
Antoine VanierHaute Autorité de Santé | HAS · Health technology Assessment Department
Antoine Vanier
MD (Public Health), PhD (Biostatistics)
Associate Professor in Public Health and Biostatistics
About
53
Publications
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Introduction
I'm currently an associate professor in public health and biostatistics within the faculty of pharmaceutical sciences of Tours.
My research interests are about the interpretation of Patient-Reported Ouctomes longitudinal data from a theoretical, methodological and stattistical point of wiew, especially response shift phenomenon and Minimal Important Difference.
Additional affiliations
November 2016 - May 2021
University of Nantes and University François-Rabelais of Tours
Position
- PostDoc Position
Description
- Post Doc researcher researcher (Nov 2016 - Aug 2020) then Researcher (since Sep 2020) in Biostatistics with a focus on the interpretation of Patient-Reported Outcomes data analyses.
Education
September 2013 - October 2016
October 2010 - August 2011
November 2009 - September 2010
Publications
Publications (53)
Background:
Using a real dataset, we highlighted several major methodological issues raised by the estimation of the Minimal Clinically Important Difference (MCID) of a Patient-Reported Outcomes instrument. We especially considered the management of missing data and the use of more than two times of measurement. While inappropriate missing data ma...
Purpose
The Working Group undertook a critical, comprehensive synthesis of the response shift work to date. We aimed to (1) describe the rationale for this initiative; (2) outline how the Working Group operated; (3) summarize the papers that comprise this initiative; and (4) discuss the way forward.
Methods
Four interdisciplinary teams, consisting...
Purpose
The extant response shift definitions and theoretical response shift models, while helpful, also introduce predicaments and theoretical debates continue. To address these predicaments and stimulate empirical research, we propose a more specific formal definition of response shift and a revised theoretical model.
Methods
This work is an int...
Background
Patient-Reported Outcomes (PROs) are standardized questionnaires used to measure subjective outcomes such as quality of life in healthcare. They are considered paramount to assess the results of therapeutic interventions. However, because their calibration is relative to internal standards in people’s mind, changes in PRO scores are diff...
During the past decade, health technology assessment bodies have faced new challenges in establishing the benefits of new drugs for individuals and health-care systems. A topic of increasing importance to the field of oncology is the so-called agnostic regulatory approval of targeted therapies for cancer (independent of tumour location and histolog...
Objectives
In France, decisions for pricing and reimbursement for medicinal products are based on appraisals performed by the National authority for health ( Haute Autorité de Santé (HAS)). During the appraisal process, additional real-world evidence can be requested as “Post-Registration Studies” (PRS) when there are uncertainties in evidence that...
Symptomatic effects of mental disorders in parents could bias their reporting on their child’s mental health. This study aimed to investigate the measurement invariance of the French version of the parental Strengths and Difficulties Questionnaire (SDQ) across parental mental health in a sample (N = 20,765) of parents of children aged 3 to 17 years...
Purpose
Our aim is to advance response shift research by explicating the implications of published syntheses by the Response Shift – in Sync Working Group in an integrative way and suggesting ways for improving the quality of future response shift studies.
Methods
Members of the Working Group further discussed the syntheses of the literature on de...
Background:
In recent years, many studies have explored the associations among impulsivity, history of abuse, the emergence of eating disorders with episodes of binge eating (EDBE) and their severity. Nevertheless, factors associated with successful clinical outcomes of EDBE are still unknown. Our study aimed to test the hypothesis that a history...
Interpreting observed changes over time in Patient-Reported Outcomes (PRO) measures is still considered a challenge. Indeed, concluding an observed change at group level is statistically significant does not necessarily equate this change is meaningful from the perspective of the patient. To help interpret within and/or between group changes in the...
A correction to this paper has been published: https://doi.org/10.1007/s11136-021-02890-6
Objective:
In early RA, some patients exhibit rapid radiographic progression (RRP) after one year, associated with poor functional prognosis. Matrices predicting this risk have been proposed, lacking precision or inadequately calibrated. We developed a matrix to predict RRP with high precision and adequate calibration.
Methods:
Post-hoc analysis...
Gambling has an inherent structural monetary component, and financial motive is one of the main motivations for gambling. Despite this, and contrary to other addictive behaviours that involve money such as compulsive buying, gambling has never been studied from a materialism perspective. The objective of the present study was to explore the links b...
Purpose:
To investigate the clinical and virologic-associated and predictive factors of intraocular pressure (IOP) evolution over time and its severity in Fuchs' heterochromic iridocyclitis (FHC).
Methods:
Consecutive patients with both clinical FHC and intraocular synthesis of rubella virus (RV)-specific antibodies were included in this study....
La détresse émotionnelle liée au diabète impacte la qualité de vie et l’équilibre métabolique ce qui rend indispensable l’exploration du vécu de la maladie. Nous avons comparé 2 approches de médecine narrative, un atelier d’écriture où le patient écrit « une lettre à son diabète » (LAMD) et le « théâtre du vécu » (TDV) où un récit est transformé en...
Objectives
To analyze long‐term cognitive status and function after cochlear implantation in profoundly deaf individuals.
Design
Prospective observational longitudinal study.
Setting
Ten academic medical centers referent for cochlear implantation.
Participants
Individuals aged 65 and older who qualified for cochlear implantation (N=70).
Measure...
Background: Postoperative operative pulmonary complications (PPCs) after hepatic surgery are associated with
increased length of hospital stays. Intraoperative blood transfusion, extensive resection and different comorbidities have been identified. Other parameters, like time of hepatic ischemia, have neither been clinically studied, though experim...
OBJECTIVE
In large vestibular schwannoma (VS) surgery, the facial nerve (FN) is at high risk of injury. Near-total resection has been advocated in the case of difficult facial nerve dissection, but the amount of residual tumor that should be left and when dissection should be stopped remain controversial factors. The objective of this study was to...
