Anthony G. Jay

Anthony G. Jay
Mayo Clinic - Rochester · Physiology

PhD

About

13
Publications
1,617
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338
Citations
Additional affiliations
August 2012 - August 2017
Boston University
Position
  • PhD Student

Publications

Publications (13)
Article
The association of unesterified fatty acid (FA) with the scavenger receptor CD36 has been actively researched, with focuses on FA and oxLDL uptake. CD36 has been shown to bind FA but this interaction has been poorly characterized to date. To gain new insights into the physiological relevance of binding of FA to CD36, we characterized FA binding to...
Article
Full-text available
Membrane-bound proteins have been proposed to mediate the transport of long-chain fatty acid (LCFA) transport through the plasma membrane (PM). These proposals are based largely on reports that PM transport of LCFA can be blocked by a number of enzymes and purported inhibitors of LCFA transport. Here, using the ratiometric pH indicator (2’,7’-bis-(...
Article
The dense formation of abnormal scar tissue after total knee arthroplasty results in arthrofibrosis, an unfortunate sequela of inflammation. The purpose of this study was to use a validated rabbit model to assess the effects on surgically-induced knee joint contractures of two combined pharmacological interventions: celecoxib (CXB) loaded on an imp...
Article
Total hip arthroplasty (THA) alleviates hip pain and improves joint function. Current implant design permits long-term survivorship of THAs, but certain metal-on-metal (MoM) articulations can portend catastrophic failure due to adverse local tissue reactions (ALTR). Here, we identified biological and molecular differences between periacetabular syn...
Article
Full-text available
CD36 is a multifunctional protein that enhances cellular fatty acid (FA) uptake, a key step in energy metabolism, and its dysregulation in multiple tissue sites is central to obesity-linked diabetes, a risk factor for atherosclerosis. Although CD36 has been implicated in FA uptake in a correlative way, the molecular mechanisms are not known. Their...
Article
Aims Arthrofibrosis is a relatively common complication after joint injuries and surgery, particularly in the knee. The present study used a previously described and validated rabbit model to assess the biomechanical, histopathological, and molecular effects of the mast cell stabilizer ketotifen on surgically induced knee joint contractures in fema...
Article
Arthrofibrosis is a common complication following total knee arthroplasty (TKA) caused by pathologic fibroblast activation and excessive collagen deposition around a synovial joint leading to debilitating loss of motion. Treatment options are limited because the pathologic mechanisms remain to be characterized. Dysregulation of the inflammatory cas...
Article
Full-text available
Membrane organization and fluidity research continues to expand and the understanding of membrane dynamics continues to be refined. Within this field of study, laurdan remains among the most popular, versatile, and established fluorescence probes. Fluorimetry and multiphoton microscopy techniques are standards for measuring laurdan fluorescence and...
Article
The scavenger receptor CD36 binds numerous small biomolecules, including fatty acids, and even large ligands such as oxidized LDL, for which it is considered a receptor. Although CD36 has often been postulated to “transport” fatty acids across the plasma membrane, fatty acids translocation (mass transport or kinetics) was not affected by expression...
Article
Retromer deficiency has been implicated in sporadic AD and animals deficient in retromer components exhibit pronounced neurodegeneration. Because retromer performs retrograde transport from the endosome to the Golgi apparatus and neuronal Aβ is found in late endosomal compartments, we speculated that retromer malfunction might enhance amyloidogenic...

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