Antonia Sambola

Antonia Sambola
University Hospital Vall d'Hebron · Department of Cardiology

MD, PhD, FESC
Consultant in Intensive Cardiac Care. Board member, Acute Cardiovascular Care Association., ESC.

About

161
Publications
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Introduction
Antonia Sambola works at the Acute Cardiac Care Unit of Department of Cardiology, University Hospital Vall d'Hebron. My interests are: acute coronary syndromes (ACS), anticoagulation and haemorragic disorders as well as infective endocarditis (IE). Currently, I am working in ACS in women, as I am involved in 'Cardiovascular Meta-analyses Research Group', and in EURO-ENDO REGISTER (IE).

Publications

Publications (161)
Article
Background Infective endocarditis (IE) is a life-threatening disease associated with high mortality and morbidity worldwide. We sought to determine how socio-economic factors might influence its epidemiology, clinical presentation, investigation and management, and outcome, in a large international multi-centre registry. Methods The EurObservation...
Article
Full-text available
Objective: To analyze if there are sex-related differences in patients with unexplained syncope and bundle branch block (BBB). Background: Despite increasing awareness that sex is a major determinant of the incidence, etiology, and the outcomes of different arrhythmias, no studies have examined differences in presentation and outcomes between men...
Article
Full-text available
Remote ischemic conditioning (RIC) and the GLP-1 analog exenatide activate different cardioprotective pathways and may have additive effects on infarct size (IS). Here, we aimed to assess the efficacy of RIC as compared with sham procedure, and of exenatide, as compared with placebo, and the interaction between both, to reduce IS in humans. We desi...
Article
Background/Introduction Mortality in right-sided infective endocarditis (RSIE) and cardiac device-related IE (CDRIE) rates have increased mainly due derived complications and heterogeneity of the disease. A better understanding of associated risk factors to mortality in these entities are required in order to develop an efficient therapy. Purpose...
Article
Background/Introduction Infective endocarditis (IE) is associated with high in-hospital mortality, ranging from 16% to 25%, despite improvement in diagnostic and therapeutic strategies, mainly due to complications and heterogeneity of the disease. Baseline risk stratification is essential, in order to focus an aggressive management toward high-risk...
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Full-text available
Background Inflammation plays a key role in atherosclerotic plaque destabilization and adverse cardiac remodeling. Recent evidence has shown a promising role of colchicine in patients with coronary artery disease. Purpose We evaluated the efficacy and safety of colchicine in post-acute myocardial infarction (MI) patients. Methods We searched five...
Article
Background In the last years a substantial effort has been made to improve the understanding of the sex-differences in cardiovascular disease. However, no studies have examined differences in presentation and outcomes between men and women presenting with syncope and bundle branch block (BBB). Aim To determinate if there are sex-specific differenc...
Article
Advances in treatment, common cardiovascular (CV) risk factors and the ageing of the population have led to an increasing number of cancer patients presenting with acute CV diseases. These events may be related to the cancer itself or the cancer treatment. Acute cardiac care specialists must be aware of these acute CV complications and be able to m...
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Full-text available
In patients with a first anterior ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention, iron deficiency (ID) was associated with larger infarcts, more extensive microvascular obstruction, and higher frequency of adverse left ventricular remodeling as assessed by cardiac magnetic resonance imaging. In mi...
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Full-text available
Background: Inflammation plays a key role in atherosclerotic plaque destabilization and adverse cardiac remodeling. Recent evidence has shown a promising role of colchicine in patients with coronary artery disease. We evaluated the efficacy and safety of colchicine in post–acute myocardial infarction (MI) patients. Methods: We searched five electro...
Article
Background There are limited data on sex‐specific outcomes and management of cardiogenic shock complicating ST‐segment elevation myocardial infarction (CS‐STEMI). We investigated whether any sex bias exists in the admission to revascularization capable hospitals (RCH) or intensive cardiac care units (ICCU) and its impact on in‐hospital mortality....
Article
Background Iron deficiency (ID) interferes with the cardioprotective pathway endothelial nitric oxide synthase/soluble guanylate cyclase/protein kinase G (eNOS/sGC/PKG), but its role in acute myocardial infarction remains unclear. Methods Patients (n=125) with a first anterior STEMI treated with PCI underwent magnetic resonance imaging in the acut...
Article
Resumen Introducción y objetivos Los sistemas de red han mostrado reducciones en el tiempo de reperfusión de los pacientes con infarto de miocardio con elevación del segmento ST (IAMCEST), así como en la mortalidad hospitalaria. Sin embargo, los datos no se han desglosado por sexo. El objetivo de este estudio es analizar la influencia del sistema...
Article
