Antoni Ruciński

Antoni Ruciński
Polish Academy of Sciences | PAN

PhD

About

71
Publications
6,872
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
493
Citations
Citations since 2016
63 Research Items
479 Citations
2016201720182019202020212022020406080100120
2016201720182019202020212022020406080100120
2016201720182019202020212022020406080100120
2016201720182019202020212022020406080100120
Additional affiliations
April 2017 - present
Institute of Nuclear Physics, Polish Academy of Science
Position
  • Professor
Description
  • Conducting the project: "Quantification of biological range uncertainties towards an improved patient treatment in CCB Cracow proton beam therapy centre"
January 2017 - March 2017
Institute of Nuclear Physics, Polish Academy of Science
Position
  • PostDoc Position
January 2015 - December 2016
INFN - Istituto Nazionale di Fisica Nucleare
Position
  • PostDoc Position
Description
  • The project focuses on the analysis of charged secondary radiation produced by 4He and 12C ion beams impinging on a PMMA target to support development of a dose profiler detector designed for ion beam therapy range monitoring (INSIDE project).
Education
September 2008 - September 2009
Universität Stuttgart
Field of study
  • Institute of Biomedical Engineering and Marienhospital Stuttgart
October 2004 - October 2009
Warsaw University of Technology
Field of study
  • Mechatronics

