Antonino Salvia

Foundation Santa Lucia | FSL · medical services direction

Importance: The emergence of the highly contagious Omicron variant of SARS-CoV-2 and the findings of a significantly reduced neutralizing potency of sera from individuals with previous SARS-CoV-2 infection or vaccination highlights the importance of studying cellular immunity to estimate the degree of immune protection to the new SARS-CoV-2 varian...

The emergence of the Omicron SARS-CoV-2 variant caused public health concerns worldwide, raising the need for the improvement of rapid monitoring strategies. The present manuscript aimed at providing evidence of the utility of a diagnostic kit for the routine testing of SARS-CoV-2 infection as a cost-effective method for tracking the Omicron varian...

Importance: The emergence of the highly contagious Omicron variant of SARS-CoV-2 and the findings of a significantly reduced neutralizing potency of sera from convalescent or vaccinated individuals imposes the study of cellular immunity to predict the degree of immune protection to the yet again new coronavirus. Design: Prospective monocentric obse...

Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is effective in preventing hospitalization from severe COVID-19. However, multiple reports of breakthrough infections and of waning antibody titers have raised concerns on the durability of the vaccine, and current vaccination strategies now propose administration of a...

Vaccination against SARSCoV2 infection has shown to be effective in preventing hospitalization for severe COVID19. However, multiple reports of breakthrough infections and of waning antibody titers have raised concerns on the durability of the vaccine, and current discussions on vaccination strategies are centered on evaluating the opportunity of a...

The COVID-19 pandemic caused by SARS-CoV-2 represents a public health emergency, which became even more challenging since the detection of highly transmissible variants and strategies against COVID-19 were indistinctly established. We characterized the temporal viral load kinetics in individuals infected by original and variant strains. Naso-oropha...

During the COVID19 pandemic, a range of vaccines displayed high efficacy in preventing disease, severe outcomes of infection, and mortality. However, the immunological correlates of protection, the duration of immune response, the transmission risk over time from vaccinated individuals are currently under active investigation. In this brief report,...

Objectives The present study compared the performance of Lumipulse G Sars-CoV-2 Ag kit with TaqPath COVID-19 RT-PCR CE IVD kit. Methods The study was conducted on 4266 naso-oropharyngeal swabs. Samples were subjected to antigen RT-PCR tests for detection of Sars-CoV-2 and related variants. Statistical analyses were conducted in R software. Result...

Objective: The aim of the present observational study is to report on the data from a large sample of inpatients, clinical staff and other workers at an Italian neurorehabilitation hospital dealing with SARS-CoV-2 infections, in order to analyze how it might have affected the management and the effectiveness of neurorehabilitation. Methods: The dat...

Aim: Study aimed to analyse how rehabilitation staff spends working time on specific activities in a neurorehabilitation hospital and to determine the number of direct activities received by patients with different levels of disease severity. Background: Few studies have investigated how clinical staff spends their time on activities in rehabili...

Background and aims To systematically review the latest evidence on established and emerging nutrition-related risk factors for incidence of and mortality from total, ischemic and haemorrhagic strokes. The present review was conducted in the framework of the work carried out through 2015 and 2016 for the preparation of the Italian Guidelines for th...

Falls in the elderly may have adverse physical, medical, psychological, social and economic consequences. Falls in older adults are a significant public health concern, especially as more than 30% of this section of the population experience one or more falls each year. To date there has been no exhaustive review that has fully captured the various...

Aims: Multi-drug resistant Klebsiella pneumoniae has become a relevant healthcare-associated pathogen. Capsule, type 1 and 3 fimbriae (mrkA gene), type 2 quorum-sensing system (luxS), synthesis of D-galactan I (wbbM), LPS transport (wzm) and poly-beta-1,6-N-acetyl-D-glucosamine (pgaA) seem involved in K. pneumoniae biofilm. Non-enzymatic antibioti...

The spread of carbapenemase-producing Enterobacteriaceae (CPE) has become a worldwide problem. Early identification and isolation of asymptomatic carriers are important for infection prevention and control measures. All inpatients (N=1427) admitted to ‘Fondazione Santa Lucia’ Rehabilitation Hospital in 2014 were screened by rectal swab; 10.2% of th...

