About
43
Publications
4,912
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
255
Citations
Current institution
Additional affiliations
September 2022 - present
September 2021 - August 2022
November 2019 - September 2021
Position
- Chef de Clinique des Universités – Assistant des Hôpitaux
Education
September 2015 - November 2020
September 2008 - October 2019
Publications
Publications (43)
Objective
To test the association between exposure to perinatal inflammation – i.e. clinical chorioamnionitis or early-onset neonatal infection – in preterm children without severe neonatal brain injury and neurodevelopmental outcome at 30 months of corrected age (CA).
Design
Cross-sectional study from a French regional cohort of clinical follow-u...
Background
To summarise the association between perinatal inflammation (PI) exposure and electroencephalography (EEG) features in preterm infants.
Methods
This systematic review included clinical studies of preterm infants born <37 weeks of gestational age (GA), who had both a PI exposure and an EEG assessment performed during the neonatal period....
Aim
To test the association between perinatal inflammation exposure and Full‐Scale IQ (FSIQ) score 7 years after neonatal arterial ischaemic stroke (NAIS).
Method
We conducted a cross‐sectional ancillary study nested in a multicentric longitudinal French cohort of infants born at term with NAIS between November 2003 and October 2006. Seventy‐three...
Background: Neonatal arterial ischemic stroke (NAIS) is the most frequent subtype of perinatal stroke. Its elusive pathophysiology, its abrupt and unexpected occurrence, and the uncertainty of the post-NAIS developmental condition may lead to parental emotional distress and psychological difficulties. The aim of this study was to summarize the curr...
The General Movement Assessment (GMA) is a validated evaluation of brain maturation essential to shaping early individual developmental trajectories of preterm infants. To ensure a reliable GMA, preterm infants should be recorded for 30 to 60 min before manually selecting at least three sequences with general movements. This time-consuming task of...
Prediction of spontaneous preterm birth in asymptomatic women remains a great challenge for the public health system. The aim of the study was to determine the informational value of EG-VEGF circulating levels for prediction of spontaneous preterm birth in the second and third trimesters in pregnant women at high risk for placenta-mediated complica...
The developmental condition of children after neonatal arterial ischemic stroke (NAIS) is characterized by cognitive and motor impairments. We hypothesized that independent walking age would be a predictor of later global cognitive functioning in this population. Sixty-one children with an available independent walking age and full-scale IQ score s...
![2D pose estimation networks architectures: a) HRNet [38], b)...](publication/373107686/figure/fig5/AS:11431281225303630@1708658294437/2D-pose-estimation-networks-architectures-a-HRNet-38-b-HigherHRNet-8-HRNet_Q320.jpg)
Infant pose estimation is crucial in different clinical applications, including preterm automatic general movements assessment. Recent infant pose estimation methods are limited by a lack of real clinical data and are mainly focused on 2D detection. We introduce a stereoscopic system for infants’ 3D pose estimation, based on fine-tuning state-of-th...
The General Movement assessment (GMA) is a validated assessment of brain maturation primarily based on the qualitative analysis of the complexity and the variation of spontaneous motor activity. The GMA can identify preterm infants presenting an early abnormal developmental trajectory before term-equivalent age, which permits a personalized early d...
Background:
Prediction of spontaneous preterm birth in asymptomatic women remains a great challenge for the public health system. The aim of the study was to determine the informational value of EG-VEGF circulating levels in pregnant women at high risk for prediction of spontaneous preterm birth in the second and third trimesters.
Methods:
A pros...
Objective:
To compare the delivery mode after labor induction with 10 mg vaginal dinoprostone insert versus oral misoprostol 50 µg/4 h for women with an unfavorable cervix.
Material and methods:
This is a retrospective observational study comparing the before/after introduction of oral misoprostol for labor induction, conducted at the Saint-Étie...
The evaluation of the autonomic reactivity of newborns by heart rate variability (HRV) analysis is a simple and essential aid to identifying pathological situations of dysautonomia. Thanks to this relatively simple and reproducible analytic tool, the pediatrician can identify and target children at high risk of life-threatening events, i.e., those...
(1) Background: The Ages and Stages Questionnaire—Third Edition (ASQ-3) is a parental screening questionnaire increasingly being used to evaluate the development of preterm children. We aimed to assess the classification performance of the ASQ-3 in preterm infant follow-up. (2) Methods: In this cross-sectional study, we included 185 children from t...
Background: The theory that D-dimer level might has a predictive or diagnostic role in preeclampsia needs to be explored. Aim of the study was to evaluate the association between serum D-dimer level and the occurrence of placenta-mediated complications (PMC) in a pregnant population at high risk.
Methods: A prospective multicenter cohort study incl...
Objective:
The aim of this study was to evaluate the pain experience of women induced by intravaginal dinoprostone (Propess®), oral misoprostol (Angusta®) or double balloon catheter (Cook®).
Methods:
This single-center prospective study was carried out in the obstetric gynecology department of the university hospital of Saint-Etienne from March...
While heart rate variability (HRV) is a relevant non-invasive tool to assess the autonomic nervous system (ANS) functioning with recognized diagnostic and therapeutic implications, the lack of knowledge on its interest in neonatal medicine is certain. This review aims to briefly describe the algorithms used to decompose variations in the length of...
