Antoine Lutz

Antoine Lutz
French Institute of Health and Medical Research | Inserm · Centre de Recherche en Neurosciences de Lyon U1028

PhD

About

131
Publications
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14,328
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Publications

Publications (131)
Preprint
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Despite attempts to unify the different theoretical accounts of the mismatch negativity (MMN), there is still an ongoing debate on the neurophysiological mechanisms underlying this complex brain response. On one hand, neuronal adaptation to recurrent stimuli is able to explain many of the observed properties of the MMN, such as its sensitivity to c...
Preprint
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Objectives Older adults with subjective cognitive decline (SCD) recruited from memory clinics have an increased risk of developing dementia and regularly experience reduced psychological well-being related to memory concerns and fear of dementia. Research on improving well-being in SCD is limited and lacks non-pharmacological approaches. We investi...
Article
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Background Older individuals with subjective cognitive decline (SCD) perceive that their cognition has declined but do not show objective impairment on neuropsychological tests. Individuals with SCD are at elevated risk of objective cognitive decline and incident dementia. Non-pharmacological interventions (including mindfulness-based and health se...
Article
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Mindfulness-based programs (MBPs) are increasingly utilized to improve mental health. Interest in the putative effects of MBPs on cognitive function is also growing. This is the first meta-analysis of objective cognitive outcomes across multiple domains from randomized MBP studies of adults. Seven databases were systematically searched to January 2...
Preprint
The perception of pain is sensitive to various mental processes such as expectation about the nociceptive stimulus or individual differences in the affective and cognitive evaluations of pain. A promising candidate to study the neurocomputational principles of pain perception is the theory of predictive processing which offers a general framework t...
Article
Background and Objectives Self-reflection (the active evaluation of ones thoughts, feelings and behaviours) can confer protection against adverse health outcomes. Its impact on markers sensitive to Alzheimer’s disease (AD), however, is unknown. The primary objective of this cross-sectional study was to examine the association between self-reflectio...
Article
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Background: This study assesses the relationships between dynamic functional network connectivity (DFNC) and dementia risk. Methods: DFNC of the default mode (DMN), salience (SN), and executive control networks was assessed in 127 cognitively unimpaired older adults. Stepwise regressions were performed with dementia risk and protective factors a...
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Studies purporting to show changes in brain structure following the popular, 8-week mindfulness-based stress reduction (MBSR) course are widely referenced despite major methodological limitations. Here, we present findings from a large, combined dataset of two, three-arm randomized controlled trials with active and waitlist (WL) control groups. Med...
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This paper presents a version of neurophenomenology based on generative modelling techniques developed in computational neuroscience and biology. Our approach can be described as computational phenomenology because it applies methods originally developed in computational modelling to provide a formal model of the descriptions of lived experience in...
Article
Full-text available
The auditory mismatch negativity (MMN) is a well characterized event-related potential component which has gained recent attention in theoretical models describing the impact of various styles of mindfulness meditation on attentional processes and perceptual inference. Previous findings highlighted a distinct modulation of the MMN amplitude by diff...
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Full-text available
Objectives Deepening our understanding of the mechanisms by which meditation practices impact well-being and human flourishing is essential for advancing the science of meditation. A recent phenomenologically grounded classification system distinguishes attentional, constructive, and deconstructive forms of meditation based on the psychological mec...
Article
Subjective cognitive decline (SCD) denotes self‐reported cognitive concerns in the absence of objective cognitive impairment. Individuals with SCD convert to dementia at twice the annual rate of healthy controls, with relatively poorer cognition in SCD conferring additional risk. Non‐pharmacological interventions are currently undergoing intensive...
Article
Self‐reflection is conceptualised as an introspective process that involves active evaluation of one’s thoughts, feelings and behaviours. Engagement in self‐reflection is thought to yield more adaptive stress responses, that in turn result in better short‐term (e.g., reduced inflammatory responses to stressors) and long‐term (e.g., recovery from ma...