Publications

Publications (71)
Article
Objective Verification of delivered proton therapy treatments is essential for reaping the many benefits of the modality, with the most widely proposed in vivo verification technique being the imaging of positron emitting isotopes generated in the patient during treatment using positron emission tomography (PET). The purpose of this work is to redu...
Article
In this work we propose the complete Data Acquisition (DAQ) system for measurement of volumetric radiotherapeutic dose deposition in tissue-like phantoms based on 3D printed plastic scintillators. The DAQ is easily extensible thanks to the modular architecture of its hardware and software components. We show results from the full measurement chain...
Article
Full-text available
Objective: This paper reports on the implementation and shows examples of the use of the ProTheRaMon framework for simulating the delivery of proton therapy treatment plans and range monitoring using positron emission tomography (PET). ProTheRaMon offers complete processing of proton therapy treatment plans, patient CT geometries, and intra-treatm...
Article
Three-dimensional (3D) printing, specifically digital light processing (DLP) technique, can be used to manufacture plastic scintillators of any shape. The purpose of this study was to determine the light output of DLP 3D-printed scintillators for dosimetry applications. Two types of plastic scintillators with dimensions 10 mm × 10 mm × 10 mm were f...
Article
Full-text available
This paper reviews the technical ecosystem of Gate, an open-source Monte Carlo simulator for medical physics. Based on the shoulders of Geant4, the principal modules (geometry, physics, scorers) are described together with brief descriptions of some key concepts (Volume, Actors, Digitizer). The main source code repositories are described together w...
Article
Particle therapy can largely benefit from the detailed and wide-range spectrometric and directional characterization of energetic charged particles provided by compact Timepix detectors. Among several physical quantities that can be derived, the assessment of the linear energy transfer (LET) which is based on the deposited energy and particle's tra...
Article
Full-text available
Background Variable relative biological effectiveness (vRBE) in proton therapy might significantly modify the prediction of RBE-weighted dose delivered to a patient during proton therapy. In this study we will present a method to quantify the biological range extension of the proton beam, which results from the application of vRBE approach in RBE-w...
Article
Full-text available
The major aim of radiation therapy is to provide curative or palliative treatment to cancerous malignancies while minimizing damage to healthy tissues. Charged particle radiotherapy utilizing carbon ions or protons is uniquely suited for this task due to its ability to achieve highly conformal dose distributions around the tumor volume. For these t...
Article
The miniaturized radiation camera MiniPIX TPX3 is designed for detailed and wide-range measurements of mixed-radiation fields present in many applications such as radiotherapy and space radiation in outer orbit. The highly integrated instrumentation utilizes a single connector for control and readout for flexible measurements and quick deployment....
Preprint
Full-text available
In vivo assessment of cancer and precise location of altered tissues at initial stages of molecular disorders are important diagnostic challenges. Positronium is copiously formed in the free molecular spaces in the patient's body during positron emission tomography (PET). The positronium properties vary according to the size of inter- and intramole...
Article
This topical review summarizes underlying concepts of nanodosimetry. It describes the development and current status of nanodosimetric detector technology. It also gives an overview of Monte Carlo track structure simulations that can provide nanodosimetric parameters for treatment planning of proton and ion therapy. Classical and modern radiobiolog...
Article
Full-text available
The purpose of this work was to validate the calculation accuracy of nanodosimetric quantities in Geant4-DNA track structure simulation code. We implemented the Jet Counter (JC) nanodosimeter geometry in the simulation platform and quantified the impact of the Geant4-DNA physics models and JC detector performance on the ionization cluster size dist...
Article
In vivo assessment of cancer and precise location of altered tissues at initial stages of molecular disorders are important diagnostic challenges. Positronium is copiously formed in the free molecular spaces in the patient’s body during positron emission tomography (PET). The positronium properties vary according to the size of inter- and intramole...
Article
Full-text available
Purpose We investigated the relationship between RBE-weighted dose (D RBE) calculated with constant (cRBE) and variable RBE (vRBE), dose-averaged linear energy transfer (LET d) and the risk of radiographic changes in skull base patients treated with protons. Methods Clinical treatment plans of 45 patients were recalculated with Monte Carlo tool FR...
Article
The J-PET tomograph is constructed from plastic scintillator strips arranged axially in concentric cylindrical layers. It enables investigations of positronium decays by measurement of the time, position, polarization and energy deposited by photons in the scintillators, in contrast to studies conducted so far with crystal and semiconductor based d...
Article
We developed a highly-selective technique to measure the energy loss and linear-energy-transfer (LET) spectra of energetic charged particles in high-resolution and over a large collection of particle-event types. Precise and wide-range spectral and tracking measurements were performed with a single semiconductor pixel detector. The quantum-counting...
Article
The 4D Treatment Planning Workshop for Particle Therapy, a workshop dedicated to the treatment of moving targets with scanned particle beams, started in 2009 and since then has been organized annually. The mission of the workshop is to create an informal ground for clinical medical physicists, medical physics researchers and medical doctors interes...
Article
Full-text available
We present commissioning and validation of F red , a graphical processing unit (GPU)–accelerated Monte Carlo code, for two proton beam therapy facilities of different beam line design: CCB (Krakow, IBA) and EMORY (Atlanta, Varian). We followed clinical acceptance tests required to approve the certified treatment planning system for clinical use. We...
Article
Full-text available
The purpose of this work was to implement a fast Monte Carlo dose calculation tool, F red , in the Maastro proton therapy center in Maastricht (Netherlands) to complement the clinical treatment planning system. F red achieves high accuracy and computation speed by using physics models optimized for radiotherapy and extensive use of GPU technology f...
Article
Full-text available
A precise characterization of therapeutic proton pencil beams is essential for the commissioning of any treatment planning system (TPS). The dose profile characterization includes measurement of the beam lateral dose profile in the beam core and far from the beam core, in the so called low-dose envelope, and requires a sophisticated detection syste...
Article
Full-text available
Purpose: In living organisms, the positron-electron annihilation (occurring during the PET imaging) proceeds in about 30% via creation of a metastable ortho-positronium atom. In the tissue, due to the pick-off and conversion processes, over 98% of ortho-positronia annihilate into two 511 keV photons. In this article, we assess the feasibility for...
Article
Full-text available