Introduction and objectives: Network systems have achieved reductions in both time to reperfusion and in-hospital mortality in patients with ST-segment elevation myocardial infarction (STEMI). However, the data have not been disaggregated by sex. The aim of this study was to analyze the influence of network systems on sex differences in primary pe...
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Full-text available
Introduction Despite the use of the new generation P2Y12 inhibitors (Ticagrelor and Prasugrel) with aspirin is the recommended therapy in acute NSTE-ACS patients, their current use in clinical practice remains quite low and might be related, among several variables, with increased comorbidity burden. We aimed to assess the prevalence of these treat...
Article
Resumen Introducción y objetivos Hay resultados contradictorios sobre si existen diferencias de sexo en la mortalidad tras el infarto agufo de miocardio (IAM). Además, hay escasez de datos sobre el impacto del sexo en los resultados tras un infarto agudo de miocardio con elevación del segmento ST (IAMCEST) o sin elevación del segmento ST (IAMSET)....
Article
Objective A systematic review and meta-analysis was performed to evaluate the safety and efficacy of drug-eluting stents (DES) vs bare-metal stents (BMS) in atrial fibrillation (AF) patients. Methods We systematically searched 5 engines until May 2019 for cohort studies and randomized controlled trials (RCTs). Primary outcomes were major bleeding...
Article
Introduction and objectives Conflicting results have been reported on the possible existence of sex differences in mortality after myocardial infarction (MI). There is also a scarcity of data on the impact of sex on outcomes after ST-segment elevation myocardial infarction (STEMI) and non-STEMI (NSTEMI). The aim of this study was to analyze sex dif...
Article
Background: Little information exists about the role of anemia in patients with acute coronary syndromes (ACS) admitted to Intensive Cardiac Care Units (ICCU). The aim of this study was to assess the prevalence of anemia and its impact on management and outcomes in this clinical setting. Methods: All consecutive patients admitted to eight differ...
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Objectives: To characterize sex differences in the composition of coronary thrombus in patients with ST-segment elevation myocardial infarction (STEMI), especially in the young (age ≤ 55 years). Background: Women have smaller coronary vessels than men and their vascular lesions can be influenced by different exposure to circulating estrogens thr...
Article
Introduction and objectives: Optimal lipid control is difficult to attain. We assessed preadmission achievement of the European Society of Cardiology targets for low-density lipoprotein-cholesterol (LDL-C) control in patients admitted for acute coronary syndrome. Methods: Fasting LDL-C levels were measured in 3164 patients admitted between 2010...
Article
Background Infective endocarditis (IE) is a life threatening disease associated with high mortality and morbidity worldwide. We sought to determine how socio-economic factors may influence variations in epidemiology, clinical presentation, investigation and management (and their consequence upon clinical outcomes) in a large international multi-cen...
Article
Resumen Introducción y objetivos En un estudio de base poblacional, se analizaron las posibles diferencias en función del sexo en la atención al dolor torácico o las palpitaciones como motivo de consulta. Métodos El estudio OFRECE incluyó una muestra aleatoria de la población española de 8.400 participantes de edad ≥ 40 años, de los que 1.132 (13...
Article
Background Sex differences are known to exist in the management of women presenting with ST elevation myocardial infarction (STEMI).Few studies have examined whether the clinical management and prognosis differs by sex when the STEMI network system is applied. Purpose To assess whether the STEMI network system improves management and prognosis bot...
Article
Background Recent studies reported a decrease in the mortality of ST-elevation myocardial infarction (STEMI) patients. This favorable evolution could not extend to women. The interaction between gender and mortality in STEMI remains controversial. Purpose To assess the impact of female sex on mortality of patients with STEMI through of period of 1...
Article
Objective Current guidelines recommend a risk-adjusted early invasive strategy (EIS) in patients with non-ST-segment elevation acute coronary syndrome (NSTEACS). The present study assesses the application if this strategy, the conditioning factors and prognostic impact upon patients with NSTEACS admitted to Intensive Cardiac Care Units (ICCU). Des...
Article
Resumen La insuficiencia cardiaca (IC) presenta aspectos diferenciales entre géneros en la epidemiología, fisiopatología, formas clínicas de presentación y tratamiento que han sido previamente estudiados. En primer lugar, la IC es una causa frecuente de muerte en la mujer (5,8 frente a 3,2% en los varones, según datos del Instituto Nacional de Esta...
Article
Introduction and objectives: There is a paucity of information about the real benefit of colchicine administration in the first episode of acute idiopathic pericarditis (AIP). The main objective of the present study was to assess the real efficacy of colchicine in patients with AIP who did not receive corticosteroids. Methods: Randomized multice...
Article
Full-text available