Article
Purpose Intracranial electroencephalography (iEEG) offers a unique window on brain dynamics with excellent temporal and spatial resolution and is less prone to recording artefacts than surface EEG. This study used a within-subject design to explore the feasibility to compare iEEG data during mind wandering, mindfulness meditation and hypnosis. Res...
Article
Alzheimer's disease (AD) represents a major health and societal issue; there is no treatment to date and the pathophysiological mechanisms underlying this disease are not well understood. Yet, there is hope that AD risk factors and thus the number of AD cases can be significantly reduced by prevention measures based on lifestyle modifications as ta...
Preprint
Full-text available
The auditory mismatch negativity (MMN) is a well characterized event-related potential component which has gained recent attention in theoretical models describing the impact of various styles of mindfulness meditation on attentional processes and perceptual inference. Previous findings highlighted a differential modulation of the MMN amplitude by...
Article
Full-text available
Meta-awareness refers to the capacity to explicitly notice the current content of consciousness and has been identified as a key component for the successful control of cognitive states, such as the deliberate direction of attention. This paper proposes a formal model of meta-awareness and attentional control using hierarchical active inference. To...
Article
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Réponse à une tribune de la Ligue des droits de l'homme qui s'inquiétait des dangers de la méditation de pleine conscience pour les enfants.
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Introduction: Older adults experiencing subjective cognitive decline (SCD) have a heightened risk of developing dementia and frequently experience subclinical anxiety, which is itself associated with dementia risk. Objective: To understand whether subclinical anxiety symptoms in SCD can be reduced through behavioral interventions. Methods: SCD...
Preprint
Full-text available
Objectives: Deepening our understanding of the mechanisms by which meditation practices impact well-being and human flourishing is essential for advancing the science of meditation. The phenomenologically grounded classification system introduced by Dahl, Lutz, and Davidson (2015) distinguishes attentional, constructive, and deconstructive forms of...
Article
Full-text available
Attribution of responsibility for the causes of suffering is one of the main factors that influence responses to individuals in distress. While the role of attributional processes on prosocial motivation has been widely investigated in social psychology, only few attempts have been made to characterize their behavioural and neurophysiological under...
Article
Full-text available
Background The way people respond to pain is based on psychological mechanisms, beliefs and expectations. Mindfulness meditation (MM) has been shown to regulate pain and mental suffering through different mechanisms such as positive reappraisal, attentional and emotional regulation. Yet, subjective experience and meaning of pain in connection with...
Article
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Objective: Mindfulness meditation can downregulate the experience of pain. However, its specific underlying regulatory mechanisms are still largely unknown. Here, we aimed to investigate the role of cognitive defusion - a form of psychological distancing from internal experiences- in mindfulness-based pain regulation. Methods: We implemented a t...
Preprint
Full-text available
Background: The way people respond to pain is based on psychological mechanisms, beliefs and expectations. Mindfulness meditation (MM) has been shown to regulate pain and mental suffering through different mechanisms such as positive reappraisal, attentional and emotional regulation. Yet, subjective experience and meaning of pain in connection with...
Preprint
Full-text available
This paper presents a version of neurophenomenology based on generative modelling techniques developed in computational neuroscience and biology. We call this approach computational phenomenology because it applies methods originally developed in computational modelling to phenomenology. The first section presents a brief review of the project to n...
Article
Reflective pondering is an introspective mechanism conceptualised as actively seeking a solution to one’s problems. Literature has consistently demonstrated positive associations between reflective pondering and improved mental health outcomes in clinical populations. Given that poor mental health (e.g. depression, anxiety) has been associated with...
Article
Full-text available
The primary focus of mindfulness‐based program (MBP) research to date has been on mental health. More recently, attention has turned to putative effects on cognition. An evidence synthesis is required to answer the key question of ‘Do MBPs confer cognitive benefit, and if so, for whom?’ A particularly crucial distinction is whether benefits differ...
