Antoine Vanier

Antoine Vanier
University of Tours | UFR · Inserm U1246 "Methods in patient-centered outcomes and health research"

MD (Public Health), PhD (Biostatistics)
Associate Professor in Public Health and Biostatistics

About

48
Publications
8,379
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603
Citations
Introduction
I'm currently an associate professor in public health and biostatistics within the faculty of pharmaceutical sciences of Tours. My research interests are about the interpretation of Patient-Reported Ouctomes longitudinal data from a theoretical, methodological and stattistical point of wiew, especially response shift phenomenon and Minimal Important Difference.
Additional affiliations
September 2020 - present
University of Tours
Position
  • Professor (Associate)
Description
  • Various courses in Biostatistics, Public Health, and epidemiology
November 2016 - May 2021
University of Nantes and University François-Rabelais of Tours
Position
  • PostDoc Position
Description
  • Post Doc researcher researcher (Nov 2016 - Aug 2020) then Researcher (since Sep 2020) in Biostatistics with a focus on the interpretation of Patient-Reported Outcomes data analyses.
November 2016 - August 2020
University of Nantes
Position
  • Lecturer
Description
  • Various courses in Biostatistics, Epidemiology and Methodology for clinical reserarch.
Education
September 2013 - October 2016
University of Nantes
Field of study
  • Biostatistics
October 2010 - August 2011
Université Paris-Saclay
Field of study
  • Biostatistics
November 2009 - September 2010
University of Nantes
Field of study
  • Epidemiology - Biostatistics - Metodology for clinical research