Background The impact of short or prolonged use of triple therapy (TT) on outcomes in patients with atrial fibrillation (AF) and high risk of bleeding undergoing percutaneous coronary intervention (PCI) is unclear. We compared clinical outcomes according to the duration of TT in patients with AF and HAS-BLED ≥ 3 at 1 year of follow-up. Methods A p...
Article
Resumen Introducción y objetivos El control lipídico óptimo es difícil de conseguir. Se evalúa el cumplimiento previo de los objetivos de la Sociedad Europea de Cardiología para el control del colesterol unido a lipoproteínas de baja densidad (cLDL) de los pacientes que ingresaron por síndrome coronario agudo. Métodos Se midió el cLDL en ayunas d...
Article
Resumen Objetivo Las guías de práctica clínica recomiendan la estrategia invasiva precoz ajustada al riesgo (EIPAR) en pacientes con síndrome coronario agudo sin elevación del segmento ST (SCASEST). El objetivo fue analizar la aplicación de la EIPAR, sus condicionantes e impacto sobre el pronóstico en pacientes con SCASEST ingresados en Unidades d...
Article
Aims: The European Society of Cardiology (ESC) EURObservational Research Programme (EORP) European Endocarditis (EURO-ENDO) registry aims to study the care and outcomes of patients diagnosed with infective endocarditis (IE) and compare findings with recommendations from the 2015 ESC Clinical Practice Guidelines for the management of IE and data fro...
Article
Full-text available
Background: Triple antithrombotic therapy (TT) is recommended for patients with nonvalvular atrial fibrillation (AF) undergoing percutaneous coronary intervention (PCI). However, there is a lack of comparative data in a real-world clinical setting between non-vitamin K antagonist oral anticoagulants (NOAC) and vitamin K antagonists (VKA). The aim o...
Article
Background: Limited data exists on the impact of sex on outcomes in non-valvular atrial fibrillation (NVAF) patients undergoing percutaneous coronary intervention (PCI). We explored the impact of sex on ischemic and bleeding events in these patients within 1-year. Methods: A prospective register included 1021 patients with NVAF undergoing PCI an...
Article
Full-text available
Aims: The European Society of cardiology (ESC) EURObservational Research Programme (EORP) European Endocarditis (EURO-ENDO) registry aims to study the care and outcomes of patients diagnosed with infective endocarditis and compare findings with recommendations from the 2015 ESC Clinical Practice Guidelines for the management of infective endocardi...
Article
Introduction and objectives: To analyze differences between sexes in the clinical management of patients presenting with symptoms of chest pain and/or palpitations within a population-based study. Methods: The OFRECE study included a random sample of 8400 individuals from the Spanish population aged 40 years and older; 1132 (13.5%) had previousl...
Article
Background: Drug-eluting stents (DES) reduce stent restenosis compared with bare-metal stents (BMS). However, their use in patients requiring long-term oral anticoagulation (OAC) is controversial owing to increased risk of bleeding associated with OAC plus antiplatelet treatment over time. Objective: To assess the safety of DES vs BMS in patient...
Article
Background: Reduction of left ventricular (LV) dilation (RD) beyond the first year after ST-segment-elevation myocardial infarction (STEMI) is unknown. We investigated its potential occurrence in comparison with stationary (SD) and progressive (PD) dilation. Methods and results: Perfusion gated SPECT features at 1 and 3 years were evaluated in 1...
Article
Background: Triple antithrombotic therapy (TT) is recommended for patients with non-valvular atrial fibrillation (AF) undergoing percutaneous coronary intervention (PCI). However, there is a lack of comparative data in a real-world clinical setting between non-vitamin K antagonist oral anticoagulants (NOAC) and vitamin K antagonists (VKA). The aim...
Article
Introduction and objectives: There is a paucity of information about the real benefit of colchicine administration in the first episode of acute idiopathic pericarditis (AIP). The main objective of the present study was to assess the real efficacy of colchicine in patients with AIP who did not receive corticosteroids. Methods: Randomized multicente...
Article
Resumen La incorporación precoz del enfermo al que se ha realizado una angioplastia con stent a su vida habitual, por ausencia de impedimentos propios de la técnica, ha permitido incluir más pronto a estos pacientes en la fase II de la rehabilitación cardiaca. Aunque la rehabilitación del paciente coronario sigue para todos los pacientes unas pauta...
Article
Resumen La incorporación precoz del enfermo al que se ha realizado una angioplastia con stent a su vida habitual, por ausencia de impedimentos propios de la técnica, ha permitido incluir más pronto a estos pacientes en la fase II de la rehabilitación cardiaca. Aunque la rehabilitación del paciente coronario sigue para todos los pacientes unas pauta...
Article
Resumen La incorporación precoz del enfermo al que se ha realizado una angioplastia con stent a su vida habitual, por ausencia de impedimentos propios de la técnica, ha permitido incluir más pronto a estos pacientes en la fase II de la rehabilitación cardiaca. Aunque la rehabilitación del paciente coronario sigue para todos los pacientes unas pauta...
Article
Resumen La incorporación precoz del enfermo al que se ha realizado una angioplastia con stent a su vida habitual, por ausencia de impedimentos propios de la técnica, ha permitido incluir más pronto a estos pacientes en la fase II de la rehabilitación cardiaca. Aunque la rehabilitación del paciente coronario sigue para todos los pacientes unas pauta...