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Introduction: Non-pharmacological treatments (NPTs) have the potential to improve meaningful outcomes for older people at risk of, or living with dementia, but research often lacks methodological rigor and continues to produce mixed results. Methods: In the current position paper, experts in NPT research have specified treatment targets, aims, a...
Preprint
Full-text available
Metacognition refers to the capacity to access, monitor, and control aspects of one’s mental operations and is central to the human condition and experience. Disorders of metacognition are a hallmark of many psychiatric conditions and the training of metacognitive skills is central in education and in many psychotherapies. This paper provides first...
Preprint
Full-text available
Attribution of responsibility for the causes of suffering is one of the main factors that influence responses to individuals in distress. While the role of attributional processes on prosocial motivation has been widely investigated in social psychology, only few attempts have been made to characterize their behavioural and neurophysiological under...
Article
Full-text available
Background Mindfulness meditation can alleviate acute and chronic pain. It has been proposed that mindfulness meditation reduces pain by uncoupling sensory and affective pain dimensions. However, studies to date have reported mixed results, possibly due to a diversity of styles of and expertise in mindfulness meditation. Furthermore, the interrelat...
Article
Importance Increasing evidence suggests that sleep-disordered breathing (SDB) increases the risk of developing Alzheimer clinical syndrome. However, the brain mechanisms underlying the link between SDB and Alzheimer disease are still unclear. Objective To determine which brain changes are associated with the presence of SDB in older individuals wh...
Article
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Awareness of mental events as mere representations rather than as accurate depictions of reality, also known as dereification, is one of the key features of mindfulness meditation. Dereification is juxtaposed to subjective realism, the process of being lost or totally immersed in the contents of one's mind. Excessive subjective realism is a hallmar...
Article
The human methylome is dynamically influenced by psychological stress. However, its responsiveness to stress management remains underexplored. Meditation practice has been shown to significantly reduce stress level, among other beneficial neurophysiological outcomes. Here, we evaluated the impact of a day of intensive meditation practice (t2-t1 = 8...
Article
Full-text available
Objectives Three previous clinical trials have shown that mindfulness-based interventions reduce depressive symptoms and improve quality of life in epilepsy. We conducted a qualitative study to gain more insight into the relevant aspects of mindfulness-based interventions for people with this condition. Methods We conducted a mindfulness-based int...
Article
Full-text available
Interest has grown in using mindfulness meditation to treat conditions featuring excessive impulsivity. However, while prior studies find that mindfulness practice can improve attention, it remains unclear whether it improves other cognitive faculties whose deficiency can contribute to impulsivity. Here, an eight-week mindfulness intervention did n...
Preprint
Background: Mindfulness Based Stress Reduction (MBSR) is a secular form of meditation training. The vast majority of the extant literature investigating the health effects of mindfulness interventions relies on wait-list control comparisons. Previous studies have found that meditation training over several months is associated with improvements in...
Article
The surge of interest about mindfulness meditation is associated with a growing empirical evidence about its impact on the mind and body. Yet, despite promising phenomenological or psychological models of mindfulness, a general mechanistic understanding of meditation steeped in neuroscience is still lacking. In parallel, predictive processing appro...
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There is increasing evidence that meditation-based training promotes healthy ageing across many dimensions. This review summarizes the existing knowledge on the effects of meditation training on healthy ageing in the domains of emotions, cognition (with a special emphasis on attentional processes), and the preservation of related brain structures....
Article
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Objective: A recent neurocomputational model proposed that anxious hypervigilance impedes perceptual learning. This view is supported by the observed modulation of the mismatch negativity (MMN), a biomarker of implicit perceptual learning processes, in anxiety disorders. However, other studies found that anxious states sensitize brain responses wi...