Purpose: The time-over-threshold (TOT) technique is being used widely due to itsimplications in developing the multi-channel readouts, mainly when fast signal processing is required. Using the TOT technique, as a measure of energy loss instead of charge integration methods, significantly reduces the signal readout costs by combining the time and e...
Preprint
Full-text available
Time-Over-Threshold (TOT) technique is being used widely due to its implications in developing the multi channel readouts mainly when fast signal processing is required. Using TOT technique as a measure of energy loss instead of charge integration methods significantly reduces the signals readout cost by combining the time and energy information. T...
Preprint
Full-text available
Physical and biological range uncertainties limit the clinical potential of Proton Beam Therapy (PBT). In this proceedings, we report on two research projects, which we are conducting in parallel and which both tackle the problem of range uncertainties. One aims at developing software tools and the other at developing detector instrumentation. Rega...
Article
Particle therapy is a therapy technique that exploits protons or light ions to irradiate tumor targets with high accuracy. Protons and ¹²C ions are already used for irradiation in clinical routine, while new ions like ⁴He and ¹⁶O are currently being considered. Despite the indisputable physical and biological advantages of such ion beams, the plann...
Chapter
Full-text available
Monte Carlo (MC) methods account for many details of the interactions of particles with human tissue in proton beam therapy. The accuracy and fast dose calculation time offered by GPU-accelerated MC treatment planning systems (TPS) pushed development of such tools to support experimental treatment plan verification in the clinical routine. The GPU-...
Article
Full-text available
In 2016 and 2017, the 8th and 9th 4D treatment planning workshop took place in Groningen (the Netherlands) and Vienna (Austria), respectively. This annual workshop brings together international experts to discuss research, advances in clinical implementation as well as problems and challenges in 4D treatment planning, mainly in spot scanned proton...
Conference Paper
Full-text available
In 2016 and 2017, the 8th and 9th 4D treatment planning workshop took place in Groningen (the Netherlands) and Vienna (Austria), respectively. This annual workshop brings together international experts to discuss research, advances in clinical implementation as well as problems and challenges in 4D treatment planning, mainly in spot scanned proton...
Article
Purpose In proton beam therapy (PBT), Monte Carlo (MC) methods offer more accurate dose recalculation than analytical treatment planning system (TPS) used in clinical routine. The purpose of this work was to implement a PBT centre beam model in MC code. This is essential when employing the code as a support tool for quality assurance procedures and...
Article
Full-text available
Proton and carbon ion beams are used in the clinical practice for external radiotherapy treatments achieving, for selected indications, promising and superior clinical results with respect to x-ray based radiotherapy. Other ions, like 4He have recently been considered as projectiles in particle therapy centres and might represent a good compromise...
Article
In this paper we report the re-analysis of the data published in (Piersanti et al. 2014) documenting the charged secondary particles production induced by the interaction of a 220 MeV/u 12C ion beam impinging on a polymethyl methacrylate (PMMA) target, measured in 2012 at the GSI facility in Darmstadt (Germany). This re-analysis takes into account...
Article
Charged particle therapy is a technique for cancer treatment that exploits hadron beams, mostly protons and carbon ions. A critical issue is the monitoring of the beam range so to check the correct dose deposition to the tumor and surrounding tissues. The design of a new tracking device for beam range real-time monitoring in pencil beam carbon ion...
Article
Nowadays there is a growing interest in Particle Therapy treatments exploiting light ion beams against tumors due to their enhanced Relative Biological Effectiveness and high space selectivity. In particular promising results are obtained by the use of $^4$He projectiles. Unlike the treatments performed using protons, the beam ions can undergo a fr...
Article
Full-text available
The interaction of the incoming beam radiation with the patient body in hadrontherapy treatments produces secondary charged and neutral particles, whose detection can be used for monitoring purposes and to perform an on-line check of beam particle range. In the context of ion-therapy with active scanning, charged particles are potentially attractiv...
Article
Full-text available
Charged Particle Therapy is a technique for cancer treatment that exploits hadron beams, mostly protons and carbons. A critical issue is the monitoring of the dose released by the beam to the tumor and to the surrounding tissues. We present the design of a new tracking device for monitoring on-line the dose in ion therapy through the detection of s...
Article
Since 2009, a 4D treatment planning workshop has taken place annually, gathering researchers working on the treatment of moving targets, mainly with scanned ion beams. Topics discussed during the workshops range from problems of time resolved imaging, the challenges of motion modelling, the implementation of 4D capabilities for treatment planning,...
Conference Paper
Purpose:Development of strategies to monitor range uncertainties is necessary to improve treatment planning in Charged Particle Therapy (CPT) and fully exploit the advantages of ion beams. Our group developed (within the framework of the INSIDE project funded by the Italian research ministry) and is currently building a compact detector Dose Profil...
Conference Paper
Purpose:In Charged Particle Therapy (CPT), besides protons, there has been recently a growing interest in 4He, 12C and 16O beams. The secondary radiation produced in the interaction of those beams with a patient could be potentially used for on-line monitoring of range uncertainties in order to fully exploit the advantages of those light ions resul...
Article
Charged particle beams are used in Particle Therapy (PT) to treat oncological patients due to their selective dose deposition in tissues and to their high biological effect in killing cancer cells with respect to photons and electrons used in conventional radiotherapy. Nowadays, protons and carbon ions are used in PT clinical routine but, recently,...
Article
Full-text available
Background and purpose Intensity-modulated particle therapy (IMPT) for tumors showing interfraction motion is a topic of current research. The purpose of this work is to compare three treatment strategies for IMPT to determine potential advantages and disadvantages of ion prostate cancer therapy. Materials and methods Simulations for three treatmen...
Article
Full-text available
Particle therapy is a technique that uses accelerated charged ions for cancer treatment and combines a high irradiation precision with a high biological effectiveness in killing tumor cells [1]. Informations about the secondary particles emitted in the interaction of an ion beam with the patient during a treatment can be of great interest in order...
Article
Radio-guided surgery (RGS) is a technique to intraoperatively detect tumour remnants, favouring a radical resection. Exploiting β - emitting tracers provides a higher signal to background ratio compared to the established technique with γ radiation, allowing the extension of the RGS applicability range. We developed and tested a detector based on p...
Article
Hadrontherapy is a technique for cancer treatment that exploits ion beams (mostly protons and carbons). A critical issue is the accuracy that is achievable when monitoring the dose released by the beam to the tumor and to the surrounding tissues. We present the design of a tracking device, developed in the framework of the INSIDE project [1], capab...