian Tabriz Azeris from a ru...
Article
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HLA-G is a non-classical HLA class I molecule with immunomodulatory properties. It was initially described at the maternal-fetal interface, and it was later found that this molecule was constitutively expressed on certain immuneprivileged tissues, such as cornea, endothelial and erythroid precursors, and thymus. The immunosuppressive effect of HLA-...
Article
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La «Quesera» de Zonzamas es una estructura megalítica representando un calendario lunisolar de 365 días con 12 meses solares y 13 lunares,similar al egipcio. Representa el año canario prehistórico («Atxano» o «la sombra del eje») que comienza el solsticio de verano. Los meses son canales y franjas alternas de roca tallada . Por otra parte, en Malta...
Article
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Se han encontrado inscripciones rupestres ibéras en todas las Islas Canarias: son mayoritariamente incisas y utilizan el semisilabario ibérico (prehistórico de Iberia y Francia, 1000 a. de C.). Analizamos estas inscripciones rupestres en La Palma: la propuesta de transcripción y traducción muestra que son funerarias y religiosas, como las de Lanzar...
Article
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Cien años después de la llegada de Cristóbal Colón a América la población del continente había caído de unos 80 millones a aproximadamente 8, desde Alaska a La Patagonia. La causa principal fueron la guerra y los nuevos microbios. San Basilio de Palenque (Colombia), cercana a Cartagena de Indias, fue construida por los esclavos africanos que eran l...
Article
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Lineal Megalithic/Paleolithic Lineal signs/lines may have a variety of purposes or representations. Some authors have proposed they represent sky, planets and stars and their movements, space/time representations or others, including letters/syllables or symbols/events. Some are painted, other incised; the latter are relatively more common in Megal...
Article
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Canarians, North Africans and Iberians show a close genetic relatedness. Greeks have a Sub-Saharan gene input according to HLA and other autosomic markers. Also, there is a genetic kinship between both Atlantic Euro Africans and North African/Arabic people. This is concordant with a drying humid Sahara Desert, which may have occurred about 6,000 ye...
Article
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HLA-G is a non-classical class I HLA molecule that induces tolerance by acting on receptors of both innate and adaptive immune cells. When overexpressed in tumors, limits surveillance by the immune system. The HLA-G gene shows several polymorphisms involved in mRNA and protein levels. We decided to study the implication of two polymorphisms (rs3711...
Article
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HLA-G allele frequencies were studied in Yucatán (Mexico) Maya Amerindians by adirect exon DNA sequencing technique. It is described that Mayas are probably one of the first populations together with Olmecs that populated Meso America and that important HLA genetic differences between Mexican and Guatemalan Mayas support that Maya languages were im...
Article
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Greeks have a Sub-Saharan gene input according to HLA and other autosomic markers. Iberians, Canarians, and North Africans show a close genetic relatedness. This is concordant with a drying humid Sahara Desert, which may have occurred about 6,000 years BC, and the subsequent northwards emigration of Saharan people may have also happened in Pharaoni...
Article
In the present paper, we show Iberian or Iberian-Guanche scripts found in the Middle of Sahara Desert, Ti-m Missaou (Tim Missao, Tim Missaw), 270 km SouthWest of Tamanrasset on Ahaggar or Hoggar Mountains (Mts.) area (Algeria). More Iberian scripts may be earthed beneath Sahara Desert sands or have been neglected by observers. We also put forward t...
Article
Greeks have a Sub-Saharan gene input according to HLA and other autosomic markers. Iberians, Canarians, and North Africans show a close genetic relatedness. This is concordant with a drying humid Sahara Desert, which may have occurred about 6,000 years BC, and the subsequent northwards emigration of Saharan people may have also happened in Pharaoni...
Article
Full-text available
Abstract - In the present paper, we show Iberian or Iberian-Guanche scripts found in the Middle of Sahara Desert, Ti-m Missaou (Tim Missao, Tim Missaw), 270 km South-West of Tamanrasset on Ahaggar or Hoggar Mountains (Mts.) area (Algeria). More Iberian scripts may be earthed beneath Sahara Desert sands or have been neglected by observers. We also p...
Article
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Fcγ receptors (FcγR), cell-surface glycoproteins that bind antigen-IgG complexes, control both humoral and cellular immune responses. The FCGR locus on chromosome 1q23.3 comprises five homologous genes encoding low-affinity FcγRII and FcγRIII, and displays functionally relevant polymorphism that impacts on human health. Recurrent events of non-alle...
Article
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HLA‐G allele frequencies were studied in Yucatán (Mexico) Maya Amerindians by a direct exon DNA sequencing technique. It is described that Mayas are probably one of the first populations together with Olmecs that populated Meso America and that important HLA genetic differences between Mexican and Guatemalan Mayas support that Maya languages were i...