Background:
In patients with rheumatoid arthritis in remission, a disease activity-driven tapering of adalimumab or etanercept relying on progressive injection spacing has not been shown to be equivalent to a maintenance strategy at full dose in terms of disease activity in the Spacing of TNF-blocker injections in Rheumatoid ArthritiS Study (STRAS...
Background
Disease activity may change over time in axial spondyloarthritis (axSpA). The objectives were to identify patterns of disease activity evolution in patients with early axSpA.
Methods
Patients from the prospective early axSpA cohort (DEvenir des Spondyloarthrites Indifférenciées Récentes (DESIR)) who fulfilled the Assessment in SpondyloA...
Objective: To assess through multivariate analysis the clinical pre- and intraoperative factors of facial nerve outcomes at day 8 and 1-year recovery of facial palsy, as compared with day 8 status among patients who underwent total resection of unilateral vestibular schwannoma.
Study Design: Case series with chart review.
Setting: Tertiary referral...
Patient-Reported Outcomes are increasingly used in health-related research. These instruments allow the assessment of subjective concepts such as Health-Related Quality of Life, anxiety level, pain or fatigue.
Initially, the interpretation of a difference in score over time was based on the assumption that the meaning of concepts and measurement s...
Objective:
To report the speech performance and sound localization in adult patients 5 years after bilateral simultaneous cochlear implantation and to evaluate the change in speech scores between 1 and 5 years.
Design:
In this prospective multicenter study, 26 patients were evaluated 5 years after implantation using long straight electrode array...
Purpose:
To determine the prognostic factors of long-term visual outcome in Birdshot Retinochoroidopathy (BRC).
Methods:
Design: Retrospective case series.
Study population:
Successive HLA-A29+ BRC patients whose latest visit was between May and August 2013 at a single tertiary centre (Pitié-Salpétrière Hospital, Paris).
Observation procedure...
The prevention of addictions in young people is a challenge for Mental and Public Health policies, and requires specific risk-screening tools. Specific personality traits, as assessed using the Substance Use Risk Profile Scale (SURPS), could play a key role in the onset and escalation of substance use. This study aimed to examine 1) measurement inv...
Triple-negative breast cancers need to be refined in order to identify therapeutic subgroups of patients.
We conducted an unsupervised analysis of microarray gene-expression profiles of 107 triple-negative breast cancer patients and undertook robust functional annotation of the molecular entities found by means of numerous approaches including immu...
To determine the statistical correlation between visual acuity (VA) and various quantitative parameters relevant to Birdshot Retinochoroidopathy (BRC) evaluation.
Hospital-based retrospective observational study.
SettingInstitutional.
Consecutive HLA29+ BRC patients were included between May and August 2013 at a single tertiary centre (Pitié-Salpét...
Background Once remission is achieved for patients with rheumatoid arthritis (RA), treatment down-titration should be attempted, for safety issues or economic reasons. One of the proposed strategies, recently tested in the STRASS trial [1], is to progressively space injections of TNF-blockers.
Objectives To assess the Incremental Cost-Effectiveness...
Background Disease activity over time in axial spondyloarthritis (axSpA) can be heterogeneous, and studies aiming to identify patterns of disease activity are sparse. In other disciplines, trajectory modelling have been applied to identify patterns of behaviour (trajectories) but no studies have attempted to distinguish subgroups with common diseas...
BACKGROUND
Recently, it has been shown that annotation of triple-negative breast tumours (TNBC) by means of immunohistochemistry (IHC) or gene-expression signatures (GES) gave different results: 20 to 30% of these tumours were not basal-like, but luminal A, B or HER2-E. In this study, we aimed at identifying gene-expression molecular subclassificat...
This simulation study was designed to provide data on the performance of Oort's procedure (OP) for response shift (RS) detection (regarding type I error, power, and overall performance), according to sample characteristics, at item level. A specific objective was to assess the impact of using different information criteria (IC), as alternatives to...
Some IRT models have the advantage of being robust to missing data and thus can be used with complete data as well as different patterns of missing data (informative or not). The purpose of this paper was to develop an algorithm for response shift (RS) detection using IRT models allowing for non-uniform and uniform recalibration, reprioritization R...
The objective of this work was to detail the incidence and mortality trends of invasive and in situ breast cancer (BC) in France, especially regarding the development of screening, over the 1990-2008 period. Data issued from nine population-based cancer registries were studied. The incidence of invasive BC increased annually by 0.8 % from 1990 to 1...
Purpose:
Comparisons of breast cancer characteristics between organized and opportunistic screening have been limited. This study was designed to compare characteristics of cancers detected by either organized or opportunistic screening as well as clinically diagnosed cancers in Loire-Atlantique (a French administrative entity), from 2003 to 2007....
Le cancer du sein est le cancer le plus fréquent et la première cause de mortalité par cancer chez la femme en France. Le programme de dépistage organisé (DO) a démarré dans des départements pilotes à la fin des années 1980 et a été généralisé à l’ensemble des départements français en 2004. L’impact du DO sur la mortalité par cancer du sein et sur...
Inappropriate prescribing in elderly is considered as common (40% of subjects from community from the 3CStudy in France had a inappropriate prescription, using Beer's criteria), and can lead to severe issues. Few studies have assessed inappropriate prescribing for elderly inpatients in acute care, with multiple tools. Our study was designed to asse...
Background and objectives The development of morbidity-mortality reviews (MMR) in high-risk units is one of the main objectives of the quality improvement policy of Nantes university hospital. Currently, 25 units are engaged in the analysis of clinical adverse events. Our surgical intensive care unit (ICU) was a forerunner in implementing this poli...