Publications

Publications (48)
Article
Full-text available
Background: Using a real dataset, we highlighted several major methodological issues raised by the estimation of the Minimal Clinically Important Difference (MCID) of a Patient-Reported Outcomes instrument. We especially considered the management of missing data and the use of more than two times of measurement. While inappropriate missing data ma...
Article
Full-text available
Purpose The Working Group undertook a critical, comprehensive synthesis of the response shift work to date. We aimed to (1) describe the rationale for this initiative; (2) outline how the Working Group operated; (3) summarize the papers that comprise this initiative; and (4) discuss the way forward. Methods Four interdisciplinary teams, consisting...
Article
Full-text available
Purpose The extant response shift definitions and theoretical response shift models, while helpful, also introduce predicaments and theoretical debates continue. To address these predicaments and stimulate empirical research, we propose a more specific formal definition of response shift and a revised theoretical model. Methods This work is an int...
Article
Full-text available
Background Patient-Reported Outcomes (PROs) are standardized questionnaires used to measure subjective outcomes such as quality of life in healthcare. They are considered paramount to assess the results of therapeutic interventions. However, because their calibration is relative to internal standards in people’s mind, changes in PRO scores are diff...
Article
During the past decade, health technology assessment bodies have faced new challenges in establishing the benefits of new drugs for individuals and health-care systems. A topic of increasing importance to the field of oncology is the so-called agnostic regulatory approval of targeted therapies for cancer (independent of tumour location and histolog...
Article
Interpreting observed changes over time in Patient-Reported Outcomes (PRO) measures is still considered a challenge. Indeed, concluding an observed change at group level is statistically significant does not necessarily equate this change is meaningful from the perspective of the patient. To help interpret within and/or between group changes in the...
Article
Full-text available
A correction to this paper has been published: https://doi.org/10.1007/s11136-021-02890-6
Article
Full-text available
Objective: In early RA, some patients exhibit rapid radiographic progression (RRP) after one year, associated with poor functional prognosis. Matrices predicting this risk have been proposed, lacking precision or inadequately calibrated. We developed a matrix to predict RRP with high precision and adequate calibration. Methods: Post-hoc analysis...
Article
Full-text available
Gambling has an inherent structural monetary component, and financial motive is one of the main motivations for gambling. Despite this, and contrary to other addictive behaviours that involve money such as compulsive buying, gambling has never been studied from a materialism perspective. The objective of the present study was to explore the links b...
Article
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Purpose: To investigate the clinical and virologic-associated and predictive factors of intraocular pressure (IOP) evolution over time and its severity in Fuchs' heterochromic iridocyclitis (FHC). Methods: Consecutive patients with both clinical FHC and intraocular synthesis of rubella virus (RV)-specific antibodies were included in this study....
Article
Full-text available
La détresse émotionnelle liée au diabète impacte la qualité de vie et l’équilibre métabolique ce qui rend indispensable l’exploration du vécu de la maladie. Nous avons comparé 2 approches de médecine narrative, un atelier d’écriture où le patient écrit « une lettre à son diabète » (LAMD) et le « théâtre du vécu » (TDV) où un récit est transformé en...
Article
Full-text available
Objectives To analyze long‐term cognitive status and function after cochlear implantation in profoundly deaf individuals. Design Prospective observational longitudinal study. Setting Ten academic medical centers referent for cochlear implantation. Participants Individuals aged 65 and older who qualified for cochlear implantation (N=70). Measure...
Article
Full-text available
Background: Postoperative operative pulmonary complications (PPCs) after hepatic surgery are associated with increased length of hospital stays. Intraoperative blood transfusion, extensive resection and different comorbidities have been identified. Other parameters, like time of hepatic ischemia, have neither been clinically studied, though experim...
Article
Full-text available
OBJECTIVE In large vestibular schwannoma (VS) surgery, the facial nerve (FN) is at high risk of injury. Near-total resection has been advocated in the case of difficult facial nerve dissection, but the amount of residual tumor that should be left and when dissection should be stopped remain controversial factors. The objective of this study was to...
Article
Full-text available
Background: In patients with rheumatoid arthritis in remission, a disease activity-driven tapering of adalimumab or etanercept relying on progressive injection spacing has not been shown to be equivalent to a maintenance strategy at full dose in terms of disease activity in the Spacing of TNF-blocker injections in Rheumatoid ArthritiS Study (STRAS...
Article
Full-text available
Background Disease activity may change over time in axial spondyloarthritis (axSpA). The objectives were to identify patterns of disease activity evolution in patients with early axSpA. Methods Patients from the prospective early axSpA cohort (DEvenir des Spondyloarthrites Indifférenciées Récentes (DESIR)) who fulfilled the Assessment in SpondyloA...
Article
Full-text available
Objective: To assess through multivariate analysis the clinical pre- and intraoperative factors of facial nerve outcomes at day 8 and 1-year recovery of facial palsy, as compared with day 8 status among patients who underwent total resection of unilateral vestibular schwannoma. Study Design: Case series with chart review. Setting: Tertiary referral...
Thesis
Full-text available
Patient-Reported Outcomes are increasingly used in health-related research. These instruments allow the assessment of subjective concepts such as Health-Related Quality of Life, anxiety level, pain or fatigue. Initially, the interpretation of a difference in score over time was based on the assumption that the meaning of concepts and measurement s...
Article
Full-text available
Objective: To report the speech performance and sound localization in adult patients 5 years after bilateral simultaneous cochlear implantation and to evaluate the change in speech scores between 1 and 5 years. Design: In this prospective multicenter study, 26 patients were evaluated 5 years after implantation using long straight electrode array...
Article
Purpose: To determine the prognostic factors of long-term visual outcome in Birdshot Retinochoroidopathy (BRC). Methods: Design: Retrospective case series. Study population: Successive HLA-A29+ BRC patients whose latest visit was between May and August 2013 at a single tertiary centre (Pitié-Salpétrière Hospital, Paris). Observation procedure...
Article
Full-text available
The prevention of addictions in young people is a challenge for Mental and Public Health policies, and requires specific risk-screening tools. Specific personality traits, as assessed using the Substance Use Risk Profile Scale (SURPS), could play a key role in the onset and escalation of substance use. This study aimed to examine 1) measurement inv...
Article
Full-text available
Triple-negative breast cancers need to be refined in order to identify therapeutic subgroups of patients. We conducted an unsupervised analysis of microarray gene-expression profiles of 107 triple-negative breast cancer patients and undertook robust functional annotation of the molecular entities found by means of numerous approaches including immu...
Article
Full-text available
To determine the statistical correlation between visual acuity (VA) and various quantitative parameters relevant to Birdshot Retinochoroidopathy (BRC) evaluation. Hospital-based retrospective observational study. SettingInstitutional. Consecutive HLA29+ BRC patients were included between May and August 2013 at a single tertiary centre (Pitié-Salpét...
Conference Paper
Background Once remission is achieved for patients with rheumatoid arthritis (RA), treatment down-titration should be attempted, for safety issues or economic reasons. One of the proposed strategies, recently tested in the STRASS trial [1], is to progressively space injections of TNF-blockers. Objectives To assess the Incremental Cost-Effectiveness...
Conference Paper
Background Disease activity over time in axial spondyloarthritis (axSpA) can be heterogeneous, and studies aiming to identify patterns of disease activity are sparse. In other disciplines, trajectory modelling have been applied to identify patterns of behaviour (trajectories) but no studies have attempted to distinguish subgroups with common diseas...
Article
Full-text available
This simulation study was designed to provide data on the performance of Oort's procedure (OP) for response shift (RS) detection (regarding type I error, power, and overall performance), according to sample characteristics, at item level. A specific objective was to assess the impact of using different information criteria (IC), as alternatives to...
Article
Full-text available
Some IRT models have the advantage of being robust to missing data and thus can be used with complete data as well as different patterns of missing data (informative or not). The purpose of this paper was to develop an algorithm for response shift (RS) detection using IRT models allowing for non-uniform and uniform recalibration, reprioritization R...
Article
Full-text available
The objective of this work was to detail the incidence and mortality trends of invasive and in situ breast cancer (BC) in France, especially regarding the development of screening, over the 1990-2008 period. Data issued from nine population-based cancer registries were studied. The incidence of invasive BC increased annually by 0.8 % from 1990 to 1...
Article
Full-text available
Purpose: Comparisons of breast cancer characteristics between organized and opportunistic screening have been limited. This study was designed to compare characteristics of cancers detected by either organized or opportunistic screening as well as clinically diagnosed cancers in Loire-Atlantique (a French administrative entity), from 2003 to 2007....
Chapter
Le cancer du sein est le cancer le plus fréquent et la première cause de mortalité par cancer chez la femme en France. Le programme de dépistage organisé (DO) a démarré dans des départements pilotes à la fin des années 1980 et a été généralisé à l’ensemble des départements français en 2004. L’impact du DO sur la mortalité par cancer du sein et sur...
Article
Full-text available
Inappropriate prescribing in elderly is considered as common (40% of subjects from community from the 3CStudy in France had a inappropriate prescription, using Beer's criteria), and can lead to severe issues. Few studies have assessed inappropriate prescribing for elderly inpatients in acute care, with multiple tools. Our study was designed to asse...
Conference Paper
Background and objectives The development of morbidity-mortality reviews (MMR) in high-risk units is one of the main objectives of the quality improvement policy of Nantes university hospital. Currently, 25 units are engaged in the analysis of clinical adverse events. Our surgical intensive care unit (ICU) was a forerunner in implementing this poli...