Preprint
The surge of interest about mindfulness meditation is associated with a growing empirical evidence about its impact on the mind and body. Yet, despite promising phenomenological or psychological models of mindfulness, a general mechanistic understanding of meditation steeped in neuroscience is still lacking. In parallel, predictive processing appro...
Article
Full-text available
Empirical descriptions of the phenomenology of meditation states rely on practitioners' ability to provide accurate information on their experience. We present a meditation training protocol that was designed to equip naive participants with a theoretical background and experiential knowledge that would enable them to share their experience. Subseq...
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Full-text available
Introduction The Age-Well observational, cross-sectional study investigates the affective and cognitive mechanisms of meditation expertise with behavioral, neuroimaging, sleep, and biological measures sensitive to aging and Alzheimer's disease (AD). Methods Thirty cognitively unimpaired individuals aged 65 years or older with at least 10,000 hours...
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Full-text available
Introduction The Age-Well clinical trial is an ongoing monocentric, randomized, controlled trial aiming to assess an 18-month preventive meditation-based intervention directly targeting the attentional and emotional dimensions of aging to promote mental health and well-being in elderly people. Methods One hundred thirty-seven cognitively unimpaire...
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Full-text available
Introduction Subjectively experienced cognitive decline in older adults is an indicator of increased risk for dementia and is also associated with increased levels of anxiety symptoms. As anxiety is itself emerging as a risk factor for cognitive decline and dementia, the primary question of the present study is whether an 8-week mindfulness-based i...
Article
Full-text available
Our recent finding of a meditation‐related increase in low‐frequency NREM sleep EEG oscillatory activities peaking in the theta‐alpha range (4‐12 Hz) was not predicted. From a consolidated body of research on sleep homeostasis, we would expect a change peaking in slow wave activity (1‐4 Hz) following an intense meditation session. Here we compared...
Article
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It is often assumed that during rapid eye movement (REM) sleep the cerebral cortex homogenously shows electroencephalogram (EEG) activity highly similar to wakefulness. However, to date no studies have compared neural oscillatory activity in human REM sleep to resting wakefulness with high spatial sampling. In the current study, we evaluated high-r...
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Meditation training can improve mood and emotion regulation, yet the neural mechanisms of these affective changes have yet to be fully elucidated. We evaluated the impact of long- and short-term mindfulness meditation training on the amygdala response to emotional pictures in a healthy, non-clinical population of adults using blood-oxygen level dep...
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Non-dual meditation aims to undo maladaptive cognitive and affective patterns by recognizing their constructed and transient nature. We previously found high-amplitude spontaneous gamma (25-40Hz) oscillatory activity during such practice. Nonetheless, it is unclear how this meditation state differs from other practices, in terms of perceptual infor...
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Psycho-affective states or traits such as stress, depression, anxiety and neuroticism are known to affect sleep, cognition and mental health and well-being in aging populations and to be associated with increased risk for Alzheimer's disease (AD). Mental training for stress reduction and emotional and attentional regulation through meditation pract...
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Contemplative practices that extend back thousands of years show a multitude of benefits for both body and mind
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Aging is associated with progressive cerebral volume and glucose metabolism decreases. Conditions such as stress and sleep difficulties exacerbate these changes and are risk factors for Alzheimer’s disease. Meditation practice, aiming towards stress reduction and emotion regulation, can downregulate these adverse factors. In this pilot study, we ex...
Article
Full-text available
Immersing ourselves in food images can sometimes make it feel subjectively real, as if the actual food were right in front of us. Excessive self-immersion into mental content, however, is a hallmark of psychological distress, and of several psychiatric conditions. Being aware that imagined events are not necessarily an accurate depiction of reality...
Conference Paper
Full-text available
Meditation practice is a non-pharmacological intervention that provides both physical and mental benefits. It has generated much neuroscientific interest in its effects on brain activity. Spontaneous brain activity can be measured by electroencephalography (EEG). Spectral powers of EEG signals are routinely mapped on a topographic layout of channel...