Article
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Rock Iberian-Guanche inscriptions have been found in all Canary Islands including La Palma: they consist of incise (with few exceptions) lineal scripts which have been done by using the Iberian semi-syllabary that was used in Iberia and France during the 1 st millennium BC until few centuries AD .This confirms First Canarian Inhabitants navigation...
Article
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Fringillidae finches form a subfamily of songbirds (Passeriformes), which are presently distributed around the world. This subfamily includes canaries, goldfinches, greenfinches, rosefinches, and grosbeaks, among others. Molecular phylogenies obtained with mitochondrial DNA sequences show that these groups of finches are put together, but with some...
Article
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HLA‐G immune modulatory genes and molecules are presently being studied by a widespread number of research groups. In the present study, we do not aim to be exhaustive since the number of manuscripts published every year is overwhelming. Instead, our aim is pointing out facts about HLA‐G function, polymorphism and pathology that have been confirmed...
Article
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Introduction: South American siskins (Genus Carduelis/Spinus) are the outcome of regional evolutionary radiation from an extant (or other extinct) species: C. notata, a North America siskin, which thrives in Mexico subtropical areas and is parental of one of the three described North American siskin radiations. Methods: Speciation and/or subspeciat...
Article
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Introduction South American siskins ( Genus Carduelis/Spinus ) are the outcome of regional evolutionary radiation from an extant (or other extinct) species: C. notata , a North America siskin, which thrives in Mexico subtropical areas and is parental of one of the three described North American siskin radiations. Methods Speciation and/or subspeci...
Article
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Two of the several rock script panels found at Mt. Tenezara volcano slope, Lanzarote Is. (Canary Islands) have been analyzed. Both of them contain a linear writing which corresponds to the ancient Iberian semi-sillabary discovered by Gomez-Moreno in 1949 AD, thus to Iberian-Guanche inscriptions which previously were referred as Latin. Ancient Iberi...
Article
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Linurgus olivaceous is a Canary. Asian and American Carpodacus seem to be distinct evolutive rediations.
Article
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Mexican Mixtec population from coastal Jamiltepec (Oaxaca) Amerindians was studied for its HLA profile. They show genetic characteristics close to Pacific Islanders and other Mexican Isthmus Amerindians (Mazatecans, Zapotecans and Mayas). Interestingly, this coastal Oaxaca Mixtec population is genetically closer to Mazatecans than to Oaxaca Mixtec...
Article
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información del artículo Historia del artículo: Recibido el 3 de junio de 2011 Aceptado el 23 de diciembre de 2011 On-line el 21 de marzo de 2012 Palabras clave: Aleutianos Atabascos Amerindios Esquimales HLA Poblamiento de América r e s u m e n Se han comparado las frecuencias alélicas de HLA de amerindios con las de otros prime-ros habitantes ame...
Article
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Quechua Amerindians established Inca Empire and chose Cuzco as their capital. Their language is closely related to that of Aymara ethnic group and both of them were originated from Titikaka Lake Altiplano area. In the present study we have analyzed Bolivian Quechua HLA profile and found that it has common characters with other Andean and Pacific Am...
Article
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Acknowledgments: This work was supported in part by grants from the Spanish Ministry of Education (PM95-57, PM96-21 and PM99-23) and the Madrid Regional Government (06/70/97 and 8.3/14/98). We are grateful to Alberto Garcia for his help with art design work on the computer.
Article
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Aymara people has been a relatively homogeneous group since Spanish Conquest by 1,532 CE, even if previously represented a group of various cultural defined populations who gave rise to them. They were and are established in Andean Altiplano around Titikaka Lake (Bolivia, Peru), Argentina and Chile neighborhood, speak Aymara language and have been...
Article
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Mexican Mayo Amerindians live in southern Sonora and North Sinaloa states. They probably come from North or are related to First American Inhabitants established further North. A non-related sample of them have volunteered to HLA study in order to achieve a profile useful for their epidemiology and future transplant interstate programs, in addition...
Article
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Huastecos or Teenek Amerindians are presently living at North East Mexico (San Luis Potosi State). They have probably one of the most ancient culture of Mexico and Central America together with Mayas and Olmec groups with which also show close relationships. Proximity to Atlantic Ocean/Mexican Gulf originated that Spaniards had very early contact w...
Article
Gorgan (Iran) have been studied for HLA-A, -B, -C, -DRB1 and -DQB1 genes for the first time. They are Turkmen and originated in East Asia around Altai Mts; they originally spoke a Turk language classified within the Turkish-Oguz group. Peripheral blood samples were collected from Gorgan City (Iran) and HLA typed by standard methodology. HLA allele...