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Projects

Projects (3)
Project
Patients Reported Outcomes (PRO) are often used in Clinical Research, mainly with the use of a score. The notion of Minimal Clinically Important difference (MCID) represents a real help for interpretation. Two main problems coexist for the MCID determination: 1. The absence of property of Interval Measure (IM) for the score having as a consequence a dependence between the MCID and the initial score of the patients; 2. The presence of Response-Shift (RS) [the perception of the measured concept by the patients changes over time]. The Rasch family models (RFM) shows several advantages compared to the score. They allow creating a measure with the IM property, and allow obtaining no bias in presence of missing data. The objective of this project is to define a MCID detection procedure in the classical and in the RFM frameworks in presence of RS and of missing data and to compare them.
Archived project
This is a collection of early works on Response Shift theory in the field of Patient-Reported Outcomes data analyses that are subsumed in the form of a PhD Thesis in Biostatistics. Here you can find the whole manuscript of the Thesis (which contains additional material to the published papers and communications) as well as published papers and communications related to the studies in the Thesis. The Thesis is composed of six main parts: _ An introduction, with a brief attempt to demonstrate that on a epistemological level, the issue of response shift in PRO analysis can be anticipated; _ A chapter of theoretical prerequisites that are the basis of the measurement of subjective concepts. In short, the notion of health, Patient-Centered Outcomes Research, Patient-Reported Outcomes and Quality of Life are defined. Then the basics in psychometrics, especially regarding the different measurement models, are presented; _ A state of the art of the international works conducted on response shift, mostly in the field of health-related research. The core idea of this part was to broadly develop various aspects related to response shift theory: like an historical perspective showing how the occurrence of the response shift notion in psychology was further translated in health-related research, the evolution of the theoretical models linking response shift to perceived HRQL, the various debates and controversies about the meaning of the occurrence of response shift phenomenon, as well as the different methods developed to detect response shift and a synthesis of major empirical results. This part was redacted to be included as a chapter of a book about the issues regarding the measurement of change in perceived health in patients living with a chronic disease; _ An original work on Oort's Procedure performances at item-level via a pilot simulation study; _ An original work exploring a theoretical hypothesis, which is a potential link between the occurrence of recoonceptualization and reprioritization response shift and the semantic complexity of concepts measured in health-related research; _ A last part dedicated to discuss some of the main results or proposals of the two original works of this thesis (the fourth and fifth part). Regarding the simulation study, the main limit (the fact an a priori inadequate estimator has been used) was discussed with more depth, along with the introduction of additional analyses performed after the publication of the seminal paper which has helped to better apprehend the potential robustness of the original results. Then, some proposals about potential refinements of the Oort's Procedure algorithm were discussed. Then, some questions about the links between operationalization and interpretation of response shift at item-level using SEM wiere proposed. A second chapter was dedicated to discuss the fifth part of the manuscript (i.e. semantic primes and response shift paper). First, a discussion about the issue of recalibration response shift in this context was introduced. Finally, this theoretical proposal was used as an example to illustrate a larger issue which is to find an adequate balance between studying complex phenomena and planning experimental designs.
Archived project