Preterm birth is defined as any birth occurring before 37 completed weeks of gestation by the World Health Organization. Preterm birth is responsible for perinatal mortality and long-term neurological morbidity. Acute chorioamnionitis is observed in 70% of premature labor and is associated with a heavy burden of multiorgan morbidities in the offspr...
Du fait de sa soudaineté et de la nécessité de soins hyperurgents, l’accident vasculaire cérébral (AVC) est d’abord un drame personnel et familial, dont plus de deux tiers des enfants et des adultes garderont des conséquences toute la vie. Si cette double dimension précoce et de long terme traverse les âges, un troisième axe plus dynamique s’invite...
Objective
To compare the cesarean section rate before and after the introduction of an expectant management protocol in patients with abnormally progressing first-stage labor.
Methods
A prospective monocentric cohort study performed between January 2012 and July 2016.
Results
267 patients were included, 97 in the control group and 170 in the stud...
La période périnatale est une période critique du développement du parenchyme cérébral. L’impact d’un stress pro-inflammatoire durant cette période critique a été étudié à l’aide de travaux épidémiologiques et d’expérimentations précliniques. Différents aspects de l’impact de l’inflammation périnatale sur le cerveau en développement ont été abordés...
Background:
Antibiotic therapy during preterm labor with intact membranes has been associated with an increased risk of neonatal death.
Objectives:
Using an established rat model of group B Streptococcus (GBS)-induced chorioamnionitis, we hypothesized that ampicillin treatment increases placental inflammation, as shown in other bacterial infecti...
Group B Streptococcus (GBS) is one of the most common bacteria isolated in human chorioamnionitis, which is a major risk factor for premature birth and brain injuries. Males are at greater risk than females for developing lifelong neurobehavioural disorders, although the origins of this sex bias remain poorly understood. We previously showed that e...
This study aims to evaluate the analytical performance of the BD Veritor™ rapid diagnostic assays (RDTs) for respiratory syncytial virus (RSV) and influenzaviruses when performed 24/7 at bedside by nurses in the pediatric emergency department (PED). The study was performed between 14/10/2015 and 19/03/2016 on nasopharyngeal aspirates (NPAs) collect...
Background
While heart rate variability (HRV) constitutes a relevant non-invasive tool to assess the autonomic nervous system (ANS) function with recognized diagnostic or therapeutic implications, there is still a lack of established data on maturation of autonomic control of heart rate during the first months of life. The Autonomic Baby Evaluation...
Objectives:
This prospective study performed in the paediatric emergency department of the University Hospital of Saint-Etienne aimed to measure the impact of the 24/7 bedside use of the Veritor™ System (Becton Dickinson) on the reduction of supplementary investigations, hospital stay and antimicrobial use.
Methods:
Influenza virus A and B antig...
Introduction
Environ 30% des nouveau-nés sont exposés à une antibioprophylaxie intrapartum. La dernière méta-analyse Cochrane évaluant l’impact de l’antibiothérapie intrapartum dans la menace d’accouchement prématuré sans rupture des membranes a mis en évidence une augmentation significative de la mortalité néonatale associée à ce traitement (RR :...
Based on the review of the literature, perinatal inflammation often induced by infection is the only consistent independent risk factor of neonatal arterial ischemic stroke (NAIS). Preclinical studies show that acute inflammatory processes take place in placenta, cerebral arterial wall of NAIS-susceptible arteries and neonatal brain. A top research...
Objectif
Sur la base de la litterature, nous faisons l’hypothese que l’hypoxie intermittente (HI) du syndrome d’apnees du sommeil (SAOS) jouerait un role majeur dans la genese des nombreuses complications neurologiques en favorisant l’apparition de modifications cerebrales propices au developpement de pathologies neurodegeneratives.
Methodes
Nous p...
ARC syndrome (arthrogryposis - renal dysfunction - cholestasis) is a rare lethal multisystemic autosomal recessive disease. A newborn of consanguineous parents of Algerian descent presented cholestatic jaundice, dehydration, and Fanconi syndrome at 10 days of life. The blood smear showed a very characteristic gray appearance of platelets. A homozyg...
1. Introduction Le syndrome ARC (Arthrogrypose-atteinte rénale (tubulopathie proximale)-cholestase) est une maladie génétique rare, autosomique récessive, responsable d’une atteinte multisystémique rapidement létale. 2. Observation Cet enfant, issu de parents cousins germains, est né au terme d’une grossesse sans particularité. L’examen clinique in...
Introduction Le syndrome d’apnées obstructives du sommeil (SAOS) est une pathologie fréquente, aux conséquences neurologiques graves. Nous émettons l’hypothèse que celles-ci sont liées à une altération de la barrière hémato-encéphalique (BHE). Résultats Le test de perméabilité au bleu Evans a révélé une augmentation significative de la perméabilité...
1. Introduction Les Déficits Immunitaires Combinés Sévères (DICS) représentent un groupe hétérogène de déficits immunitaires cellulaires graves caractérisés par une lymphopénie sévère touchant les lymphocytes T. Leur incidence est estimée à 1/75000 naissances vivantes. Le déficit en Adénosine Désaminase 1 (ADA1) est une erreur innée du métabolisme...
Severe combined immune deficiencies (SCIDs) are a heterogeneous group of severe cellular immunodeficiencies. Early diagnosis is essential to allow adapted care before life-threatening systemic infections or complications associated with live vaccines. Adenosine deaminase 1 deficiency (ADA1) is an inborn error of metabolism leading to severe lymphop...
