Antoine Giraud

Antoine Giraud
University College Cork | UCC · INFANT Research Centre

M.D., Ph.D.

About

27
Publications
2,883
Reads
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105
Citations
Additional affiliations
November 2019 - September 2021
Centre Hospitalier Universitaire de Saint-Étienne
Position
  • Chef de Clinique des Universités – Assistant des Hôpitaux
November 2016 - October 2017
McGill University
Position
  • Research intern
Education
September 2015 - November 2020
University of Lyon
Field of study
  • Developmental Neurosciences
September 2008 - October 2019
Université Jean Monnet
Field of study
  • Pediatrics

Publications

Publications (27)
Article
Full-text available
Based on the review of the literature, perinatal inflammation often induced by infection is the only consistent independent risk factor of neonatal arterial ischemic stroke (NAIS). Preclinical studies show that acute inflammatory processes take place in placenta, cerebral arterial wall of NAIS-susceptible arteries and neonatal brain. A top research...
Article
Full-text available
Group B Streptococcus (GBS) is one of the most common bacteria isolated in human chorioamnionitis, which is a major risk factor for premature birth and brain injuries. Males are at greater risk than females for developing lifelong neurobehavioural disorders, although the origins of this sex bias remain poorly understood. We previously showed that e...
Article
Full-text available
Objective To test the association between exposure to perinatal inflammation – i.e. clinical chorioamnionitis or early-onset neonatal infection – in preterm children without severe neonatal brain injury and neurodevelopmental outcome at 30 months of corrected age (CA). Design Cross-sectional study from a French regional cohort of clinical follow-u...
Article
Full-text available
Background To summarise the association between perinatal inflammation (PI) exposure and electroencephalography (EEG) features in preterm infants. Methods This systematic review included clinical studies of preterm infants born <37 weeks of gestational age (GA), who had both a PI exposure and an EEG assessment performed during the neonatal period....
Article
Full-text available
While heart rate variability (HRV) is a relevant non-invasive tool to assess the autonomic nervous system (ANS) functioning with recognized diagnostic and therapeutic implications, the lack of knowledge on its interest in neonatal medicine is certain. This review aims to briefly describe the algorithms used to decompose variations in the length of...
Article
Full-text available
Preterm birth is defined as any birth occurring before 37 completed weeks of gestation by the World Health Organization. Preterm birth is responsible for perinatal mortality and long-term neurological morbidity. Acute chorioamnionitis is observed in 70% of premature labor and is associated with a heavy burden of multiorgan morbidities in the offspr...
Article
Du fait de sa soudaineté et de la nécessité de soins hyperurgents, l’accident vasculaire cérébral (AVC) est d’abord un drame personnel et familial, dont plus de deux tiers des enfants et des adultes garderont des conséquences toute la vie. Si cette double dimension précoce et de long terme traverse les âges, un troisième axe plus dynamique s’invite...
Article
Objective To compare the cesarean section rate before and after the introduction of an expectant management protocol in patients with abnormally progressing first-stage labor. Methods A prospective monocentric cohort study performed between January 2012 and July 2016. Results 267 patients were included, 97 in the control group and 170 in the stud...
Thesis
Full-text available
La période périnatale est une période critique du développement du parenchyme cérébral. L’impact d’un stress pro-inflammatoire durant cette période critique a été étudié à l’aide de travaux épidémiologiques et d’expérimentations précliniques. Différents aspects de l’impact de l’inflammation périnatale sur le cerveau en développement ont été abordés...
Article
Background: Antibiotic therapy during preterm labor with intact membranes has been associated with an increased risk of neonatal death. Objectives: Using an established rat model of group B Streptococcus (GBS)-induced chorioamnionitis, we hypothesized that ampicillin treatment increases placental inflammation, as shown in other bacterial infecti...