Article
HLA-A, -B, -C and -DRB1 alleles and haplotypes have been studied in a group of Aleuts from Bering Island (Commander Islands, Russia). Many of their ancestors were original from other Aleutian Islands, like Attu and Atka Islands (USA) and may have had a low degree of admixture with Russians. HLA haplotypes are found to be specific and quite differen...
Article
Mapuche Amerindians live now widespread in Central South Chile and Argentina and speak “Mapudungun”, an unclassified language. A group of Chilean Mapuche was studied for HLA genes using standard techniques. Typical Amerindian HLA genes and haplotypes are found in the population, like HLA-DRB1*14:02, −08:02 and class II haplotype DRB1*08:02-DQB1*04:...
Chapter
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Fringillidae finches form a subfamily of songbirds (Passeriformes), which are presently distributed around the world. This subfamily includes canaries, goldfinches, greenfinches, rosefinches, and grosbeaks, among others. Molecular phylogenies obtained with mitochondrial DNA sequences show that these groups of finches are put together, but with some...
Article
Emiratis belong to the United Arab Emirates (UAE) country. UAE is placed at the East part of the Arabian Peninsula, protruding into the Arabia Gulf and was populated since 130,000 years ago. First humans migrating out of Africa went probably across this territory. HLA-A, -B, -C, -DRB1, -DQB1, -DQA1 were typed in order to obtain HLA profile for clin...
Article
Wayu Amerindians live around Guajira Peninsula shared by Colombia and Venezuela. Wayu from Colombia have been studied for their HLA profile and these data put in context with both genetic and cultural relatedness to Pacific Islanders. HLA-A*24 and HLA-B*35 (most likely HLA-A*24:02 and HLA-B*35:05) and HLA-DRB1*04:03 and HLA-DQB1*03:02 are shared bo...
Article
Uros people live in floating reed islands in Titikaka Lake in front of Puno town (Peru). They could have started Tiwanaku culture and shared genes and culture with Pacific Islanders; it is particularly relevant the giant hat covered men statues found in both Tiwanaku at Titikaka Lake shore and Easter Island (3,700 km far from Chile in Pacific Ocean...
Article
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It is noticed that the abundant Malta cart-ruts fabrication by different cut shape in rocks is similar to "Quesera"/Cheeseboard Lanzarote rock prehistoric lunisolar calendar building. Even more, some Malta cart-ruts associated structures are similar to this Lanzarote rock calendar. Cart-ruts are hand made artifacts that in Malta started to be built...
Article
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This present paper is an integral part of another paper which completes the work (Int. J. Mod.
Article
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Several studies confirmed the association of HLA-DRB1 and -DQB1 alleles with altered risk of type 1 diabetes (T1D). However, data from individual studies based on small sample sizes yielded often conflicting findings in African Arabs. This is a systematic review and meta-analysis aimed at comprehensively evaluating this association with T1D, using...
Article
Original San Basilio de Palenque population (North Colombia) fled from Spanish traders that carried them as slaves and they funded in nearby Maria mountains a fortified town (Palenque). They started helping new Africans brought as slaves to flee and join them. Most of them spoke a Bantu-Congo language and nowadays they speak the only one extant Ban...
Article
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Zonzamas "Quesera" (Zonzamas "Cheeseboard") is a lunisolar calendar according to evidences shown in the present paper.
Article
We have studied Wiwa/Sanja Amerindians HLA-A, -B, -C, -DRB1 and DQB1 allele frequencies and extended haplotypes in 52 unrelated individuals from “El Encanto” town at Guanachaca riverside. High frequency alleles were in general present in other Amerindian populations. Also, three extended haplotypes and eight ones were respectively both “new found”...
Article
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This is the first genetic anthropology study on Arabs in MENA (Middle East and North Africa) region. The present meta-analysis included 100 populations from 36 Arab and non-Arab communities, comprising 16,006 individuals, and evaluates the genetic profile of Arabs using HLA class I (A, B) and class II (DRB1, DQB1) genes. A total of 56 Arab populati...
Data
Neighbor-Joining dendrograms, based on standard genetic distances (SGD), showing relatedness between Arabs and other populations using generic HLA-DRB1* allele frequencies data. Populations’ data were taken from references detailed in Tables 1 and 2. Bootstrap values from 1.000 replicates are shown. (TIF)
Data
Genetic distances between three groups of Arab Jews based on HLA-DRB1 and -DQB1 alleles frequencies. (DOC)
Data
Neighbor-Joining dendrograms, based on standard genetic distances (SGD), showing relatedness between Arabs and other populations using generic HLA-B* allele frequencies data. Populations’ data were taken from references detailed in Tables 1 and 2. Bootstrap values from 1.000 replicates are shown. (TIF)