Introduzione: Identificare all’accettazione, nell’IRCCS Fondazione Santa Lucia [FSL], i pazienti colonizzati da Enterobatteri Produttori di Carbapenemasi [CPE] per attuare tempestivamente misure di controllo come indicato dal Ministero della Salute per i reparti più a rischio di diffusione di CPE [RR]. Metodi: Tutti gli accettati nel 2014 in degenz...

Patients newly admitted to rehabilitation centres are at high risk for colonization with multidrug-resistant bacteria because many of them have experienced prolonged stays in other healthcare settings and have had high exposure to antibiotics. We conducted a prospective study to determine the prevalence of and risk factors for colonization with ext...

The study aims were: 1) to define the prevalence of and risk factors for colonization by ESBL-producing Enterobacteriaceae (ESBL-Ent) among healthcare workers (HCWs) and family members (FMs) of ESBL-Ent-colonized patients in rehabilitation units (RUs) and 2) to compare ESBL-Ent isolates from these three groups. The study included 286 FMs of 194 ESB...

The international project MOSAR was conducted in five rehabilitation centers; patients were screened for rectal carriage of extended-spectrum β-lactamase (ESBL)-producing members of the Enterobacteriaceae. Among 229 Klebsiella pneumoniae isolates, four clonal groups (CG) or complexes (CC) prevailed: CG17 in France, CG101 in Italy, CG15 in Spain, an...

This report examines hand hygiene practices among 171 therapists from an Italian hospital for neuromotor rehabilitation, the Fondazione Santa Lucia of Rome. Compliance with hand hygiene measures was assessed by direct observation during daily neurorehabilitative activities. This study highlights that attention to this task is generally poor among t...

The prospective project MOSAR was conducted in five rehabilitation units: BM (France), FS (Italy), GI (Spain), and LH and TA (Israel). Patients were screened for carriage of Enterobacteriaceae resistant to expanded-spectrum cephalosporins (ESCs) from admission until discharge. The aim of this study was to characterize clonal structure, and extended...

The aims of our study were to analyse the risk factors for colonization by Extended-spectrum β-lactamases (ESBL)-producing Proteus mirabilis (ESBL-PM) in rehabilitation patients and to characterize the molecular features of these strains. The study was conducted in two rehabilitation centres located in Rome, Italy (Fondazione Santa Lucia IRCCS (FSL...

Background: Malnutrition in hospitalised patients is often underestimated. The present study aimed to evaluate the validity of a questionnaire for the semi-quantitative evaluation of food intake compared to weighed records in patients who were hospitalised for the rehabilitation of neurological disorders. Methods: Food intake at breakfast, lunch...

Clin Microbiol Infect 2012; 18: E164–E169 This study aimed to determine the prevalence of and risk factors for methicillin-resistant Staphylococcus aureus (MRSA) carriage among patients newly admitted to rehabilitation centres. It is a prospective study examining MRSA carriage on admission to seven rehabilitation wards in four countries. Risk facto...

Il Servizio Sanitario Nazionale (SSN), istituito con la legge 833/78 [1], identifica tra gli obiettivi: a. la prevenzione delle malattie e degli infortuni in ogni ambito di vita e di lavoro; b. la diagnosi e la cura degli eventi morbosi, quali che ne siano le cause, la fenomenologia e la durata; c. la riabilitazione degli stati di invalidità e di i...

This paper reports the consensus achieved by a panel convened by the IRCCS Fondazione S. Lucia, on different aspects of the relationships between diet, nutrition and stroke: according to a well-defined evidence-based approach. The recommendations are subdivided in three main sections regarding the assessment of nutritional status, the estimation of...

The aim of this study was to evaluate: 1) whether the reduction in duration of in-patient rehabilitation imposed by the Italian Ministry of Health's circular of 29/6/95 has been accompanied by a decline in the results achieved; and 2) whether the system of basing payments on diagnosis related group (DRG) criteria is capable of correctly evaluating...