Article
This study aims to evaluate the analytical performance of the BD Veritor™ rapid diagnostic assays (RDTs) for respiratory syncytial virus (RSV) and influenzaviruses when performed 24/7 at bedside by nurses in the pediatric emergency department (PED). The study was performed between 14/10/2015 and 19/03/2016 on nasopharyngeal aspirates (NPAs) collect...
Article
Full-text available
Background While heart rate variability (HRV) constitutes a relevant non-invasive tool to assess the autonomic nervous system (ANS) function with recognized diagnostic or therapeutic implications, there is still a lack of established data on maturation of autonomic control of heart rate during the first months of life. The Autonomic Baby Evaluation...
Article
Objectives: This prospective study performed in the paediatric emergency department of the University Hospital of Saint-Etienne aimed to measure the impact of the 24/7 bedside use of the Veritor™ System (Becton Dickinson) on the reduction of supplementary investigations, hospital stay and antimicrobial use. Methods: Influenza virus A and B antig...
Article
Introduction Environ 30% des nouveau-nés sont exposés à une antibioprophylaxie intrapartum. La dernière méta-analyse Cochrane évaluant l’impact de l’antibiothérapie intrapartum dans la menace d’accouchement prématuré sans rupture des membranes a mis en évidence une augmentation significative de la mortalité néonatale associée à ce traitement (RR :...
Article
Objectif Sur la base de la litterature, nous faisons l’hypothese que l’hypoxie intermittente (HI) du syndrome d’apnees du sommeil (SAOS) jouerait un role majeur dans la genese des nombreuses complications neurologiques en favorisant l’apparition de modifications cerebrales propices au developpement de pathologies neurodegeneratives. Methodes Nous p...
Article
ARC syndrome (arthrogryposis - renal dysfunction - cholestasis) is a rare lethal multisystemic autosomal recessive disease. A newborn of consanguineous parents of Algerian descent presented cholestatic jaundice, dehydration, and Fanconi syndrome at 10 days of life. The blood smear showed a very characteristic gray appearance of platelets. A homozyg...
Poster
Full-text available
1. Introduction Le syndrome ARC (Arthrogrypose-atteinte rénale (tubulopathie proximale)-cholestase) est une maladie génétique rare, autosomique récessive, responsable d’une atteinte multisystémique rapidement létale. 2. Observation Cet enfant, issu de parents cousins germains, est né au terme d’une grossesse sans particularité. L’examen clinique in...
Poster
Full-text available
Introduction Le syndrome d’apnées obstructives du sommeil (SAOS) est une pathologie fréquente, aux conséquences neurologiques graves. Nous émettons l’hypothèse que celles-ci sont liées à une altération de la barrière hémato-encéphalique (BHE). Résultats Le test de perméabilité au bleu Evans a révélé une augmentation significative de la perméabilité...
Poster
Full-text available
1. Introduction Les Déficits Immunitaires Combinés Sévères (DICS) représentent un groupe hétérogène de déficits immunitaires cellulaires graves caractérisés par une lymphopénie sévère touchant les lymphocytes T. Leur incidence est estimée à 1/75000 naissances vivantes. Le déficit en Adénosine Désaminase 1 (ADA1) est une erreur innée du métabolisme...
Article
Severe combined immune deficiencies (SCIDs) are a heterogeneous group of severe cellular immunodeficiencies. Early diagnosis is essential to allow adapted care before life-threatening systemic infections or complications associated with live vaccines. Adenosine deaminase 1 deficiency (ADA1) is an inborn error of metabolism leading to severe lymphop...

Projects

Projects (2)
Project
Adult Emergencies have huge difficulties to struggle the crowding during winter seasons. The Influenza virus is of the main cause of this and the elderly people are of main concern. Recently we have shown that the VRS virus which impacts mostly the infant population also impacts the adult population. With suitable diagnostic codes (ICD-10) we are in position to show that the adult flow at the emergency can be predicted by the infant flow few weeks before the coming of elderly people. This project aims so at predicting the coming at emergencies based on the patient flow for infant diagnosed bronchiolitis.